Gum disease clues: could hippo proteins be the missing link?
NCT ID NCT07759466
First seen Aug 12, 2026 · Last updated Aug 14, 2026 · Updated 2 times
Summary
This study investigates whether proteins from the Hippo signaling pathway—known to control cell growth and bone health—are present at different levels in the gum fluid of people with healthy gums, gingivitis, or periodontitis. Researchers will collect fluid samples from 75 participants and measure these proteins along with markers of cell death and bone metabolism. The goal is to see if these proteins could serve as indicators of periodontal disease activity or progression.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- ELISA biomarker analysis of gingival crevicular fluid
- What this could lead to
- If certain Hippo pathway proteins are found at different levels in gum disease, they could become biomarkers for early detection or targets for new treatments.
- What could go wrong
- This is a small observational study, so it can only show associations, not cause and effect. The findings may not apply to everyone or lead to practical tests.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Inonu University Faculty of Dentistry
Malatya, 44210, Turkey (Türkiye)
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