PREGNANCY

This study tests whether giving pregnant women farming supplies, training, and access to a demonstration farm can reduce food shortages and improve health for them and their babies. 410 pregnant women in Kenya, half living with HIV, will be randomly assigned to receive the progra…

This study looks at whether a fortified milk product designed for pregnant and breastfeeding women can improve the nutrient content of their breast milk. Researchers will compare women who consume the product with those who do not, focusing on key vitamins, minerals, and DHA. The…

This study tests whether a natural supplement called inorganic nitrate can help control high blood pressure in pregnant women with chronic hypertension. About 144 women will receive either the supplement or a placebo from the second trimester onward. The goal is to see if it lowe…

This study compares three different programs to help pregnant women and new mothers reach a healthy weight. About 795 participants will receive nutrition and physical activity counseling plus help overcoming barriers like food access. The goal is to see which program works best f…

This study tests a digital platform that helps pregnant women with overweight or obesity manage their weight gain. 144 women will use the platform, track their weight and activity, and meet weekly with a dietitian. The goal is to see if the tool helps control weight gain and impr…

This study tests whether adding a community health worker coaching program to remote blood pressure monitoring helps women who had high blood pressure during pregnancy better control their blood pressure and improve heart health after delivery. About 240 women will be enrolled an…

This study tests whether taking an iron pill every other day works as well as taking one every day to treat iron-deficiency anemia in pregnant people. About 120 participants will be randomly assigned to one of two groups. The goal is to see which schedule better restores healthy …

This study looks at two ways to help pregnant and postpartum people with substance use disorder stay in treatment. One approach screens for social needs like housing or childcare and connects them to community help. The other offers small rewards for positive recovery actions. Th…

This study looks at whether automated insulin delivery (AID) systems can safely manage blood sugar during labor and delivery for pregnant people with type 1 diabetes. About 150 participants will be randomly assigned to use either an AID system or standard intravenous insulin. The…

This study tests whether bacteria from the mother can restore the natural gut health of babies born by C-section. Researchers will compare these maternal bacteria to standard probiotics and to untreated babies. The goal is to see if the treatment makes the C-section babies' gut b…

This study compares a technology-enhanced therapy program (including a mobile app) to standard medication monitoring for pregnant people taking buprenorphine for opioid use disorder. About 37 participants will be randomly assigned to either four therapy sessions plus app access o…

This study is testing whether giving monthly cash payments to pregnant women living with HIV in Botswana helps them better manage their health. Researchers want to see if the money reduces stress, helps women take their HIV medication more consistently, and keeps them connected t…

This study tests whether a short self-report questionnaire called T-ACE can accurately identify pregnant women who may be drinking alcohol at risky levels. Researchers will compare the questionnaire results with a blood test that measures alcohol use over the past three weeks. Ab…

This study tests a new, portable device called VITA that uses a camera to take pictures of blood vessels in the ear to check for anemia (low iron) in pregnant women. The goal is to see if this quick, painless method works as well as standard blood tests. About 300 pregnant women …

This study is testing a device that uses a blood or saliva sample to predict if a pregnant woman will develop postpartum depression (PPD) after giving birth. Researchers will enroll 1,000 pregnant women and collect samples during the third trimester, then follow up for three mont…

This study aims to validate a new blood test designed to predict a woman's risk of developing postpartum depression. Up to 500 pregnant women will have a blood draw in their third trimester and then be followed for six months after giving birth to see if they develop depression. …

This study looks at how exercise and physical activity during and after pregnancy change the makeup of breastmilk. Researchers want to see if these changes affect how babies use energy and grow, which could help prevent childhood obesity. About 200 mothers who plan to breastfeed …

This study is testing whether eating fermented poi every day can improve the balance of good bacteria in the body and lower the risk of gestational diabetes during pregnancy. Fifty pregnant women between 10 and 24 weeks will eat one pound of poi daily for four weeks and receive n…

This study tests whether taking a probiotic called LP299V twice daily can improve iron levels in pregnant women at risk for iron deficiency anemia. Researchers will enroll 250 women and follow them from early pregnancy through labor. The goal is to find a safe, low-cost way to pr…

This study looks at whether different types of exercise (aerobic, resistance, or both) during pregnancy can improve the health of both mother and baby. Overweight or obese pregnant women will be randomly assigned to an exercise group or a no-exercise group. Their babies will be c…

This study looks at whether giving pregnant women free organic vegetables and teaching them about healthy eating can lower their exposure to pesticides. Researchers will compare pesticide levels in urine between women who get the organic food and those who eat normally. The goal …

This study looks at whether it's better to give the RSV and Tdap vaccines together at one visit or separately during pregnancy. Researchers will check safety, immune response, and how well the study runs. About 60 healthy pregnant people will take part.

This study tests whether taking vitamin D supplements can prevent preeclampsia from returning in pregnant women who had it in a previous pregnancy. About 146 women will be randomly assigned to take either vitamin D or a placebo pill until 36 weeks. Researchers will track blood pr…

This study tests whether using a toothpaste and mouthwash made with lactoferrin (a natural protein) can prevent gum disease in pregnant women. Forty pregnant women in their second trimester will either use both the toothpaste and mouthwash, or just the toothpaste, along with regu…

This study is testing whether a program using text message support and small financial rewards can help low-income pregnant women quit smoking. It will enroll 30 women to see if this combined approach is practical and acceptable compared to text messages alone. The goal is to pre…

This study tests a virtual program called MOVIN that helps pregnant and postpartum people with depression or anxiety. Participants work with a care coordinator online to create a personalized treatment plan, with support from their doctor and a psychiatrist if needed. The goal is…

This study tests if a small, non-invasive device that stimulates a nerve in the leg can safely and effectively relieve Restless Legs Syndrome (RLS) in pregnant women. Fifteen pregnant participants between 21 and 26 weeks will use the device for 30-minute sessions as needed over 8…

This study tests whether a program using a Fitbit and coaching texts can help pregnant women sit less and get more moderate exercise. Researchers will track 60 women from early pregnancy through the third trimester. The goal is to see if this approach improves mental health, redu…

This study tests whether taking coenzyme Q10 (as a toothpaste) and probiotics (as a daily supplement) alongside regular dental cleanings can improve gum health in pregnant women. Forty pregnant women between 4-8 months will be split into two groups: one gets the Q10 toothpaste pl…

This study looks at whether a 12-week program of Baduanjin, a gentle mind-body exercise, can help reduce low back and pelvic pain in pregnant women. About 84 women carrying a single baby and between 14-20 weeks pregnant will participate. The goal is to see if this safe exercise i…

This study tests whether a single dose of cabergoline can prevent breast symptoms like pain, swelling, and milk leakage after an abortion or pregnancy loss between 12 and 18 weeks. About 348 participants will receive either cabergoline or a placebo right after the procedure and r…

This study tests whether MitoQ, a type of antioxidant that targets cell powerhouses, can improve blood vessel function in pregnant people with preeclampsia. Researchers will measure blood vessel health in the arm, skin, and placenta. The goal is to see if MitoQ can help prolong p…

This study tests whether a 6-week mindfulness meditation program helps pregnant women feel less stressed, anxious, and depressed compared to standard support. About 70 pregnant women will take part, with half doing weekly meditation sessions. Researchers will also check if the pr…

This pilot study tests a gentle strength and resistance exercise program designed for high-risk pregnant women who are on bed rest in the hospital. The goal is to see if these simple bed-based exercises can improve physical health, emotional well-being, sleep, and quality of life…

This study aims to find the most effective dose of epidural medicine to quickly relieve labor pain within 30 minutes. Researchers will test a combination of two drugs in 50 pregnant women. They will also track side effects and how satisfied the women are with their pain relief.

This study looks at whether using a tourniquet (a tight band) during surgery for a condition called placenta accreta can improve newborn health scores. The condition happens when the placenta grows too deeply into the womb and doesn't come out easily after birth, which can cause …

This study tests a device called NeuroCuple™, which uses no medication, to manage pain after cesarean delivery. Researchers will compare it to a sham device and standard care in 180 women. The goal is to see if it reduces pain and the need for opioid painkillers.

This study tests two common labor-inducing drugs, misoprostol and pitocin, in 300 pregnant people with a BMI of 30 or higher. The goal is to see which drug, when used with a foley catheter, leads to a faster delivery. Results will help doctors choose the best option for this grou…

This study aims to create a large collection of health information and biological samples from pregnant and postpartum people, including those with pregnancy complications and healthy volunteers. Researchers will use this resource to better understand and study pregnancy-related …

This study looks at how stress affects pregnant women and whether simple stress management techniques can lower stress hormone levels. Researchers will measure cortisol in saliva before and after these techniques. The goal is to understand how social factors and chronic stress im…

This study looks at whether doulas (birth support people) who receive extra training in mental health can help pregnant women in rural Montana feel more confident and supported. About 75 pregnant women will be split into three groups: one gets a specially trained doula, one gets …

This study observes how drinking 200 ml of water two hours before a planned C-section affects stomach volume in pregnant women with and without diabetes. Researchers will use ultrasound to measure stomach contents and assess the risk of aspiration (stomach contents entering the l…

This study follows 200 pregnant women with severe mental illness to see how taking antipsychotics or other psychiatric medications affects their mental health and their baby's development. Researchers will compare women on antipsychotics, other medications, or no medication, look…

This study aims to create a prediction tool for pregnant women with aplastic anemia, a rare blood disorder that raises risks of bleeding, infection, and complications like preterm birth. Researchers will follow 300 women to identify factors that lead to poor outcomes for mother a…

This study looks at how pregnancy changes the course of inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. Researchers will follow 945 women from a French registry to count disease flares during pregnancy and after childbirth. The goal is to bette…

This study looks at whether a continuous glucose monitor (CGM) helps pregnant women with type 2 diabetes track their blood sugar better than the traditional finger-stick method. About 70 participants will be randomly assigned to use either a CGM or finger-stick testing from enrol…

This study uses special MRI scans to measure blood flow and oxygen levels in the placenta during pregnancy. Researchers will compare 30 women with obesity to those with normal weight to see if there are differences. The goal is to better understand how obesity might affect nutrie…

This study looks at whether two simple calculations using heart rate and blood pressure taken before surgery can predict which women will experience a dangerous drop in blood pressure during a planned C-section. About 300 women having elective C-sections will be observed. If thes…

This study looks at how two different prenatal vitamins—a capsule and a gummy—affect iron levels in healthy pregnant women. About 40 women in their second trimester will take one of the two supplements daily for 12 weeks. Researchers will measure changes in iron, folate, and omeg…

This study monitors 75 pregnant or postpartum women who have taken Ultomiris for conditions like PNH or aHUS. Researchers will track pregnancy complications, maternal health issues, and infant outcomes up to 1 year after birth. The goal is to better understand the risks and safet…

This study follows pregnant women with a severe hemophilia A gene and their babies after birth. The goal is to learn why some mothers have heavy bleeding after delivery and why some children develop antibodies that make treatment less effective. About 500 mother-child pairs will …

This study follows 50 pregnant women who have taken the medication Epidiolex (used for seizures) to see if it causes any complications for the mother or baby. Researchers will track pregnancy outcomes and check infants for birth defects or other health issues up to 12 months afte…

This study looks at the long-term health of children (age 16 and older) whose mothers had a solid organ transplant before pregnancy. Researchers want to see if these children have higher risks for heart or kidney problems, possibly due to the mother's transplant medications. Abou…

This study involves 200 pregnant women who plan to deliver vaginally but may need a C-section. Researchers want to see if asking for consent right when they arrive at the hospital or only if it becomes necessary makes the experience better. Participants will share their feelings …

This study looks at how blood clots form and break down in pregnant women, and how these changes might lead to complications like blood clots or high blood pressure. Researchers will study 100 women with natural pregnancies to find patterns that could help predict risks. The goal…

This study aims to find out which factor—physical activity, diet, or anxiety—most influences excessive weight gain in pregnancy. Researchers will follow 150 pregnant women in their third trimester, collecting data through questionnaires. The goal is to better understand the cause…

This study looks at whether Cambodia's health system is ready to give pregnant women a multiple micronutrient supplement (MMS) instead of just iron and folic acid. Researchers will interview healthcare providers, survey 630 pregnant women, and monitor vitamin supplies. The goal i…

This study compares an AI tool (iDAScore) to an embryologist for ranking frozen embryos in IVF. About 1,325 participants will have their embryos ranked either by AI or by a human expert. The goal is to see if both methods lead to a similar number of transfers needed to achieve pr…

This study looks at how tiny particles released by the placenta into the mother's blood affect pregnancy complications like pre-eclampsia and gestational diabetes. Researchers will collect blood, urine, and tissue samples from 360 pregnant and non-pregnant women to understand the…

This study looks at how pregnant and non-pregnant women absorb and use vitamin D, especially in relation to obesity and genetic background. Researchers will give a small dose of labeled vitamin D and track it with blood tests over 40 days. The goal is to better understand vitamin…

This study looks at how much leucine, a key protein building block, healthy pregnant women need during early and late pregnancy. Researchers will give participants special meals and collect breath, urine, and one blood sample to track how the body uses leucine. The goal is to imp…

This study looks at why pregnant women at high altitude have higher rates of poor fetal growth and preeclampsia. Researchers will collect tissue samples from women having scheduled C-sections in Denver (low altitude) and Summit County (high altitude) to compare how their blood ve…

This study looks at whether where you place your arm during a blood pressure check changes the reading in pregnant women. About 300 pregnant women will have their blood pressure taken with their arm in different positions—supported at heart level, on their lap, or hanging at thei…

This study follows 200 babies diagnosed with intra-uterine growth restriction (IUGR) during pregnancy. Using advanced imaging, researchers will track subtle changes in the brain, heart, and placenta over time. The goal is to better understand how IUGR affects development and to i…

This study collects daily urine samples from 1,500 women who are trying to get pregnant. Participants use a Clearblue Ovulation test to find their most fertile days and provide samples for up to 3 menstrual cycles. The samples are stored in a biobank for future research on pregna…

This study will follow 250 pregnant women diagnosed with preeclampsia, a serious condition involving high blood pressure and organ stress. Researchers will collect health data and samples from mothers and babies during pregnancy, at birth, and a few months after. The goal is to l…

This study looks at how quickly the stomach empties in women during early labor when they drink either water or a carbohydrate sports drink, and whether an epidural changes that speed. About 108 pregnant women at 36 weeks or more will participate. The goal is to better understand…

This study looks at how the information given to mothers about labor induction influences their childbirth experience. Researchers will also examine if social media plays a role. The study will involve 50 pregnant women who are scheduled for labor induction.

This study is building a large collection of microbiome samples (like stool, saliva, and skin cells) from 600 people of all ages, including healthy volunteers and those with various conditions. The goal is to create a resource for future research to better understand how the micr…

This study is testing whether having groceries delivered to their homes can help low-income pregnant young women gain a healthy amount of weight and eat better. About 570 women in early pregnancy will take part. The goal is to learn if this simple support can improve health for m…

This study is a worldwide registry that will follow about 10 women with Fabry disease who take the medication pegunigalsidase alfa around the time of pregnancy or while breastfeeding. Researchers will track pregnancy outcomes and infant health for up to one year after birth. The …

This study looks at whether tiny plastic particles in our environment might play a role in gut inflammation and diseases like Crohn's. Researchers will measure microplastics in stool samples from pregnant women, healthy people, and their family members. The goal is to understand …

This study collects placenta tissue, umbilical cord blood, and maternal blood from 1,250 pregnant women at delivery. Researchers will use these samples to learn how the placenta changes in conditions like preterm birth, diabetes, and obesity. The goal is to better understand preg…

This study is testing a new way to support pregnant people in Rhode Island by connecting them with community health workers, doulas, and services like food and housing help. The goal is to see if this support leads to healthier moms and babies and reduces racial gaps in health ou…

This study looks at how well 50 pregnant women in Kenya absorb iron from three different types of prenatal supplements. Researchers will test if taking iron every other day might work better than daily doses. The goal is to find the best way to prevent iron deficiency during preg…

This study tests new MRI coils and imaging techniques to get clearer pictures of fetuses. About 300 pregnant women (18-40 weeks) with healthy or complicated pregnancies will participate. The goal is to improve image quality over standard fetal MRI and ultrasound.

This study looks at how the immune system helps the body accept a pregnancy during the first three months. Researchers will analyze blood samples from 100 women undergoing IVF to understand which immune cells and genes are linked to healthy pregnancies or miscarriages. The goal i…

This study tests how easy and useful a new digital program called Hope-D is for managing weight during pregnancy and for 6 months after giving birth. The program includes a digital pathway, personalized plans, and coaching. About 30 pregnant women with a BMI of 30 or higher will …

This study looks at how the bacteria and diet of pregnant women with inflammatory bowel disease (IBD) may influence gut inflammation in their babies. Researchers will collect samples from 80 mothers and infants over a year to find patterns that could lead to better dietary advice…

This study looks at how historical trauma and everyday stress may affect pregnancy outcomes in Indigenous American women. Researchers will gather information from 80 pregnant women about their experiences and measure how their bodies respond to stress. The goal is to find new way…

This study collects information from about 100 women with Pompe disease who received the medication Nexviazyme (avalglucosidase alfa) while pregnant or breastfeeding, and their babies. Researchers will track pregnancy complications, birth outcomes, and infant growth and developme…

This study looks at how the antibiotics ceftriaxone and benzathine penicillin G are processed in the bodies of pregnant women. About 78 pregnant women and 22 infants will take part to help doctors understand the right doses and ensure safety. The goal is to improve treatment for …

This study will test whether taking Perelel trimester-specific prenatal supplements leads to better nutrition for mothers and babies compared to standard generic prenatal vitamins. About 600 pregnant women will take one of the two supplements daily and provide blood samples each …

This study follows healthy women who are trying to get pregnant, as well as women who are not, to collect samples and learn about the molecular signals between mother and embryo during the first two weeks after fertilization. The goal is to better understand what leads to a healt…

This study tests whether pasteurized donor human milk (PDHM) is a practical feeding option for infants exposed to HIV. Ten caregivers in Saskatchewan will try PDHM as a supplement to breastfeeding or formula and report any challenges. The goal is to learn if donor milk can be off…

This study follows 400 pregnant women diagnosed with gestational diabetes to learn how the condition affects both mother and baby during pregnancy and after birth. Researchers will collect health data and samples from mothers and infants at several points, including after deliver…

This study is testing two new ultrasound methods to see if they can tell the difference between healthy pregnancies and those affected by fetal growth restriction (FGR), where the baby is smaller than expected. Researchers will compare these new scans in 60 pregnant women, some w…

This study is testing whether adding MRI scans to standard ultrasound can help doctors better see and diagnose birth defects in unborn babies. About 1500 pregnant women will get a fetal MRI to check if it provides clearer details than ultrasound alone. The goal is to improve how …

This study looks at bone density in 100 pregnant women (ages 30-45) between weeks 35 and 41 of pregnancy. Half are carrying one baby, half are carrying twins. Researchers use a special ultrasound-like scan (REMS) and questionnaires to see if twin pregnancies cause greater bone lo…

This study looks at whether sipping water or a carbohydrate-rich drink before a planned C-section is safer and helps women recover better. About 190 women will be randomly assigned to one of the two drinks. Researchers will use ultrasound to check stomach contents and ask women a…

This study looks at how the body processes aspirin in pregnant women who are at risk for preeclampsia, a serious condition involving high blood pressure. Researchers will measure aspirin byproducts and markers of metabolic health in 50 participants. The goal is to understand if d…

This study looks at whether offering different types of food assistance to pregnant women who struggle to afford enough food can work in a real-world clinic setting. About 60 pregnant women in their first trimester will be enrolled and followed for 6 months. The goal is to see if…

This study follows 150 pregnant women infected with parvovirus B19 to see how often the virus passes to the fetus and what complications may arise. Researchers will track pregnancy outcomes, newborn health, and long-term effects. The goal is to better understand risks and improve…

This study follows 60 women with cystic fibrosis who are planning a pregnancy, are pregnant, or have recently given birth. Researchers will track their lung function, nutrition, and mental health, as well as the health of their babies. The goal is to learn what extra care or scre…

This study is comparing blood pressure readings taken from the arm versus the ankle in women having a planned C-section. The goal is to see if using an ankle cuff gives similar readings, which could allow the cuff to be placed away from the mother's arms. If successful, this coul…

This study is testing whether a smartphone app called 'HappyMums' can help researchers better understand and predict depression during pregnancy. The app collects information about mental health through activities, questionnaires, and phone sensors from 1,000 pregnant people who …