Can a single dose of ayahuasca quiet seizures that Aren't epileptic?
NCT ID NCT07747324
First seen Aug 05, 2026 · Last updated Aug 06, 2026 · Updated 1 time
Summary
This early-stage trial is testing whether a single oral dose of ayahuasca can reduce the frequency of psychogenic non-epileptic seizures (PNES) in adults aged 18 to 60. Participants must have PNES confirmed by video-EEG and will taper off psychiatric medications before the dose. The study will track seizure frequency to see if this traditional brew might offer a new way to manage this challenging condition.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Ayahuasca (a plant-based brew containing DMT and harmala alkaloids), given as a single oral dose
- What this could lead to
- If successful, this could point toward a new treatment option for psychogenic non-epileptic seizures, a condition with few effective therapies.
- What could go wrong
- This is a small, early-phase, open-label trial, so results may not be conclusive. Ayahuasca can cause intense psychological effects and requires tapering off psychiatric medications, which carries risks.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Ribeirão Preto Medical School
RECRUITINGRibeirão Preto, São Paulo, 14048900, Brazil
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