University Of Sao Paulo

This trial tests a one-time treatment called CAR-T cell therapy for people with systemic lupus erythematosus (lupus) that hasn't improved with standard medications. The therapy uses a patient's own immune cells, which are modified in a lab to find and destroy the B cells that dri…

This study tests whether a special collagen matrix can replace tissue taken from the roof of the mouth to fix receding gums. Forty adults with at least two areas of gum recession will receive either the collagen matrix or a standard palate graft. The main goal is to see how much …

This study tests whether a new experimental effervescent tablet can clean removable partial dentures better than a commercial cleanser or water. Fifteen adults with denture stomatitis will wear dentures with small material discs to collect plaque, then soak them daily in one of t…

This study tests a harm reduction approach for people who use anabolic-androgenic steroids (AAS) without a prescription. Participants will receive four counseling sessions to help them reduce their steroid use and improve their health. The trial will measure changes in steroid us…

This study compares a new, simpler treatment called CTZ paste against the standard root canal procedure for infected baby teeth in emergency settings. The CTZ paste is placed directly into the tooth without drilling or cleaning the root canals, aiming to kill bacteria and save th…

This study tests whether testosterone implants placed under the skin can safely and effectively raise testosterone levels in men with low testosterone (hypogonadism). Thirty men will receive four implants and be monitored for six months. The goal is to see if this method provides…

This study tests whether taking high-dose omega-3 (fish oil) pills for 12 weeks can reduce inflammation and cell damage in women with lupus who are in remission. Researchers will measure changes in blood markers and telomere length, which is linked to aging. The goal is to see if…

This study tests whether an AI-powered electric toothbrush and visual teaching materials can improve oral hygiene in children with autism. Fifty kids aged 5-13 will either use a manual toothbrush with picture guides or the smart toothbrush with an app. Researchers will check plaq…

This study tests whether keeping blood sugar tightly controlled after brain surgery can reduce surgical site infections. About 544 adults having elective clean brain surgery will be randomly assigned to either intensive insulin therapy (target 140-180 mg/dL) or standard care (81-…

This study tests whether taking a daily vitamin B complex pill for 8 weeks can help people recover feeling in their lower lip, chin, or gum after dental procedures like wisdom tooth removal. Fifty adults with nerve numbness will be randomly assigned to get either the vitamins or …

This study tests whether a short form of cognitive-behavioral therapy (CBT) can help prevent suicide in Brazilian adults who have recently attempted suicide or had strong suicidal thoughts. About 150 participants will receive either 12 sessions of CBT or standard supportive thera…

This study looks at whether beetroot juice can quickly lower blood pressure in pregnant women with pre-eclampsia, a serious condition causing high blood pressure. Researchers will give beetroot juice or a placebo to 60 pregnant women and measure changes in blood pressure, blood m…

This study tests whether empagliflozin, a drug used for diabetes, can help reduce depression in people with bipolar disorder who also have insulin resistance. Twenty adults with bipolar depression will take the drug for 12 weeks alongside their usual treatment. The goal is to see…