Psychiatric disorder

This Phase 1 trial tests an experimental vaccine called AV-1980R that targets tau protein, a key player in Alzheimer's disease. The study enrolls 48 cognitively healthy adults aged 65-80 who have biological signs of early Alzheimer's. Researchers will check if the vaccine is safe…

This trial tests whether matching cognitive training to a person's specific thinking deficits can improve real-world outcomes for incarcerated individuals with substance use disorders. Participants are assigned to one of two types of training—one targeting attention to context, t…

This study tests an investigational drug called KarXT to see if it can prevent the return of psychosis (like hallucinations or delusions) in people with Alzheimer's disease. About 410 participants aged 55-90 will receive either KarXT or a placebo for 38 weeks. The main goal is to…

This trial tests whether digital follow-up through a patient portal and exercise app can help people with mental disorders stick to a 12-week high-intensity interval training program. Participants will be randomly assigned to receive either digital follow-up or standard care, wit…

This trial is testing whether an experimental oral medication called SEP-363856 (ulotaront) can reduce anxiety symptoms in adults with generalized anxiety disorder (GAD). About 384 participants will receive either the drug or a placebo daily for 8 weeks. The main goal is to see i…

This study tests whether a virtual session with a peer recovery coach can help incarcerated adults with substance use disorders connect to addiction treatment and recovery resources. About 550 participants in jail will either get the coaching or just standard information. Researc…

This study tests whether listening to a specific 40 Hz sound for one hour a day, five days a week over 12 weeks, can improve memory, brain activity, sleep, and quality of life in older adults with mild cognitive impairment or mild dementia. Half of the participants will receive t…

This pilot study tests whether a non-invasive brain stimulation technique called tACS can help teens (ages 12-18) with major depression when added to their usual medication. Thirty participants will receive either real or sham stimulation daily for several weeks. The goal is to s…

This trial is testing whether huperzine A, given as a controlled-release tablet, can improve thinking and daily living skills in people with mild-to-moderate Alzheimer's dementia. Participants will receive either huperzine A, a placebo, or an existing Alzheimer's drug (donepezil)…

This trial tests whether an internet-based form of cognitive behavior therapy (CBT) can reduce symptoms of common mental disorders like anxiety, depression, and stress-related conditions in adults seeking primary care. About 500 participants will be randomly assigned to either th…

This study tests whether a non-invasive brain stimulation technique called rTMS, given before cognitive-behavioral therapy, can help adults with cocaine use disorder quit. Thirty participants will receive either real or sham rTMS daily for 3 weeks, followed by 12 weeks of weekly …

This study tests an experimental drug called senicapoc in people with mild Alzheimer's or mild cognitive impairment. The goal is to see if it can reduce brain inflammation and slow down memory loss. About 55 participants will take either the drug or a placebo for 52 weeks, with r…

This study investigates whether a mobile app called reSET can help men who have sex with men, are living with HIV, and have a stimulant use disorder reduce their drug use and keep their HIV under control. Participants use the app for 12 weeks, completing modules on topics like ma…

This study tests an experimental drug called ABBV-1758 in about 210 people with Alzheimer's disease. The drug is given by IV or injection every 4 weeks for 24 weeks. Researchers are checking if it is safe and whether it can reduce amyloid plaques in the brain, a hallmark of Alzhe…

This early-stage study tests a new drug called ALN-5288 in 50 adults with mild cognitive impairment or dementia caused by Alzheimer's disease. The drug is given via a spinal injection and aims to safely reduce tau protein levels in the brain. The main goal is to check safety and …

This study tests whether psilocybin, a psychedelic substance, given with psychological support is safe and helps reduce symptoms of anorexia nervosa in young adults aged 16 to 35. Participants receive two doses of psilocybin (25 mg) four weeks apart, plus therapy before, during, …

This study tests whether a combination drug called OLZ/SAM (olanzapine plus samidorphan) causes less weight gain than olanzapine alone in teenagers with schizophrenia or bipolar I disorder. About 220 teens aged 10-17 will take either the combo or olanzapine for 52 weeks. The main…

This early-stage study tests a new drug called VV119 in healthy adults and people with schizophrenia. The main goal is to check if the drug is safe and how the body processes it. About 40 participants will take multiple doses to find the right amount for future studies.

This study tests whether suvorexant, a medicine used for sleep problems, can help people with alcohol use disorder (AUD) by changing how the brain's dopamine system works. About 180 adults (ages 18-75) with AUD and healthy volunteers will take either suvorexant or a placebo daily…

This study tests an experimental drug called MK-2214 in 340 people with early Alzheimer's disease. The goal is to see if it can slow the buildup of a harmful protein called tau in the brain, which damages brain cells. Participants will receive either the drug or a placebo, and re…

This trial is testing the safety of a medication called lumateperone in children and teenagers who have schizophrenia, bipolar disorder, or autism spectrum disorder. Participants take the drug once daily for 26 weeks, and researchers monitor for side effects. The goal is to see i…

This study is checking the long-term safety of a drug called KarXT in teenagers (13-17) with schizophrenia, and a combination of KarXT and KarX-EC in children (5-17) with irritability linked to autism. About 400 participants who completed earlier studies will take the drug for up…

This study tests whether a gentle electrical current applied to the scalp during reading lessons can improve reading skills in children aged 7 to 17 with dyslexia or reading difficulties. Half the participants receive active stimulation, while the other half receive a sham (place…

This study tests a program called CONNECT Multilingual, designed to help Spanish and Cantonese speakers quit smoking while they undergo lung cancer screening. About 439 current smokers aged 50-80 will receive personalized video doctor messages, text support, and help getting nico…

This study tests a computerized task where teens push or pull a joystick in response to images, aiming to change automatic habits around cannabis and alcohol. Fifty-two participants aged 13-17 who use both substances will be followed for three months. The goal is to see if this s…

This trial tests whether combining aerobic exercise with a targeted reading therapy, called Phono-Motor Therapy, can improve reading skills in people who have reading difficulties after a stroke. Participants will receive both interventions, and researchers will measure changes i…

This phase 3 trial is testing whether the drug KarXT can safely and effectively treat schizophrenia in adolescents aged 13 to 17. About 166 teens will receive either KarXT or a placebo, and researchers will track changes in symptoms like delusions and social withdrawal. The goal …

This trial is testing whether an integrated care pathway (ICP) can help reduce depressive symptoms in adolescents aged 13 to 18 who seek help at community mental health agencies. Participants will receive either the ICP or treatment as usual, and researchers will track changes in…

This study tests a program that sends personalized text messages and provides nicotine patches to help people with HIV in Cambodia stop smoking. Researchers will enroll 800 smokers and check if they quit after 6 months using self-reports and breath tests. The goal is to find a pr…

This early-phase trial tests a gene therapy called AVB-101 for people with frontotemporal dementia caused by GRN gene mutations. The therapy delivers a working copy of the GRN gene directly into the brain during a one-time procedure. The study will enroll 18 adults aged 30-75 to …

This trial tests whether giving far fewer opioid pills after hip arthroscopy, combined with gabapentin and extra-strength Tylenol, can control pain as well as the standard 30-pill opioid prescription. About 170 adults undergoing their first hip arthroscopy will be randomly assign…

This study is testing a new drug called ML-007C-MA for adults with schizophrenia. The goal is to see if it is safe and works well over a full year. About 500 people who have recently been in a related study or are new to the trial will take the drug twice daily. Researchers will …

This study looks at whether helping clinics offer more take-home doses of methadone (instead of daily visits) helps people stay in treatment for opioid use disorder. Researchers will work with 36 clinics and about 318 patients to see if this approach reduces emergency visits and …

This study tests whether changing treatment can help smokers who relapse early after trying to quit. 544 participants who want to quit smoking will receive free nicotine patches, lozenges, varenicline, or e-cigarettes for 12 weeks. All visits are remote, and the study lasts 6 mon…

This study tests whether a combination of two drugs, KarXT and KarX-EC, can improve cognitive impairment in people with mild to moderate Alzheimer's disease. About 586 participants will receive either the drug combo or a placebo. The trial measures changes in thinking, daily func…

This phase 3 trial is testing whether an experimental oral medication called SEP-363856 (ulotaront) can reduce anxiety symptoms in adults with generalized anxiety disorder. Participants will receive one of two fixed doses of the drug or a placebo for 8 weeks. The main goal is to …

This study tests a drug called mivelsiran in 58 adults with Down syndrome who have early-stage Alzheimer's. Participants receive either the drug or a placebo via injection into the spine every few months for two years. The goal is to see if the drug can reduce brain changes linke…

This study tests whether tirzepatide, a drug approved for weight management, can help people with alcohol use disorder and related liver disease drink less and improve liver health. 120 adults will receive weekly injections of tirzepatide or a placebo for 12 weeks. Researchers wi…

This trial is testing whether esketamine nasal spray, when added to a person's usual antidepressant, can help adults with major depression who haven't improved after trying two or more medications. Participants will receive supervised esketamine treatments over several weeks and …

This early-stage trial tests a drug called ALN-APP (mivelsiran) in 60 adults with mild cognitive impairment or mild dementia due to early-onset Alzheimer's disease. The drug is given via a spinal injection to see if it safely lowers certain proteins linked to Alzheimer's in the b…

This trial tests whether adding two 'chronotherapeutics'—bright light therapy in the morning and a slow-release melatonin pill at night—to standard antidepressants can better ease depression in adults who also have insomnia. About 184 people with major depression and sleep proble…

This study compares obstacle course training and neuromotor task training in 28 children aged 7-10 with developmental coordination disorder (DCD). Both programs run twice a week for 9 weeks and aim to improve motor planning and functional mobility. Researchers will measure skills…

This study tests if semaglutide, a drug used for diabetes, can help veterans with alcohol use disorder drink less. About 622 veterans will get either the drug or a placebo shot for 28 weeks. The goal is to see if it safely reduces heavy drinking and improves health.

This study compares a new, lower-energy seizure therapy (LAP-ST) to standard electroconvulsive therapy (ECT) for quickly reducing suicidal thoughts in people with depression, bipolar disorder, or schizoaffective disorder. The goal is to see if the gentler approach works just as w…

This study tests whether a single dose of psilocybin (the active ingredient in magic mushrooms) combined with therapy can change brain activity and reduce drinking in people with alcohol use disorder. Two hundred participants will receive either psilocybin or a placebo, plus supp…

This trial tests a program called Kupambana for young people with HIV in Zambia. It combines weekly peer-led support groups to reduce stigma with a voucher for vocational training and a financial literacy session. Researchers want to see if this approach can improve mental health…

This study tests whether combining two types of stimulation—one that targets a nerve in the ear (or a surgically implanted neck device) and another that uses magnetic pulses on the scalp—can better relieve symptoms of treatment-resistant depression. Participants attend six treatm…

This trial tests whether adding metacognitive training—exercises that help people think about their own thinking—to standard word-finding rehabilitation can improve language skills in people with chronic aphasia after a stroke. The study involves 18 participants who will receive …

This study tests a mobile app and financial rewards to help veterans quit smoking before major elective surgery. Smoking increases the risk of complications after surgery, but quitting can be hard. The program uses a carbon monoxide monitor and app to verify abstinence, with ince…

This study tests whether tirzepatide, a drug used for diabetes and weight loss, can help people with moderate to severe opioid use disorder stay in treatment and use fewer opioids when added to their regular buprenorphine medication. About 310 adults who recently started buprenor…

This trial investigates whether combining two medications—reboxetine and methylphenidate—can reduce PTSD symptoms by improving attention and emotional regulation. Adults with PTSD will receive either the drug combination or a placebo for about a month, and researchers will measur…

This trial tests whether heart rate variability biofeedback (HRVB) — a technique that uses guided breathing to improve the body's stress response — can help veterans with both PTSD and substance use disorder. Participants will be randomly assigned to receive either HRVB or presen…

This trial tests whether methylphenidate, a standard ADHD medication, can reduce attention and hyperactivity problems in children and adolescents with KBG syndrome, a rare genetic condition often accompanied by ADHD-like symptoms. Participants receive alternating blocks of the dr…

This trial tests whether 16 weeks of high-intensity interval training (HIIT) can improve blood vessel function and thinking skills in adults aged 50 and older living with HIV. Participants are randomly assigned to either HIIT or continuous moderate exercise. The study also explor…

This study tests a program called LAGOM designed to improve heart health and quality of life for people with psychotic disorders. 644 adults from six clinics in Gothenburg will either receive the LAGOM program or standard care. The program includes regular check-ups, motivational…

This study tests whether a rotigotine skin patch (Neupro), already approved for Parkinson's disease, can help people with cocaine use disorder cut back on cocaine use when combined with behavioral therapy. Forty adults aged 25 to 70 with moderate to severe cocaine use disorder wi…

This study tests whether offering financial rewards to Alaska Native adults and their family members helps them quit smoking. About 1,312 participants will be randomly assigned to receive the family-based incentive program or standard support. Success is measured by a saliva test…

This phase 2 trial tests whether an oral drug called SAR448851 can slow the progression of early Alzheimer's disease. It includes people with mild cognitive impairment or mild dementia due to Alzheimer's, who have brain amyloid plaques. Participants receive either the drug or a p…

This study tests whether a single dose of psilocybin, taken with psychological support, can ease symptoms of major depression. It also explores whether adding a non-invasive device that gently stimulates the ear—called transcutaneous auricular vagus nerve stimulation—can boost or…

This study tests whether an internet-based depression treatment called cognitive behavioral therapy (iCBT-D) can prevent insulin resistance from getting worse in adults with HIV who are on antiretroviral therapy and have depression. Researchers will compare the online therapy pro…

This phase 2 trial is testing whether an experimental tablet called ALKS 7290 can reduce ADHD symptoms in adults. About 312 adults with ADHD will take either the drug or a placebo daily for 4 weeks. Researchers will measure changes in symptom scores and watch for side effects to …

This trial tests whether a wearable device called RGn600 can slow cognitive decline in people with mild-to-moderate Alzheimer's disease. The device, worn as a helmet and abdominal belt, delivers red-to-near-infrared light and static magnetic fields, aiming to reduce inflammation …

This study tests whether a computerized training program designed to improve response inhibition — the ability to stop an automatic action — can reduce symptoms in people with obsessive-compulsive disorder, trichotillomania (hair-pulling), or skin-picking disorder. Participants a…

This pilot study looks at two strategies to help pregnant and postpartum people with substance use disorder stay in treatment. One strategy screens for social needs like housing or childcare and connects patients to support. The other offers rewards for recovery-supportive behavi…

This study tests a drug called LHP588 in 300 people with mild-to-moderate Alzheimer's who also have a gum infection from P. gingivalis bacteria. The drug aims to target that bacteria to slow down memory and thinking decline. Participants take a daily capsule for up to 48 weeks, a…

This study tests whether starting a monthly extended-release buprenorphine injection (Sublocade) in jail helps people with opioid use disorder stay on treatment after release. Two hundred men entering jail with a daily buprenorphine prescription will be randomly assigned to eithe…

This study tests whether adding the diabetes drug metformin to standard antidepressants helps people with both depression and obesity lose weight and feel better. Researchers will also check if certain gene variants affect how well the combination works. The trial involves 200 ad…

This study follows 300 adults with Parkinson's disease, essential tremor, or dystonia who receive deep brain stimulation (DBS). DBS uses a device implanted in the chest to send electrical pulses to brain areas controlling movement. Researchers will track symptom severity, medicat…

This trial tests whether an 8-week virtual mindfulness program can help substance use peer workers reduce their own relapse risk and burnout. Peer workers—people in recovery who support others with substance use issues—often face high stress. The study compares the mindfulness pr…

This trial tests a new model of care called PEN-Plus, which brings specialized treatment for severe chronic diseases like diabetes, heart conditions, and sickle cell disease to first-level hospitals in Zambia. The goal is to train local health workers and set up clinics to manage…

This study tests an experimental medicine called brenipatide to see if it helps adults with alcohol use disorder drink less and reduce cravings. About 1,100 participants will receive either the drug or a placebo by injection for nearly a year. The goal is to find a safe, effectiv…

This trial tests whether a 12-session healthy lifestyle program—focusing on physical activity, nutrition, sleep, and stress management—can lower cardiovascular risk in adults with posttraumatic stress disorder (PTSD). Participants are adults with PTSD symptoms who are also overwe…

This study tests whether adding brenipatide to standard schizophrenia medication is safe and effective. About 450 adults with schizophrenia will receive either brenipatide or a placebo for up to 12 months. The study looks at weight changes, cognitive function, and time to relapse…

This study tests two approaches to improve thinking and reduce inflammation in people with HIV who drink alcohol. One approach uses a probiotic supplement to restore healthy gut bacteria. The other uses a mild electrical device worn on the ear to stimulate a nerve linked to infla…

This study tests donanemab, an experimental drug, against a placebo in 140 Chinese adults who show early signs of Alzheimer's risk. Participants receive the drug intravenously every few weeks for up to 3 years. The goal is to see if donanemab can delay memory loss and help mainta…

This study tests whether adding a new drug called brenipatide to standard depression treatment can delay the return of major depressive symptoms. About 1000 adults with major depression who are already on stable medication will receive either brenipatide or a placebo as a shot, p…

This phase 2 trial tests whether donanemab, an antibody given by IV, can slow worsening of thinking and daily function in people with early cognitive decline and Lewy body dementia. The study enrolls 350 participants who also have signs of two brain proteins (amyloid and alpha-sy…

This Phase 3 trial tests trontinemab, an antibody given by IV, in 800 people with early Alzheimer's (mild cognitive impairment to mild dementia). Half get the drug, half get a placebo, for 72 weeks. The goal is to see if it slows decline in memory, thinking, and daily activities.

This phase 3 study tests whether brenipatide can help adults with moderate-to-severe alcohol use disorder drink less and feel less urge to drink. About 1,100 motivated participants will receive either the drug or a placebo for 56 weeks. The main goal is to see changes in drinking…

This trial tests whether a natural compound from citrus fruits, hesperidin, can improve cognitive function in overweight and obese adults aged 55 to 75. Participants take either a placebo, a low dose, or a high dose of hesperidin daily for 10 weeks. The study measures changes in …

This Phase 3 trial tests whether trontinemab can slow down Alzheimer's in people with early symptoms like mild memory problems. About 800 volunteers will receive either the drug or a placebo by IV for 72 weeks. The study measures changes in thinking, daily function, and safety.

This trial compares two parenting programs for caregivers who have depression and are seeking help for their child's emotional or behavioral difficulties. The experimental program, ADAPT, is designed to address the unique emotional needs of depressed parents, while the control is…

This study tests whether adding the drug brenipatide to standard treatment can delay the return of bipolar symptoms compared to a placebo. About 400 adults with bipolar I or II will self-inject the study drug or placebo for at least 6 months. The main goal is to see how long it t…

This Phase 2 trial tests whether adding brenipatide to standard buprenorphine treatment helps people with opioid use disorder stay off opioids longer. About 465 participants will receive either brenipatide or a placebo injection alongside their usual medication. The study measure…

This trial tests whether a brief, individually tailored parent training program—just three sessions with optional boosters—can reduce behavioral difficulties in children aged 2 to 12, compared to usual care. Parents of children referred to mental health centers are randomly assig…

This early-stage trial is testing whether a single oral dose of ayahuasca can reduce the frequency of psychogenic non-epileptic seizures (PNES) in adults aged 18 to 60. Participants must have PNES confirmed by video-EEG and will taper off psychiatric medications before the dose. …

This study tests a program called Returning to the Land, designed for young Native American caregivers (ages 14-19) who have a child aged 1-5. The program uses time in a biodiverse outdoor setting to address caregiver substance use and support children's emotional and behavioral …

This study tests whether combining yoga with a mild electrical brain stimulation technique, called tDCS, can improve thinking and memory in people with psychosis. Participants will be randomly assigned to receive either active tDCS during yoga or a sham (inactive) version, and re…

This trial tests whether a single dose of levetiracetam, a drug used for epilepsy, can reduce overactivity in the hippocampus — a brain area linked to thinking and memory problems in psychosis. People aged 18–40 who are at risk of psychosis will take either the drug or a placebo …

This study tests two types of non-invasive brain stimulation (rTMS) to help veterans stop smoking. About 56 veterans who smoke at least 10 cigarettes a day will receive either standard or precision-guided rTMS over three weeks. Researchers will measure how much smoking decreases …

This expanded access program offers continued treatment with OLZ/SAM, a combination of olanzapine and samidorphan, to adolescents with schizophrenia or bipolar I disorder who have already completed a year-long study of the drug. The goal is to provide ongoing access to the medica…

This study tests whether adding cognitive behavioral therapy (CBT) can help children and teens with obsessive-compulsive disorder (OCD) safely stop their medication without symptoms returning. Participants first receive CBT for 12 to 18 weeks, then continue with maintenance sessi…

This study tests whether deep brain stimulation (DBS) can safely treat severe, treatment-resistant bipolar depression. The approach uses a brain implant that delivers stimulation and simultaneously monitors brain signals linked to depression and mania. The goal is to see if this …

This trial investigates whether combining repetitive transcranial magnetic stimulation (rTMS) with aerobic exercise can treat depression and improve walking in people who have had a stroke. Participants will receive either real or sham rTMS along with exercise sessions over 12 we…

This study tests whether combining aerobic exercise with computerized cognitive training, both delivered via telehealth, can improve thinking and motivation in people who have recently experienced a first episode of schizophrenia. About 100 participants will receive cognitive tra…

This trial tests whether two different eating plans—time-restricted eating (eating within a 10-hour window each day) and a Mediterranean diet—can help people with bipolar disorder. Participants will track their eating, sleep, and mood for two weeks, then follow one of the diets f…

This early-phase study tests whether spironolactone, a drug currently used for high blood pressure and heart failure, can be safely used in people with alcohol use disorder. Twenty participants will each stay at a clinic four times, taking either the drug or a placebo for five da…

This study tests a new drug, GSK4532990, in about 393 adults with liver inflammation from alcohol use. The goal is to see if it safely reduces liver stiffness and improves liver function over 52 weeks. Participants receive either the drug or a placebo, and researchers monitor sid…

This study tests whether the diabetes drug metformin can prevent blood sugar increases caused by statins in people with schizophrenia. Researchers will give 400 patients either metformin or a placebo alongside atorvastatin for six months. The goal is to see if metformin helps kee…

This study tests a personalized approach to brain stimulation for people with major depression that hasn't improved with standard treatments. A device implanted in the brain measures each person's unique depression-related brain activity and delivers small electrical impulses to …

This study tests a new approach where nurses, rather than doctors, adjust methadone doses for people starting treatment for opioid addiction. The goal is to see if this makes it easier for patients to stay in care for at least three months. The trial will enroll 182 adults in Fre…

This study tests whether giving smokers a personalized quit plan based on their genes, health history, and biomarkers helps more people stop smoking than standard advice. About 850 smokers and their doctors from primary care clinics will take part. The goal is to see if tailored …

This trial tests whether machine learning can help choose the most effective digital mental health program for each person with anxiety or depression. About 1,800 adults will be randomly assigned to one of three online therapy programs, and the study will use the results to build…

This study compares two weight-loss strategies: GLP-1 medications (like semaglutide or tirzepatide) versus a structured diet and exercise program. Adults with a BMI of 27.5 or higher are followed for three months to see which approach better improves heart and metabolic markers, …

This trial tests whether a single session of low-intensity focused ultrasound aimed at a brain region linked to reward and craving can safely reduce substance cravings and prevent relapse in people with severe opioid or amphetamine use disorder. Sixty participants will receive th…

This trial investigates whether a next-generation deep brain stimulation (DBS) system can reduce symptoms in people with major depression that hasn't improved with standard treatments. The device uses directional current steering to precisely target brain networks thought to be i…

This trial tests whether a smartphone app called TRIS, paired with a Bluetooth breathalyzer and small daily cash rewards for verified abstinence, can help people with alcohol use disorder drink less. Participants submit three breath samples each day; those who are sober earn ince…

This trial tests whether a single injection of [18F]-APN-1607, a radioactive tracer that binds to tau protein, can produce PET images that match the actual tau buildup found in the brain after death. It includes healthy volunteers and people with mild cognitive impairment or Alzh…

This phase III trial is evaluating whether an experimental PET imaging agent, [18F]Fluorbetazine, can accurately detect amyloid-beta plaques in the brain—a hallmark of Alzheimer's disease. The study will include about 400 adults aged 40 and older with normal cognitive function, m…

This study tests whether an online parenting program, eHealth Familias Unidas, can reduce symptoms of depression, anxiety, and suicidal behavior in Hispanic adolescents aged 12 to 16. The program involves 13 online sessions that aim to strengthen family communication and protecti…

This study tests a simple talking therapy for heart surgery patients while they are still in the ICU. The therapy uses a visitor book with photos and family messages to help patients process stressful memories. Researchers hope this can prevent posttraumatic stress disorder (PTSD…

This study tests whether using hearing aids and related support can help slow memory decline in adults aged 55-75 who have mild to moderate hearing loss and early signs of memory problems. Participants are randomly assigned to receive either a hearing intervention or a health edu…

This study tests whether a 'practice coaching' program can help opioid treatment clinics offer more HIV and hepatitis C testing to their patients. Clinics are randomly assigned to receive either coaching focused on HIV testing, coaching that adds hepatitis C testing, or just info…

This pilot study will test a 10-session virtual group program called Parents and Babies, designed to prevent postpartum depression in LGBTQ+ parents. The program teaches coping skills based on cognitive-behavioral therapy. Researchers will enroll 16 LGBTQ+ individuals who are pre…

This trial tests whether a self-guided mindfulness app can help reduce pain after a cesarean delivery and prevent postpartum depression. The study enrolls women aged 18-45 who are scheduled for a planned C-section, have a history of depression, and show mild depressive symptoms. …

This trial tests whether proactively connecting household smokers to quit-smoking resources through a child's pediatric care visit increases their use of evidence-based treatments and quit rates. Adult household members who smoke are offered options like nicotine replacement, var…

This study tests whether the drug HT-4253 can lower Alzheimer's risk in people aged 50-75 who carry the APOE4 gene and have high levels of amyloid in their blood. The 112 participants will receive either the drug or a placebo for 48 weeks. The main goal is to see if the drug can …

This trial tests whether a single online session can help prevent eating disorders in young adults at risk. Participants will complete a screening survey and then receive a brief intervention that teaches about habits and how to change them. The study aims to see if this approach…

This study tests a digital tool called the Family Check-Up Online, designed to prevent family violence and improve child mental health. About 1,270 families with children aged 11-14 will use the program, with some getting extra coach support. Researchers will measure changes in p…

This phase 3 trial tests whether acoramidis can prevent or delay transthyretin amyloidosis (ATTR) in 587 adults who carry a faulty gene but have no symptoms yet. ATTR causes sticky plaques to build up in the heart and nerves, leading to heart failure and nerve damage. Acoramidis …

This study explores whether visiting a museum can support the social and emotional well-being of autistic adults. Researchers plan to enroll 90 autistic adults aged 18 to 50 with average intellectual ability. Participants choose one of three options: a solo museum visit, five gui…

This pilot study tests a 12-week therapy called Integrated Suicide and Trauma Therapy (ISTT) in 20 adults with a history of childhood trauma and current suicidal thoughts. The therapy combines coping skills training with trauma-focused treatment to address both suicide risk and t…

This study is developing and testing a smartphone app called ACT to RECOVER, designed to help veterans receiving medication for opioid use disorder improve their daily functioning and quality of life. The app is based on Acceptance and Commitment Therapy (ACT), a well-supported a…

This Phase 2 trial will test whether adding selenium supplements to standard antidepressant medication (fluoxetine) can improve depression symptoms in 172 children and adolescents aged 12-18 with major depressive disorder. Participants will receive either selenium or a placebo fo…

This study tests whether real-time brain training (amygdala neurofeedback) can help people with borderline personality disorder (BPD) feel less intense negative emotions. Participants will either receive real feedback from their own brain activity or a fake (sham) signal while vi…

This study tests a program called Grow with Grit, where school nurses screen children aged 8-12 in rural Montana for anxiety using a standard questionnaire. Children who show signs of anxiety receive a brief, 3-5 minute coping-skills session during a regular nurse visit, along wi…

This study tests whether a ketogenic diet (high fat, low carb) can improve brain energy and reduce psychiatric symptoms in people with early bipolar disorder. Fifty participants will follow either the ketogenic diet or standard dietary guidelines for 12 weeks. Researchers will me…

This Phase 3 study tests whether CYB003, a psilocin analog (related to the active ingredient in magic mushrooms), can safely reduce depression symptoms in 330 adults with major depressive disorder. Participants receive either one of two doses of CYB003 or a placebo, along with ps…

This trial tests whether an internet-based cognitive behavior therapy (CBT) program can reduce symptoms of anxiety, depression, and stress in adults with mild mental health issues who visit primary care. Participants are randomly assigned to either the online CBT program, which i…

This study tests whether a strict high-fat, low-carbohydrate (ketogenic) diet can help ease depression in people with bipolar disorder. Thirty adults aged 18 to 50 with bipolar I or II will follow the diet for 8 weeks while researchers track mood changes and heart health. The goa…

This study tests a new drug called SPT-300 in 360 adults with major depressive disorder, with or without anxiety. Participants will receive either the drug or a placebo for 6 weeks to see if it reduces depression symptoms. The goal is to find a safe and effective new treatment op…

This Phase 3 trial tests whether fenfluramine (Fintepla) can reduce behavioral and emotional symptoms in people with Rett syndrome. About 200 participants will receive either the drug or a placebo for 14 weeks. The study measures changes in behavior, sleep, and overall condition …

This pilot study tests whether engaging in enjoyable activities and virtual reality can reduce alcohol cravings and drinking in people with alcohol use disorder. About 44 adults will attend up to 10 visits, comparing active sessions (games, VR, crafts) with passive sessions (watc…

This study tests an experimental drug called ITI-1284 for people with generalized anxiety disorder (GAD) whose current treatment isn't working well enough. About 705 adults will receive either ITI-1284 or a placebo added to their usual therapy. The goal is to see if the drug safe…

This study looks at whether over-the-counter hearing aids can improve communication for older adults with mild cognitive impairment and mild to moderate hearing loss. Fifty participants and their communication partners will be randomly assigned to try hearing aids first or receiv…

This study tests whether an adapted questionnaire, called the Care Partner Hospital Assessment Tool (CHAT-AD), can help care partners of hospitalized people with Alzheimer's disease or related dementias feel more prepared to provide care after discharge. Participants are unpaid f…

This study explores whether hypnosis can help people with stroke, traumatic brain injury, or multiple sclerosis improve their attention and reduce fatigue. About 48 participants will receive hypnosis sessions alongside standard care, while researchers monitor brain activity with …

This trial tests whether daily music training—either piano practice or listening to music—can improve behavior and thinking in children with fetal alcohol spectrum disorder (FASD). Each child will do both activities for 12 weeks each, in a random order, with tests before and afte…

This pilot study will test whether a mobile phone app can help reduce depression symptoms in African American adults. Eight participants will attend six weekly 90-minute classes through the app and complete surveys over four months. The goal is to see if this approach is effectiv…

This trial tests two ways to bring nature to older adults stuck in the hospital for weeks: watching 360-degree nature videos through a virtual reality headset, or listening to audio guides that prompt them to imagine the same scenes. Both approaches use identical nature themes—me…

This study tests an experimental drug called icalcaprant for treating depression in people with bipolar I or II disorder. About 195 adults will take either the drug or a placebo daily for 6 weeks. Researchers will measure changes in depression symptoms and watch for side effects.

This trial explores whether wearing a bright light device for 60 minutes each morning for five weeks can help new mothers with postpartum depression. It focuses on whether the treatment is practical and acceptable to participants, and how it might be implemented in real-world set…

This pilot study tests a bedtime routine called 'The Power Down' for autistic children aged 6 to 10 who have trouble settling down to sleep. The routine uses gentle massage and calming sounds to help children relax before bed. Caregivers will lead the routine each night for two w…

This trial tests a short virtual program designed to help older adults with early-stage dementia and their family caregivers work together on medication management. The program includes education about dementia, discussions about beliefs around independence and help, and creating…

This trial tests whether using a weighted blanket at night and during the day can improve sleep in children aged 5-12 with ADHD who still have sleep problems despite standard care. Half the children will receive a weighted blanket, while the other half gets a non-weighted sham bl…

This study tests if a noninvasive, at-home brain stimulation device (tDCS) can safely ease symptoms of major depression. Two hundred adults with depression will use the device themselves at home for 10 weeks, with video check-ins. The goal is to see if this approach reduces depre…

This study tests whether psilocybin, the active ingredient in magic mushrooms, can help veterans with depression that hasn't improved with at least two other treatments. 240 veterans will receive either psilocybin or a placebo in a controlled setting. The goal is to see if it red…

This study tests whether suvorexant, a sleep medication, can help people with opioid use disorder fall asleep and stay asleep. About 300 participants will receive either suvorexant or a placebo. The goal is to see if the drug improves total sleep time and is safe to use.

This study tests a computer-based therapy for adults with social anxiety disorder. Researchers want to see if it reduces anxiety and improves quality of life. About 80 people aged 18 to 60 with social anxiety will participate. The therapy is designed to be a new, accessible treat…

This study compares two brain-training programs for adults with ME/CFS who experience brain fog. Both programs include computer games and a mild nerve stimulation device, but one focuses on processing speed and daily tasks while the other emphasizes relaxation and healthy habits.…

This trial tests a structured, 8-session program designed to help adults who stutter feel less anxious and more confident in job interviews. The program uses techniques like cognitive restructuring, voluntary stuttering, and simulated interviews to gradually reduce fear of negati…

This study looks at whether a store-bought weighted blanket can help children aged 5-12 with ADHD who have trouble sleeping. 100 kids will use the blanket every night for 4 weeks, and researchers will track their sleep with a wrist monitor. The goal is to see if the blanket incre…

This study tests two experimental drugs, EXV-802 and EXV-801, to see if they can safely reduce agitation in people with Alzheimer's dementia. About 300 participants aged 55-90 with moderate to severe agitation will receive either the drug or a placebo twice daily for 6 weeks. The…

This study tests whether a nasal spray containing oxytocin (a natural hormone) can help adults with binge-eating disorder eat less often in binges. About 60 adults will receive either the oxytocin spray or a placebo for 8 weeks. Researchers will track changes in binge frequency a…

This study tests a new form of transcranial magnetic stimulation (TMS) for post-traumatic stress disorder (PTSD). Unlike standard TMS, which takes 6-7 weeks, this accelerated version delivers 10 sessions per day for 5 days. Researchers will enroll 40 adults with PTSD to see if ac…

This study tests whether psilocybin (the active ingredient in magic mushrooms) combined with therapy can help reduce depression, anxiety, and stress in adults whose parents survived genocide. One hundred participants will receive a single 25mg dose under supervision, followed by …

This study explores whether rhythmic auditory stimulation (like a metronome beat) can improve walking and brain function in people with Alzheimer's disease or mild cognitive impairment. Participants will walk while listening to rhythmic sounds, and researchers will measure change…

This study investigates whether a single dose of psilocybin, the active compound in magic mushrooms, can reduce rumination—repetitive negative self-focused thinking—in people with major depressive disorder. Researchers will use brain scans to see how psilocybin changes activity i…

This large study tests a collaborative care model (COMPASS+) that adds a mental health care manager to regular obstetric care for pregnant and postpartum people. The care manager offers short-term therapy, tracks symptoms, and works with doctors and a psychiatrist to create perso…

This study looks at whether teaching people with a colostomy or ileostomy how to care for their stoma helps them adjust better, feel better about their body, and manage their daily life. About 100 adults who had planned stoma surgery will take part. The goal is to see if educatio…

This trial tests whether a structured talk therapy called ConquerFear can help people with advanced cancer manage their fear of the disease progressing. It compares ConquerFear to a supportive-expressive approach, which focuses on emotional expression and support. The study invol…

This study tests whether adding a computer task called gaze-contingent music reward therapy (GCMRT) to standard cognitive behavioral therapy (CBT) helps reduce anxiety in children aged 8 to 17. In GCMRT, children look at faces on a screen while pleasant music plays or stops depen…

This study tests an experimental oral medication (BMS-986368) to reduce agitation in people with Alzheimer's disease. About 120 participants will receive either a low dose, high dose, or placebo. The main goal is to see if the drug safely decreases agitated behaviors, such as pac…

This study looks at whether a simple, non-needle ear acupressure technique can lower anxiety and pain in women having breast surgery after a first breast cancer diagnosis. About 66 women will either get standard care or standard care plus ear acupressure. The goal is to see if th…

This study tests whether a structured nursing program—including patient education, emotional support, and clear communication—can help men feel more resilient and less anxious when undergoing a transrectal prostate biopsy. Around 120 men scheduled for the procedure will receive t…

This study tests whether low-intensity focused ultrasound (LIFU), a gentle sound wave technique, can safely improve speech fluency in people who stutter. Twenty adults who stutter will receive LIFU or a sham treatment, and researchers will measure changes in stuttering severity a…

This study tests Mom-Net, an online cognitive behavioral therapy program with coaching, for low-income mothers with depression whose children are in Head Start. About 960 mothers will be assigned to Mom-Net or usual care, with coaching provided by Head Start staff. The goal is to…

This phase 2 trial at MD Anderson Cancer Center is testing whether psilocybin-assisted psychotherapy can safely help ease depression and anxiety in 30 adults with advanced cancer who are on maintenance therapy. Participants receive either psilocybin or a placebo (niacin) along wi…

This study tests a culturally adapted decision aid for Chinese American family caregivers of people with moderate to advanced dementia who face feeding difficulties. The tool, called CMCFODA, provides information on tube feeding versus hand feeding and includes personalized coach…

This study tests whether psilocybin, the active ingredient in magic mushrooms, combined with talk therapy can safely help cancer survivors with depression or anxiety. Twenty adults who have finished cancer treatment and have no brain involvement will receive a single dose of psil…

This study tests a new drug called RR-HNK (related to ketamine) to see if it safely reduces obsessive-compulsive disorder (OCD) symptoms. About 45 adults with OCD who haven't improved with standard treatments will receive two doses of the drug or a placebo. The main goal is to me…

This phase 2 trial is investigating whether two doses of psilocybin (25 mg each, given 4 weeks apart) combined with psychotherapy are safe and acceptable for people with bipolar II disorder who are experiencing depression and suicidal thoughts. The study enrolls 10 adults aged 25…

This phase 2 trial tests whether DT-101 can ease depression symptoms in adults with major depressive disorder who are already on antidepressant medication. About 118 participants will receive either DT-101 or a placebo, and researchers will track changes in depression scores over…

This trial investigates whether a low-dose psilocybin oral solution can safely ease symptoms of generalized anxiety disorder (GAD). Adults aged 18-60 with a GAD diagnosis and moderate-to-severe anxiety will first receive open-label psilocybin for four weeks, then those who respon…

This trial tests whether a single dose of clonidine, given during surgery, can reduce emergence agitation—crying, thrashing, and confusion—when infants wake from anesthesia. The study includes infants aged 3 to 12 months undergoing general anesthesia with sevoflurane. Half receiv…

This study tests a new drug called KH-001, taken as a fast-dissolving tablet under the tongue 15 minutes before sex, to see if it helps men with lifelong premature ejaculation last longer. About 40 men in stable relationships will try the drug or a placebo for 4 weeks each, with …

This trial explores whether a non-invasive device that delivers mild electrical stimulation to the head can help reduce anxiety before meals in adults hospitalized for eating disorders. Participants will use the Alpha-Stim AID device for 20-minute sessions before breakfast, lunch…

This phase 3 trial tests whether a combination of two drugs, KarXT and KarX-EC, can safely reduce agitation in people with Alzheimer's disease. About 352 adults will receive either the drug combo or a placebo for 14 weeks. The main goal is to see if agitation symptoms improve, as…

This study tests a quick, non-invasive brain stimulation method called accelerated intermittent theta-burst stimulation (aiTBS) to see if it can improve mood in people with borderline personality disorder (BPD) who are also experiencing a major depressive episode. About 45 adults…

This study tests whether a non-invasive brain stimulation technique called rTMS can improve symptoms of major depression and chronic pain at the same time. Fifty-four adults with moderate depression and pain will receive 30 sessions of active rTMS over several weeks. Researchers …

This early-stage trial tests BXCL501, a dissolving film placed under the tongue, to quickly reduce agitation in children and teens aged 10-17 with schizophrenia or bipolar disorder. About 140 participants will receive either the drug or a placebo. The study measures changes in ag…

This study tests whether combining virtual reality therapy with a mild brain stimulation technique can help veterans and civilians in Ukraine cope with PTSD. Participants attend 10 therapy sessions using VR goggles to safely face traumatic memories, with some also receiving a gen…

This trial tests whether watching cartoons or squeezing a stress ball can reduce fear, anxiety, and pain in children aged 4-10 during allergy skin testing. Ninety children will be randomly assigned to one of three groups: cartoon-watching, stress ball use, or routine care. Resear…

This study is developing and testing an online platform called LEND that shares personal stories from people with dementia and their carers. The goal is to see if these relatable narratives can boost wellbeing, confidence, and quality of life for both groups. The trial involves i…

This trial tests an experimental drug called LTX-001 in adults with schizophrenia who are experiencing a sudden worsening of symptoms. Participants stay in a research unit for about five weeks and receive either LTX-001 or a placebo. The main goal is to see if the drug is safe an…

This study tests whether a single dose of the drug Epidiolex (cannabidiol, or CBD) can reduce feelings of anxiety, physical stress signs, and brain activity linked to anxiety in people with social anxiety disorder. About 50 adults aged 18-55 with significant social anxiety will t…

This Phase 3 trial tests whether adding NBI-1065845 to standard antidepressants can better ease depression symptoms in 200 adults who haven't fully responded to current treatments. Participants take the drug or a placebo for 8 weeks, and doctors measure changes in mood and daily …

This study tests whether a noninvasive brain stimulation technique called iTBS can improve working memory in people with early-stage schizophrenia. Researchers will use magnetic pulses and EEG to measure brain activity before and after stimulation. The goal is to see if iTBS can …

This study tests an experimental drug called cleminorexton in 222 adults with narcolepsy type 1 or 2. The drug mimics a natural brain protein that helps keep people awake. The goal is to see if it safely reduces daytime sleepiness and improves daily functioning. Participants must…

This study tests SloMo, a digital therapy that helps people with psychosis who fear harm from others. It combines face-to-face sessions with a mobile app to help users notice worries and slow down fast thinking. 150 participants across three NHS trusts will try the therapy, with …

This study tests a remote behavioral therapy called PAT-AN for adults recovering from anorexia. The therapy focuses on enhancing the brain's reward response to non-food experiences, like hobbies or socializing, to reduce reliance on weight-loss behaviors. Participants will receiv…

This study tests whether a specialized speech therapy that focuses on word meanings can help people with mild-to-moderate semantic aphasia—a condition where brain damage impairs understanding and use of words. Participants first undergo a control period of standard language exerc…

This trial tests whether a non-invasive brain-stimulation device called transcranial direct current stimulation (tDCS) can reduce symptoms of moderate-to-severe depression in pregnant people. Participants use the device at home for 15 sessions over three weeks, while a comparison…

This phase 3 study is testing an oral drug called DT120 (related to LSD) against a placebo in 165 adults with major depressive disorder. Participants will take the drug or placebo for 12 weeks, followed by a 40-week period where everyone can receive DT120. The main goal is to see…

This trial tests whether an ultrasound-guided nerve block, using the anesthetic bupivacaine, can reduce pain and the need for opioid painkillers after laparoscopic gallbladder removal. Sixty adults with a healthy weight and low surgical risk will receive either the nerve block or…

This early-stage study at Johns Hopkins is testing whether cannabidiol (CBD) can reduce stress and nicotine withdrawal symptoms in people who smoke. Ninety healthy smokers will receive CBD and then be exposed to stress while researchers measure their mood, heart rate, and stress …

This study tests a single injection of apimostinel, a fast-acting antidepressant, in 150 adults with major depression. Half also receive digital cognitive training sessions to see if it extends the drug's effects. The trial is placebo-controlled and double-blind, meaning neither …

This trial tests whether a smartphone app called AffectUs can help people with schizophrenia or schizoaffective disorder better recognize emotions and interpret social situations. Participants use the app for 10 weeks, five times a week, while continuing their usual treatment. Th…

This trial tests whether Deprexis, a self-guided online program, can reduce depressive symptoms and improve daily functioning in veterans with mild to moderate depression. Participants will use the 12-module program over 8 weeks, and their progress will be compared to those recei…

This study tests whether psilocybin (the active ingredient in magic mushrooms) is safe and tolerable for veterans with spinal cord injury who also have depression. Thirty participants will receive low, medium, or high doses and be monitored for side effects like pain, muscle spas…

This study tests an online wellness course that teaches diet, exercise, stress reduction, and self-care to people with rheumatoid arthritis, lupus, Sjogren's syndrome, and similar conditions. Researchers want to see if the program reduces fatigue and improves quality of life. Abo…

This study tests whether a non-invasive brain stimulation technique called transcranial magnetic stimulation (TMS) can reduce symptoms of borderline personality disorder (BPD). Up to 30 adults with BPD will receive either real or sham TMS over several weeks. Researchers will trac…

This study tests whether AI-powered modules, accessed through a phone or computer app, can help autistic individuals improve social communication. Participants practice skills like empathy, asking questions, and listening, receiving feedback via voice recognition. The goal is to …

This study tests a wearable device worn on the ear that stimulates nearby nerves to change brain signals. The goal is to see if it can reduce chronic pain and ease symptoms of opioid withdrawal. Adults aged 18 to 65 with chronic pain who are tapering off opioid medication will re…

This Phase 3 trial is testing whether an experimental drug called NBI-1065845 can help reduce depression symptoms in adults who haven't responded well to standard antidepressants. About 200 participants will take either the drug or a placebo alongside their current antidepressant…

This study tests whether a virtual reality program can help children with ADHD improve their attention by repeatedly exposing them to distractions in a simulated classroom. The idea is that, like getting used to a loud noise, children may become less reactive to distracting sight…

This study tests whether a single dose of psilocybin, given with psychological support, can improve depression in people with Parkinson's disease. Sixty adults aged 40 to 80 with mild to moderate Parkinson's and depressive symptoms will receive either a low or high dose of psiloc…

This study tests a new anonymous online therapy program called Restory for people with PTSD after sexual abuse. It is designed for 140 adults who have experienced sexual violence at least one month ago. The therapy uses a type of talk therapy done over the internet, and the goal …

This study tests a program called Parenting STAIR Modular (PSTAIR-M) for military-connected mothers who have experienced trauma and have young children aged 2-10. The program helps mothers manage PTSD and depression symptoms while improving their parenting skills. Researchers wil…

This trial tests whether listening to music before, during, and after surgery can lower anxiety, reduce pain, and cut down on painkiller use. About 410 healthy adults having day surgery, gynecologic surgery, or cesarean section will be involved. Participants in the music group wi…

This study tests whether cannabidiol (CBD) can reduce the need for strong painkillers (opioids) in people with end-stage prostate cancer that has spread and no longer responds to standard treatments. About 58 participants will receive either CBD or a placebo three times daily for…

This study looks at whether cannabis can help veterans who have PTSD and thoughts of suicide. About 500 veterans who have used cannabis in the past year will take part. Researchers will track changes in PTSD symptoms, mood, and suicide risk over time using interviews and question…

This study tests whether a new form of exposure therapy, called Expectancy Focused Exposure (EFE), can reduce anxiety symptoms and prevent fear from returning more effectively than traditional exposure therapy. Adults with anxiety disorders—such as social anxiety, panic disorder,…

This study tests a short, three-session online program designed to help caregivers of people with advanced prostate cancer manage their fear that the cancer will progress. The program teaches techniques like detached mindfulness to help caregivers relate to worrying thoughts in a…

This study looks at whether adding hypnosis or relaxation sessions to standard psychological care can lower anxiety in children, teens, and young adults who have finished treatment for pediatric cancer. About 558 participants aged 7 to 25 who are in remission and have anxiety wil…

This study tests whether a computer-based working memory training program can help veterans with PTSD improve their ability to unlearn fear responses. 120 veterans will be randomly assigned to either the training or a sham version. The goal is to see if the training changes brain…

This study tests whether a smartphone app called Bodhi AIM can help youth aged 13–20 who are on probation or in related legal programs improve their psychological wellbeing and reduce distress. Participants use the app for one month, following daily guided meditations. The trial …

This study tests a device called Neuclare that is placed on the head to see if it can temporarily improve planning and problem-solving skills in people with mild cognitive impairment or very early Alzheimer's disease. About 138 adults aged 55 to 90 who are already on memory medic…

This study tests a brief group therapy called Acceptance and Commitment Therapy for insomnia (ACT-i) in 76 adults aged 18-59 with chronic insomnia and mild depression or anxiety. Participants are randomly assigned to either ACT-i or a general support group. The goal is to see if …

This trial compares two types of nerve blocks given before breast surgery to see which better prevents chronic pain that can last for months. Women aged 18-65 scheduled for mastectomy will receive either a serratus posterior superior intercostal plane block or an erector spinae p…

This study tests a new medicine called ACP-211 in adults with major depression who haven't gotten better with standard antidepressants. About 153 people will receive either the drug or a placebo for 28 days. The main goal is to see if ACP-211 reduces depression symptoms more than…

This trial tests a technology-based program called the Parenting Young Children Check-up (PYCC) for parents of children aged 2 to 5 with challenging behavior. Fifty parents from a Detroit pediatric clinic serving low-income families will be randomly assigned to either the program…

This study tests whether a non-invasive brain stimulation technique called TMS can reduce cravings and opioid use in people with opioid use disorder. One hundred participants will receive either real or sham TMS sessions over 8 weeks, with follow-up visits for about 5 months. The…

This study tests a tool called HART that helps caregivers of people with Alzheimer's or related dementias find health apps suited to their needs. Fifteen family caregivers will use the tool for four weeks and provide feedback on how easy it is to use and whether it improves their…

This study tests whether lumateperone (Caplyta) can help older adults (60+) whose depression hasn't improved with other treatments. One hundred participants will take either the drug or a placebo alongside their current antidepressant for 10 weeks. Researchers will measure change…

This study tests a smartphone app called CALM that teaches veterans with traumatic brain injury and PTSD strategies to improve focus, planning, and self-control. One hundred veterans and a family member or friend will be randomly assigned to use the app or receive brain health ed…

This study tests whether a single injection of RE104 can reduce symptoms of depression or mixed depression and anxiety in people with adjustment disorder caused by a serious medical illness like cancer, ALS, multiple sclerosis, Parkinson's disease, or idiopathic pulmonary fibrosi…

This study compares two types of nerve blocks—SPSIPB and ESPB—for pain relief after breast surgery. 54 women will be randomly assigned to receive one block before anesthesia. Researchers will measure pain scores and opioid use in the first 24 hours to see which block works better…

This study tests a new medication called PP-01 to help adults with cannabis use disorder manage withdrawal symptoms when they stop using cannabis. About 420 participants will receive PP-01, an existing drug (nabilone), or a placebo daily for 34 days, with a one-week hospital stay…

This study will test if an internet-based cognitive behavioral therapy (iCBT) program can help reduce symptoms of mild-to-moderate anxiety and depression in adults in Singapore. About 390 participants will either receive the 8-week online program with counselor check-ins or conti…

This study tests whether a brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can help ease depression in people with schizophrenia. Researchers will give up to 20 sessions of active or sham rTMS to 120 participants and use brain scans to see h…

This study tests a group-based program called GEARS that teaches emotion regulation skills to adults with ADHD. Researchers will compare 150 participants who receive GEARS to those on a waiting list, measuring changes in emotional control, ADHD symptoms, and quality of life. The …

This study tests whether a nerve block (injecting numbing medicine near a nerve in the ear) can reduce pain and the need for strong painkillers after middle ear surgery. About 56 adults having ear surgery will be randomly assigned to get the nerve block or standard care. The main…

This study tests a program that teaches family caregivers how to help their loved ones with mild to moderate dementia manage chronic pain. Researchers will work with 60 people (30 patients and their caregivers) to see if the training improves pain coping and quality of life. The …

This pilot study tests whether repeated transcranial magnetic stimulation (rTMS) can reduce stuttering in adults. Two participants will receive 10 rTMS sessions, and researchers will measure changes in brain activity and speech. The goal is to see if this non-invasive treatment c…

This study tests whether a daily medication called vortioxetine can safely reduce depression symptoms in Japanese teenagers aged 12 to 17 with major depressive disorder. About 180 participants will receive either the drug or a placebo for 14 weeks, with follow-up for 4 more weeks…

This pilot study tests a new one-day treatment for people with borderline personality disorder (BPD) who have suicidal thoughts. It combines a medication called D-cycloserine with up to 20 short sessions of transcranial magnetic stimulation (TMS) over 12 hours. The study enrolls …

This study tests whether psilocybin, the active ingredient in magic mushrooms, can help relieve severe pain in people with advanced cancer when opioids don't work. Fifteen participants will receive psilocybin capsules along with therapy sessions. The goal is to see if this approa…

This study tests an AI companion called Baba that calls or texts older adults who live alone. Baba uses conversational AI to chat, track emotions, and alert caregivers if needed. The goal is to see if regular conversations can reduce loneliness and improve mood over 12 weeks.

This study tests whether a short, four-session therapy program that helps people rethink their identity and memories related to drinking can reduce alcohol use and cravings. Sixty adults with alcohol use disorder will be randomly assigned to either receive this therapy plus usual…

This study investigates whether adding the steroid dexamethasone to a standard ultrasound-guided nerve block (transversalis fascia plane block) can improve pain control after cesarean delivery. Researchers will compare opioid use, pain scores, and recovery quality in women who re…

This study tests whether a generative AI chatbot can help new mothers learn about pelvic floor health and reduce feelings of loneliness after childbirth. Researchers will compare standard postpartum care with or without access to the chatbot over 4 weeks. The trial involves 130 f…

This study tests two digital mindfulness programs—one live over Zoom and one self-paced app—to see if they can reduce depression in younger breast cancer survivors. It includes 402 women diagnosed at or before age 50 who finished cancer treatment at least 6 months ago and have el…

This study compares using virtual reality glasses versus the standard 'show-do' technique to reduce dental anxiety in 54 children with moderate to severe hearing impairment. The children will have their pulse and anxiety scores measured during a dental cleaning. The goal is to se…

This study is testing a new online exercise program made specifically for people with chronic brain injury. Researchers want to see if it helps them be more active and feel more confident about exercising. Sixty adults with chronic brain injury will take part; half will use the n…

This study tests whether a type of talk therapy called behavioral activation, delivered over telehealth, can reduce depression and suicidal thoughts in teens aged 12-17. Participants will attend weekly virtual sessions for 8-10 weeks, learning to engage in enjoyable and meaningfu…

This study is testing a mobile app called MAYA that provides cognitive behavioral therapy (CBT) to help adults who have had a stroke manage anxiety and depression. About 10 participants aged 40-79 will use the app and provide feedback on how easy and helpful it is. The goal is to…

This trial tests whether aromatherapy with rose oil or a massage using that oil can reduce pain, anxiety, and discomfort in women after a cesarean delivery. About 90 first-time mothers will be randomly assigned to receive one of these treatments or a placebo. The goal is to see i…

This pilot study tests whether listening to music in the evening can help people with Alzheimer's disease or related disorders fall asleep faster and behave more calmly. Researchers will compare music therapy to audiobooks in 48 adults living in secure care units. The goal is to …

This study tests whether a new medication called azetukalner can reduce depression symptoms in adults with moderate-to-severe major depressive disorder. About 450 participants will receive either the drug or a placebo for 6 weeks. The main goal is to see if the drug improves mood…

This study tests whether a type of magnetic brain stimulation called iTBS can help people with PTSD. Researchers will give 140 adults either real or fake (sham) stimulation to see if it reduces symptoms like flashbacks and anxiety. The goal is to find a new, non-drug treatment op…

This study tests whether a new oral drug called zelquistinel can reduce depression symptoms in adults with major depressive disorder. Participants take one tablet weekly for 6 weeks and have their depression severity checked at each clinic visit. The trial compares the drug again…

This study tests whether three months of flicker stimulation (using near-infrared light or visual occlusion glasses) can improve thinking, movement, and mood in healthy older adults and those with subjective cognitive decline. Sixty participants aged 65-89 will be assigned to dif…

This early-phase study at Yale will test whether a single 25mg dose of psilocybin is safe and well-tolerated in 10 veterans who smoke daily and have chronic pain. Researchers will monitor side effects and explore whether the drug can improve pain and boost motivation to quit smok…

This trial tests a peer-led program called Honest, Open, Proud (HOP) for veterans with mental health or substance use disorders who have been involved with the justice system. The program helps participants decide whether, when, and how to disclose their conditions, with the goal…

This study tests whether a digital avatar (virtual coach) program can help young adults aged 18-29 who come to the emergency department with alcohol misuse and suicidal thoughts. About 60 participants will either use the avatar program with supportive texts or a free suicide safe…

This study tests an experimental drug called azetukalner in 450 adults with moderate-to-severe major depression. Participants take the drug or a placebo daily for 6 weeks to see if it reduces depression symptoms like low mood and loss of pleasure. The goal is to find a new treatm…

This study tests whether using a mobile app called the Safe and Sound Protocol (SSP) can help adults who are in treatment for substance use and have a history of trauma. About 100 participants will either use the active SSP or a sham version for up to 5 hours over a week, alongsi…

This small study will test whether giving a 15-20 minute massage during infusion therapy can reduce pain and anxiety in women with gynecologic cancer. Twenty-four participants will be randomly assigned to receive either a hand, foot, or neck/shoulder massage or simply talk with t…

This study tests whether a 16-week social skills program, called PEERS, can improve social functioning in adults with autism spectrum disorder (ASD). Researchers will measure changes in social symptoms and brain activity related to social processing. The goal is to see if this be…

This study tests whether theatrical improvisation can help children and adolescents aged 8 to 17 who have elevated anxiety or depression. Participants are randomly assigned to one of three groups: improv combined with wellness techniques (like cognitive-behavioral skills), improv…

This trial tests a structured, parent-assisted social skills program called PEERS® for adolescents with autism spectrum disorder. The program uses cognitive-behavioral techniques to teach practical skills for making and maintaining friendships. Researchers will measure changes in…

This study tests a couple group therapy program designed for adults with autism spectrum disorder (ASD) and their partners. The program teaches communication skills like using "I" statements, focusing on conversations, and giving positive feedback. The goal is to improve relation…

This trial tests whether watching cartoons or having a parent present during dental treatment better reduces anxiety in children aged 4 to 11. Researchers will measure heart rate and oxygen levels to see which approach is more calming. The goal is to find simple, non-drug ways to…

This trial tests whether a structured social skills program, called PEERS, can help adults with autism improve their social interactions and relationships. Participants aged 18 to 45 with relational difficulties and a caregiver's support will either join the program or be in a co…

This study tests a web-based platform called KulaMind-Recovery designed to help loved ones of people recovering from substance use disorders. The platform offers skill-building modules, one-on-one video sessions, text-based coaching, and a community forum. Researchers will see if…

This study tests a smartwatch-based program designed to help people with post-stroke aphasia—a condition that impairs language—improve their ability to name objects. Over six weeks, participants receive daily prompts to name pictures and answer simple yes/no questions about the i…

This trial tests whether a structured education session for family members of ICU patients about to receive a tracheostomy can lower their anxiety, boost their psychological well-being, and increase their satisfaction with care. Half of the participants get the structured program…

This trial tests whether a non-invasive electrical stimulation applied to specific acupoints on the fingers can improve memory, attention, and decision-making in people who have had a stroke. Adults aged 35 to 80 with mild to moderate cognitive impairment after an ischemic stroke…

This trial tests whether listening to binaural beats — a type of sound that may gently nudge brain waves — can improve cognitive function in older adults with mild cognitive impairment living in nursing homes. Participants listen to old songs with or without embedded binaural bea…

This early-stage pilot study is testing whether psilocybin, a psychedelic compound, can be safely combined with trauma-focused psychotherapy for people with post-traumatic stress disorder (PTSD). Thirteen participants will receive two doses of psilocybin in a controlled setting, …

This trial tests whether a 12-week online program that blends family-based treatment with dialectical behavior therapy can reduce the heavy burden often felt by caregivers of teenagers with anorexia nervosa. Caregivers are randomly assigned to either this combined program or a ge…

Endometriosis often causes long-lasting pelvic pain that can disrupt daily life. This trial tests whether specialized pelvic floor physical therapy, combined with a structured exercise program, can lower pain more than a placebo version of the therapy. Women aged 18 to 45 with co…

This phase 2 trial is testing whether the drug lumateperone can reduce stuttering symptoms in adults with moderate to severe childhood-onset stuttering. Participants take either lumateperone (21 mg or 42 mg) or a placebo daily for several weeks. Researchers will measure changes i…

This trial tests a technology-based program called the Parenting Young Children Check-up (PYCC) for parents of children ages 2 to 5 with challenging behaviors. The program includes an initial check-up, text messages, and a website. Researchers will compare families who receive th…

This trial tests whether an 8-week mindful self-compassion training can reduce symptoms of anxiety and depression in adults diagnosed with generalized anxiety disorder, social anxiety disorder, panic disorder, or major depressive disorder. Participants are randomly assigned to th…

This trial tests whether a video-delivered therapy called Tele-PROTECT can reduce depression and increase feelings of safety and empowerment in older adults who have experienced elder abuse. Around 140 English- and Spanish-speaking participants aged 60 and older will receive eith…

This study aims to collect cognitive performance data from 1,000 healthy adults aged 18 to 100 using a fully digital, voice-recognition-based testing platform. Participants complete a one-time, 30-45 minute online assessment covering memory, language, attention, and problem-solvi…

This study aims to understand what happens in the brain when someone thinks about or attempts suicide. Researchers will use brain scans, sleep monitoring, blood tests, and questionnaires to compare four groups: people with recent suicidal thoughts or attempts, those with past sui…

This study looks at how the brains of children with anxiety disorders work differently from healthy children. Researchers will use brain scans and thinking tasks to track changes over a year, before and after standard treatments like therapy or medication. The goal is to find pat…

This study uses special PET scans to measure inflammation in the brains of people with Alzheimer's, Parkinson's, ALS, and other neurodegenerative diseases. Researchers will compare these scans to those from healthy volunteers to see if inflammation levels differ. The goal is to d…

This study aims to understand the genetic causes of brain development disorders, including Aicardi syndrome, polymicrogyria, and Dandy-Walker malformation. Researchers will analyze genetic data from 2000 participants with these conditions, all confirmed by MRI. The goal is to use…

This study looks at how social behaviors and feelings of connection impact treatment for opioid use disorder. Researchers will collect daily reports from 230 patients and a close friend or family member over several weeks. The goal is to find patterns that could lead to more pers…

This study looks at whether a drug called fampridine, which blocks potassium channels in the brain, can improve working memory in people with cocaine use disorder. Forty chronic cocaine users will receive either the drug or a placebo and then take memory tests. The goal is to und…

This study aims to learn more about childhood-onset behavioral, psychiatric, and developmental disorders by observing people of all ages who have these conditions, along with their family members. Researchers will collect medical histories, perform psychiatric assessments, and ma…

This observational study uses brain scans (MRI) and behavioral tasks to compare people with and without alcohol dependence. Researchers want to see if differences in brain structure and activity relate to personality, behavior, and genetics. Up to 1,000 adults will participate in…

This study aims to see if people with major depressive disorder have lower levels of an enzyme called PDE4B in their brains compared to healthy volunteers. Researchers will use PET and MRI scans along with an experimental radioactive tracer to measure this enzyme. The study invol…

This study aims to create a large data repository by collecting smartphone data and daily surveys from 10,000 adults who use alcohol or drugs. Participants will use an app that tracks phone activity and location, and answer short surveys about mood and substance use. The goal is …

This study looks at how changing sleep schedules affects attention, mood, and the internal body clock in teens aged 13-17 with ADHD. Over three weeks, participants follow different sleep patterns—including a short-sleep week and a week with extended sleep timed either to match or…

This study tests a new approach called RIGHTimeCPV, designed to help children with poor-prognosis cancer and their families talk more openly with doctors about the future. Participants choose a communication companion and attend a special visit to share their preferences. The goa…

This study aims to find the genetic causes of movement disorders and dementias by analyzing DNA from up to 12,000 participants, including patients and their family members. Researchers will collect blood or saliva samples and look for gene mutations linked to these conditions. Th…

This study tests a new radioactive tracer to see if it can measure brain inflammation in people with Alzheimer's disease or mild cognitive impairment. Researchers will compare scans from 90 volunteers (patients and healthy older adults) to understand how inflammation relates to m…

This study looks at whether oral nicotine pouches (like ZYN) can be a good substitute for cigarettes or smokeless tobacco. Researchers will test different nicotine levels and forms to see which ones reduce cravings and appeal to users. 160 adult tobacco users will try the pouches…

This pilot study will compare the Clubhouse Model—a structured, community-based program where members work together to run the clubhouse—to standard outpatient care for adults with schizophrenia. Researchers will measure changes in thinking, daily functioning, and brain activity …

This study looks at children and teens ages 7-17 who have severe mood problems like chronic anger, sadness, or irritability, along with extreme tantrums. Researchers will use interviews, tests, and brain imaging to understand what happens in the brain. Up to 2,350 participants wi…

This study looks at how alcohol changes a brain protein called PDE4B, which may be linked to alcohol use disorder. Healthy social drinkers aged 21 to 70 will have brain scans before and after receiving alcohol. The goal is to understand how alcohol affects this protein, which cou…

This study looks at how ketamine affects the brain in people with major depression and healthy volunteers. Researchers use brain scans, blood tests, and other measures to understand why a single dose works quickly but briefly. The goal is to find biomarkers that could lead to bet…

This study looks at how the liver processes fat in people with alcohol use disorder who are quitting drinking. Researchers will take two small liver samples—one early in detox and one after four weeks—to compare gene activity. The goal is to understand how the liver clears fat wh…

This study follows 600 people aged 55 to 85 with early, middle, or late-stage Alzheimer's disease for 12 months. Researchers will track changes in memory, daily activities, behavior, and traditional Chinese medicine symptom patterns. They will also observe whether those receiving…

This NIH study aims to understand what causes depression in teenagers and how the brain changes with the condition. Researchers will compare depressed teens with healthy ones using interviews, computer tasks, and brain scans. Eligible participants may also receive free talk thera…

This study uses yearly PET scans to track amyloid protein buildup in the brains of 400 adults aged 55 and older over 5 years. Participants are already part of the Baltimore Longitudinal Study of Aging. The goal is to see how these brain changes relate to memory loss and other thi…

This study aims to find differences between organic tics (related to diagnosed disorders) and functional tics (caused by problems in brain-body communication). Researchers will use sensors to measure muscle activity and brain waves in 75 adults with tics and healthy volunteers. P…

This study looks at whether doulas with extra training in mental health support can help pregnant women in rural Montana feel more confident and less depressed. About 75 pregnant women will be split into three groups: one with a specially trained doula, one with a regular doula, …

This pilot study explores whether adding a digital health platform called Lōvu to standard prenatal care is practical and well-received by pregnant people. Participants use a Bluetooth scale, blood pressure cuff, and fetal Doppler that send data to their care team, alongside ment…

This study follows 436 women undergoing hysterectomy for non-cancerous reasons to see if certain pre-surgery assessments can predict who will develop chronic pain lasting months after the operation. Researchers measure pain sensitivity using a pressure device on the shoulders, an…

This study looks at how chemotherapy for colon or rectal cancer affects thinking and memory. Researchers will track changes in brain function and blood proteins in 60 patients during and after treatment. The goal is to find tests that could identify who is at risk for 'chemo brai…

This study tests whether simple reminders—called nudges—sent to doctors and patients can increase the use of genetic testing for people with certain conditions like Parkinson's disease, ALS, or heart problems. The trial will compare different ways of prompting genetic testing, su…

This study tests whether showing an aphasia identification card helps healthy volunteers better understand a person with aphasia. 160 service workers will listen to sentences from a speaker with aphasia, with or without seeing the card first. Researchers will measure comprehensio…

This study follows 500 adults already receiving care for depression, bipolar disorder, or suicide risk at the NIH. Researchers will conduct weekly interviews and optional tests like blood draws and brain scans to track symptoms and treatment responses. The goal is to better under…

This study aims to understand brain changes in people with mild cognitive impairment (MCI) and Alzheimer's disease. Researchers will use MRI, EEG, cognitive tests, and blood and stool samples to find differences between healthy individuals and those with cognitive impairment. The…

This study uses advanced MRI (3T fMRI) to look at brain activity in people who have or will have deep brain stimulation (DBS) implants. DBS is a treatment for conditions like Parkinson's disease, tremor, and obsessive-compulsive disorder. The researchers will scan participants un…

This study looks at whether a group support program is practical and helpful for female partners of men who have viewed child sexual abuse material. Researchers will check if 15-20 women can be recruited within a year and if they find the program useful. The goal is to understand…

This study looks at how physical activity, sleep, and light exposure relate to mood in people with bipolar disorder, major depression, or no mood disorder. Over two years, participants wear activity monitors and complete smartphone diaries for up to 20 days at a time. The goal is…

This study investigates how people with hearing loss, including cochlear implant users, experience listening effort from moment to moment. Researchers will track eye movements and pupil dilation as participants repeat sentences that are manipulated to be harder to understand. The…

This international observational study will follow 50,000 people with Alzheimer's disease or related dementias for many years. Researchers will collect real-world data from routine doctor visits to track how the disease progresses and how treatments are used and tolerated. The go…

This trial asks whether a gentle electrical current applied to the scalp during language lessons can speed up and improve how adults learn a new language. Healthy adults who are learning or planning to learn a language are randomly assigned to receive either real or sham (placebo…

This study aims to understand why people with Alzheimer's disease differ from each other and from healthy older adults. Researchers will use advanced brain imaging (7T MRI), brain wave recordings (EEG), and blood and stool samples to look for patterns that might reflect different…

This study explores whether dream yoga practices can improve sleep and reduce anxiety. About 70 healthy adults with mild anxiety will learn techniques using virtual reality and home sleep monitors. The goal is to understand how these practices affect brain activity and dreaming, …

This study looks at whether giving opioid treatment programs (OTPs) regular reports on how well they retain patients, plus a quality-improvement toolkit, can help more people stay in treatment for at least 90 days. Some clinics will also get extra help from an outside facilitator…

This observational study looks at how the brain responds when watching others perform actions, focusing on the mirror neuron system. Researchers will measure brain activity in healthy adults and infants, including those at risk for developmental delays, using EEG and fNIRS. The g…

This study screens 360 adults with neurodegenerative disorders like ALS, frontotemporal dementia, and progressive supranuclear palsy. Researchers will use medical history, physical exams, memory tests, movement analysis, MRI scans, and other tests to find common features and diff…

This study is testing whether low-intensity focused ultrasound (LIFUS) can safely change brain activity in people with conditions like Parkinson's disease, essential tremor, epilepsy, or substance abuse. Researchers will use brain recordings and movement tests to see if the ultra…

This study investigates how acetate, a substance produced when the body breaks down alcohol, is used by the brain in heavy drinkers. Researchers will use a special imaging technique to track acetate metabolism and measure stress hormone levels. The goal is to understand the link …

This study uses a special PET scan to measure amyloid plaques in the brains of 160 people with Alzheimer's disease. Researchers want to see how these plaques relate to race and heart health risks. Participants are already part of a larger Alzheimer's study at the University of Al…

This early-stage study will test how a hemp-based CBD lotion with a small amount of THC is absorbed by the body. Twenty healthy adults will use the lotion in a clean, controlled environment. Researchers will measure cannabinoid levels in saliva, blood, and urine over time to unde…

This study tests a 9-session program called Changing Lives and Changing Outcomes-9 for people with serious mental illness who have been involved with the legal system. The program is designed to help participants understand their mental health better and reduce their chances of f…

This study tests whether a short video-based training program, called the ICU Delirium Playbook, can improve how intensive care unit (ICU) nurses understand and recognize delirium—a sudden confusion that affects many critically ill patients. Nurses at one hospital will complete q…

This study uses a special PET scan to measure a harmful protein called tau in the brains of 160 people with Alzheimer's disease. Researchers want to see how tau buildup relates to a person's thinking abilities, race, and heart health risks. Participants are already part of a larg…

This study looks at whether a condition called alexithymia—difficulty recognizing and describing emotions—affects pain levels and quality of life in people with chronic pain who use a spinal cord stimulator. Researchers will ask 20 participants to fill out questionnaires about em…

This study builds a large French cohort of 1,000 people experiencing a major depressive episode to examine their sleep and circadian rhythms. Researchers will use sleep recordings (polysomnography) and psychiatric evaluations to identify distinct patient subgroups and potential b…

This study aims to find biological markers that predict how well people with major depressive episodes respond to light therapy. Researchers will treat 173 adults with unipolar or bipolar depression using a bright light box for 4 weeks. By measuring sleep, mood, and circadian rhy…

This early-phase study is looking at how cannabidiol (CBD) affects the appeal and pain-relieving effects of cannabis. Researchers will give 23 healthy adults different doses of CBD for 14 days and then measure how much they like active cannabis and how it changes their pain sensi…

This trial tests a group-based program called Lev-g, designed to help adults with or without disabilities adopt healthier habits. The program includes three sessions plus a booster, using motivational interviewing and behavioral analysis to support change. Researchers will measur…

This study follows 1,000 children who have surgery for a brain tumor in the back part of the brain. Up to 1 in 4 of these children develop a condition called Cerebellar Mutism Syndrome, where they lose the ability to speak. Researchers want to understand why this happens and how …

This study investigates whether people who recently had a stroke (within 21 days) can learn new arm movements using a rehabilitation robot called REAplan. Researchers will compare their learning ability with healthy individuals and those who had a stroke long ago. The goal is to …

This study will test an enhanced version of a suicide safety planning app called ViraSafe in 100 teens and young adults (ages 13-24) who have recently attempted suicide or had serious suicidal thoughts. The goal is to see if the app helps them engage more with coping skills and t…

This observational study will survey over 300 Ukrainian women to understand how war influences their decisions about pregnancy and childbirth, and their mental health during the perinatal period. Participants will complete questionnaires about their well-being, reproductive choic…

This study explores whether data from your smartphone can warn doctors when depression symptoms are about to return. Researchers will collect phone data from 320 adults who have been treated for depression and are currently well. They will compare this data with monthly mood ques…

This study follows people who received inpatient treatment for stress-related conditions like depression, adjustment disorder, or burnout. Researchers will track their health and work ability for up to three years after discharge, using online questionnaires. The goal is to under…

This study tests a new program for adults in prison who have both ADHD and substance use disorder. The program includes workshops to improve care and support. Researchers will check if the program is acceptable and if it improves quality of life.

This study looks at whether brain activity synchronizes differently in people with schizophrenia during social interactions. Researchers will compare 100 participants—some with schizophrenia and some without—as they chat and do tasks together while wearing EEG caps. The goal is t…

This study asks children aged 6-16, their parents, and clinicians to vote on the most important research topics in pediatric anesthesia and perioperative medicine. Over 1,000 participants in Switzerland will complete online surveys to create a ranked list of the top 10 priorities…

This study from Stanford University is looking at how a 6-week math training program changes brain activity and thinking skills in children with math learning disabilities (dyscalculia). About 180 children aged 6-12 will do math problems on a tablet at home and get weekly one-on-…

This study follows 130 adults undergoing surgery for stomach or esophageal cancer to see how often they experience postoperative delirium—a state of confusion and disorientation after anesthesia. Researchers will also check whether depression, frailty, poor nutrition, or muscle l…

This study at the National Institute of Mental Health screens up to 16,000 people with mood or anxiety disorders, as well as healthy volunteers, to see if they can join other research studies. Participants undergo evaluations like psychiatric interviews, brain scans, and lab test…

This study looks at why people taking medications for opioid use disorder often have trouble sleeping. Researchers think special light-sensitive cells in the eye might be involved. They will measure pupil responses, brain waves during sleep, and daily sleep patterns in 200 adults…

This study tests whether a special team of doctors, nurses, and peer supporters can help people with substance use disorders get the follow-up care they need after a hospital stay. The team meets patients in the hospital and provides support and treatment after they leave, helpin…

This study tests a training program called INSPIRE designed for healthcare teams caring for people with substance use disorder during childbirth. The program includes online learning and in-person simulations. Researchers want to see if the training changes healthcare providers' …

This study looks at how nicotine changes brain function in people with and without major depressive disorder (MDD). Researchers will give 620 non-smokers either a nicotine patch or a placebo and then scan their brains using MRI. Participants will also answer questions about their…

This study looks at older adults hospitalized for heart, lung, or orthopedic issues to see how many also have undiagnosed mild cognitive impairment or dementia. Participants take a memory test at admission, and those with possible problems get a full brain evaluation and a follow…

This study looks at whether family members can help identify delirium—a sudden confusion that can occur during serious illness—in adult ICU patients. Family members will complete a short assessment after visiting, while nurses continue their usual screening. Researchers will comp…

This study tests whether a non-invasive electrical brain stimulation technique called TES-TI can temporarily alter sleep spindles—brain rhythms often reduced in schizophrenia. Researchers will apply the stimulation during sleep in 20 people (half with schizophrenia spectrum disor…

This study follows 17-year-olds in Nice who are receiving psychiatric care and will soon transition to adult mental health services. It aims to measure how many teens in this situation exist, describe their profiles, and map their care paths over a year. The goal is to identify f…

This study tests whether suvorexant, a drug approved for insomnia, can reduce cravings and brain responses linked to smoking in daily smokers. Researchers will also study how it affects thinking and reward processing in non-smokers. The goal is to understand if blocking a brain c…

This study is testing whether a special PET imaging tracer, [18F]PI-2620, can detect tau protein buildup in the brains of people with Parkinson's disease, including those with a genetic form linked to the LRRK2 gene. About 60 participants will undergo high-resolution brain scans …

This study looks at whether listening to music before a medical procedure can influence heart rate variability (HRV), a measure of the heart's ability to adapt to stress, and whether it relates to anxiety and depression. About 120 adults scheduled for procedures at three hospital…

This early-stage study is testing an experimental drug called LY3439539 in 30 people with mild-to-moderate Alzheimer's disease. The main goal is to see if the drug changes certain proteins in the spinal fluid that are linked to Alzheimer's. Participants will receive the drug thro…

This study uses brain scans to understand why some people relapse to opioid use during treatment. Researchers at Yale will follow 240 adults recently started on methadone or buprenorphine, tracking their brain connectivity and drug use for six months. The goal is to identify patt…

This study investigates whether transcranial magnetic stimulation (TMS), a non-invasive technique that uses magnetic pulses to stimulate brain areas, can influence the coupling between heart and brain activity in individuals with depressive tendencies. Participants will undergo b…

This study will test whether a mobile app that teaches people about how addiction affects the brain is easy to use and acceptable for people receiving medication treatment for opioid or stimulant use disorders. Forty participants will use the app and complete surveys. The goal is…

This study uses a special PET scan tracer, [18F]MH.MZ, to measure serotonin 2A receptors in the brains of people with neurodegenerative diseases like Parkinson's. Researchers want to see if these receptors differ between patients with psychosis and healthy people of the same age.…

This study is testing whether a smartphone app can help people in Michigan on Medicaid who are recovering from both opioid and alcohol use disorders. The app uses rewards to encourage healthy behaviors. Researchers want to see if people find the app useful and easy to use, and if…

This study looks at whether successfully treating moderate-to-severe sleep apnea can improve memory and reduce biological markers linked to Alzheimer's disease in older adults. About 200 cognitively healthy people aged 55-85 will either receive immediate sleep apnea treatment or …

This trial compares an online training program (COPEWeb) to in-person training for behavioral health providers. The goal is to see if the online version is as effective at teaching providers to deliver a combined treatment for PTSD and substance use disorders. Providers will be r…

This study looks at whether learning about well-being can improve how romantic partners think and feel. About 2,000 couples with mild depression symptoms will take online surveys about their emotions and relationship satisfaction. The goal is to see if gaining knowledge about wel…

This study follows 100 pregnant women with opioid use disorder who are already receiving standard treatment. Researchers will track health outcomes for both mothers and babies, such as relapse and withdrawal symptoms. The goal is to find better ways to predict and prevent complic…

This study tests whether adding 8 weeks of mindfulness training to a single dose of psilocybin (the active ingredient in magic mushrooms) improves mental health more than psilocybin alone. Forty healthy adults who have never used psychedelics or done formal mindfulness training w…

This study looks at adults with spinal deformity to understand which factors—like pain, daily functioning, mental health, and frailty—most influence quality of life. It follows 320 people receiving either conservative care, first-time corrective surgery, or a reoperation, using q…

This study will compare how synthetic nicotine and a nicotine analogue (6-methylnicotine) behave in the body versus traditional tobacco-derived nicotine. Twenty-four regular vapers will vape e-liquids containing these substances, and researchers will measure their levels in the b…

This study looks at how people with depression or anxiety respond to different types of psychotherapy—individual sessions or an online program. It aims to find clues that predict who benefits most from each approach. By understanding these factors, doctors may better match patien…

This study tests two group-based parenting programs—HOT DOCS for children 0-5 and DOCS K-5 for kindergarten through 5th grade—designed to help caregivers manage disruptive behaviors and reduce parenting stress. Researchers will enroll 800 caregivers and professionals who speak En…

This study looks at whether a simple eye test can predict how well people with treatment-resistant depression will respond to a brain stimulation therapy called TMS. Researchers will measure how the pupils react to light before and after TMS treatment in 44 adults. The goal is to…

This study will put 56 healthy adults aged 25-60 through 27 hours of sleep deprivation and alcohol consumption (to a 0.08% BAC) in a lab over 110 hours. Researchers will measure how these stressors affect thinking, movement, and brain scans. The goal is to better predict and mana…

This study looks at whether brain wave patterns and inflammation markers in the blood can help predict how well electroconvulsive therapy (ECT) works for people with severe depression that hasn't improved with medication. Researchers will measure these markers before and after EC…

This study looks at whether adjusting sleep timing and using bright light therapy can improve mood and sleep in perimenopausal women with depression. Researchers will have 120 women either advance or delay their sleep for one night, then use a light box for 30 minutes daily for t…

This study looks at two sedative drugs, remimazolam and midazolam, used to put older adults (65+) to sleep for non-cardiac surgery. The goal is to see which one offers better heart and blood pressure stability, faster recovery, and fewer complications like confusion after surgery…

This study looks at brain activity in 100 adults with major depression who are receiving a treatment called accelerated TMS. Researchers use a special brain scanner (TD-fNIRS) to see if patterns of brain activity can predict who will respond well to the treatment. Healthy volunte…

This study looks at whether the immune system's T-cells react differently in people with Parkinson's disease or Alzheimer's disease compared to healthy older adults. Researchers will collect blood samples from 120 participants—30 with Parkinson's, 30 with Alzheimer's or mild cogn…

This study looks at how people with opioid-use disorder learn and make choices compared to those without the disorder. Participants will complete a computer task where shapes are paired with different food odors. The goal is to understand if differences in learning and decision-m…

This study aims to understand how ketamine produces rapid antidepressant effects by using a special brain scan (GluCEST) to measure changes in glutamate, a key brain chemical. Ten adults with treatment-resistant depression will receive a single ketamine infusion and undergo imagi…

This study tests whether a 4-week ketogenic diet changes how the brain responds to alcohol. Twenty adults will follow the diet and undergo alcohol tolerance tests and brain scans before, during, and after the diet. The goal is to understand how ketosis affects alcohol metabolism …

This study is looking at whether detailed heart imaging can help predict heart problems in people with liver cirrhosis who undergo a procedure called TIPSS, which creates a shunt to relieve pressure in the liver. Participants will have heart MRIs and echocardiograms before, short…

This study is developing new MRI techniques to better understand how drug addiction changes the brain. Researchers will scan 1,000 healthy adults, smokers, and drug users to improve imaging methods. The goal is to create tools that can reveal the brain's structure and function in…

This study explores whether mild electrical stimulation of the spine can change how the brain processes body signals, which may be disrupted in major depression. Researchers will test different stimulation levels in 67 adults with depression to see if it affects brain activity an…

This study follows 260 adults newly diagnosed with cancer who have no prior sleep issues. Researchers will track how insomnia develops over the first year, using questionnaires to measure sleep quality and severity. The goal is to understand what factors—like treatment type or em…

This study investigates how the gut-brain axis—the communication network between gut bacteria and the brain—might be involved in pediatric obsessive-compulsive disorder (OCD). Researchers will compare gut microbiome, blood metabolites, brain imaging, and EEG data from children wi…

This study looks at how six short, 15-minute self-regulation techniques — like exercise, breathing, aromatherapy, music, virtual reality, and tapping — affect the body and brain of one woman with ADHD and stabilized bipolar disorder. Researchers will measure heart rate, brain wav…

This study follows people with several types of spinocerebellar ataxia (SCA) — rare genetic diseases that cause balance, coordination, and speech problems — to learn how these conditions change over time. Researchers will collect blood samples, perform neurological exams, and use…

This study is testing whether a program delivered remotely (by video or phone) that combines exercise and dementia caregiving support is practical and helpful for older adults with Down syndrome and their caregivers. About 40 participants will take part. The goal is to see if the…

This study follows pregnant women and their children from the first trimester through toddlerhood to explore how stress, early social experiences, and genetics interact. Using simple at-home activities like questionnaires, video recordings, and cheek swabs, researchers will look …

This study will follow 15 people aged 5 to 50 with 7q11.23 microduplication syndrome, a rare genetic condition linked to autism and social difficulties. Researchers will track developmental milestones, social skills, and behavior using interviews and questionnaires. The goal is t…

This study aims to measure how often brief suicidal crises—acute, reversible episodes lasting less than 24 hours—occur among adults attending psychiatric outpatient care in France. Researchers will ask about 150 patients to complete a questionnaire about their experiences over th…

This study follows 450 people with treatment-resistant depression who are starting or continuing treatment with either IV ketamine or Spravato (esketamine) nasal spray. Over five years, researchers will track how satisfied patients are with their treatment, how well it works, and…

This study examines the prevalence of neurodevelopmental disorders like ADHD and autism among youth who have committed crimes. Researchers will analyze records from juvenile offenders to explore how these conditions relate to the types and frequency of criminal behavior. The goal…

This study is testing whether a smartwatch can help predict when a person with bipolar disorder or major depressive disorder might experience a manic or depressive episode. Researchers will track 100 participants for a year, collecting data on heart rate, sleep, and activity leve…

This study investigates whether brain wave patterns (measured by EEG) and inflammatory markers in the blood can help predict how well older adults with depression or bipolar disorder respond to electroconvulsive therapy (ECT). Researchers will compare EEG recordings and blood sam…

This long-term study follows people with or at genetic risk for frontotemporal lobar degeneration (FTLD), a group of brain disorders that cause changes in behavior, language, and movement. Researchers will use brain scans, memory tests, and blood samples to measure how the diseas…

This study investigates repetitive behaviors—like repeating words or actions—in people with Alzheimer's disease. Researchers want to understand how common these behaviors are, what types occur, and whether they are linked to memory problems or lack of awareness of the condition. …

This study follows 700 people with substance use disorders over two years to see how addiction symptoms, especially craving, are connected and whether those connections change as addiction severity shifts. Participants complete annual diagnostic assessments and two-week periods o…

This study investigates whether markers of inflammation in the blood could serve as diagnostic or severity biomarkers across several psychiatric conditions, including bipolar disorder, schizophrenia, and depressive episodes with psychotic features. Researchers will collect blood …