University Of Sao Paulo

This study tests two fast-acting approaches to prevent suicide in teens and adults who recently attempted suicide or have severe suicidal thoughts. One group receives a single intravenous dose of esketamine, another gets a one-on-one crisis planning session, and a third gets enha…

This study looks at whether starting strong immune-suppressing drugs early can help control Vogt-Koyanagi-Harada (VKH) disease, a rare condition that causes eye inflammation and vision loss. Researchers will treat 40 newly diagnosed patients with high-dose steroids and other immu…

This study tests whether adding a special light treatment (antimicrobial photodynamic therapy) to standard deep cleaning helps people with obesity and gum disease. 24 participants will receive either standard cleaning alone or cleaning plus the light therapy. Researchers will che…

This study tests whether a gel made from polynucleotide and hyaluronic acid, combined with a bone graft, can help repair bone defects caused by advanced gum disease. 66 adults with severe periodontitis will receive either standard surgery, surgery with bone graft alone, or surger…

This study tests whether a natural substance called inorganic nitrate can safely lower blood pressure in pregnant women with chronic hypertension. About 144 women will receive either nitrate or a placebo from the second trimester onward. The goal is to see if nitrate reduces the …

People with bipolar disorder face double the risk of heart disease and die 14 years earlier on average. This study tests whether a personalized nutrition program—based on Brazil's dietary guidelines—can improve heart health markers like cholesterol, blood sugar, and body fat. Eig…

This phase 3 trial tests a new approach called sonophotodynamic therapy (Sono-PDT) for nodular basal cell carcinoma, a common skin cancer. The treatment combines a light-activated cream with sound waves in a single visit. Researchers will check if the tumor is gone after one mont…

This study compares two surgical techniques—Latarjet and modified Eden-Hybinette—for people with repeated shoulder dislocations. It involves 60 adults who have significant bone loss or failed prior surgery. The goal is to see which method better prevents future dislocations and r…

This study is testing an artificial intelligence tool called Tia Bete that helps people with type 1 diabetes count carbohydrates and adjust their insulin doses in real time. Researchers will enroll 50 participants (children and adults) and track their blood sugar control, quality…

This study tests a 6-month lifestyle program designed to prevent obesity and eating disorders in transgender and gender-diverse adolescents aged 10-14. Participants attend monthly group sessions and receive weekly supportive messages. The goal is to improve quality of life and bo…

This pilot study is testing a device that sends a mild electrical current to the brain (tACS) to see if it can reduce anxiety and improve sleep in people with generalized anxiety disorder and chronic insomnia. Thirty adults will receive 20 sessions over four weeks. The goal is to…

This study tests whether adding telerehabilitation (home-based, supervised and independent arm exercises) to usual care improves arm function and reduces disability after a stroke. Twenty adults in Brazil who had a stroke about 4 months ago will participate. The goal is to see if…

This study looks at whether taking creatine supplements while doing supervised weight training for 12 weeks can help men with prostate cancer who are on hormone therapy (ADT) maintain or improve their muscle mass, strength, and physical function. ADT often causes muscle loss and …

This study looks at whether a supervised aerobic exercise program, combined with a single session of pain education, can reduce migraine-related disability and improve sensory and muscle function. One hundred women with migraine will either exercise on a treadmill three times a w…

This study tests whether adding antimicrobial photodynamic therapy (aPDT) – a light-based treatment – to standard gum cleaning can reduce bad breath (halitosis) in people with type 2 diabetes and advanced gum disease. Thirty-two participants will receive either standard care or s…

This study compares two ways to manage pain after minimally invasive pectus excavatum repair: freezing the intercostal nerves (cryoanalgesia) versus an epidural block. About 40 participants aged 13 and older will be randomly assigned to one method. The goal is to see which approa…

This phase 3 trial tests whether adding lacosamide to standard treatment helps people with bipolar disorder who are currently in a major depressive episode. Forty adults who haven't responded to at least two prior treatments will receive either lacosamide or a placebo for 12 week…

This study tests a noninvasive treatment called REAC that uses gentle electrical signals to help rebalance brain activity after a severe traumatic brain injury. Researchers will compare real REAC sessions to a sham (fake) version in 60 patients to see if it improves brain wave pa…

This study tests whether a single dose of ayahuasca or esketamine can reduce symptoms of posttraumatic stress disorder (PTSD). Ten adults with PTSD will receive one of the two drugs in a double-blind design. The goal is to see if either substance can provide rapid relief from PTS…

This study tests whether adding a physiotherapy protocol—pelvic floor muscle training and cold therapy—to standard care can reduce perineal pain in first-time mothers who had tears or an episiotomy during vaginal delivery. 82 women will be randomly assigned to either usual care (…

This study looks at whether a special low-FODMAP diet and probiotics can reduce chronic pelvic pain in women who have both endometriosis and irritable bowel syndrome (IBS). Researchers will compare three groups: one getting the diet plus a placebo, one getting the diet plus probi…

This study is testing how a single dose of ayahuasca or esketamine affects the way healthy women see their bodies. Twenty volunteers will be randomly assigned to receive one of the two substances. The goal is to understand changes in body image perception, not to treat any condit…

This study compares a single dose of ayahuasca or esketamine to see how they affect the menstrual cycle and premenstrual symptoms in 20 healthy women. Participants will track their symptoms using a questionnaire. The goal is to understand if these substances can influence PMS, bu…

This study is testing whether a smartwatch, combined with artificial intelligence and remote doctor check-ins, can help detect heart issues like atrial fibrillation and unstable angina earlier than usual. Researchers at the University of Sao Paulo will enroll 520 adults with hear…