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Can a Patient's own blood help heal gums without surgery?

NCT ID NCT07791238

Disease control Sponsor: Cairo University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 27, 2026 · Last updated Aug 28, 2026 · Updated 1 time

Summary

This trial tests whether a gel made from a patient's own blood, called injectable platelet-rich fibrin (I-PRF), can improve the results of a minimally invasive non-surgical treatment for advanced gum disease. Researchers will compare three approaches: the standard deep-cleaning procedure alone, the procedure plus I-PRF, and the procedure plus I-PRF with an added antiseptic called chlorhexidine. Adults with stage III periodontitis and at least one deep gum pocket will be followed for six months to measure changes in pocket depth, gum attachment, and markers of inflammation.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Injectable platelet-rich fibrin (I-PRF), a biological product made from the patient's own blood, used alone or with chlorhexidine, alongside minimally invasive non-surgical periodontal therapy.
What this could lead to
If it works, this could offer a more effective way to treat advanced gum disease without surgery, potentially reducing pocket depths and improving gum attachment.
What could go wrong
This is an early-phase trial with a small number of participants, so results may not apply broadly. The added benefit of I-PRF over standard care is uncertain, and there is a risk of no significant improvement.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1/2

Runs two stages together: safety and dose first, then whether the treatment works.

Participants

About 63 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Oct 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patient-related criteria: * Patient consulting in the outpatient clinic. * Age ≥ 18 years old. * Able to tolerate the study procedures. * Patient ready to perform oral hygiene instructions. * Compliance with the maintenance program. * Provide informed consent. * Accepts the 6 months follow-up period. Teeth related criteria: * Presence of at least one radiographic intrabony defect depth ≥3 mm. * Patients with at least 10 teeth per arch. * Presence at least of two teeth with PD ≥ 6 mm per quadrant. * Isolated inter-proximal defect on a single-rooted tooth or mandibular molar, not extending to the furcation area. * Untreated patients diagnosed with stage III with slow/moderate rate of progression grade (A/B) Periodontitis. Exclusion Criteria: * Patient-related criteria: * Medically compromised patients. * Pregnant or nursing women. * Uncooperative patients. * Smokers (\> 10 cigarettes/day). Teeth related criteria: * Furcation involvement. * Mobility ≥ degree 1 * Acute periodontal or endodontic abscesses * Third molars * Non-surgical periodontal treatment in the past 6 months, or surgical periodontal treatment in the past 12 months. * Antibiotic treatment or anti-inflammatory treatment within 6 months prior to periodontal therapy. * Previous periodontal surgery.

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Conditions

The condition(s) this trial relates to.

periodontal disorder periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Bony defects Periodontal disease

How to take part

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  1. The official record

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    Open the record ↗

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