PREGNANCY

This study looks at whether it's better to give the Tdap (whooping cough) and RSV (lung virus) vaccines together at one visit or separately at different visits during pregnancy. Researchers will track safety, immune response, and how well the study runs. About 60 healthy pregnant…

This study tests whether giving monthly cash payments to pregnant women with HIV in Botswana helps them focus better, take their HIV medication regularly, and stay in care after giving birth. About 100 women will receive the payments or usual care. The goal is to see if this simp…

This study tests whether adding coenzyme Q10 toothpaste and daily probiotics to regular dental cleanings can improve gum health in pregnant women. Forty pregnant women between 4-8 months will be split into two groups: one gets the extra supplements, the other doesn't. The study l…

This study looks at whether a therapy program with a mobile app helps pregnant people taking buprenorphine for opioid use disorder stay in treatment longer, compared to just tracking their medication. About 37 pregnant women will be randomly assigned to either four therapy sessio…

This study tests whether a natural compound called inorganic nitrate can help control high blood pressure in pregnant women with chronic hypertension. About 144 women will receive either nitrate or a placebo from the second trimester onward. The goal is to see if nitrate can safe…

This study tests whether bacteria from the mother can restore the natural gut health of babies born by C-section better than standard probiotics. About 100 healthy infants will receive a daily oral bacterial product for one or four weeks. Researchers will compare their gut bacter…

This study tests whether giving pregnant women farming tools, seeds, and training can reduce food shortages and improve health for them and their babies. About 410 pregnant women in Kenya will join, half of whom are living with HIV. Participants will either get the farming suppor…

This study tests whether taking an iron pill every other day works as well as taking one every day to treat iron-deficiency anemia in pregnant women. About 120 pregnant women with low iron will be randomly assigned to one of two groups. The goal is to see if alternate-day dosing …

This study compares three different programs to help pregnant women maintain a healthy weight and avoid keeping on too much weight after giving birth. About 795 women who are early in pregnancy will join one of two special programs or receive standard care. The programs provide n…

This study looks at whether automated insulin delivery (AID) systems can safely manage blood sugar during labor and delivery for pregnant people with type 1 diabetes. Researchers will compare AID to standard IV insulin in 150 participants. The goal is to improve newborn blood sug…

This study tests whether adding a community health worker-led lifestyle program to remote blood pressure monitoring helps women who had high blood pressure during pregnancy. About 240 women will be followed for 6 months after delivery to see if the extra coaching improves blood p…

This study tests a digital platform that helps pregnant women with overweight or obesity manage their weight gain. 144 women will use the platform, track their weight and activity, and meet weekly with a dietitian. The goal is to see if the tool helps control weight gain and impr…

This study looks at two ways to help pregnant and postpartum people with substance use disorder stay in treatment. One approach screens for social needs like housing or childcare and connects them to community help. The other offers small rewards for positive recovery actions. Th…

This study is testing a new blood test that may predict if a pregnant woman will develop postpartum depression (PPD) after giving birth. Researchers will enroll up to 500 pregnant women and collect a blood sample during the third trimester. Participants will then be checked for d…

This study checks if a short questionnaire called T-ACE can correctly identify pregnant women who may be drinking alcohol at risky levels. Researchers will compare the questionnaire results with a blood test that measures alcohol use over the past three weeks. About 2,425 pregnan…

This study is testing a portable device called VITA that uses a special camera to take pictures of blood vessels in the ear to check for anemia (low iron) in pregnant women. The goal is to see if this quick, painless method works as well as standard lab blood tests. The study wil…

This study is testing a device that uses a blood or saliva sample to predict if a pregnant woman will develop postpartum depression (PPD) after giving birth. Researchers will enroll 1,000 pregnant women and collect samples during the third trimester, then follow up for three mont…

This study looks at whether different types of exercise (aerobic, resistance, or both) during pregnancy can lower the risk of obesity in children. About 300 overweight or obese pregnant women will be assigned to an exercise group or a no-exercise group. Their babies will be check…

This study tests whether taking a probiotic called LP299V twice daily can help pregnant women at risk of iron deficiency absorb more iron from their diet. The goal is to prevent iron deficiency anemia and its serious complications, like preterm birth. Researchers will enroll 250 …

This pilot study is testing whether eating fermented poi every day can improve the balance of good bacteria in the body and lower the risk of gestational diabetes during pregnancy. Fifty pregnant women between 10 and 24 weeks will eat one pound of poi daily for four weeks and rec…

This study tests whether using a toothpaste and mouthwash made with lactoferrin can help prevent gum disease in pregnant women. Forty pregnant women in their second trimester will be split into two groups: one using both the toothpaste and mouthwash, and the other using only the …

This study looks at whether giving pregnant women free organic vegetables and teaching them about healthy eating can lower their exposure to pesticides. About 210 pregnant women in Strasbourg, France, will take part. Researchers will measure pesticide levels in urine to see if th…

This study tests whether taking vitamin D supplements can prevent preeclampsia from returning in pregnant women who had it before. About 146 women will be randomly assigned to take either vitamin D or a placebo pill until 36 weeks of pregnancy. Researchers will track blood pressu…

This study looks at how exercise and physical activity during and after pregnancy change the makeup of breastmilk. Researchers want to see if these changes affect how babies use energy and grow, which could help prevent childhood obesity. About 200 mothers who plan to breastfeed …

This study tests whether misoprostol or pitocin works better to start labor in pregnant women with a BMI of 30 or higher. About 300 participants will receive one of the drugs along with a foley catheter. The main goal is to see which method leads to a faster delivery.

This study looks at whether a gentle mind-body exercise called Baduanjin can help pregnant women with low back and pelvic pain. About 84 women in their second trimester will do the exercise for 12 weeks. Researchers will measure pain levels and quality of life to see if it helps.

This study tests a device called NeuroCuple™ that uses no medication to manage pain after cesarean delivery. About 180 women will be randomly assigned to receive the device, a sham device, or standard care. The goal is to see if the device reduces pain and the need for opioid pai…

This study tests a virtual program called MOVIN that helps pregnant and postpartum people with depression or anxiety. Participants work with a care coordinator online to create a personalized treatment plan, with support from their doctor and a psychiatrist if needed. The goal is…

This study looks at whether sipping water or a carbohydrate-rich drink before a planned C-section is safer and leads to a better recovery. About 190 women will be randomly assigned to one of the two drink groups. Researchers will use ultrasound to check stomach contents and ask w…

This study aims to find the most effective dose of epidural medicine to relieve labor pain within 30 minutes. About 50 women in active labor will receive a specific epidural technique, and researchers will measure pain scores and side effects. The goal is to improve comfort and s…

This study tests a smoking cessation program for low-income pregnant women. It combines text message support with financial rewards to see if it helps them quit. The study will compare this approach to text messages alone and measure how well it works and if participants find it …

This study tests whether a program that includes a Fitbit, a physical activity partner, and coaching text messages can help pregnant women reduce sitting time and increase moderate physical activity. Researchers will enroll 60 women who are 8-12 weeks pregnant and currently inact…

This pilot study tests a simple exercise program designed for high-risk pregnant women who are on bed rest in the hospital. The program includes resistance and strength training done while lying in bed. Researchers want to see if it improves physical health, emotional well-being,…

This study tests whether MitoQ, a mitochondrial antioxidant, can improve blood vessel function and placental health in pregnant people with severe preeclampsia. Researchers will measure blood flow in the arm and skin, and examine placental vessels after delivery. The goal is to s…

This study looks at whether a 6-week mindfulness meditation program can help pregnant women feel less stressed, anxious, or depressed, and improve bonding with their baby. About 70 pregnant women will either take the mindfulness program or receive standard psychological support. …

This study tests if a small, non-invasive device that stimulates a nerve in the leg can safely and effectively relieve Restless Legs Syndrome (RLS) in pregnant women. Fifteen pregnant participants between 21 and 26 weeks will use the device for 30-minute sessions as needed over 8…

This study tests whether a single dose of cabergoline can prevent breast symptoms like pain, swelling, and milk leakage after an abortion or pregnancy loss between 12 and 18 weeks. About 348 participants will receive either cabergoline or a placebo right after the procedure and r…

This study looks at whether using a tourniquet (a tight band) during surgery for a condition called placenta accreta can improve newborn health scores. The condition happens when the placenta grows too deeply into the womb and doesn't come out easily after birth, which can cause …

This study is observing 250 pregnant women diagnosed with preeclampsia to better understand how this serious condition develops and affects both mother and baby. Researchers will collect health data and samples during pregnancy, at birth, and after delivery. The goal is to learn …

This study looks at whether taking Perelel-brand prenatal supplements (designed for each trimester) is better than generic prenatal vitamins for the health of pregnant women and their babies. Researchers will measure nutrient levels in the blood of 600 pregnant women who have foo…

This study tests how easy and useful a new digital program called Hope-D is for managing weight during pregnancy and for 6 months after giving birth. It includes 30 pregnant women with a BMI of 30 or higher. The goal is to see if the program is user-friendly and ready for a large…

This study looks at how quickly the stomach empties in women during early labor when they drink either water or a carbohydrate sports drink. It also checks if having an epidural changes that speed. About 108 pregnant women at 36 weeks or more will take part. The goal is to better…

This study looks at how blood clots form and break down in pregnant women, and whether these changes can lead to complications like blood clots or high blood pressure. Researchers will study 100 women aged 18-40 with natural pregnancies. The goal is to use machine learning to fin…

This study looks at whether taking blood pressure at the ankle works as well as the usual arm measurement during planned C-sections. About 110 pregnant women will have both measurements taken at the same time. If ankle readings are reliable, it could allow mothers to hold their b…

This study looks at how tiny plastic particles (microplastics) in our environment might affect gut health and inflammation, especially in pregnant women and their families. Researchers will measure microplastics in stool samples and study the gut bacteria of 46 participants. The …

This study tests a nutrition education program for 250 first-time pregnant women in northern Ghana. The program focuses on eating a variety of local foods to improve protein, energy, and iron intake. Researchers will measure how the program affects women's health knowledge, diet,…

This study looks at whether Cambodia's health system is ready to give pregnant women a multiple micronutrient supplement (MMS) instead of just iron and folic acid. Researchers will interview healthcare providers, survey 630 pregnant women, and monitor vitamin supplies. The goal i…

This study aims to improve fetal MRI imaging by designing special coils and testing new techniques for pregnant women. Researchers will compare the quality of these advanced images to standard fetal MRI and ultrasound. The goal is to get clearer, more reliable images to help doct…

This study looks at whether specially trained doulas can help pregnant people in rural Montana feel more confident and supported, and reduce symptoms of depression and anxiety after childbirth. About 75 participants will be split into three groups: one gets regular doula care, on…

This study looks at how the gut bacteria and diet of pregnant women with inflammatory bowel disease (IBD) may affect their baby's gut health. Researchers will collect samples from 80 mothers and their infants over a year to measure gut inflammation and identify patterns. The goal…

This study follows 200 babies diagnosed with intra-uterine growth restriction (IUGR) using advanced imaging to track subtle changes in the brain, heart, and placenta over time. Researchers will link these findings to the babies' development after birth and in early childhood. The…

This study is creating a large collection of samples (like stool, saliva, and skin swabs) from up to 600 people of all ages, both healthy and with various conditions. The goal is to help researchers learn how the tiny organisms living in and on our bodies affect our health and pl…

This study is a worldwide registry that will follow about 10 women with Fabry disease who take the medication pegunigalsidase alfa during pregnancy or while breastfeeding. Researchers will track the health of both mothers and their babies for up to one year after birth. The goal …

This study looks at why pregnant women living at high altitude have higher rates of poor fetal growth and preeclampsia. Researchers will collect tissue samples from 84 women having scheduled C-sections in Denver (low altitude) and Summit County (high altitude). By comparing blood…

This study is creating a large collection of health information and biological samples from pregnant and postpartum people, including those with pregnancy complications and healthy volunteers. The goal is to provide a resource for researchers to better understand and improve outc…

This study is testing whether adding advanced MRI scans to standard ultrasound can help doctors better detect and understand birth defects in unborn babies. About 1,500 pregnant women will receive a fetal MRI to see if it provides clearer images of the baby's organs. The goal is …

This study follows 50 pregnant women who have taken the epilepsy medication Epidiolex (or Epidyolex) to see if it affects pregnancy outcomes or the health of their baby up to 12 months old. Researchers will track complications like birth defects, miscarriage, and preterm delivery…

This study looks at whether the way you hold your arm during a blood pressure check changes the reading in pregnant women. About 300 pregnant women will have their blood pressure taken with their arm in different positions—supported at heart level, on their lap, or hanging at the…

This study looks at how tiny particles released by the placenta, called extracellular vesicles, affect pregnancy complications like pre-eclampsia and gestational diabetes. Researchers will collect samples from 360 pregnant and non-pregnant women to understand these particles' rol…

This study is testing two new ultrasound techniques to see if they can better detect fetal growth restriction (FGR), a condition where a baby is smaller than expected. Researchers will compare these scans in 60 pregnant women, some with healthy pregnancies and some with FGR. The …

This study looks at the safety of the drug Ultomiris when used during pregnancy. Researchers will track 75 pregnant or postpartum women who take Ultomiris for conditions like PNH or aHUS. They will record pregnancy complications, maternal health issues, and infant health outcomes…

This study follows pregnant women with a severe hemophilia A gene and their babies after birth. The goal is to learn why some mothers have heavy bleeding after delivery and why some children develop antibodies that make hemophilia treatment less effective. By observing 500 mother…

This study follows 200 pregnant women with severe mental illness to see how taking antipsychotic medication affects their mental health and their baby's development. Researchers will compare women taking antipsychotics, other psychiatric drugs, or no medication. They will track p…

This study looks at how pregnancy, childbirth, and breastfeeding affect inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. Researchers will track 945 women from the EPIMAD registry to count disease flares during and after pregnancy. The goal is to…

This study looks at how the information given to mothers about labor induction affects their childbirth experience. Researchers will also examine if social media plays a role. The study involves 50 pregnant women who are scheduled for labor induction. Participants will answer que…

This study aims to see if a package of community-based services—including care coordination, doula support, and help with food, housing, and transportation—can improve health outcomes for mothers and babies in Rhode Island. About 3,000 birthing people from six clinics will take p…

This study uses MRI scans to measure blood flow and oxygen levels in the placenta during the second and third trimesters of pregnancy. Researchers will compare women who were obese before pregnancy with those who had a normal weight, to see if there are differences in how the pla…

This study follows 60 women with cystic fibrosis (CF) who are planning a pregnancy, are pregnant, or have recently given birth. Researchers will track their lung function, nutrition, and mental health, as well as the health of their babies. The goal is to learn what extra care or…

This study looks at whether a continuous glucose monitor (CGM) helps pregnant women with type 2 diabetes track their blood sugar better than the usual finger-stick method. About 70 participants will be randomly assigned to use either a CGM or finger-stick testing from enrollment …

This study looks at how historical trauma and everyday stress may impact pregnancy outcomes in Indigenous American women. Researchers will collect information from 80 pregnant women about their experiences and measure how their bodies respond to stress. The goal is to understand …

This study looks at the best time to get a patient's permission for a possible C-section during labor. About 200 pregnant women planning a vaginal birth will be randomly assigned to give consent either when they arrive at the hospital or only if a C-section seems needed. After de…

This study looks at how the body processes aspirin in pregnant women who are at risk for preeclampsia, a serious condition involving high blood pressure. Researchers will measure markers of metabolic health, like fatty acids and salicylate levels, in 50 participants. The goal is …

This study collects safety information from about 100 women with Pompe disease who received the drug Nexviazyme during pregnancy or breastfeeding, and from their babies. Researchers will track pregnancy complications, birth outcomes, and infant growth and development through the …

This study looks at whether having groceries delivered can help low-income pregnant young women gain a healthy amount of weight and eat better. About 570 women in early pregnancy will take part. The goal is to learn if this simple support can improve health for moms and babies.

This pilot study will test whether pasteurized donor human milk (PDHM) is a practical feeding option for 10 infants exposed to HIV. Caregivers will use PDHM as a supplement to breastfeeding or formula, and researchers will track how often it's used and any challenges. The goal is…

This study looks at whether two simple calculations using heart rate and blood pressure, taken before surgery, can predict which women will experience a dangerous drop in blood pressure after receiving spinal anesthesia for a planned C-section. Researchers will monitor 300 pregna…

This study compares an AI tool (iDAScore) to manual ranking by embryologists for selecting which frozen embryo to transfer first in IVF. About 1,325 patients will be randomly assigned to either method. The goal is to see if the AI can match human experts in helping achieve pregna…

This study follows healthy women who are trying to get pregnant, as well as those who are not, to collect samples and data during the first two weeks after fertilization. The goal is to learn how the mother's body and the early embryo talk to each other at the molecular level. Th…

This study looks at whether a special fortified milk product, designed for pregnant and breastfeeding women, can improve the nutrient content of breast milk. Researchers will compare breast milk from women who drink this product with those who don't, focusing on key nutrients lik…

This study looks at how drinking clear water two hours before a planned C-section affects stomach volume in pregnant women with and without diabetes. Researchers will use ultrasound to measure stomach contents before and after drinking. The goal is to better understand aspiration…

This study looks at how two different prenatal vitamins—a capsule and a gummy—affect iron levels in healthy pregnant women. About 40 women in their second trimester will take one type daily for 12 weeks. The goal is to see if the capsule leads to higher iron levels compared to th…

This study looks at how the immune system helps the body accept a pregnancy during the first three months. Researchers will analyze blood samples from 100 women undergoing IVF to identify immune cells and genes linked to healthy pregnancies or miscarriages. The goal is to better …

This study looks at how stress affects pregnant women and whether simple stress management techniques can lower stress hormone levels. Researchers will measure cortisol in saliva before and after these techniques. The goal is to understand how social factors and chronic stress im…

This study aims to create a prediction tool for pregnant women with aplastic anemia, a rare blood disorder that raises risks of bleeding, infection, and complications like preterm birth. Researchers will follow 300 women to identify factors that lead to poor outcomes for mother a…

This study is testing whether pregnant women at risk of depression are willing to use a mobile app called HappyMums throughout their pregnancy. The app collects mental health data through questionnaires and phone usage. Researchers hope this information can one day help predict a…

This study looks at how pregnancy, body weight, and genetic background affect the way women absorb and use vitamin D. Researchers will give 160 pregnant and non-pregnant women a small dose of labeled vitamin D and track it in their blood over 40 days. The goal is to better unders…

This study looks at how the antibiotics ceftriaxone and benzathine penicillin G are processed in the bodies of pregnant women. Researchers will measure drug levels in the blood during different stages of pregnancy to find the right doses. About 110 pregnant women and some of thei…

This study looks at the long-term health of children (16 and older) whose mothers had a solid organ transplant before pregnancy. Researchers want to see if these children have higher risks for heart or kidney problems, possibly due to the mother's anti-rejection medications. Abou…

This study collects placenta tissue, umbilical cord blood, and maternal blood from 1,250 pregnant women at delivery. Researchers will use these samples to learn how the placenta changes in healthy and complicated pregnancies, and how those changes may affect the baby's long-term …

This study aims to find out which factor—physical activity, diet, or anxiety—most influences excessive weight gain in pregnancy. Researchers will follow 150 pregnant women in their third trimester, collecting data through questionnaires. The goal is to better understand the cause…

This study looks at how much leucine, a key protein building block, healthy pregnant women need during early and late pregnancy. Researchers will give participants special meals and collect breath, urine, and one blood sample to track how the body uses leucine. The goal is to imp…

This study collects daily urine samples from 1,500 women who are trying to get pregnant. Participants use a Clearblue Ovulation test to find their most fertile days and provide samples for up to 3 menstrual cycles. The samples are stored in a biobank for future research on pregna…

This study looks at how well 50 pregnant women in Kenya absorb iron from three different types of prenatal supplements. Researchers will test if taking iron every other day might work better than daily doses. The goal is to find the best way to prevent iron deficiency during preg…

This study follows 400 pregnant women diagnosed with gestational diabetes to learn how the condition affects both mother and baby during pregnancy and after birth. Researchers will collect health data and samples from mothers and infants at several points, including after deliver…

This study looks at bone density in 100 pregnant women (ages 30-45) between weeks 35 and 41 of pregnancy. Half are carrying one baby, half are carrying twins. Researchers use a special ultrasound-like scan (REMS) and questionnaires to see if twin pregnancies cause greater bone lo…

This study looks at whether offering different types of food assistance to pregnant women who struggle to afford enough food can work in a real-world clinic setting. About 60 pregnant women in their first trimester will be enrolled and followed for 6 months. The goal is to see if…

This study follows 150 pregnant women infected with parvovirus B19 to see how often the virus passes to the fetus and what complications may arise. Researchers will track pregnancy outcomes, newborn health, and long-term effects. The goal is to better understand risks and improve…