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Could everyday vitamins tame brain inflammation linked to obesity?

NCT ID NCT07782411

Disease control Sponsor: Autonomous University of Morelos Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 24, 2026 · Last updated Aug 25, 2026 · Updated 1 time

Summary

This trial tests whether taking vitamin C, vitamin E, or both daily for 12 weeks can lower markers of brain inflammation and change appetite-related brain signals in Mexican adults with obesity. Participants are randomly assigned to one of the supplements or a combination, and researchers measure inflammation and neuropeptide levels before and after the intervention. The goal is to see if these common vitamins might improve brain health and appetite regulation in people with obesity.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
ascorbic acid (vitamin C) and alpha-tocopherol (vitamin E), taken alone or together
What this could lead to
If effective, these common vitamins could offer a simple, low-cost way to ease brain inflammation and appetite dysregulation in obesity, potentially supporting weight management.
What could go wrong
This is an early-stage trial with a modest size, and results may not apply broadly. Vitamins may not meaningfully change brain markers, and high doses can cause side effects like stomach upset.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 192 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Aug 2026

An estimate. Start dates often move.

Expected to finish

Aug 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

40 to 59 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Adults aged 40 to 59 years, Mexican men and women. 2. Obese group: Body mass index (BMI) \> 30 kg/m²; body fat percentage \> 25% in men and \> 35% in women; waist circumference \> 90 cm in men and \> 80 cm in women. 3. Non-obese group: BMI \< 24.9 kg/m²; body fat percentage \< 25% in men and \< 35% in women; waist circumference \< 90 cm in men and \< 80 cm in women. 4. Willingness to sign the informed consent form. Exclusion Criteria: 1. Individuals with renal diseases, hepatic diseases, or those under pharmacological treatment for any condition associated with acute inflammation. 2. Individuals currently undergoing treatment for obesity (pharmacological, nutritional, or physical activity programs). 3. Individuals taking dietary supplements or multivitamins.

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Conditions

The condition(s) this trial relates to.

Neuroinflammatory Diseases neuronitis Obesity obesity disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Neuroinflammation Obesity (bmi>30)

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University Medical Center, Universidad Autónoma del Estado de Morelos

    Cuernavaca, Morelos, 62210, Mexico

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