University Of Sao Paulo

This trial tests whether 16 weeks of supervised exercise, with or without daily taurine supplements, can reduce fat stored inside the muscles of women aged 60–75 with obesity. Researchers will use MRI scans, muscle biopsies, and blood tests to measure changes in muscle compositio…

This study tests whether a gentle, targeted electrical stimulation to the brain (HD-tDCS) can safely improve how stroke survivors perceive vertical balance. Participants who have had a stroke affecting one side of the brain will receive either active or sham stimulation while per…

This study looks at whether combining high-intensity interval training with recovery in low oxygen (hypoxia) and taurine supplements can improve body composition, metabolism, and mitochondrial function in women with obesity. Fifty women aged 25–45 with a BMI of 30–35 will exercis…

This study aimed to compare two surgical techniques for covering exposed tooth roots caused by gum recession, using a porcine (pig) collagen matrix as a graft material. The trial planned to enroll 20 non-smoking adults with multiple gum recessions. However, the study was withdraw…

This study tests whether eye-tracking can predict if the drug brexpiprazole will improve symptoms in adults with major depressive disorder. One participant will take brexpiprazole or placebo while researchers measure their visual attention to emotional images. The goal is to see …

This study tests whether a pelvic floor massage technique (Thiele massage) can reduce pain during sex in women with chronic pelvic pain. It compares in-person treatment with guided self-massage at home via telehealth. The goal is to see if telehealth can be as effective as in-per…

This study tests whether combining transcranial magnetic stimulation (TMS) with virtual reality exercises and physical therapy can improve symptoms like balance, fatigue, and thinking in people with multiple sclerosis. Thirty participants will receive both real and sham TMS in a …

This pilot study tests whether a wearable device that delivers intermittent white light at 60 Hz can safely help people with moderate to severe depression. Thirty adults on stable antidepressant medication will wear the goggles for 30 minutes daily over two weeks. The main goal i…

This study compares two brain stimulation treatments—electroconvulsive therapy (ECT) and magnetic seizure therapy (MST)—for people with severe depression that hasn't improved with standard medications. About 100 adults with major depression or bipolar depression will receive one …

This study tests whether inhaling lavender and lemongrass essential oils through a personal necklace can reduce pain and anxiety during active labor. 70 women in labor will be randomly assigned to receive either the aromatherapy or a placebo (sweet almond oil). Researchers will m…

This study tests whether inhaling lavender, peppermint, or a mix of both can change how sensitive people with migraine are to pressure pain. Two hundred adults with migraine will inhale one of the oils or a control solution for 15 minutes. Researchers measure pain thresholds befo…

This study tests whether donepezil, a drug used for dementia, can help people with chronic tinnitus (ringing in the ears). 70 adults with long-term tinnitus received either donepezil or a placebo for 3 months. Researchers measured changes in tinnitus severity using standard quest…

This study investigates whether chronic gum disease (periodontitis) is linked to changes in the autonomic nervous system — the body's automatic 'wiring' that controls heart rate, digestion, and stress responses. Researchers will measure heart rate variability, a marker of nervous…

This study looks at how nutritional counseling and exercise affect telomeres—the protective caps on our chromosomes that shorten as we age—in elderly women. Researchers will compare women with and without obesity, measuring changes in telomere length and other aging markers after…

This study compares how well different tourniquet models block blood flow when placed on the arm, forearm, leg, and thigh. Forty healthy volunteers will each receive eight tourniquet applications over three days. The goal is to see if placement location affects how quickly and co…

This study tests whether oils from echium and ahiflower plants can raise omega-3 levels in the blood as effectively as fish oil. Fifteen healthy adults will try each oil for 8 weeks, with blood tests before and after. The goal is to find a sustainable, plant-based option for hear…