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Can a single shot of long-acting anesthetic ease gum surgery pain for longer?

NCT ID NCT07725731

Symptom relief Sponsor: The University of Texas Health Science Center at San Antonio Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 24, 2026 · Last updated Jul 28, 2026 · Updated 2 times

Summary

This trial tests whether a long-acting anesthetic called liposomal bupivacaine can reduce pain after gum surgery better than the standard medium-acting anesthetic. Adults scheduled for gum surgery on 2 to 5 teeth will receive one of the two anesthetics injected near the surgical site after the procedure. Participants will report their pain levels and painkiller use over the following days to see which option provides better relief.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
liposomal bupivacaine (Exparel) or standard bupivacaine with epinephrine
What this could lead to
If it works, this could offer longer-lasting pain relief after gum surgery, reducing the need for painkillers.
What could go wrong
This is an early-phase trial with only 58 participants, so results may not apply to everyone. The long-acting anesthetic may cause prolonged numbness or other side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1/2

Runs two stages together: safety and dose first, then whether the treatment works.

Participants

58 people

The number who actually took part.

Started

Oct 2024

Finished

Jun 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 89 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Ability of subject to understand and the willingness to sign a written informed consent document. 2. Males and females; Age 18 to 89 years old 3. Require flap surgery of 2 to 5 teeth in a continuous site (including flap debridement, flap osseous, extractions, and Guided Tissue Regeneration (GTR) procedures 4. In either the maxillary or mandibular arch. Exclusion Criteria: 1. Pregnancy, or those planning to become pregnant 2. Allergy or any medical issue using Bupivacaine 3. Inability to take non-steroidal anti-inflammatory drugs (NSAIDS) or acetaminophen 4. Non-English speaking 5. Patients requiring narcotic medications for IV sedation 6. Patients requiring either IV or oral steroids during the perioperative period 7. Patients with liver disease

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Conditions

The condition(s) this trial relates to.

periodontal disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Periodontal surgery

Contacts and locations

Locations

  • University of Texas Health Science Center at San Antonio

    San Antonio, Texas, 78229, United States

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