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Could gum inflammation affect thyroid health during pregnancy?

NCT ID NCT07787676

Knowledge-focused Sponsor: Postgraduate Institute of Dental Sciences Rohtak Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
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Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

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Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

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Status unknown
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First seen Aug 26, 2026 · Last updated Aug 27, 2026 · Updated 1 time

Summary

This study looks at whether gum health is linked to thyroid function in pregnant women. Researchers will examine the gums and measure thyroid-related blood markers in 100 healthy pregnant women in their second trimester. The goal is to see if gum inflammation is associated with thyroid hormone levels, which could inform future integrated dental and prenatal care.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If a link is found, it could support combining dental and prenatal care to improve maternal and fetal health.
What could go wrong
This is an observational study, so it cannot prove cause and effect. The findings may not apply to all pregnant women.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Sep 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population will include systemically healthy females aged between 18- 45 years in second trimester of pregnancy attending out patient department of Department of Gynaecology, PGIMS, Rohtak for regular antenatal evaluation.

Ages

18 to 45 years

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Pregnant women aged 18-45 years * Singleton pregnancy * Gestational age between 13 and 27 weeks (second trimester) * Presence of ≥20 natural teeth (excluding third molars) * Willingness to participate in the study and provide written informed consent * Attendance at the antenatal clinic during the study period * Ability to undergo full-mouth periodontal examination Exclusion Criteria: * History of previously diagnosed thyroid disorders (diagnosed prior to pregnancy or currently) * Current use of thyroid-related medication * Presence of systemic diseases known to affect periodontal status or inflammatory response (e.g., diabetes mellitus, gestational diabetes mellitus, autoimmune diseases, cardiovascular disorders) * Use of antibiotics, anti-inflammatory drugs, corticosteroids, or immunosuppressive agents within the previous 3 months * Current or past tobacco use in any form (smoking or smokeless) * Alcohol consumption during pregnancy * Multiple gestations (e.g., twin or higher-order pregnancy) * History of periodontal therapy or professional dental cleaning within the last 6 months * Presence of acute infections or inflammatory conditions at the time of examination * Pregnancy-related complications such as gestational diabetes mellitus, preeclampsia, or threatened abortion * Inability or unwillingness to comply with study procedures * Presence of acute oral infections or inflammatory conditions at the time of examination (periapical abscess, acute pericoronitis)

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Conditions

The condition(s) this trial relates to.

periodontal disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Periodontal disease Pregnancy Thyroid disease pregnancy

How to take part

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  1. The places running it

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  2. The official record

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Contacts and locations

Locations

  • Post Graduate Institute of Dental Sciences

    Rohtak, Haryana, 124001, India

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