Could exercise boost taurine in older women with obesity?
NCT ID NCT07711899
First seen Jul 17, 2026 · Last updated Jul 21, 2026 · Updated 2 times
Summary
This study investigates how taurine—a natural amino acid linked to inflammation and cell health—differs between metabolically healthy and unhealthy older women with obesity. Researchers will measure taurine levels before and after a 16-week combined exercise program. The goal is to understand whether exercise can influence taurine and potentially improve health in this group.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- 16-week combined physical training program
- What this could lead to
- If successful, this could point toward low-cost exercise strategies to improve health in older women with obesity by understanding taurine's role.
- What could go wrong
- This is a small, early observational study with only 36 participants, so results may not apply broadly. It measures taurine levels, not clinical outcomes.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 36 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Oct 2026
An estimate. Start dates often move.
- Expected to finish
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Mar 2030
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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60 to 75 years
- Sex
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Female participants only
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria * Women aged 60 to 75 years. * Residents of the city or region of Ribeirão Preto, São Paulo, Brazil. * Physically inactive for at least 3 months. * Body mass index (BMI) ≥ 30 kg/m² (PAHO, 2002). * Body fat percentage ≥ 35%, according to obesity diagnostic criteria (Batsis et al., 2016; Rubino et al., 2025). Classified into one of two obesity phenotypes based on Zembic et al. (2021): Metabolically Healthy Obesity (MHO/OMS): all of the following criteria must be met: * Systolic blood pressure (SBP) \< 130 mmHg; * Waist-to-hip ratio \< 0.95; * Fasting blood glucose \< 126 mg/dL. Metabolically Unhealthy Obesity (MUO/OMNS): meets two or fewer of the above criteria. Exclusion Criteria Clinical conditions * Contraindication to physical exercise. * Current or previous diagnosis of: * Neoplasms; * Autoimmune diseases; * Hepatic diseases; * Coronary diseases; * Renal diseases; * Neurodegenerative diseases; * Infectious diseases. Previous or ongoing treatments * Use of medication for thyroid disorders. * Participation in exercise training programs, nutritional counseling, or weight loss treatment within the 3 months preceding the intervention. Lifestyle habits * Current smoking. * Alcohol consumption. For MHO Group: * Medication use * Hypoglycemic agents * Insulin (Bell, Kivimäki, \& Hamer, 2014). * Protocol adherence \*Attendance at less than 80% of the training sessions (De Carvalho et al., 2021).
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
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