Simple blood test could spare prostate cancer patients from unnecessary scans

NCT ID NCT07553754

Recruiting now Diagnosis Sponsor: Xijing Hospital Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study aims to develop a blood test that detects RNA from tiny particles (exosomes) to predict if prostate cancer has spread to the bones. Researchers will analyze blood samples from 1,000 men with newly diagnosed prostate cancer and compare results with PSMA PET scans. The goal is to create a test that can reliably rule out bone metastasis, potentially reducing the need for expensive imaging in low-risk patients.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Plasma exosomal RNA signature (liquid biopsy test)
What this could lead to: If successful, this blood test could safely rule out bone metastasis in low-risk prostate cancer patients, avoiding unnecessary PSMA PET scans and reducing healthcare costs.
What could go wrong: This is an early-phase diagnostic study with a target specificity of only 30%, meaning many patients may still need imaging. The test is not yet validated for routine clinical use.

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Conditions

The condition(s) this trial relates to.

disease metastatic carcinoma in the bone prostate cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BIOMARKER DISCOVERY AND VALIDATION BONE METASTASIS EXOSOMAL RNA LIQUID BIOPSY PROSTATE CANCER (DIAGNOSIS) PSMA PET TREAMENT-NAIVE

Contacts and locations

Locations

Affiliated Hospital of Yan'an University
RECRUITING

Yan’an, Shaanxi, China
General Hospital of Ningxia Medical University
RECRUITING

Yinchuan, Ningxia, China
Qinghai University Affiliated Hospital
RECRUITING

Xining, Shaanxi, China
Shaanxi Provincial People's Hospital
RECRUITING

Xi'an, Shaanxi, China
The First Hospital of Lanzhou University
RECRUITING

Lanzhou, Gansu, China
The Second Affiliated Hospital of Shaanxi University of Chinese Medicine
RECRUITING

Xianyang, Shaanxi, China
Weinan Central Hospital
RECRUITING

Weinan, Shaanxi, China
Xijing 986 Hospital
RECRUITING

Xi'an, Shaanxi, China
Xijing Hospital
RECRUITING

Xi'an, Shaanxi, 710032, China

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