Obesity disorder

This phase 3 trial tests whether switching from common GLP-1 weight-loss drugs to a new medication called maridebart cafraglutide can help adults with obesity or overweight maintain their weight loss. About 300 participants who have already lost at least 10% of their body weight …

This phase 3 trial tests whether maridebart cafraglutide (MariTide) can reduce heart failure events like hospitalizations and urgent visits in people with obesity and a specific type of heart failure (preserved or mildly reduced ejection fraction). About 5,056 participants will r…

This Phase 2b trial tests whether adding enobosarm (a muscle-preserving drug) to semaglutide (a weight-loss drug) helps older adults lose more fat and keep muscle. About 200 people aged 65 and older who are overweight or obese will take both drugs or semaglutide alone. The goal i…

This study tests a new medicine called NNC0487-0111 in about 5,600 people who have both heart failure and obesity. Participants receive either the drug or a placebo as a weekly injection. The goal is to see if the drug reduces the risk of heart failure worsening, hospitalization,…

This study tests whether a 4-week healthy cooking program for home cooks can help Emirati adults with overweight or obesity lose weight and eat better. The trained cooks prepare nutritious meals for their families over 3 months. Researchers track weight, waist size, blood pressur…

This study tests whether a gentle electrical current applied to a brain area involved in fullness can reduce food intake and promote weight loss. Over 4 weeks, 148 obese adults will receive either real or fake stimulation while following a reduced-calorie diet. The goal is to see…

This study tests whether wearing a continuous glucose monitor (CGM) for 3 months helps adults with prediabetes better control their blood sugar and stick to lifestyle changes compared to standard finger-prick testing. About 80 participants will be randomly assigned to use a CGM o…

This study tests a temporary stomach balloon called Orbera365 to help people with obesity lose weight. About 144 adults with a BMI between 28 and 50 who have not succeeded with diet and exercise will get the balloon. The main goal is to see if at least 5% of body weight is lost a…

This study compares two lifestyle programs for people with type 2 diabetes or prediabetes: one using a ketogenic diet and the other a low-fat diet. Over 12 months, researchers will track changes in weight, blood sugar, blood pressure, and heart health. The goal is to see which di…

This early-stage trial tests whether TIX100, a daily oral pill, is safe and tolerable in healthy adults who are overweight or obese. Over 28 days, participants receive either TIX100 or a placebo, and researchers monitor for side effects and how the drug moves through the body. Th…

This study tests a virtual weight management program for 60 adults with obesity and advanced kidney disease who want to lose weight to become eligible for a kidney transplant. Participants either join the program (which includes coaching and a weight-loss medication called semagl…

This early-stage trial tests a new drug called ALN-6222 in 88 adults with obesity (BMI 30-40). Participants receive a single injection of either the drug or a placebo. The main goal is to check safety and how the body processes the drug, not weight loss. It is the first time this…

This early-stage study tests a new way to deliver semaglutide—a drug used for weight management—using a small, needle-free patch that sticks to the skin. The patch, called VX-201, aims to provide the same benefits as injections without the need for needles. The trial includes hea…

This study tests whether a 16:8 time-restricted eating diet (eating only during an 8-hour window each day) helps people with obesity manage their weight, both those who have had bariatric surgery and those who haven't. Researchers will measure changes in body weight, fat mass, an…

This study tests whether limiting food intake to an 8-hour window each day (without counting calories) can reduce liver fat in people with obesity and a type of fatty liver disease called MASLD. Seventy-two participants will either follow this eating pattern plus standard advice,…

This study tests a once-weekly injection called NNC0487-0111 in 300 adults with overweight or obesity and moderate-to-severe obstructive sleep apnea who use a breathing device. The goal is to see if the drug helps with weight loss and reduces breathing pauses during sleep. Partic…

This study tests whether mobile health technology, like smartphone apps and activity trackers, can help overweight or obese African American women increase their physical activity. Participants will wear a wrist device to track steps and sleep, use a study app, and may receive co…

This study tests whether a daily supplement of Akkermansia muciniphila (AKM Lab-01), a type of gut bacteria, can help overweight or obese adults lose weight safely. Two hundred participants will take either the supplement or a placebo for 3 months. Researchers will measure change…

This study tests whether oxytocin nasal spray can help teenagers with obesity manage their weight. Over 12 weeks, participants aged 10-18 will take the spray or a placebo four times daily. Researchers will measure changes in body mass index, body fat, and appetite to see if oxyto…

This study tests whether a simple, home-based breathing exercise program can improve brain health and reduce inflammation in adults with obesity. Thirty participants will do 8 weeks of high- or low-resistance breathing training, like weightlifting for the breathing muscles. Resea…

This phase 3 trial is testing a once-weekly injection called enicepatide in 300 Chinese adults who are obese or overweight, with or without type 2 diabetes. The drug works by mimicking two gut hormones to reduce appetite and improve blood sugar control. Participants will receive …

This study looks at whether inducing labor at 39 weeks of pregnancy is better than waiting for labor to start naturally in women with a BMI of 30 or higher. The goal is to see if early induction lowers the chance of needing a C-section. About 1,900 women in Denmark will take part…

This study tests whether a combination of a special diet, omega-3 and L-carnitine supplements, and resistance exercise can improve muscle quality and reduce fat in veterans with HIV and obesity. The trial will enroll 70 participants and measure changes in muscle density, metaboli…

This study tests two versions of the experimental drug cagrilintide in 234 adults with overweight or obesity. Participants receive either version D or version B by injection once a week for about 6 months. The goal is to see how the drug is processed in the body, not to measure w…

This study tests an experimental drug called ARO-INHBE in 180 adults with obesity, some of whom also have type 2 diabetes. The drug is given as a shot under the skin, either alone or combined with the existing weight-loss drug tirzepatide. The main goal is to check safety and how…

This study tests whether a virtual weight management program that includes a support person (like a family member or friend) helps Veterans with obesity lose weight. 320 Veterans and their partners will participate in 8 virtual sessions over 14 weeks. The main goal is to see if t…

This study tests a once-weekly injection called NNC0487-0111 in 300 adults with overweight or obesity and moderate-to-severe obstructive sleep apnea who do not use a CPAP machine. The goal is to see if the drug helps with weight loss and reduces breathing pauses during sleep. Par…

This study tests whether using a handheld breathing trainer for a few minutes each day can lower blood pressure in adults with obesity. Researchers will compare high-resistance versus very-low-resistance breathing exercises over eight weeks. The goal is to find a time-efficient w…

This study tests a new version of sleeve gastrectomy (a weight loss surgery) that adds a Nissen fundoplication to reduce acid reflux. Researchers will compare 30-day complication rates between the new technique and standard sleeve gastrectomy in 100 adults with obesity. The goal …

This study tracks 200 adults with obesity in the EU who choose to get the Orbera365 intragastric balloon. The balloon is placed in the stomach and filled with saline to help people feel full and eat less. Researchers will monitor serious side effects and how much weight participa…

This study tests a new once-weekly medicine called eloralintide to help people with obesity or overweight and type 2 diabetes lose weight. About 1035 adults will receive either the drug or a placebo for around 75 weeks. Researchers will measure changes in body weight, fat, waist …

This Phase 2 trial is testing several experimental drugs—including tirzepatide and others—for long-term weight management in adults with obesity or overweight. About 1,481 participants will receive one of the drugs or a placebo. The goal is to see if these treatments are safe and…

This phase 3 trial tests whether adding tirzepatide (a weight-loss drug) to mirikizumab (an anti-inflammatory drug) helps people with moderate-to-severe ulcerative colitis who are also overweight or obese. The goal is to see if the combination can reduce both gut symptoms and bod…

This study compares two blood sugar targets for overweight or obese women with gestational diabetes. One group aims for stricter goals (fasting under 90 mg/dL, after meals under 120 mg/dL), while the other follows standard targets (fasting under 95 mg/dL, after meals under 140 mg…

This study tests whether a 12-week low-calorie meal replacement diet can improve heart function and exercise ability in people with heart failure with preserved ejection fraction (HFpEF) who are also obese. 63 adults will be randomly assigned to either the diet or standard care. …

This phase 3 trial is testing a new weekly injection called enicepatide for weight loss in 2000 adults with obesity or overweight who do not have type 2 diabetes. Participants will receive either the drug or a placebo for 72 weeks. The main goal is to see how much weight they los…

This study investigates whether taking spermidine, a natural compound found in wheat germ, can improve blood fat levels and body weight in overweight or obese adults with high cholesterol. Participants take either spermidine capsules or a placebo daily for one month. The goal is …

This study tests whether a minimally invasive procedure called endoscopic sleeve gastroplasty (ESG), which reduces stomach size by 70%, can help reverse fatty liver disease (MASH) in people with obesity. Researchers will compare ESG plus lifestyle changes to lifestyle changes alo…

This study tests two experimental drugs, macupatide and eloralintide, alone or together, to help adults with obesity or overweight and type 2 diabetes lose weight. About 200 participants will receive the drugs or a placebo for 48 weeks. The main goal is to see how much weight the…

This study tests a new once-weekly injection called eloralintide to help adults with obesity or overweight lose weight. About 1980 people who do not have type 2 diabetes will take part for up to 75 weeks, with some continuing for 2 more years. The goal is to see if the drug safel…

This study follows 175 adolescents and adults with monogenic obesity—a rare form caused by specific gene changes—who are taking semaglutide (Ozempic/Wegovy). Researchers will track weight and BMI changes over 4 years to see if the drug helps control weight in this group. The goal…

This study tests a new weekly injection called eloralintide in 900 adults with obesity or overweight who are already taking a weekly incretin drug (like Ozempic or Wegovy) but still have excess weight. Participants will receive either eloralintide or a placebo for about 80 weeks …

This study tests an experimental drug called KDS2010 for weight loss in 75 overweight or obese adults. Participants take the drug or a placebo daily for 12 weeks. The main goal is to see how much weight they lose and if the drug is safe. It is a Phase 2a trial, meaning it is stil…

This study is testing a new approach for people with obesity and type 2 diabetes. It combines two procedures done through the mouth: one uses mild electric pulses to regenerate the lining of the upper intestine, and the other reduces stomach size by stitching it like a sleeve. Th…

This Phase 3 trial is testing a new weekly injection called enicepatide for weight loss in 1600 people who are obese or overweight and also have type 2 diabetes. The drug works by mimicking natural hormones that help control appetite and blood sugar. Participants will receive eit…

This study compares weight loss using semaglutide (a drug) versus a calorie-restricted diet in 100 people with obesity and heart failure with reduced ejection fraction. The goal is to see which approach better improves peak oxygen uptake, a measure of exercise capacity, after 52 …

This phase 3 trial tests a weekly injection called eloralintide in 800 adults with moderate-to-severe obstructive sleep apnea who are also overweight or have obesity. The study looks at whether the drug can improve sleep apnea symptoms and help with weight loss. Participants are …

This study looks at whether strength training (like weightlifting) can help adults taking GLP-1 obesity drugs keep their muscle and improve mental health. Forty inactive adults with obesity will either do supervised resistance exercise twice a week for 3 months or just take the m…

This study tests a once-monthly injection called berobenatide to help adults with overweight or obesity lose weight. About 954 participants will receive either the drug or a placebo for 20 months. The goal is to see if the drug is safe and effective for weight loss, including in …

This study is testing a mobile app called Adhera Caring Digital Program for Obesity (ACDP-O) in 280 families. The app provides personalized education, mental health monitoring, and wearable device integration to support weight management and well-being in adolescents and young ad…

This Phase 2b trial is testing whether two experimental drugs, macupatide and eloralintide, can help adults with obesity or overweight lose weight. About 400 participants will receive either one or both drugs or a placebo for 64 weeks. The study measures weight change and safety,…

This study tests whether adding the weight-loss drug tirzepatide to the Crohn's drug mirikizumab helps people with moderate-to-severe Crohn's disease who are also overweight or have obesity. About 290 adults will receive either mirikizumab alone or mirikizumab plus tirzepatide. T…

This early-phase study tests a new oral drug called GS-4571 in healthy people, non-diabetic obese individuals, and non-obese people with type 2 diabetes. The main goals are to see how the drug moves through the body, how safe it is, and how food or acid-reducing drugs affect it. …

This early-stage trial is testing a new drug called AMG 513 in 80 adults with obesity. The main goal is to see if the drug is safe and how the body handles it. Participants will receive either the drug or a placebo by injection, and researchers will monitor for side effects and m…

This study tests an experimental oral drug, ERX1000, for weight loss in 80 adults with obesity (BMI 30-50). Participants will take the drug or a placebo daily for 24 weeks. The main goals are to check safety and see how much weight is lost. This is an early-phase trial, so the dr…

This study tests a new weekly injection called KAI-9531 to help people with obesity or overweight lose weight. It is for adults who do not have diabetes but have weight-related health problems like high blood pressure or sleep apnea. About 1800 participants will receive either th…

This study tests a once-daily pill called orforglipron to help teenagers with obesity or overweight lose weight. About 150 teens will take either the pill or a placebo for 18 months, along with lifestyle advice. The goal is to see if the pill safely reduces body mass index (BMI) …

This Phase 3 trial tests a new drug called KAI-9531, given as a weekly injection, in 1700 adults who are overweight or obese and have type 2 diabetes. The study compares KAI-9531 to a placebo to see if it leads to greater weight loss and better blood sugar control over 76 weeks. …

This study tests whether a weekly injection of tirzepatide, combined with healthy eating and exercise, helps adolescents with obesity and related conditions like high blood pressure or prediabetes lose weight and improve their health. About 300 teens who completed a prior study c…

This phase 3 study is testing whether a new drug called maridebart cafraglutide (MariTide) can reduce the risk of heart attacks, strokes, and death in people with heart disease who are overweight or obese. About 12,800 participants will receive either the drug or a placebo, added…

This study tests an experimental drug called BGE-102 in 160 adults with obesity and heart risk factors. The goal is to see if it lowers inflammation (measured by hsCRP) safely. Participants take either BGE-102 or a placebo daily for 12 weeks.

This Phase 3 trial is testing an oral medication called orforglipron for chronic weight management in children and teens with obesity or overweight. The study will enroll 125 participants who have already tried lifestyle changes without success. The goal is to see if the drug is …

This study tests a new weekly injection called KAI-9531 to help people with obesity lose weight. It involves 1,200 adults who do not have diabetes and compares KAI-9531 to semaglutide (a known weight-loss drug) and a placebo. The main goal is to see how much weight participants l…

This study tests whether the drug maridebart cafraglutide can reduce liver fat and body weight in adults who are overweight or obese and have high liver fat. Participants will also follow a reduced-calorie diet and increase physical activity. The trial involves 180 adults and las…

This early-stage trial tests a new daily pill called CX11 in 90 adults with obesity or overweight who also have weight-related health problems like high blood pressure or prediabetes. The study aims to see if the pill is safe and helps with weight loss compared to a placebo. Part…

This study tests an experimental oral medication, KAI-7535, taken once daily to help people with obesity or overweight lose weight. About 320 adults with at least one weight-related condition (like high blood pressure or sleep apnea) will receive either the drug or a placebo for …

This study is testing whether two different versions of the drug survodutide are equally effective in the body. It involves 80 healthy overweight or obese adults who will receive both formulations in a crossover design. The goal is to see if the new formulation matches the origin…

This study looks at whether eating most of your daily calories in the morning or the evening leads to better long-term weight loss. About 174 adults with obesity will follow a reduced-calorie diet and exercise plan for 12 months. Researchers will track weight, sleep, and appetite…

This study tests whether a daily pill called phentermine helps teenagers aged 12 to 18 with obesity lose weight. About 240 teens will take either the drug or a placebo for 52 weeks. The main goal is to see how much their body mass index (BMI) changes, while also checking for side…

This early-stage study tests a new drug called LY3971297 in healthy volunteers, people with obesity and high blood pressure, and those with reduced kidney function. The main goal is to check for side effects and measure how the drug moves through the body. The study involves up t…

This study tests whether tirzepatide, a drug used for diabetes and weight loss, is practical and acceptable for postmenopausal women who have had hormone receptor-positive breast cancer and are obese. Thirty participants will take the drug weekly for 24 weeks, with monthly check-…

This study tests an experimental drug called ALN-2232, given alone or together with the approved weight-loss drug tirzepatide, in 156 adults with obesity. The goal is to see if the combination is safe and leads to more weight loss than either drug alone. Participants will receive…

This study looks at a program called Building Healthy Families, designed to help children ages 5-13 who are overweight or obese, along with their parents. The program focuses on healthy eating, physical activity, and lifestyle changes for the whole family. Researchers want to see…

This study tests a program called MiWeigh that helps people with obesity and related conditions like diabetes or high blood pressure lose weight. Participants get a personalized plan from a doctor, access to a website, and weekly check-ins. The goal is to see if this approach lea…

This early-stage trial tests a new drug called AZD1043 in 104 healthy adults who are overweight or obese. The goal is to check the drug's safety and how the body processes it. Participants receive either the drug or a placebo by injection. The study includes people of Japanese an…

This study tests a new medicine, maridebart cafraglutide, for adults with obstructive sleep apnea who are overweight or obese and already use a CPAP machine. The goal is to see if the drug can reduce breathing pauses during sleep and help with weight loss over 52 weeks. About 250…

This large phase 3 trial is testing a new once-weekly injection called MET097 for weight loss in 3501 adults with obesity or overweight (but without diabetes). Participants will receive either the drug or a placebo for up to 84 weeks. The main goal is to see how much weight peopl…

This study investigates whether certain genetic variations influence how much weight people lose when taking the FDA-approved weight loss drug Contrave (naltrexone/bupropion). Over 40 weeks, 120 adults with obesity will first follow a calorie-restricted diet for 12 weeks, then ad…

This study tests two experimental drugs, PF-08653945 and PF-08653944, given alone or together, for weight loss in adults with overweight or obesity. About 872 participants will receive either the drugs or a placebo injection. The main goal is to see how much weight they lose over…

This study will test if a 'produce prescription' program, called Eat Well, helps veterans with high blood pressure and food insecurity. About 1,500 veterans in North Carolina will either get money for fruits and vegetables for 6 or 12 months, or standard care. Researchers will tr…

This study looks at whether adding tirzepatide (a weight-loss drug) to standard ixekizumab treatment helps adults with active psoriatic arthritis who are overweight or obese. About 200 participants will receive both medications for up to 12 months. The goal is to see if this comb…

This study tests whether a lifestyle program tailored to a person's specific obesity type helps them lose more weight and keep it off. Researchers at Mayo Clinic will enroll 228 adults with obesity and give them either a standard or a personalized diet and exercise plan for 12 mo…

This pilot study tests a 6-month program that teaches families about healthy eating and activity, and delivers fresh fruits and vegetables to their homes. About 30 children aged 4 to 10 with obesity, along with their caregivers, will take part. The main goal is to see if the prog…

This early-stage study tests a new daily pill, RO7795081, in 30 healthy Chinese adults who are overweight or have obesity. The main goal is to check the drug's safety and how the body handles it. Participants will receive either the drug or a placebo, and researchers will monitor…

This study tests whether a program called Sisters for Heart Health can help farmworker women ages 18-50 reduce stress, feel less isolated, and improve their heart health. Participants will join weekly peer support groups led by trained community health workers for 10 weeks. The s…

This early-stage study is testing an experimental drug, MBX 4291, in 124 adults with obesity. The main goal is to check the drug's safety and how the body processes it. Participants will receive either the drug or a placebo as a shot under the skin, and researchers will monitor f…

This study looks at whether adding a GLP-1 weight-loss drug after bariatric surgery helps people with obesity lose more weight and avoid regaining it. About 200 Chinese adults aged 18-60 who are having sleeve gastrectomy will be randomly assigned to get the drug or not. The goal …

This study tests whether adding appetite-suppressant drugs (topiramate or phentermine) to lifestyle counseling can help people who have regained weight after bariatric surgery. About 120 adults who had sleeve gastrectomy or gastric bypass at least 18 months ago and regained at le…

This study tests if adding health coaching to regular home visiting services helps pregnant and new moms lose weight gained during pregnancy. The goal is to reduce long-term risks for heart disease and diabetes. Researchers will enroll 360 women who are overweight before pregnanc…

This study tests a program that helps people with obesity who are waiting for a kidney transplant lose weight. Participants will receive education, a calorie tracking app, a continuous glucose monitor, a weight scale, and a food scale. The goal is to see if this program is practi…

This study investigates whether combining supervised resistance exercise three times a week with a high-protein diet can reduce frailty and improve balance in obese women aged 60–70 who have sarcopenia (age-related muscle loss). Sixty participants are randomly assigned to either …

This study is for overweight or obese women aged 18–45 with atypical endometrial hyperplasia, a precancerous condition of the uterine lining. Participants will receive either a levonorgestrel-releasing IUD (Mirena) or megestrol acetate pills, combined with a weight management pro…

This pilot study tests a device that gently stimulates a nerve in the ear (taVNS) to help overweight or obese people who didn't lose much weight after 12 weeks of diet and exercise. 24 participants will get either real or sham stimulation twice daily for 12 more weeks, while cont…

This early-stage trial tests a new drug called NNC0497-0040 in healthy people, those with overweight or obesity, and people with type 1 diabetes who are also overweight. The goal is to see if the drug is safe and tolerable when given as a weekly injection. About 146 participants …

This Phase 3 trial tests whether the drug HRS-7535 can lower blood pressure better than a placebo in 648 adults with hypertension who are also overweight or obese. Participants will take the drug or placebo for up to 48 weeks, and researchers will measure changes in blood pressur…

This early-stage study tests an experimental oral drug called RO7795081 in 40 healthy overweight or obese adults. The main goals are to check safety and how the drug interacts with common statins (rosuvastatin and pitavastatin). Participants will receive the drug or a placebo in …

This study tests a weight loss program for adult survivors of childhood acute lymphoblastic leukemia (ALL) who are overweight or have obesity. Participants receive a weekly injection of tirzepatide plus remote, supervised resistance exercise three times a week for 28 weeks. The g…

This study examines weight loss in adults who took semaglutide (a prescription weight management drug) as part of their routine care. Researchers will analyze medical records from about 35,000 people with overweight or obesity to see how much weight they lost and whether they ach…

This study tests a new drug called NNC0487-0111, given as a once-weekly injection, to see if it helps people with obesity lose weight safely. About 1,150 adults who have tried to lose weight before will receive either the drug or a placebo. The main goal is to measure how much bo…

This study tests whether combining two experimental drugs, MET233 and MET097, can help adults with obesity or overweight lose weight, including those with type 2 diabetes. About 381 participants will receive either the drug combination or a placebo to check safety and how well th…

This early-stage study tests a new drug, WVE-007, given as a shot under the skin to help with weight loss. It includes about 296 adults who are overweight or have obesity, some with pre-diabetes or type 2 diabetes. The main goal is to check safety and how the drug moves through t…

This study looks at how obesity affects recovery from post-COVID conditions in older Veterans. Researchers will test if a weight loss program with diet and exercise can reduce inflammation and improve physical function and quality of life. The study involves 150 Veterans, some wi…

This study is testing whether adding the weight-loss drug tirzepatide to the standard psoriasis medication ixekizumab helps people with moderate-to-severe plaque psoriasis who are also overweight or obese. About 200 adults will receive tirzepatide injections for up to 12 months. …

This study tests whether a new medicine called NNC0487-0111, given as a weekly injection, is safe and effective for weight loss in adults with obesity. About 600 participants will receive either the active drug or a placebo (dummy injection) for comparison. The main goal is to me…

This study tests a once-weekly injection called NNC0487-0111 in 630 adults who are overweight or obese and have type 2 diabetes. Participants receive either the active drug or a placebo for about a year. The main goal is to see how much weight they lose, with additional checks on…

This study tests whether a structured cardiac rehabilitation program with exercise and lifestyle coaching, started after a standard catheter ablation procedure, can help obese patients with atrial fibrillation stay free from the heart rhythm disorder longer. Researchers will foll…

This study tests whether a 12-week telephone health coaching program, called Support Your Heart, is practical and helpful for young adults aged 18-39 who have at least two heart disease risk factors (like poor sleep, inactivity, or high blood pressure). Twenty participants in the…

This pilot study tests whether a gentle electrical stimulation of the ear (taVNS) can help overweight or obese people lose more weight when they haven't lost enough on the medication tirzepatide alone. 24 participants will receive either active ear stimulation or a sham (fake) st…

This early-stage trial tests a single dose of the experimental drug IBIO-600 in 32 overweight or obese adults. The main goal is to see if the drug is safe and tolerable, and to measure how it moves through the body. Researchers will also look at its effect on body composition. Th…

This Phase 3 study tests whether a new drug called CagriSema helps people with severe obesity (with or without type 2 diabetes) lose more weight than the existing drug semaglutide. About 2,500 participants will receive either CagriSema or semaglutide for 83 weeks. The main goal i…

This study tests whether eating all meals within a 9-hour window each day for 12 weeks can improve insulin sensitivity and other heart health markers in 100 adults with obesity and prediabetes. Participants will be randomly assigned to either a 9-hour eating window or a 14-hour w…

This study tests whether taking a probiotic for 3 months can improve how the body processes fats after a meal in adults aged 50-70 who are overweight or moderately obese but otherwise healthy. 66 participants will receive either the probiotic or a placebo. The main goal is to see…

This study is testing whether bariatric surgery (like gastric bypass) can safely reduce the risk of major heart problems—such as heart attacks, strokes, and heart failure—in people with severe obesity and high heart risk. About 700 participants will be randomly assigned to either…

This study tests a non-invasive brain stimulation method (temporal interference stimulation) aimed at improving metabolism in people with stable bipolar disorder who also have obesity. Researchers will measure changes in key metabolic molecules like GLP-1. The study enrolls 70 ad…

This Phase 3 trial tests a drug called IBI362 in people with mild to moderate high blood pressure who are also overweight or obese. Participants receive weekly injections of either the drug or a placebo for 48 weeks. The main goal is to see if IBI362 lowers blood pressure more th…

This study tests if tirzepatide, a weekly injection, can help overweight or obese people with well-controlled HIV lose weight and reduce chronic inflammation. Twelve adults will receive increasing doses over 12 weeks, with a 4-week safety follow-up. Researchers will measure chang…

This study follows overweight and obese adults aged 45-65 to see if a tailored program of counseling, supervised exercise, and digital tools helps them lose weight and improve heart health over 18 months. Participants are compared to a group that only gets general written advice.…

This early-phase study aims to see if a natural substance called angiotensin-(1-7) can improve how the body uses insulin in people with obesity, insulin resistance, and high blood pressure. About 26 adults aged 18-60 will receive the peptide or a placebo infusion, and researchers…

This study tests an experimental drug called CS060380, taken with the weight-loss drug semaglutide, in adults with both fatty liver disease (MASH) and obesity. About 120 participants will be randomly assigned to get either CS060380 or a placebo for 36 weeks, then everyone gets CS…

This study tests a weight loss program for 522 low-income adults with obesity in Louisiana. Participants receive health coaching, digital self-monitoring tools, and group support to find community wellness resources. The goal is to see if this approach leads to greater weight los…

This study tests a new magnetic device that creates a shortcut in the gut to help with weight loss and blood sugar control, comparing it to the popular drug semaglutide (Ozempic/Wegovy). Twenty adults with obesity and type 2 diabetes will be randomly assigned to either the one-ti…

This early-stage study tests the safety and tolerability of a new injectable drug called ABBV-295 in 48 adults with obesity. Participants will receive either the drug or a placebo over several weeks. Researchers will monitor side effects, changes in body weight, and how the drug …

This study tests tirzepatide, a once-weekly injection, in 344 Indian adults with type 2 diabetes or obesity. Over 46 weeks, researchers will check for serious side effects and measure weight loss and blood sugar control. The goal is to see if this drug is safe and effective for t…

This study looks at how well the drug tirzepatide works in everyday life for people with obesity (without diabetes) or type 2 diabetes (with or without obesity). About 160 adults in Paraguay will take the drug as part of their regular care and be followed for 52 weeks. Researcher…

This study tests whether weighing yourself every day can help teens with obesity manage their weight. About 99 teens aged 12 to 18 will be split into three groups: usual care, usual care plus a simple scale, or usual care plus a smart scale that sends data to their doctor. The st…

This study compares two weight-loss surgeries—SASI bypass and sleeve gastrectomy—in 220 adults with severe obesity. The goal is to see which one leads to more weight loss and fewer problems like acid reflux. Participants will be randomly assigned to one of the two procedures and …

This Phase 3 trial tests a new medicine called MET097, given as a weekly injection, to help adults with overweight or obesity and type 2 diabetes lose weight. About 999 people will take part, with two-thirds getting the real drug and one-third getting a placebo. The study lasts a…

This study is testing whether e-cigarettes or nicotine replacement therapy (patches and lozenges) can help obese smokers quit or reduce smoking. Sixty participants will use one of the two products for 8 weeks, and researchers will track how many cigarettes they smoke, their carbo…

This study tests whether taking tirzepatide (Mounjaro/Zepbound) for three months before bariatric surgery reduces inflammation and leads to better weight loss and fewer complications. Fifty adults with obesity scheduled for surgery will either receive the drug or standard diet an…

This study tests a 16-week behavioral program called T1DAL, designed specifically for teens with type 1 diabetes who have overweight or obesity. About 50 teens will be randomly assigned to either the program or usual care. The program includes virtual group sessions and one-on-on…

This study directly compares two popular weight-loss medications, tirzepatide and semaglutide, in 120 adults with obesity and metabolic syndrome. Participants will be randomly assigned to one drug and monitored for 12 months using advanced body scans, blood tests, and AI analysis…

This study tests whether a supervised, equipment-free high-intensity interval training (HIIT) program can improve heart and muscle fitness, body composition, and blood markers in adults aged 18-55 who are overweight or obese. Participants will do body-weight exercises in small gr…

This study tests a personalized program to help people who have lost weight keep it off. About 30 adults who lost at least 7% of their body weight in the past 6 months will receive weekly texts, surveys, and possibly health coaching over 26 weeks. The goal is to see if this appro…

This study tests whether eating all your food within 8 hours each day (time-restricted eating) helps people with obesity keep weight off after losing it. About 212 participants will follow a calorie-restricted diet to lose 8-10% of their body weight, then be split into two groups…

This study looks at what happens to your body when you take anti-obesity medications like semaglutide or tirzepatide, and whether adding aerobic or resistance exercise helps preserve muscle and bone while losing fat. About 40 adults will be assigned to either standard care (medic…

This study tests whether empagliflozin, a drug used for diabetes, can reduce chronic inflammation in people with obesity and metabolic syndrome. Researchers will measure immune cells and blood vessel function in 74 adults. The goal is to find a new way to lower heart disease risk…

This study tests whether eating 3 whole eggs every day for 4 weeks can improve metabolic health and choline levels in adults with obesity. Twenty participants aged 30-65 with a BMI over 30 will eat the eggs while continuing their normal lifestyle. Researchers will measure liver h…

This study tests a personalized diet and exercise program guided by a smartphone app in 140 obese adults with coronary heart disease. Participants receive custom meal plans and daily weight tracking to help them lose weight safely. The goal is to see if this approach improves wei…

This Phase 1 study looks at how CagriSema, semaglutide, and cagrilintide affect muscle health in 100 adults aged 50-70 with obesity and slightly high blood sugar. Participants will receive one of the drugs or a placebo for up to 15 months. The main goal is to measure how well mus…

This early study looks at whether taking tirzepatide (Mounjaro) after sleeve gastrectomy surgery helps people lose more weight and improve conditions like diabetes and high blood pressure. About 42 adults with obesity will be split into two groups: one gets surgery alone, the oth…

This study tests whether a supplement called Xanthigen helps overweight adults lose weight. About 180 people with a BMI between 27 and 30 will take either a low dose, high dose, or placebo for 16 weeks. Researchers will measure weight, BMI, and waist size to see if the supplement…

This study compares time-restricted eating (eating only within a 12-hour window each day) to standard calorie-restricted diets in 128 children aged 8-17 with obesity. Over 48 weeks, researchers will measure weight loss and how well children stick to the diet. The goal is to find …

This study tests a telehealth program to help cancer survivors quit smoking, lose weight, and get more active. About 1500 participants will either get coaching sessions or just information. The goal is to see which approach works better for improving long-term health.

This study gives overweight teens ages 12-17 free weekly produce from a local farm for 8 weeks, along with educational videos. Researchers want to see if this program is practical and if it increases fruit and vegetable intake, improves blood pressure, and helps with weight. Fift…

This study tests a new surgical device (a metal clip) to create a second food pathway in the stomach for people with type 2 diabetes who are overweight or mildly obese (BMI 25-35). The goal is to improve blood sugar control without causing too much weight loss or needing lifelong…

The PROVE trial is testing whether a weight loss program combined with walking exercise can improve or maintain walking ability in people with peripheral artery disease (PAD) who are overweight. 212 participants will be randomly assigned to either weight loss plus exercise or exe…

This study tests whether adding a special light treatment (antimicrobial photodynamic therapy) to standard deep cleaning helps people with obesity and gum disease. 24 participants will receive either standard cleaning alone or cleaning plus the light therapy. Researchers will che…

This study looks at whether a combination of physical exercise and a nutritional supplement (phenylcapsaicin) can improve body composition, metabolism, and overall health in adults aged 50-65 who are overweight but not obese. Participants must have at least two signs of mild meta…

This study tests whether using a sit-stand desk at work can improve insulin sensitivity and reduce diabetes risk in 198 overweight, sedentary adults with prediabetes or other risk factors. Participants are randomly assigned to stand 2 or 3 hours per day at a sit-stand desk, or to…

This 12-week study tests whether replacing highly processed soy foods (like soy burgers) with less processed options (like tofu or edamame) can lower blood pressure and improve heart health in 300 adults with obesity, hypertension, and often type 2 diabetes. Participants use a di…

This early-stage trial is testing a new drug, HM17321, to see if it is safe and how the body processes it. About 90 healthy and obese adults will receive either the drug or a placebo as a shot under the skin. The main goal is to check for side effects, not to treat obesity yet.

This study tests whether adding a digital behavioral tool called Evira to standard obesity medication (liraglutide or semaglutide) helps teens with obesity lose more weight than medication alone. Forty adolescents aged 12-17 will be randomly assigned to either the combination or …

This trial tests a 9-month program for women who had preeclampsia during their first pregnancy. The program includes online screening, group meetings, and a smartphone app to help monitor blood pressure and weight. Researchers want to see if it improves heart health and promotes …

This study looks at whether a special lifestyle program can help women ages 18-25 with a BMI between 25 and 50 lose weight and reduce inflammation better than standard weight loss advice. About 32 women will take part over 12 months. The goal is to improve long-term health by tar…

This study tests whether giving free summer day camp vouchers to low-income children with overweight or obesity can help them manage their weight. Eighty children aged 5-11 who are on Medicaid will be randomly assigned to either receive a voucher for an 8-week summer day camp or …

This study tests whether a dietary supplement called capsinoid, found in sweet peppers and chilies, can activate brown fat in obese adolescents. Brown fat is a type of body fat that burns calories to produce heat, which may help with weight control. The study will involve 38 teen…

This study tests whether tirzepatide, a drug used for weight loss and diabetes, can slow tumor growth in people with obesity-driven endometrial cancer. About 20 participants will take the drug before their scheduled hysterectomy. Researchers will compare cancer cell activity in t…

This study compares two versions of gastric bypass surgery for people who regained weight or didn't lose enough after an initial sleeve gastrectomy. Researchers will track weight loss, quality of life, and food tolerance over 5 years in 240 adults. The goal is to find out if addi…

This study tests whether semaglutide (Ozempic) helps people with HIV and obesity lose more weight than diet and exercise alone. About 80 participants will receive either semaglutide injections or standard lifestyle advice for 28 weeks. Researchers will also check how the drug aff…

This study tests a coordinated weight loss program where parents and children work together to eat healthier, be more active, and support each other. About 90 families will join, with parents attending their own program while kids take part in a pediatric weight management clinic…

This study tests two types of distal gastric bypass surgery for people who regained weight or didn't lose enough after an initial Roux-en-Y gastric bypass. About 150 participants will be randomly assigned to one of the two procedures and followed for three years. The main goals a…

This study tests whether UBT251 is safe and effective for people who are overweight or have obesity. About 333 participants will receive either UBT251 or a placebo injection. The main goals are to check for side effects and measure weight change over time.

This study tests whether resistance exercise and extra protein can help preserve muscle mass in people starting weight-loss drugs like semaglutide or tirzepatide. 232 adults with obesity will be randomly assigned to one of four groups: control, extra protein, exercise, or both. T…

This study is testing whether a daily capsule made from fermented fruits and vegetables (Rutazyme®) can improve body fat, waist size, and blood markers in adults with obesity. Forty participants will take either the supplement or a placebo for 12 weeks. Researchers will measure c…

This study tests if weight-loss surgery is better than standard medical treatment for making nonalcoholic steatohepatitis (NASH) with advanced liver scarring disappear without making the scarring worse. It involves 100 obese adults with NASH and significant liver fibrosis. Partic…

This study tests whether a virtual group exercise program combined with health education can lower fall risk and increase physical activity in older veterans who have both obesity and signs of muscle loss (sarcopenia). About 50 veterans aged 55 and older will take part. The goal …

This study looks at whether adding a GLP-1 drug (semaglutide) to bariatric surgery helps people with severe obesity lose more weight and keep it off. About 200 adults aged 18-60 with a BMI of 35 or higher and related health issues will be followed for a year. The goal is to see i…

This early-stage trial is testing a new drug called brenipatide in 150 healthy people with overweight or obesity. Participants receive different doses of the drug or a placebo as injections under the skin. The study lasts about 42 weeks and aims to see how well the drug works for…

This study tests tirzepatide, a medication already used for obesity, in 60 adults who have both type 1 diabetes and obesity. Participants will receive either tirzepatide or standard care to see if it helps with weight loss and is safe. The goal is to understand if this drug can b…

This study tests whether a dietary supplement made from omega-3 fatty acids (called SPM) can reduce blood vessel damage caused by inflammation in people with obesity and high blood pressure. Researchers will give 60 participants either the supplement or a placebo for 12 weeks and…

This study tests whether the drug tirzepatide, given once weekly, helps adults with obesity (but without diabetes) lose weight and avoid developing type 2 diabetes. About 3,000 participants will receive either tirzepatide or standard care for up to 5 years. The goal is to see if …

This study compares three weight loss approaches in 492 adults with obesity: a new stepped-care program that starts with minimal support and adds help only if needed, the standard Diabetes Prevention Program, and a self-guided option. The goal is to see if the smarter program can…

This study tests whether a mango and chia-based drink can improve the gut bacteria of 100 obese children aged 8 to 16 in Paraguay. The children will drink the beverage for 6 weeks, and researchers will analyze their stool samples before and after to see if the drink changes their…

This phase 3 trial tests an injectable drug called XW003 (Ecnoglutide) in 140 obese adults with obstructive sleep apnea who do not use CPAP machines. The goal is to see if the drug reduces breathing pauses during sleep and helps with weight loss. Participants receive either the d…

This study tests a new digital tool called P3-EX that helps doctors create personalized exercise plans for patients with heart disease risk factors like high blood pressure, diabetes, and obesity. Researchers will recruit 24 doctors and 48 patients to compare the new tool with a …

This study looks at whether a structured weight loss program, with or without added exercise, can improve physical function and emotional well-being in obese veterans who have had a stroke. Researchers will enroll 130 participants aged 35-85 who had a stroke at least 6 months ago…

This study tests an injection called XW003 in 140 obese adults with obstructive sleep apnea who already use a breathing machine (PAP). The goal is to see if the drug reduces breathing pauses during sleep and helps with weight loss. Participants will receive either the drug or a p…

This study compares a new weekly injection, HDM1005, to the existing drug tirzepatide for weight loss in 372 adults with obesity but without diabetes. Participants receive either HDM1005 or tirzepatide for 52 weeks, plus diet and exercise counseling. The main goal is to measure h…

This study tests a modified version of sleeve gastrectomy, a common weight-loss surgery, to see if it can reduce or prevent acid reflux (GERD) that often occurs after the standard procedure. About 44 adults with obesity and GERD will be randomly assigned to receive either the sta…

This study tests whether a family-focused healthy lifestyle program (iAmHealthy) plus clinic-level changes can help manage obesity in children aged 6–11 living in rural areas. Over 1,000 families will take part in group education sessions and individual health coaching, or receiv…

This study tests whether a strict low-carbohydrate diet combined with lifestyle guidance can help obese men (BMI 30+) lose weight and improve their fertility. Researchers will track weight, semen quality, and reproductive outcomes in 98 men aged 22-40. The goal is to find a non-d…

This study tests a digital program for overweight teens aged 12-18 that uses AI coaching, games, and real-time feedback to encourage healthy eating and exercise. Two hundred participants will either use the digital program or receive standard health education for three months. Th…

This early-stage study tests an experimental drug called ARO-ALK7 in 138 adults with obesity, some of whom also have type 2 diabetes. The drug is given as an injection and aims to help with weight loss and blood sugar control. The main goal is to check safety and how the body pro…

This study looks at whether taking blood pressure medication in the morning or evening works better for obese people with high nighttime blood pressure. Obese individuals often have disrupted natural rhythms that raise their heart disease risk. Researchers will give 160 participa…

This study tests whether electro-acupuncture can improve insulin resistance in people with obesity. 60 participants will be randomly assigned to receive either real electro-acupuncture or a sham (fake) version. The main goal is to see if the treatment lowers a key measure of insu…

This study is testing whether eating 2.5 cups of fresh watermelon every day for six weeks can improve gut health, including increasing good bacteria, and boost heart health in young adults aged 18-30 who are overweight or have obesity. Participants will be randomly assigned to ea…

This early-stage trial tests the safety of a new oral drug, IBI3032, in 104 people. Part A gives a single dose to healthy volunteers, while Part B gives multiple doses over 4 weeks to people with overweight or obesity. The goal is to check for side effects and how the drug moves …

This study tests whether a low dose of the weight-loss drug mazdutide, an intensive lifestyle program, or both can help people with obesity maintain weight loss for a year after initially losing weight with a higher drug dose. About 420 adults with a BMI between 28 and 45 will ta…

This early-stage trial tests a new drug called DA-1726 in 139 people with obesity. The main goal is to check safety and side effects. Researchers will also measure how the drug moves through the body and its effect on weight. Participants receive either the drug or a placebo, and…

This early-stage trial tests a new drug called SYH9017 in 66 Chinese adults who are overweight or obese. The main goal is to check the drug's safety and how the body processes it after single and multiple doses. Participants will receive either the drug or a placebo, and research…

This study is testing a low-dose version of the drug semaglutide to help obese adults lose weight and improve heart health. The trial includes 60 Pakistani adults who are obese but do not have diabetes. Participants will receive weekly injections for 24 weeks, along with diet and…

This study tests whether artificial intelligence can better predict difficult airway management in 340 obese patients undergoing bariatric surgery. Researchers will compare AI predictions using standard measurements like mouth opening and neck length against actual views during i…

LiverSeek is a study testing an automated screening program for advanced liver fibrosis in people aged 50-75 with risk factors like diabetes or obesity. When a routine blood test is done, the lab system automatically calculates a fibrosis score and, if needed, orders additional t…

This study tests a program called PINPOINT that helps women with obesity or diabetes get screened for cervical cancer. About 20 women who are behind on screening will be offered options like self-collection or a Pap smear. The goal is to see if the program is practical and well-l…

This study looks at whether offering free center-based childcare during the summer can help prevent unhealthy weight gain in preschoolers from low-income households. Researchers will enroll 300 children who attend needs-based pre-K programs. The goal is to see if the structure an…

This study tests two parenting programs for families with newborns. One program teaches parents how to recognize baby hunger and fullness cues and offers nutrition advice. The other provides safety tips like safe sleep and car seat use. Researchers will track the babies' growth a…

This study looks at whether different types of exercise (aerobic, resistance, or both) during pregnancy can improve the health of both mother and child. Researchers will follow 300 overweight or obese pregnant women and their babies for one year after birth. The goal is to find t…

This study tests a 9-month program to prevent obesity in 2,340 primary school children aged 6-12 in Pakistan. The program includes health education, daily physical activity, parent workshops, and regular feedback via WhatsApp. Half the schools will get the program, the other half…

This study tests whether combining a food prescription program with education on healthy feeding practices can help parents prevent chronic diseases like obesity in their children. Researchers will enroll 375 parents of children aged 4-8 in Texas. Participants will receive either…

This study is testing a mobile health platform designed to help children ages 8-12 who don't get enough sleep (less than 8.5 hours per night) sleep longer. The goal is to see if improving sleep can help prevent obesity. The study will enroll 5,000 children and track their sleep d…

This study looks at whether whole or low-fat (1%) milk is better for preventing obesity in toddlers. Researchers will give 625 children either whole or low-fat milk for one year and measure changes in waist size and body mass index. The goal is to find out which milk type support…

This study tests whether a smartwatch-based program, combined with coaching from healthcare staff, can improve heart health in overweight or obese adults who have early signs of problems like high blood pressure or prediabetes. The program focuses on exercise and diet, and tracks…

This study tests whether community health workers can help adults with chronic illnesses get up-to-date on COVID-19 and flu vaccines. Participants receive up to three counseling sessions in English or Spanish to address their vaccine concerns. The goal is to reduce health dispari…

This study tests whether playgroups or parent education classes can help toddlers develop healthy eating and activity habits. About 300 families with toddlers aged 18-36 months will be randomly assigned to one of three groups: a playgroup, a parent education class, or continuing …

This study looks at whether taking a daily supplement made from artichoke by-products, combined with a calorie-controlled Mediterranean diet, can help prevent type 2 diabetes in people who are overweight or obese. Researchers will measure changes in insulin resistance and weight …

This study tests whether regularly warming the legs with a portable sauna blanket can improve blood vessel health and lower the risk of high blood pressure disorders in pregnant women with obesity. About 118 women will use the blanket at home for 16 weeks, starting early in pregn…

This study tests a family-centered program to help Hispanic families lose weight and prevent obesity. About 1,319 parents and their children ages 8-12 will take part. The program uses text messages and family support to encourage healthy eating and activity.

This study tests a program called Healthy Family Foundations for military families expecting their first child. The program includes 10 online group classes (5 before birth, 5 after) to help parents support each other with healthy eating, activity, and parenting. Researchers will…

This study tests a 9-session group program for parents of children aged 6 months to 3 years, focusing on healthy eating, physical activity, and sleep. About 526 families from Spain will take part, with half receiving the program and half getting usual care. The goal is to see if …

This study tests a program called Futuros Fuertes 2.0, which gives low-income Latino families health coaching and text messages during the first two years of a child's life. The goal is to promote healthy feeding, limit screen time, and improve sleep to prevent obesity. Half of t…

This study tests an online program called Families in Balance Online, designed to help parents of 2- to 5-year-olds build healthy routines around meals, sleep, and screen time. About 300 families with low income will be randomly assigned to either this interactive program or a se…

This study tests whether giving a fecal microbiota transplant to babies born by C-section can improve their gut bacteria and help prevent overweight or obesity later in life. Researchers will track the growth and gut health of 534 infants who receive the transplant shortly after …

This study tests whether a program that addresses chronic pain can help teens with obesity stay in weight management treatment. Fifty adolescents aged 12-18 with both obesity and musculoskeletal pain will either receive the Pain and Weight Treatment (PAW) plus standard care, or p…

This study tests whether online group education and lifestyle coaching can improve quality of life and health markers in women with PCOS and obesity. Forty non-pregnant women aged 18-49 will be assigned to either the virtual program or usual care. Researchers will measure changes…

This study looks at whether the timing of a 9-hour eating window (early, mid, or late in the day) affects blood sugar control in people with obesity who have or are at risk for type 2 diabetes. Over 7 days, 120 participants will follow one of three time-restricted eating schedule…

This study tests whether early time-restricted eating (eating only during a set morning window) helps postpartum women with overweight lose weight and improve heart health. Sixty women 6-16 weeks after a healthy pregnancy will either follow this eating schedule or eat normally fo…

This study tests whether cagrilintide, a new injectable drug, causes fewer stomach side effects than a placebo in people with obesity who previously quit GLP-1 medications due to nausea, vomiting, or diarrhea. About 114 participants will receive either cagrilintide or a dummy sho…

This study is testing whether a time-restricted eating plan (eating only during an 8-10 hour window each day) combined with a healthy plant-based diet is safe and doable for people with liver cancer, cirrhosis, or fatty liver disease. Fifty overweight or obese adults will either …

This Phase 3 study tests a once-weekly injection called eloralintide in 900 adults with osteoarthritis of the knee who are also overweight or obese. The goal is to see if it reduces knee pain and helps with weight loss compared to a placebo. Participants will be in the study for …

This study is testing a new, ultra-thin endoscope that goes through the nose without sedation, instead of the usual mouth-and-sedation approach. Researchers want to see if it improves patient experience and lowers costs for people in bariatric care. About 100 adults will try the …

This study tests different types of weekly feedback to help people lose weight. 300 adults with overweight or obesity will receive feedback on their calorie intake, diet quality, or physical activity. The goal is to find which feedback works best for improving weight loss.

This study tests whether 10 minutes of daily brain games on a phone can help teens aged 14-17 with overweight improve their self-control around food. Over three weeks, participants play games designed to strengthen inhibitory control and receive a short nutrition lesson. The goal…

This trial compares a new 'low impact' laparoscopic technique using lower gas pressure and smaller incisions to standard laparoscopy for sleeve gastrectomy in 128 obese patients. The goal is to see if it reduces post-surgery pain and improves lung function. Participants are rando…

This study tests whether the Thrive AI Health app can help adults with type 2 diabetes or overweight improve their daily habits like diet, exercise, and sleep. About 20 participants will either use the app or not, and researchers will compare changes over time. The app uses artif…

This study tests whether a 16-week hydration program can reduce side effects like nausea and dehydration in people starting GLP-1 medications (such as Ozempic or Wegovy). Researchers will track 30 adults aged 18-60 who recently started the drug, measuring hydration levels and sid…

This study tests whether giving lidocaine through a stomach tube can reduce nausea and vomiting after weight-loss surgery. About 100 obese adults having laparoscopic sleeve gastrectomy will receive either lidocaine or a saltwater placebo right after surgery. Researchers will trac…

This study tests whether a wrist-worn device called Reletex Reliefband can reduce nausea and vomiting after bariatric sleeve gastrectomy. The device uses mild electrical pulses to stimulate nerves and suppress nausea. Researchers will compare it to a sham device in 100 adults to …

This study looks at whether adding pork protein to the diet can help middle-aged women with overweight or obesity who are taking GLP-1 medications (like Ozempic or Wegovy) maintain muscle and improve well-being. Over 12 weeks, 75 women will continue their medication and eat prote…

This pilot study tests whether tirzepatide, a medication used for diabetes and weight loss, can reduce the frequency and severity of hot flashes in postmenopausal women with obesity. Researchers will also measure markers of biological aging, like cellular senescence and epigeneti…

This early-stage study tests whether a new drug called NNC0113-5840 is safe for people with overweight or obesity. About 48 adults aged 18-55 with a BMI between 25 and 35 will receive either the drug or a placebo. The main goal is to check for side effects and how the drug moves …

This Phase 3 trial tests whether a once-weekly injection called NNC0487-0111 can help people with overweight or obesity and knee osteoarthritis lose weight and feel less pain. About 400 adults will receive either the drug or a placebo for several weeks. Researchers will measure c…

This Phase 3 study tests a once-weekly injection called NNC0487-0111 in 400 adults who are overweight or obese and have knee osteoarthritis. The goal is to see if it helps with weight loss and reduces knee pain compared to a placebo. Participants receive either the active drug or…

This early-stage study tests a new drug called ALV-100 in 180 adults who are overweight or obese, with or without type 2 diabetes. The main goal is to check the drug's safety and how the body processes it. Participants receive either the drug or a placebo, and researchers will mo…

This study tests if a mild electrical patch placed on the skin (called TENS) can prevent breathing problems after weight-loss surgery in people with severe obesity. About 70 participants will be randomly assigned to receive either TENS or a fake device. The main goal is to see if…

This study looks at whether adding a special whey protein supplement to a high-fat meal can improve markers of heart and brain health in postmenopausal women who are overweight and at moderate risk for heart disease. Sixteen women will each try the supplement and a placebo on sep…

This study tests a once-weekly injection called retatrutide to see if it can reduce chronic low back pain and help with weight loss in people who have obesity or overweight. About 586 participants will receive either the drug or a placebo for up to 80 weeks. The goal is to find a…

This study tests whether starting gentle, supervised movement soon after bariatric surgery and continuing it at home can help manage pain and improve recovery. Researchers will track pain levels, physical function, and quality of life in 112 participants. The goal is to find a si…

This study tests whether a 4-week emotion regulation and self-monitoring program can help overweight and obese teens ages 11-14. Participants attend weekly telehealth groups and track their mood and health behaviors. Researchers will measure changes in brain activity, blood marke…

This early-stage study tests a new injection called SHR-2906 to see if it is safe and tolerable. It involves 124 healthy volunteers and obese patients. The goal is to check for side effects and how the drug moves through the body.

This study tests a medicine called cagrilintide to see how it affects appetite and how much people eat. About 120 adults with overweight or obesity will receive either the drug or a placebo for around 30 weeks. The goal is to measure changes in total energy intake from meals and …

This study is testing a weight loss program that uses a smartphone app and a coach to help teens and young adults who are overweight after a stem cell transplant. The goal is to see if the program can help them lose weight and build healthy eating habits. About 20 people who are …

This study looks at whether blowing balloons can improve lung function and reduce shortness of breath in obese children aged 6 to 12. Thirty-eight children will be split into two groups: one will blow balloons, the other will do a simple running exercise. Researchers will measure…

This study tests whether personalized nutrition and exercise plans can reduce frailty and improve body composition in prostate cancer survivors who are on hormone therapy (ADT). Fifty participants will receive diet advice, exercise coaching, and educational sessions. Researchers …

This study tests whether adding very short, intense exercise bursts (called 'exercise-snacks') to a standard weight-management program can improve physical fitness in obese adolescents. Forty-eight teens will either do six mini-exercise sessions daily for three weeks or just rece…

This study tests whether a 5-week program of aerobic and resistance exercises can improve muscle quality, body composition, and quality of life in 84 adults who recently had bariatric surgery. Participants are split into an exercise group and a usual-care group. The goal is to se…

This early-stage study tests whether a once-weekly injection called NNC0487-0111 can lower how much people with obesity eat and reduce their appetite. About 120 adults will receive either the drug or a placebo for several months. The goal is to see if the treatment changes energy…

This study looks at two ways to manage pain during weight-loss surgery (sleeve gastrectomy) in 70 adults. One group gets standard opioid painkillers, the other gets a mix of non-opioid drugs. The goal is to see if the opioid-free approach can reduce opioid use and still control p…

This study tests whether a negative pressure wound therapy (NPWT) device, which uses a vacuum to help wounds heal, works better than standard bandages for the abdominal incision in obese patients having breast reconstruction surgery. About 80 participants will be randomly assigne…

This pilot study tests whether semaglutide (Ozempic), a drug used for diabetes and obesity, is safe and tolerable for weight loss in people with advanced lung disease. Eight participants with conditions like COPD or pulmonary fibrosis will take weekly injections for 12 weeks. Res…

This study looks at whether adding peanuts to daily meals for 12 weeks can help adults on GLP-1 medications (like semaglutide or tirzepatide) feel fuller, have more energy, and improve their diet quality. About 64 adults who have been on these meds for at least 6 months will part…

This Phase 3 study tests whether tradipitant can reduce nausea and vomiting caused by GLP-1 weight-loss drugs. About 280 healthy overweight or obese adults will receive either tradipitant or a placebo. The goal is to see if tradipitant helps people tolerate these medications bett…

This early-stage study is testing an experimental drug called LY4064912 in 144 healthy volunteers and people with overweight or obesity. The main goal is to check safety and how the body handles the drug, not yet to prove it works for weight loss. Participants will receive either…

This study looks at whether special breathing exercises (inspiratory muscle training) can improve lung function and reduce inflammation in people with obesity. Researchers will measure breathing, muscle strength, and blood markers in 40 adults aged 30-60 with a BMI of 30 or highe…

This early-stage study tests a new drug called RT-114 in 60 healthy volunteers to see if it is safe and how the body processes it. Some participants will get the drug as a shot or pill, while others will get a placebo. The goal is to gather initial safety data before testing in p…

This study tests whether a synbiotic supplement (a mix of probiotics and prebiotics) can improve gut health and reduce mild stomach discomfort in adults aged 50-70 who are overweight. Participants take the supplement or a placebo daily for 8 weeks, and researchers measure changes…

This early-stage trial is testing whether combining two experimental weight loss drugs—cagrilintide and a GIP receptor agonist—causes fewer stomach side effects like nausea and vomiting compared to taking cagrilintide alone. About 100 women who are overweight or obese will receiv…

This study tests whether a single 40-minute infrared sauna session, done before a meal, can lower blood sugar spikes in overweight adults. Fifteen participants at risk for metabolic issues will wear a continuous glucose monitor and compare sauna versus rest. The goal is to see if…

This study tests whether a gentle brain stimulation technique called tDCS, combined with cognitive training, can help veterans with obesity reduce impulsive behavior and lose weight. About 124 veterans will be randomly assigned to receive either real or fake stimulation during tr…

This study looks at how common and severe gum disease is in people with obesity. Researchers will check dental health, analyze saliva for signs of inflammation, and look at genes linked to obesity. They will also study the bacteria in dental plaque to understand the connection be…

This study follows 1,500 children ages 8 to 17 over several years to learn how genes, sleep, mood, and environment affect eating behavior and overall health. Participants wear wrist monitors, answer smartphone surveys, and provide samples like blood and stool. The goal is to iden…

This study aims to learn how type 2 diabetes and obesity in young people affect heart and blood vessel health over time. About 930 participants aged 12 to 25, including those with diabetes, overweight but not diabetic, and healthy lean individuals, will be followed for up to 25 y…

This early-stage study looks at how a new weight-loss drug, maridebart cafraglutide, changes the way the body processes oral contraceptives. It involves 45 postmenopausal women aged 45 to 65 who are overweight or obese. The goal is to see if the drug affects birth control hormone…

This study aims to learn more about heart and blood vessel diseases by observing people who have them or are at risk. Researchers will collect samples and perform tests like imaging and stress tests on up to 5,000 participants, including healthy volunteers and relatives of affect…

This natural history study will look at how metabolism relates to body size and composition in 2,000 people aged 2 and older, including healthy volunteers and those with conditions like diabetes, obesity, or cancer. Participants will stay in the hospital for two days to undergo v…

This study follows 1,500 pregnant women and their children for up to 18 years to understand how a mother's health, lifestyle, and environment affect her child's growth and risk for obesity, diabetes, and fatty liver. Mothers attend visits during pregnancy and after birth, while c…

This study looks at whether childhood trauma is linked to changes in stress hormones and inflammation in obese women. Researchers will measure cortisol levels in saliva and urine, along with other markers, in 102 women. The goal is to better understand how past experiences might …

This study looks at how being overweight or obese changes blood pressure during different breathing tasks and exercise. Researchers at Florida State University will measure blood pressure in 80 healthy adults at rest and during aerobic and breathing muscle tests. The goal is to b…

This study looks at whether a program to reduce sitting time and increase light activity before bariatric surgery helps women with obesity achieve better weight loss and health. Seventy-two women scheduled for surgery will be guided to replace sedentary behavior with movement. Re…

This study follows 200 obese Chinese patients undergoing weight-loss surgery to understand how nonalcoholic fatty liver disease (NAFLD) progresses. Researchers will take liver biopsies during surgery and track health markers over time. The goal is to find better ways to predict a…

This study looks at people who had an endoscopic sleeve gastroplasty (ESG) at least 5 years ago to see if they kept the weight off. Researchers will measure total body weight loss at the 5-year mark. The goal is to understand the long-term success of this weight-loss procedure.

This observational study will follow 10,000 adults with obesity or overweight to understand how the disease progresses and what factors predict treatment success. Researchers will analyze medical records from 2000 onward, looking at heart and metabolic complications over 5 to 10 …

This observational study follows 150 people with MEHMO syndrome or related conditions to better understand how the disease progresses. Researchers will collect medical history, imaging, and lab samples to find biological markers that could help monitor the disease. No treatment i…

This study is tracking 2,000 adults over time to understand how obesity and disruptions to the body's internal clock (circadian rhythm) influence aging and heart health. Participants will provide health data, questionnaires, and biological samples during annual check-ups. The goa…

This early-stage study looks at how ZT002, a long-acting experimental drug for weight management, affects the way the body processes four common medications (metformin, warfarin, rosuvastatin, and digoxin). About 60 overweight or obese but otherwise healthy adults aged 18-45 will…

This study follows 750 severely or morbidly obese patients who have undergone bariatric surgery at a single hospital in France. Researchers aim to track long-term weight loss and improvements in related health issues such as diabetes and high blood pressure. By observing real-wor…

This study is testing whether mixed reality (MR) versions of common mobility tests, like the Timed Up and Go test, are as accurate and reliable as the traditional versions for overweight and obese adults. About 119 participants will perform both MR and conventional tests using a …

This study looks at whether raising the head and torso 25 degrees helps people with severe obesity (BMI over 40) breathe better through a facemask while under general anesthesia. Fifty adults scheduled for elective surgery will be placed in both a flat and a head-elevated positio…

This study looks at whether a person's genetic makeup can predict how much weight they will lose on the drugs semaglutide or tirzepatide. Researchers will follow 220 adults with obesity who are starting one of these medications for six months. By analyzing genetic risk scores and…

This pilot study aims to see if a new program can help people manage their weight after they stop taking anti-obesity medications. Researchers will test if the program is easy to run and acceptable to patients. About 214 participants will either receive the new program or usual c…

This study looks at tiny particles called extracellular vesicles (EVs) released from fat cells. Researchers want to understand how these particles carry signals that may affect heart and liver health in people with obesity. About 100 adults having weight-loss surgery will provide…

This study compares how natural sugar (sucrose) and the artificial sweetener sucralose affect blood sugar control and metabolism in 120 adults with normal weight, overweight, or obesity. Participants will consume low or high doses of each sweetener in solid or liquid form over 12…

This study looks at how obesity and body fat affect heart disease risk in 2,000 healthy African American men and women. Researchers will measure body fat, blood fats, and insulin function to see if risk factors differ by sex. The goal is to understand why heart disease rates are …

This study will enroll 20 adults with severe obesity who are scheduled for weight-loss surgery. Researchers want to see if advanced tools like MRI and 3D body scans give a clearer picture of health changes than just measuring weight or waist size. Participants will be followed fo…

This study looks at how a person's genetics, gut microbiome, and behaviors influence how well they tolerate and respond to the weight-loss drug tirzepatide. Researchers will follow 200 overweight or obese adults for up to 12 months, tracking weight changes, side effects, and whet…

This study looks at how long you need to fast and whether temporarily stopping GLP-1 medications (like liraglutide or semaglutide) affects how much food stays in your stomach. It involves 75 people with obesity who are already taking these drugs. The goal is to understand stomach…

This study follows 100 obese patients starting dialysis to understand why they are less likely to receive a kidney transplant. Researchers will track health changes over two years and compare them to non-obese patients. The goal is to identify barriers and improve access to trans…

This study tracks 800 obese patients at Nîmes University Hospital to see if they develop alcohol or other addictions during obesity treatment, especially after bariatric surgery. Researchers will use questionnaires and blood tests to understand these behaviors. The goal is to imp…

This study aims to describe the physical and behavioral traits of overweight and obese adults compared to lean individuals. Researchers will measure hormones, metabolism, food preferences, fitness, sleep, and thinking patterns in 2,000 participants. The goal is to better understa…

This study looks at whether a special care pathway for obesity helps patients feel more capable of managing their condition. About 133 adults with obesity will fill out questionnaires on self-efficacy, quality of life, and mood, and some will join focus groups. The goal is to see…

This study looks at how a six-month hybrid training program (combining cardio and strength exercises) affects muscle cells in 30 overweight or obese adults. Researchers will measure changes in mitochondria, blood vessels, and other muscle components. The goal is to understand the…

This study looks at why people with obesity often regain weight after losing it through a behavioral weight loss program. About 205 adults aged 25-59 will first lose at least 7% of their body weight, then be followed for a year to track how much weight they regain. The goal is to…

This study is tracking 10,000 adults with obesity to see how well integrated traditional Chinese medicine and Western medicine work in real-world settings. Researchers will collect health records, lab results, and lifestyle data to compare different treatment approaches. The goal…

This study follows 40 women with severe obesity who are scheduled for weight loss surgery. Researchers will measure changes in sexual function, sex hormone levels, mood, and quality of life before surgery and 6 months after. Partners will also report on their own sexual health. T…

This study looks at two ways of giving a standard liquid meal to measure how the body handles sugar. One method gives everyone the same number of calories, while the other adjusts the calories based on a person's size. Researchers want to find out which method gives more consiste…

This study tests a smartphone app designed to help adults taking GLP-1 medications for obesity or type 2 diabetes eat better. About 50 participants will use the app for 6 weeks to track their diet and learn about nutrition. The goal is to see if the app is helpful and easy to use…

This study follows 165 adults undergoing bariatric surgery to see if certain pre-surgery traits—like anxiety, depression, eating behaviors, and weight-related quality of life—can predict how their quality of life changes over the two years after surgery. Participants complete que…

This study compares two ways of using a breathing machine during weight-loss surgery in 34 obese patients. One method controls the flow of air, the other controls the volume. Researchers want to see which method keeps the lungs and heart more stable during surgery. Participants w…

This study looks at how changing the amount and type of food you eat affects the energy your body uses to digest and process that food. Healthy adults aged 18 to 60 will stay in a clinic for about 35 days, eating only provided meals and spending multiple 24-hour periods in a seal…

This study looks at whether overweight girls start puberty earlier than girls of normal weight. Researchers will use breast ultrasound and other tests to tell the difference between breast tissue and fatty tissue. The study involves 150 healthy girls ages 8-14 who have some breas…

This study compares two common anesthesia methods—intravenous drugs and inhaled gases—to see how they affect thinking skills after sleeve gastrectomy (weight-loss surgery). Researchers will measure how quickly patients wake up and follow commands, and test their memory and attent…

This study looks at how the body absorbs esomeprazole (a stomach acid reducer) when taken as a tablet or dissolved in water, in people who had gastric bypass surgery a year ago. Fifty participants will have a small device placed in their stomach pouch to measure acid levels, and …

This study follows 30 people aged 16–80 with obesity who are starting weight-loss medication. Researchers will track changes in hunger, fullness, cravings, and portion size using questionnaires and interviews at 0, 3, 12, and 18 months. The goal is to understand how eating behavi…

This study is testing new magnetic resonance imaging (MRI) techniques to get clearer pictures of the heart and blood vessels without using radiation. Researchers will compare these new MRI methods to standard tests like angiography and CT scans. Up to 4,000 adults—including healt…

This study works with Black churches in Washington, D.C. to understand heart health risks like obesity, high blood pressure, and diabetes. About 200 adults will get a health exam, wear an activity monitor for a month, and answer health questions. The results will help design a fu…

This study investigates how exercise affects the structure and function of fat tissue in adults aged 18-40 with obesity or metabolic syndrome. Participants are randomly assigned to either an exercise program or a sedentary control group. All undergo a 10% weight loss phase, then …

This study tests whether starting with a low-carb diet and then switching to low-fat leads to more body fat loss than the opposite order. Over 8 weeks, 42 overweight adults will eat only provided meals and track their weight, activity, and glucose. Researchers want to see if diet…

This study is looking at whether GLP-1 receptor agonists—drugs used for type 2 diabetes and obesity—can also improve dry eye disease. Researchers will measure changes in tear stability and eye surface health in 100 patients who have not taken these drugs before. The goal is to un…

This study looks at why teens with obesity often regain weight after losing it. Researchers think hormones that control appetite might be involved. Over 35 weeks, 260 teens will follow a meal replacement plan and then be monitored for weight regain. The goal is to understand the …

This study looks at how certain immune cells, called meta-inflammatory monocytes, along with body composition and diet, may contribute to insulin resistance in adolescents. Researchers will collect blood samples and health information from 175 teens aged 14-18, including those wi…

This study looks at how obesity impacts the physical abilities and daily activities of people over 65. Researchers will compare obese and normal-weight seniors using fitness tests and questionnaires. The goal is to understand how excess fat, combined with age-related muscle loss,…

This study aims to understand how the body defends its weight by measuring energy use and intake after a short fast. Twelve men and women who are either underweight or have obesity will fast for two days, then eat freely for two days in a special chamber. The results will help de…

This study is looking at what happens to muscle and bone when people lose weight using the drug tirzepatide. Researchers want to see if adding protein shakes and resistance exercise can protect muscle and bone. The study will enroll 50 adults with obesity and track changes over 6…

This study aims to understand how the hormone insulin controls blood sugar in different people. Researchers will test a new procedure called the graded insulin suppression test (GIST) in 15 healthy volunteers and those at higher risk for type 2 diabetes. Participants receive medi…

This study compares two common anesthetics—propofol and sevoflurane—in 70 obese patients undergoing back surgery. Researchers will measure inflammation markers in blood samples taken before and after surgery to see which anesthetic causes less immune system disruption. The goal i…

This study tests whether a cone-shaped blood pressure cuff placed on the forearm gives more accurate readings than the standard cuff on the upper arm in pregnant women. High blood pressure during pregnancy can lead to serious decisions like early delivery or C-section, so better …

This early-stage study looks at how the experimental drug BI 456906 attaches to receptors in the liver and pancreas that control appetite and weight. About 30 adults with obesity will receive either BI 456906 or the approved weight-loss drug semaglutide for 17 weeks. Researchers …

This study looks at whether a special type of high-intensity interval training can help overweight adults maintain healthy vitamin D levels during winter. Thirty participants will either exercise three times a week for 12 weeks or just follow a balanced diet. Researchers will mea…

This study is testing whether taking a sirtuin activator supplement every day for six months can improve how the body processes fats and sugars, and possibly slow cell aging. Researchers will compare the supplement to a placebo in 120 women aged 40-65 who are overweight or obese.…

This study looks at why some people lose muscle and strength after weight loss surgery, and why others regain weight. Researchers will track eating habits, grip strength, and body changes in 110 bariatric patients for a year. They will also study genes and metabolism to find fact…

This study looks at why fat tissue in the belly area doesn't respond normally in people with obesity. Researchers will measure how fat cells release fatty acids in different body areas. The goal is to understand the basic biology of fat tissue, not to test a treatment. 24 adults …

This study follows 1,000 people who had bariatric surgery 5 years ago to learn why some maintain significant weight loss while others do not. Researchers will track weight, type of surgery, and other factors to improve patient counseling and tailor surgical choices. The goal is t…

This study looks at how a supplement called nicotinamide riboside (NR) and a low-carb, high-fat 'ketogenic' diet affect the way the body burns fat and uses energy. Researchers will measure changes in metabolism in 100 overweight or obese adults. Participants will eat a standard d…

This study looks at 100 adults with severe obesity to see if the type of weight-loss surgery—sleeve gastrectomy or gastric bypass—changes binge eating, depression, and anxiety differently. Participants fill out questionnaires before surgery and for 12 months after. The goal is to…

This study looks at why some children are less affected by food advertising than others. Researchers will use brain scans and eating tests in 200 kids aged 7-9 to find traits that protect against overeating. The goal is to understand what makes certain children resilient to food-…

This study looks at two different training programs for doctors and health workers at community health centers. The goal is to see which training helps patients lose weight better and get more people to use weight management services. About 6,200 adults and youth on Medicaid will…

This study looks at what happens when people sleep only a few hours on weekdays but catch up on weekends. Researchers want to see if this pattern harms blood sugar, blood pressure, and body fat compared to getting enough sleep every night. The study involves 72 adults aged 18 to …

This study looks at genetic and chemical markers in fat tissue from 500 people with severe obesity who are having weight-loss surgery. Researchers collect a small amount of belly fat during the operation and take blood samples afterward. The goal is to understand why some patient…

This study looks at 50 adults having either sleeve gastrectomy or gastric bypass to see if routine stool tests can reveal differences in gut function after surgery. Participants provide stool and blood samples before and 6 months after their operation. Researchers will check for …

This study tracks 420 people to see how bariatric surgery affects drinking behavior using a special device called a drinkometer. It measures things like sip size and speed, and looks at how gut hormones and sex differences play a role. The goal is to better understand why surgery…

This study is testing whether a substance in the blood called 1,5-anhydroglucitol can serve as a marker for how well the pancreas is working in obese children, with or without type 2 diabetes. Researchers will measure levels of this marker in 50 children aged 12 to 16 and compare…

This observational study will follow 100 adults starting anti-obesity medications like semaglutide or tirzepatide. Researchers will track changes in body fat, lean muscle, bone density, handgrip strength, and nutrition over time. The goal is to understand the real-world effects o…

This study is recruiting 100 adults with obesity to find out what factors predict weight loss after taking weight-loss drugs or having bariatric surgery. Researchers will track participants over time, measuring things like eating behaviors, thinking skills, and biological markers…

This study looks at how losing weight changes the fat stored inside your muscles, called intermuscular adipose tissue (IMAT). Researchers want to see if weight loss reduces inflammation and improves how your muscles respond to insulin. Seventy adults with obesity will follow a 12…

This study looks at whether eating peanuts every day can improve bone health, metabolism, and physical function in overweight or obese adults aged 50-75 during a 6-month weight loss program. Participants will be randomly assigned to eat either a daily peanut snack or a nut-free s…

This study aims to see if a short, interval fitness test (the IFT 30-15) can reliably measure heart and lung fitness in both healthy people and those with high blood pressure or obesity. Researchers will compare results from this test with a standard treadmill test and a six-minu…

This study is recruiting 8,000 young Chinese adults with obesity (BMI 30 or higher) to investigate how genes and clinical features contribute to obesity and metabolic syndrome. Researchers aim to better understand the underlying causes, which could eventually lead to improved tre…

This study looks at how growth hormone affects beta-cells, which make insulin, in people with a family history of type 2 diabetes. Researchers will compare 30 obese adults with and without a family history of diabetes. The goal is to better understand why some people develop diab…

This study looks at how semaglutide, a drug used for diabetes and weight loss, changes fat tissue around the kidneys, heart, and liver in people with type 2 diabetes and chronic kidney disease. Researchers will compare patients taking semaglutide to those not taking it. The goal …

This study looks at how time restricted eating (eating only during a 6-hour window each day) affects metabolism and immune function in healthy women aged 18-50 with different body sizes. Participants will stay in the clinic for 5 days, follow the eating schedule for 3 days, and u…

This study collects data from 500 children with severe, early-onset obesity to find genetic causes. Researchers will track how many kids have genetic variants linked to obesity and monitor changes in their BMI over time. The goal is to better understand the role of genetics in se…

This study looks at how growth hormone affects beta-cells, which make insulin to control blood sugar, in women who had gestational diabetes. Researchers will compare women with and without a history of gestational diabetes to better understand risk factors. The goal is to learn m…

This study looks at 240 adults aged 40-60 to see if being overweight or obese in midlife is linked to early signs of Alzheimer's in the brain. Participants will have metabolic tests and brain scans (MRI and PET) to measure inflammation, brain shrinkage, and protein buildup. The g…

This study is not testing a new drug or treatment. Instead, researchers want to make sure their lab tests and equipment give accurate and repeatable results when studying conditions like obesity, diabetes, heart disease, and bone loss. Up to 100 healthy volunteers and people with…

This study looks at two blood inflammation markers, SII and SIRI, to see if they can help predict metabolic problems like insulin resistance and fatty liver in people who are overweight or have obesity. Researchers will follow 200 adults for up to 3 years, tracking their diet, la…

This study looks at why some children become overweight or obese by examining their eating habits, brain activity, and family history. Researchers will measure how kids' brains respond to food and how well they control their eating. The goal is to find early clues that could lead…

This study uses advanced heart MRI to see how bariatric surgery and cardiac rehabilitation change the heart's structure and function. Researchers will scan 150 adults before and 6-12 months after these metabolic treatments. The goal is to understand how the heart adapts to these …

This study looks at whether the amount of lean (fat-free) body mass before surgery can predict how much weight people lose in the two years after Roux-en-Y gastric bypass. Researchers will follow 91 adults with severe obesity who are scheduled for the procedure, measuring body co…

This observational study looks at the bacteria in dental plaque of 170 people with obesity (BMI 30+) who are scheduled for bariatric surgery. Researchers want to see if the types and amounts of mouth bacteria differ between those with obesity (BMI 30-35) and those with morbid obe…

This study looks at how being overweight affects insulin sensitivity and heart-lung fitness in people with type 1 diabetes. Researchers will compare participants with and without diabetes, before and after a 15-week high-intensity interval training program. The goal is to underst…

This study looks at whether breathing a low-density helium-oxygen gas mixture can reduce breathlessness and improve exercise capacity in people with heart failure with preserved ejection fraction (HFpEF) and obesity. Researchers will measure how much oxygen the body uses during b…

This study collects blood and tissue samples from 270 severely obese patients during bariatric surgery to uncover new biological factors that lead to type 2 diabetes. Participants are grouped by their metabolic status: those with diabetes, insulin resistance, or normal insulin se…

This study looks at how obesity affects the heart and blood vessels, and how these change after bariatric surgery. Researchers will collect blood, urine, stool, and fat tissue samples from 85 adults before and after surgery. They aim to understand how fat tissue and gut bacteria …

This trial tests two types of opioid-free anesthesia in 70 people having weight-loss surgery. One method uses a gas called desflurane, the other uses intravenous drugs. Researchers will measure stress hormones in the blood to see which approach causes less stress on the body. The…

This study looks at how weight loss (using tirzepatide) and a biologic drug (ixekizumab) affect the body in people with psoriatic arthritis who are overweight or obese. About 45 adults will receive one or both treatments. Researchers will take samples of skin, joint tissue, and f…

This early-phase study tests whether a natural odor, when inhaled, can be detected in the cerebrospinal fluid (the fluid around the brain and spine) within 30 minutes. 32 lean and obese adults who are already scheduled for a spinal tap will sniff either the odor or a placebo. The…

This study follows 2,500 adults aged 30-75 in Puerto Rico to track chronic diseases like heart disease, diabetes, and obesity. Researchers will collect data on diet, stress, and lifestyle over two years to identify trends and risk factors. The goal is to guide public health prior…

This study is looking at how the timing of meals, along with genetics, affects weight loss in a Mediterranean population. Researchers will track nearly 6,000 overweight adults to see if eating lunch later makes it harder to lose weight. The goal is to understand if when we eat is…

This study looks at how fasting insulin and insulin resistance differ based on age, sex, race/ethnicity, body weight, and PCOS diagnosis. Researchers will analyze data from 150 adults to find patterns that may explain why some groups face higher metabolic risks. The goal is to be…

This study is testing whether following a Mediterranean-style diet based on U.S. dietary guidelines improves heart health more when combined with weight loss. Researchers will provide all meals for 70 adults with obesity or excess body fat for eight weeks. Participants will be sp…

This study is testing whether a 3-week program of eating walnuts, supervised exercise, and nutrition counseling is practical for American Indian adults recently diagnosed with cancer. The 30 participants will follow the program before starting their cancer treatment. Researchers …

This study tests whether people with prediabetes and obesity change their eating and activity habits when they can see their glucose levels in real time versus when the data is hidden. Thirty-four adults will wear a continuous glucose monitor during both an open and a blinded pha…

This study looks back at medical records of 150 adults aged 18-60 who took GLP-1 drugs like semaglutide for weight loss. Researchers want to understand how these drugs change taste perception, food preferences, and eating behaviors. The goal is to learn more about why these medic…

This study is testing a 24-week program that combines nutrition counseling, exercise, sleep tips, and stress management for cancer survivors who are overweight. Researchers want to see if the program is practical and helpful for improving sleep quality, reducing stress, and boost…

This study looks at tiny particles released from fat cells, called extracellular vesicles, and how they relate to blood vessel function in people with obesity. Researchers will compare normal-weight and obese adults, then have obese participants follow a 12-week weight loss diet.…

This early-phase study tests the safety and how the body handles a new injection called HEC-007. It involves 126 healthy adults and overweight or obese individuals. Researchers will monitor side effects, measure drug levels in the blood, and check changes in weight and other heal…

This study will track 1,200 adults in semi-rural Tanzania to find out how common chronic kidney disease (CKD) is and what factors increase the risk. Participants will have blood and urine tests at the start, after 90 days, and again after one year. The goal is to create better wa…

This study tests whether dosing the anesthetic propofol based on adjusted body weight is better than total body weight for obese patients. Using a computer-controlled system, researchers will monitor brain activity to maintain the right depth of anesthesia. The goal is to avoid o…

This study will use special 'tracer' molecules (stable isotopes) to measure how the body of an adult with obesity processes protein and sugar. Eight participants will each undergo two test sessions: one measuring protein breakdown and another measuring glucose tolerance. The goal…

This study looks at stomach tissue from 100 obese patients undergoing weight-loss surgery and compares it to tissue from lean individuals. Researchers are counting immune cells called macrophages and mast cells, as well as blood vessel density, to see if obesity-related inflammat…

This study looks at how a high-protein drink versus a high-carbohydrate drink influences what people choose to eat afterward. Researchers will test 45 adults with normal weight, overweight, or obesity to see if the type of meal changes their 'food memory' and calorie intake. The …

This study looks at how different types of exercise—moderate, vigorous, or short bursts—change inflammation levels in the body. Researchers want to see if exercise can help reduce the low-grade inflammation linked to obesity and heart disease. The study is recruiting 33 overweigh…

This early-stage study is testing whether a new weekly injection called NNC0662-0419 changes how the body processes birth control pills and a common painkiller. Researchers will measure drug levels in the blood of 45 women who cannot become pregnant and have overweight or obesity…

This study looks at whether losing weight and breathing low-oxygen air (like at high altitude) can help people with obesity absorb more iron. Iron deficiency is common in obesity, possibly due to inflammation. The study will measure iron absorption before and after a 6-week progr…

This study collects information from medical records and patient visits to see how well endoscopic bariatric therapies (EBTs) work for weight loss and if they are safe. It includes adults who have had or plan to have an EBT within six months. The goal is to track weight changes a…

This study looks at how limiting eating to an 8-hour window each day (time-restricted feeding) affects the immune system of women with severe obesity. Researchers will compare two groups of women with obesity—one following the 8-hour eating schedule and one eating normally—and al…

This early-stage study tests an experimental drug called PF-08653944 in 20 overweight or obese adults. Researchers want to see how it affects the speed at which the stomach empties food, using a common painkiller as a marker. The main goals are to understand the drug's effects an…

This study tests whether using a special tube to measure pressure inside the chest can help doctors set breathing machines better for severely obese patients with acute lung injury. About 40 adults with a BMI over 40 and moderate to severe ARDS will take part. The goal is to see …

This study will check how often muscle loss (sarcopenia) happens in 300 adults with obesity. Researchers will measure muscle mass, strength, and physical function, and look at factors like age, diet, and activity. The goal is to help doctors better identify and manage this condit…

This study aims to see if a specially designed education module helps people with spinal cord injury (SCI) learn about their increased risk for heart disease, obesity, and metabolic problems. Researchers will enroll 250 adults with SCI and measure changes in knowledge, body weigh…

This study looks at how two types of bariatric surgery (RYGB and SG) change bone marrow fat and bone loss in 40 postmenopausal women with obesity. Researchers will measure bone marrow fat before and after surgery and check for links to hormones, blood sugar, and bone markers. The…

This study uses advanced MRI scans to track changes in muscle and fat in the body and heart over 12 months in 50 adults starting semaglutide for type 2 diabetes or weight loss. Participants will undergo MRI scans, physical tests, blood samples, and questionnaires. The goal is to …

This study looks at how severe obesity can lead to a type of heart failure called HFpEF, where the heart becomes stiff and has trouble filling with blood. Researchers will study 250 people with obesity using heart ultrasounds and blood tests to find early signs of heart problems.…

This early-stage study tests a single dose of Zovaglutide (ZT002), an experimental drug for overweight and obesity, in 40 adults with varying levels of kidney function. Researchers will measure how the drug moves through the body and check for side effects. The goal is to underst…

This study looks at whether a community program rooted in Native Hawaiian values can improve the well-being of young people aged 12-25 who have health issues like asthma, obesity, or mental health concerns. About 100 youth from the Wai'anae area will take part in cultural activit…

This study tracks bone health in 120 teens aged 12–21 with obesity who are either starting a GLP-1 drug (like semaglutide) or following lifestyle changes. Over 24 months, researchers measure bone density and strength using scans and lab tests. The goal is to see if these popular …

This study looks at what happens inside your fat tissue when you lose weight with or without exercise. 68 adults with obesity will lose 10% of their body weight through diet, with some also doing moderate exercise. Researchers will measure insulin sensitivity, fat breakdown, and …

This study follows 1,000 people who are having weight-loss (bariatric) surgery. Researchers will measure changes in weight, body fat, blood sugar, cholesterol, and other health markers before surgery and at several follow-up visits over two years. The goal is to better understand…

This study looks at how tirzepatide, a weight-loss drug, affects muscle mass and strength in adults aged 50 and older with obesity. Researchers want to know if losing weight with this drug also causes harmful muscle loss that could lead to frailty. Twenty participants will take t…

This study looks at how the body's internal clock affects fat tissue in people with and without obesity. Researchers want to see if eating around the clock changes these rhythms. The goal is to better understand obesity, not to test a treatment. 40 healthy, sedentary adults are n…

This study looks at how resistance training (like lifting weights) affects fat breakdown in obese postmenopausal women who also have prediabetes. Researchers want to see if this type of exercise can improve how the body uses fat, which might help prevent type 2 diabetes. The stud…

This study looks at whether eating dinner earlier in the evening, in sync with your body's internal clock, helps burn more fat and control blood sugar. Researchers will compare early versus late dinner in 32 adults—some healthy weight, some with obesity and prediabetes. Participa…

This study looks at how body composition (like weight and fat distribution) relates to airway tone and reactivity. Researchers will use a device called an oscillometer to measure airway resistance in 100 people who are already scheduled for a methacholine challenge test. The goal…

This study looks at why adults who carry extra weight around their belly don't respond to insulin the same way lean people do. Researchers will measure how fat is released from different parts of the body in 48 overweight and lean volunteers. The goal is to better understand how …

This study looks at how fat tissue changes when people gain weight from overeating. Researchers will ask 58 overweight adults to either maintain their weight or eat 30% more calories for a short time. By tracking fat cell growth and other changes, they hope to understand why some…

This study looks at how a heart hormone called atrial natriuretic peptide (ANP) affects metabolism and heart health. Researchers will test 200 adults with different genetic versions of ANP to see how their bodies respond to exercise and sugar. The goal is to understand why some p…

This early-stage trial is testing whether a one-week course of diazoxide can reduce the production of new fat in the liver. The study involves 25 adults with obesity, insulin resistance, and fatty liver disease. Participants will take either the drug or a placebo and undergo bloo…

This study looks at how the hormone insulin controls blood sugar and fat in healthy adults and those at risk for type 2 diabetes. Researchers will give participants a single dose of a drug called alpelisib, which blocks some of insulin's effects, to see if the liver can still mak…

This study looks at 150 adults with obesity to see if there are differences in fat, muscle, and metabolism between those who were obese as children and those who became obese as adults. Participants will provide tissue samples, blood, and urine, and undergo a weight loss program.…

This study will screen blood pressure in over 22,000 children aged 5-18 across South Africa. The goal is to create the country's first reference charts for normal blood pressure, since current charts are based on US and European data. This will help doctors correctly diagnose and…

This study looks at whether a ketogenic diet can help people with obesity maintain weight loss by increasing the calories their body burns and reducing appetite. Twenty adults will first lose weight on a low-calorie diet, then follow a keto diet for six weeks while researchers me…