Pregnancy and mental health: new study investigates antipsychotic risks for mom and baby

NCT ID NCT06049953

Recruiting now Knowledge-focused Sponsor: Icahn School of Medicine at Mount Sinai Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This observational study follows 74 pregnant individuals with severe mental illness to see how taking antipsychotics (versus other medications or no medication) affects psychiatric stability and infant development. Participants complete psychiatric interviews, donate blood, and have their babies undergo behavior evaluations and brain activity tests. The goal is to better understand the trade-offs between treating maternal mental illness and potential risks to the child.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Antipsychotics
What this could lead to: If successful, this study could help doctors and pregnant individuals make more informed decisions about using antipsychotics during pregnancy, balancing maternal mental health with infant safety.
What could go wrong: This is an observational study, not a controlled trial, so it cannot prove cause and effect. Results may be influenced by underlying illness severity or other factors, and the small sample size limits generalizability.

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Conditions

The condition(s) this trial relates to.

bipolar disorder psychiatric disorder psychotic disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANTIPSYCHOTICS PREGNANCY

Contacts and locations

Locations

Icahn School of Medicine at Mount Sinai
RECRUITING

New York, New York, 10029, United States

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