Obesity disorder

This study tests two experimental drugs, PF-08653945 and PF-08653944, given alone or together, for weight loss in adults with overweight or obesity. About 872 participants will receive either the drugs or a placebo injection. The main goal is to see how much weight they lose over…

This study tests a once-monthly injection called berobenatide to help adults with overweight or obesity lose weight. About 954 participants will receive either the drug or a placebo for 20 months. The goal is to see if the drug is safe and effective for weight loss, including in …

This study tests whether mobile health technology, like smartphone apps and activity trackers, can help overweight or obese African American women increase their physical activity. Participants will wear a wrist device to track steps and sleep, use a study app, and may receive co…

This Phase 3 trial is testing a new weekly injection called enicepatide for weight loss in 1600 people who are obese or overweight and also have type 2 diabetes. The drug works by mimicking natural hormones that help control appetite and blood sugar. Participants will receive eit…

This trial is testing an experimental once-daily pill called ASC30 in adults who are overweight or have obesity and also have type 2 diabetes. The study aims to see if ASC30 can help with long-term weight loss and improve blood sugar control compared to a placebo. Participants wi…

This Phase 3 trial is testing an experimental once-daily oral medication called ASC30 in adults with obesity or overweight who also have weight-related health conditions like high blood pressure or sleep apnea. The study aims to see if ASC30 can lead to significant weight loss ov…

This phase 3 trial is testing a new weekly injection called enicepatide for weight loss in 2000 adults with obesity or overweight who do not have type 2 diabetes. Participants will receive either the drug or a placebo for 72 weeks. The main goal is to see how much weight they los…

This phase 3 trial is testing a once-weekly injection called enicepatide in 300 Chinese adults who are obese or overweight, with or without type 2 diabetes. The drug works by mimicking two gut hormones to reduce appetite and improve blood sugar control. Participants will receive …

This study tracks 200 adults with obesity in the EU who choose to get the Orbera365 intragastric balloon. The balloon is placed in the stomach and filled with saline to help people feel full and eat less. Researchers will monitor serious side effects and how much weight participa…

This Phase 2 trial tests a minimally invasive endoscopic procedure for weight loss in 10 adults with obesity (BMI 30-40, or 27-29.9 with related health issues). The procedure combines two techniques: one to reduce appetite by ablating part of the stomach lining, and another to sl…

This phase 3 trial tests whether HRS9531 tablets can help overweight or obese adults lose weight over 52 weeks. About 425 participants will receive either the drug or a placebo. The study measures weight change and the proportion of people losing at least 5% of their body weight.

This trial tests a 9-month program for women who had preeclampsia during their first pregnancy. The program includes online screening, group meetings, and a smartphone app to help monitor blood pressure and weight. Researchers want to see if it improves heart health and promotes …

This study tests an experimental drug called ALN-2232, given alone or together with the approved weight-loss drug tirzepatide, in 156 adults with obesity. The goal is to see if the combination is safe and leads to more weight loss than either drug alone. Participants will receive…

This study investigates whether a 16-week course of a probiotic supplement can increase feelings of fullness (satiety) and alter the composition of gut bacteria in healthy adults aged 20–70 with a BMI of 25 or higher. Participants take either the probiotic or a placebo daily and …

This study tests a new digital tool called P3-EX that helps doctors create personalized exercise plans for patients with heart disease risk factors like high blood pressure, diabetes, and obesity. Researchers will recruit 24 doctors and 48 patients to compare the new tool with a …

This early-stage trial tests a new drug called ALN-6222 in 88 adults with obesity (BMI 30-40). Participants receive a single injection of either the drug or a placebo. The main goal is to check safety and how the body processes the drug, not weight loss. It is the first time this…

This study tests whether taking daily protein supplements and doing resistance exercises (like lifting weights) can prevent too much muscle loss after bariatric surgery. About 400 patients will be randomly assigned to either standard care or standard care plus the protein and exe…

This study tests whether adding hands-on cooking classes to a standard weight loss program helps young adults (18-35) with mild-to-moderate intellectual disabilities lose more weight and keep it off. Over 24 months, 114 participants will either follow a healthy eating plan with c…

This trial tests whether taking inulin, a type of dietary fiber, for two weeks can improve cardiovascular health, muscle function, and the balance of gut and vaginal bacteria in perimenopausal women who are overweight or have obesity. Participants will take either inulin or a pla…

This trial tests whether a mobile app called NutriSteppe can improve blood sugar control and weight loss in adults with type 2 diabetes or obesity who are already taking GLP-1 medications like semaglutide. Over 12 weeks, half the participants will use the app for personalized mea…

This early-stage study tests whether a new oral drug, VRB-103, is safe and tolerable when taken alone or with another drug (ecnoglutide) in people with obesity or overweight. About 336 participants will receive either the drug or a placebo. The goal is to check for side effects, …

This trial tests a smartphone app that sends brief mindfulness and self-compassion exercises immediately after a person regains weight or skips a weigh-in. The goal is to help people stay motivated and continue healthy behaviors instead of giving up. About 120 adults with overwei…

This trial investigates whether an investigational drug called NNC0487-0111, given as a once-weekly injection, can change how much energy the body uses in adults with overweight or obesity. It compares the drug against a low-calorie diet and a placebo, focusing on metabolic rates…

This study tests a weight loss program for 522 low-income adults with obesity in Louisiana. Participants receive health coaching, digital self-monitoring tools, and group support to find community wellness resources. The goal is to see if this approach leads to greater weight los…

This phase 3 trial tests a once-daily oral drug called aleniglipron for chronic weight management in 3600 adults with obesity or overweight who also have a weight-related health condition. Participants take the drug or a placebo for 76 weeks, along with diet and exercise changes.…

This study tests whether taking semaglutide (Wegovy) for at least three months before a first-time atrial fibrillation ablation can improve heart rhythm outcomes. 200 overweight or obese adults scheduled for ablation will be randomly assigned to either standard care or semaglutid…

This phase 3 study tests aleniglipron, an oral medication taken once daily, for helping adults with obesity or overweight and type 2 diabetes manage their weight over the long term. Participants receive either aleniglipron or a placebo for 76 weeks. The main goal is to see how mu…

This early-stage trial tests a new drug called AZD1043 in 104 healthy adults who are overweight or obese. The goal is to check the drug's safety and how the body processes it. Participants receive either the drug or a placebo by injection. The study includes people of Japanese an…

This study tests whether a daily pill called phentermine helps teenagers aged 12 to 18 with obesity lose weight. About 240 teens will take either the drug or a placebo for 52 weeks. The main goal is to see how much their body mass index (BMI) changes, while also checking for side…

This pilot study tests whether adding powder made from Chardonnay grape skins and seeds to the daily diet can improve gut and heart health. The study includes postmenopausal women aged 45-70 with excess weight and high triglycerides. Participants will consume the powder daily, an…

This early-stage study tests the safety and tolerability of a new injectable drug called ABBV-295 in 48 adults with obesity. Participants will receive either the drug or a placebo over several weeks. Researchers will monitor side effects, changes in body weight, and how the drug …

This study tests whether adding the diabetes drug metformin to standard antidepressants helps people with both depression and obesity lose weight and feel better. Researchers will also check if certain gene variants affect how well the combination works. The trial involves 200 ad…

This Phase 2 study will test whether a once-daily cannabis gummy can help people with obesity lose weight. Forty adults aged 18–65 with a BMI of 30 or higher will receive either the cannabis gummy or a placebo for a set period. The main goal is to measure changes in body weight.…

This study tests whether a weekly injection of tirzepatide, combined with healthy eating and exercise, helps adolescents with obesity and related conditions like high blood pressure or prediabetes lose weight and improve their health. About 300 teens who completed a prior study c…

About 20% of severely obese patients need their breathing tube reinserted after it's removed, which raises risks of pneumonia and longer hospital stays. This study tests whether using noninvasive breathing support (alternating between two devices) for 24 hours after tube removal …

This trial compares two weight-loss surgeries in people with severe obesity (BMI 50-60). One is the standard Roux-en-Y gastric bypass, the other a newer sleeve gastrectomy with duodenojejunal bypass. The goal is to see which procedure leads to healthier hormone responses after me…

This study tests a new once-weekly injection called eloralintide to help adults with obesity or overweight lose weight. About 1980 people who do not have type 2 diabetes will take part for up to 75 weeks, with some continuing for 2 more years. The goal is to see if the drug safel…

This Phase 2 trial is testing several experimental drugs—including tirzepatide and others—for long-term weight management in adults with obesity or overweight. About 1,481 participants will receive one of the drugs or a placebo. The goal is to see if these treatments are safe and…

This study tests whether a type of talk therapy called Acceptance and Commitment Therapy (ACT) can help people who have had bariatric surgery stay physically active and avoid regaining weight. Researchers will compare ACT to standard education about exercise in 164 adults who had…

This trial tests whether a natural compound from citrus fruits, hesperidin, can improve cognitive function in overweight and obese adults aged 55 to 75. Participants take either a placebo, a low dose, or a high dose of hesperidin daily for 10 weeks. The study measures changes in …

This program allows individual patients with serious or life-threatening conditions to request early access to retatrutide before it is fully approved. The drug is intended to help control the disease, but ongoing management may still be needed. Eligibility is determined on a cas…

This study tests a new once-weekly medicine called eloralintide to help people with obesity or overweight and type 2 diabetes lose weight. About 1035 adults will receive either the drug or a placebo for around 75 weeks. Researchers will measure changes in body weight, fat, waist …

This study tests a new weekly injection called eloralintide in 900 adults with obesity or overweight who are already taking a weekly incretin drug (like Ozempic or Wegovy) but still have excess weight. Participants will receive either eloralintide or a placebo for about 80 weeks …

This study tests whether adding the weight-loss drug tirzepatide to the Crohn's drug mirikizumab helps people with moderate-to-severe Crohn's disease who are also overweight or have obesity. About 290 adults will receive either mirikizumab alone or mirikizumab plus tirzepatide. T…

This study tests a new tablet called DA-302168S to help people lose weight. It is for adults aged 18-75 who are overweight or obese. The study will compare the drug to a placebo to see if it is safe and effective. About 840 people will take part in China.

This trial tests whether a low-calorie diet combined with intensive lifestyle coaching can help adults with type 2 diabetes achieve remission—meaning blood sugar levels return to normal without medication. Participants are randomly assigned to either the intervention or standard …

This Phase 2b trial is testing whether two experimental drugs, macupatide and eloralintide, can help adults with obesity or overweight lose weight. About 400 participants will receive either one or both drugs or a placebo for 64 weeks. The study measures weight change and safety,…

This study tests an experimental drug called BI 3034701 to help people with obesity or overweight lose weight. About 300 adults aged 18-74 will receive either the drug or a placebo injection for 42 weeks, along with diet and exercise advice. Researchers will measure weight change…

This phase 3 trial tests whether adding tirzepatide (a weight-loss drug) to mirikizumab (an anti-inflammatory drug) helps people with moderate-to-severe ulcerative colitis who are also overweight or obese. The goal is to see if the combination can reduce both gut symptoms and bod…

This phase 3 trial tests a weekly injection called eloralintide in 800 adults with moderate-to-severe obstructive sleep apnea who are also overweight or have obesity. The study looks at whether the drug can improve sleep apnea symptoms and help with weight loss. Participants are …

This study tests whether a behavioral program that reduces evening light exposure and encourages finishing meals at least four hours before bedtime can improve how the body handles sugar. Overweight adults aged 18-45 who habitually sleep less than 6.5 hours per night will be rand…

This study tests whether empagliflozin, a drug used for diabetes, can reduce chronic inflammation in people with obesity and metabolic syndrome. Researchers will measure immune cells and blood vessel function in 74 adults. The goal is to find a new way to lower heart disease risk…

This early-stage study tests an experimental oral drug called RO7795081 in 40 healthy overweight or obese adults. The main goals are to check safety and how the drug interacts with common statins (rosuvastatin and pitavastatin). Participants will receive the drug or a placebo in …

This study looks at whether inspiratory muscle training—exercises that strengthen breathing muscles—can improve asthma in children aged 6 to 17 with moderate to severe asthma. It compares two training intensities against a sham (inactive) device over 8 weeks. The trial also exami…

This trial tests whether extending nightly sleep by about 2 hours in adults who habitually sleep less than 6.5 hours can improve insulin sensitivity and reduce cardiometabolic risk. Participants are overweight or obese adults aged 18-45 without diabetes or sleep disorders. They a…

This study tests a once-weekly injection called NNC0487-0111 in 300 adults with overweight or obesity and moderate-to-severe obstructive sleep apnea who use a breathing device. The goal is to see if the drug helps with weight loss and reduces breathing pauses during sleep. Partic…

This study tests a new medicine, maridebart cafraglutide, for adults with obstructive sleep apnea who are overweight or obese and already use a CPAP machine. The goal is to see if the drug can reduce breathing pauses during sleep and help with weight loss over 52 weeks. About 250…

This trial is testing whether semaglutide, a medication used for obesity, can improve heart health in young adults (ages 18-30) who have both type 1 diabetes and obesity. Participants will receive either semaglutide or a placebo for a year. The study will measure changes in body …

This phase 3 trial tests whether the drug maridebart cafraglutide (MariTide) can help people with obesity or overweight lose weight and keep it off over the long term. Participants who completed an earlier trial will receive either the drug or a placebo. The study measures weight…

This trial is testing whether an experimental drug called BGM0504 can help people with early-stage type 2 diabetes and obesity achieve better blood sugar control and weight loss than a standard treatment, semaglutide. Participants will receive either BGM0504 or semaglutide as a o…

This study tests a once-weekly injection called NNC0487-0111 in 630 adults who are overweight or obese and have type 2 diabetes. Participants receive either the active drug or a placebo for about a year. The main goal is to see how much weight they lose, with additional checks on…

This study tests whether a virtual weight management program that includes a support person (like a family member or friend) helps Veterans with obesity lose weight. 320 Veterans and their partners will participate in 8 virtual sessions over 14 weeks. The main goal is to see if t…

This trial compares two approaches for treating advanced metabolic dysfunction-associated steatohepatitis (MASH), a serious liver condition linked to obesity. About 120 adults with MASH and liver fibrosis will be randomly assigned to either metabolic surgery (gastric bypass or sl…

This pilot study tests whether a gentle electrical stimulation of the ear (taVNS) can help overweight or obese people lose more weight when they haven't lost enough on the medication tirzepatide alone. 24 participants will receive either active ear stimulation or a sham (fake) st…

This study compares two weight-loss strategies: GLP-1 medications (like semaglutide or tirzepatide) versus a structured diet and exercise program. Adults with a BMI of 27.5 or higher are followed for three months to see which approach better improves heart and metabolic markers, …

This early-stage study tests a new way to deliver semaglutide—a drug used for weight management—using a small, needle-free patch that sticks to the skin. The patch, called VX-201, aims to provide the same benefits as injections without the need for needles. The trial includes hea…

This early-stage trial tests the safety of an investigational injection called HRS9531 in 48 Chinese adolescents aged 12 to 17 who are obese. Participants receive either the drug or a placebo, and researchers monitor side effects, drug levels in the blood, and changes in weight a…

This trial tests whether a one-year intensive lifestyle program is feasible for children aged 10–16 with severe obesity and their families. The program includes personalized visits with a nutritionist, physiotherapist, and therapist, plus regular doctor check-ups. The main goal i…

This study tests a new drug called efsubaglutide alfa in Chinese adolescents aged 12 to 17 with obesity. The goal is to check the drug's safety, how the body processes it, and its effects on weight. Participants receive either the drug or a placebo injection weekly for 12 weeks. …

This Phase 3 study tests whether a new drug called CagriSema helps people with severe obesity (with or without type 2 diabetes) lose more weight than the existing drug semaglutide. About 2,500 participants will receive either CagriSema or semaglutide for 83 weeks. The main goal i…

This study investigates whether combining bariatric surgery with a GLP-1 receptor agonist (semaglutide) leads to greater and more sustained weight loss than surgery alone in people with obesity. Researchers will follow 400 participants across multiple centers in China for up to t…

This trial investigates an experimental drug called GUB-UCN2 for people with obesity and type 2 diabetes. The study includes healthy volunteers and those with the conditions, testing the drug alone or alongside standard care. The main goal is to check safety and how the drug beha…

This trial tests whether a 50 microgram dose of misoprostol works better than a 25 microgram dose for starting labor in pregnant women with a BMI over 40. The goal is to see if the higher dose can lead to more vaginal deliveries and fewer cesarean sections. Participants will rece…

This trial tests whether a diet adapted to Puerto Rican culture can lower the risk of heart disease, type 2 diabetes, and obesity. Researchers will compare culturally tailored nutrition advice—emphasizing traditional healthy foods and limiting unhealthy ones—with standard healthy…

This study tests an experimental oral medication, KAI-7535, taken once daily to help people with obesity or overweight lose weight. About 320 adults with at least one weight-related condition (like high blood pressure or sleep apnea) will receive either the drug or a placebo for …

This trial tests whether a liquid form of semaglutide, applied under the tongue, can help adults with obesity lose weight. Semaglutide is a hormone-like drug that reduces appetite. The study compares the liquid to a standard semaglutide tablet and a placebo. Researchers want to s…

This study tests whether adding guided resistance training and the medication semaglutide can help people with chronic kidney disease stick to a program that replaces one hour of sitting per day with light walking. The goal is to reduce sedentary time, which is linked to worse ki…

This phase 2 trial tests whether adding an experimental drug called AT673 to the standard diabetes medication semaglutide leads to greater weight loss and better blood sugar control in adults with type 2 diabetes who are overweight or obese. Participants receive either a low or h…

This early-stage trial investigates a new drug called BI 3034701 in Japanese adults. Part 1 includes people with obesity or overweight (BMI 27 or higher) to see if the drug is safe and how the body processes it over 16 weeks. Part 2 includes healthy volunteers with a BMI between …

This phase 3 trial tests whether switching from common GLP-1 weight-loss drugs to a new medication called maridebart cafraglutide can help adults with obesity or overweight maintain their weight loss. About 300 participants who have already lost at least 10% of their body weight …

This study tests whether a structured exercise and nutrition program can slow the loss of muscle mass, strength, and function in adults aged 65 and older with type 2 diabetes and obesity who are taking semaglutide. Participants receive either standard health advice or a 26-week p…

This study tests whether semaglutide, a drug used for weight loss, can reduce markers of heart disease risk in adolescents aged 12 to 15 with severe obesity (class 2 or 3). Participants receive semaglutide and undergo heart scans, body composition tests, and blood work over about…

This study tests a family-based program for teens aged 12-17 with obesity. Families receive monthly group medical visits, six cooking classes, and twelve months of groceries tailored to health goals like weight management. The goal is to see if this combination helps lower BMI an…

This study tests whether a 4-week healthy cooking program for home cooks can help Emirati adults with overweight or obesity lose weight and eat better. The trained cooks prepare nutritious meals for their families over 3 months. Researchers track weight, waist size, blood pressur…

This study tests whether adding sleep coaching to a standard weight-loss program helps teens with overweight or obesity lose more weight and improve their eating habits. Fifty adolescents aged 14–18 who have sleep issues (like trouble falling asleep or short sleep) will join a 16…

This trial tests whether an acceptance-based healthy lifestyle program helps adolescent girls with overweight or obesity lose more weight than standard health education. Participants attend group sessions for six months, either in person or online, and complete health assessments…

This study tests whether different types of patient education—group classes, a website, or free dental hygiene samples—can improve drinking habits and oral care in people who have had bariatric surgery. Many patients face tooth decay and enamel erosion after surgery due to change…

This study tests a digital tool called PREVENT that helps doctors in rural clinics give personalized advice on physical activity and healthy eating to patients with obesity. The tool creates tailored behavior-change recommendations and shows a map of local resources like parks or…

This early-stage trial tests a microneedle patch called DWRX5003 that delivers semaglutide, a drug used for obesity and type 2 diabetes. The study involves 72 healthy adults to check safety and how well the drug enters the body compared to standard injections. It is not yet testi…

This early-stage study tests whether a new drug, eloralintide, can improve how the body responds to insulin and manage weight in 115 adults with overweight or obesity. Participants will receive either the drug or a placebo injection and be monitored for about 35 weeks. The goal i…

This early-stage study tests an experimental drug called LY4174794 in 108 healthy volunteers who are overweight or have obesity. The main goal is to check the drug's safety and how the body processes it, not to measure weight loss. Participants will receive either the drug or a p…

This study investigates whether sleeping in a low-oxygen environment (similar to an altitude of about 8,500 feet) for 8 hours each night can enhance weight loss in adults with obesity who are also following a reduced-calorie diet. Over 8 weeks, participants use a special tent at …

This study compares three different 12-month online weight loss programs for adults with obesity. One program focuses on standard behavioral techniques, another on preventing future health problems, and a third on promoting future benefits of a healthy weight. Researchers aim to …

This study tests a new medicine called NNC0487-0111 in about 5,600 people who have both heart failure and obesity. Participants receive either the drug or a placebo as a weekly injection. The goal is to see if the drug reduces the risk of heart failure worsening, hospitalization,…

This study investigates whether adding cardiovascular or resistance exercise to standard obesity medication helps adults with overweight or obesity retain lean muscle mass while losing weight. Participants are prescribed an FDA-approved obesity medication by their doctor and are …

This pilot study tests whether tirzepatide, a drug already used for type 2 diabetes and obesity, can improve markers of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) in people with obesity. Eight participants will take tirzepatide for 12 months and undergo bloo…

This study compares three diets for weight loss in adults with type 1 diabetes who are overweight or obese. Participants will follow either a moderate carbohydrate restriction, an early time-restricted eating plan, or a standard calorie-restricted diet. The goal is to see which a…

This study looks at whether a 9-week program led by a dietician can help people with chronic spinal cord injury lose body fat and improve how their body uses insulin. Twenty adults who use wheelchairs will take part in telehealth sessions and have their body composition and insul…

This study investigates whether drinking a fiber-rich kodo millet porridge every day for 12 weeks can improve gut bacteria diversity and metabolic health in overweight or obese adults. Participants will consume a standardized porridge beverage while keeping their usual diet and a…

This trial compares two ways of monitoring blood sugar in adults recently diagnosed with type 2 diabetes (within the last 3 months). Half of the 80 participants use a real-time continuous glucose monitor (CGM) that provides constant feedback, while the other half use standard fin…

This study uses MRI scans to measure how weight loss treatments affect fat in the liver, pancreas, and other organs of adolescents aged 12 to 18 with severe obesity. Researchers compare two approaches: GLP-1 receptor agonist drugs combined with lifestyle changes versus lifestyle …

This study tests a program to help new mothers with chronic conditions like high blood pressure, diabetes, or depression transition smoothly from obstetric to primary care after giving birth. The program includes automatically scheduling a primary care visit, sending personalized…

This study tests a once-weekly injection called NNC0487-0111 in 300 adults with overweight or obesity and moderate-to-severe obstructive sleep apnea who do not use a CPAP machine. The goal is to see if the drug helps with weight loss and reduces breathing pauses during sleep. Par…

This study tests a new medicine called NNC0662-0419 in 230 adults with obesity (BMI 30 or higher). Researchers want to see if different ways of increasing the dose over time can reduce stomach side effects while still helping people lose at least 25% of their body weight. The stu…

This phase 3 trial is testing a new daily pill called elecoglipron for weight loss in 4500 adults who are obese or overweight, with or without type 2 diabetes. Participants will take the pill or a placebo for 72 weeks, alongside diet and exercise. The main goal is to see how much…

This study looks at whether a 12-week structured diet and exercise plan can help adults aged 50 and older with obesity and insulin resistance lose fat and improve muscle function. Participants will receive all meals and exercise three times a week under supervision. The goal is t…

This study tests whether a new medicine called NNC0487-0111, given as a weekly injection, is safe and effective for weight loss in adults with obesity. About 600 participants will receive either the active drug or a placebo (dummy injection) for comparison. The main goal is to me…

This study tests a culturally tailored sleep program called Sleep BETTER for African American pregnant women who are overweight or obese. The program combines sleep hygiene tips and cognitive-behavioral techniques to help improve glucose metabolism and reduce pregnancy complicati…

This study tests whether Taiwan green propolis, a natural bee product, can improve blood lipids and body fat in adults with metabolic dysfunction-associated steatotic liver disease (MASLD), a common fatty liver condition linked to obesity and high cholesterol. About 60 participan…

This study explores whether a short-term low-energy diet (using meal replacements) can help adolescents aged 12–17 with obesity and type 2 diabetes lose weight and potentially achieve diabetes remission. Participants follow the diet for 12 weeks, then gradually reintroduce food o…

This Phase 1 study tests a new drug called REGN20934 in 90 adults who are overweight or obese. The main goal is to check the drug's safety, side effects, and how the body processes it. Participants receive a single dose of either the drug or a placebo, and researchers monitor the…

This study tests whether wearing a continuous glucose monitor (CGM) for 3 months helps adults with prediabetes better control their blood sugar and stick to lifestyle changes compared to standard finger-prick testing. About 80 participants will be randomly assigned to use a CGM o…

This study compares two lifestyle programs for people with type 2 diabetes or prediabetes: one using a ketogenic diet and the other a low-fat diet. Over 12 months, researchers will track changes in weight, blood sugar, blood pressure, and heart health. The goal is to see which di…

This early-stage trial tests whether TIX100, a daily oral pill, is safe and tolerable in healthy adults who are overweight or obese. Over 28 days, participants receive either TIX100 or a placebo, and researchers monitor for side effects and how the drug moves through the body. Th…

This study tests whether a 16:8 time-restricted eating diet (eating only during an 8-hour window each day) helps people with obesity manage their weight, both those who have had bariatric surgery and those who haven't. Researchers will measure changes in body weight, fat mass, an…

This study tests whether oxytocin nasal spray can help teenagers with obesity manage their weight. Over 12 weeks, participants aged 10-18 will take the spray or a placebo four times daily. Researchers will measure changes in body mass index, body fat, and appetite to see if oxyto…

This study looks at whether inducing labor at 39 weeks of pregnancy is better than waiting for labor to start naturally in women with a BMI of 30 or higher. The goal is to see if early induction lowers the chance of needing a C-section. About 1,900 women in Denmark will take part…

This study tests whether a combination of a special diet, omega-3 and L-carnitine supplements, and resistance exercise can improve muscle quality and reduce fat in veterans with HIV and obesity. The trial will enroll 70 participants and measure changes in muscle density, metaboli…

This study tests two versions of the experimental drug cagrilintide in 234 adults with overweight or obesity. Participants receive either version D or version B by injection once a week for about 6 months. The goal is to see how the drug is processed in the body, not to measure w…

This study tests a new version of sleeve gastrectomy (a weight loss surgery) that adds a Nissen fundoplication to reduce acid reflux. Researchers will compare 30-day complication rates between the new technique and standard sleeve gastrectomy in 100 adults with obesity. The goal …

This study compares two blood sugar targets for overweight or obese women with gestational diabetes. One group aims for stricter goals (fasting under 90 mg/dL, after meals under 120 mg/dL), while the other follows standard targets (fasting under 95 mg/dL, after meals under 140 mg…

This study investigates whether taking spermidine, a natural compound found in wheat germ, can improve blood fat levels and body weight in overweight or obese adults with high cholesterol. Participants take either spermidine capsules or a placebo daily for one month. The goal is …

This study follows 175 adolescents and adults with monogenic obesity—a rare form caused by specific gene changes—who are taking semaglutide (Ozempic/Wegovy). Researchers will track weight and BMI changes over 4 years to see if the drug helps control weight in this group. The goal…

This study tests an experimental drug called KDS2010 for weight loss in 75 overweight or obese adults. Participants take the drug or a placebo daily for 12 weeks. The main goal is to see how much weight they lose and if the drug is safe. It is a Phase 2a trial, meaning it is stil…

This study is testing a new approach for people with obesity and type 2 diabetes. It combines two procedures done through the mouth: one uses mild electric pulses to regenerate the lining of the upper intestine, and the other reduces stomach size by stitching it like a sleeve. Th…

This study compares weight loss using semaglutide (a drug) versus a calorie-restricted diet in 100 people with obesity and heart failure with reduced ejection fraction. The goal is to see which approach better improves peak oxygen uptake, a measure of exercise capacity, after 52 …

This study looks at whether strength training (like weightlifting) can help adults taking GLP-1 obesity drugs keep their muscle and improve mental health. Forty inactive adults with obesity will either do supervised resistance exercise twice a week for 3 months or just take the m…

This study is testing a mobile app called Adhera Caring Digital Program for Obesity (ACDP-O) in 280 families. The app provides personalized education, mental health monitoring, and wearable device integration to support weight management and well-being in adolescents and young ad…

This study tests an experimental oral drug, ERX1000, for weight loss in 80 adults with obesity (BMI 30-50). Participants will take the drug or a placebo daily for 24 weeks. The main goals are to check safety and see how much weight is lost. This is an early-phase trial, so the dr…

This study tests an experimental drug called BGE-102 in 160 adults with obesity and heart risk factors. The goal is to see if it lowers inflammation (measured by hsCRP) safely. Participants take either BGE-102 or a placebo daily for 12 weeks.

This early-stage trial tests a new daily pill called CX11 in 90 adults with obesity or overweight who also have weight-related health problems like high blood pressure or prediabetes. The study aims to see if the pill is safe and helps with weight loss compared to a placebo. Part…

This study looks at whether eating most of your daily calories in the morning or the evening leads to better long-term weight loss. About 174 adults with obesity will follow a reduced-calorie diet and exercise plan for 12 months. Researchers will track weight, sleep, and appetite…

This study investigates whether certain genetic variations influence how much weight people lose when taking the FDA-approved weight loss drug Contrave (naltrexone/bupropion). Over 40 weeks, 120 adults with obesity will first follow a calorie-restricted diet for 12 weeks, then ad…

This study will test if a 'produce prescription' program, called Eat Well, helps veterans with high blood pressure and food insecurity. About 1,500 veterans in North Carolina will either get money for fruits and vegetables for 6 or 12 months, or standard care. Researchers will tr…

This study tests whether a lifestyle program tailored to a person's specific obesity type helps them lose more weight and keep it off. Researchers at Mayo Clinic will enroll 228 adults with obesity and give them either a standard or a personalized diet and exercise plan for 12 mo…

This pilot study tests a 6-month program that teaches families about healthy eating and activity, and delivers fresh fruits and vegetables to their homes. About 30 children aged 4 to 10 with obesity, along with their caregivers, will take part. The main goal is to see if the prog…

This study looks at whether adding a GLP-1 weight-loss drug after bariatric surgery helps people with obesity lose more weight and avoid regaining it. About 200 Chinese adults aged 18-60 who are having sleeve gastrectomy will be randomly assigned to get the drug or not. The goal …

This study tests if adding health coaching to regular home visiting services helps pregnant and new moms lose weight gained during pregnancy. The goal is to reduce long-term risks for heart disease and diabetes. Researchers will enroll 360 women who are overweight before pregnanc…

This study investigates whether combining supervised resistance exercise three times a week with a high-protein diet can reduce frailty and improve balance in obese women aged 60–70 who have sarcopenia (age-related muscle loss). Sixty participants are randomly assigned to either …

This study is for overweight or obese women aged 18–45 with atypical endometrial hyperplasia, a precancerous condition of the uterine lining. Participants will receive either a levonorgestrel-releasing IUD (Mirena) or megestrol acetate pills, combined with a weight management pro…

This pilot study tests a device that gently stimulates a nerve in the ear (taVNS) to help overweight or obese people who didn't lose much weight after 12 weeks of diet and exercise. 24 participants will get either real or sham stimulation twice daily for 12 more weeks, while cont…

This early-stage trial tests a new drug called NNC0497-0040 in healthy people, those with overweight or obesity, and people with type 1 diabetes who are also overweight. The goal is to see if the drug is safe and tolerable when given as a weekly injection. About 146 participants …

This Phase 3 trial tests whether the drug HRS-7535 can lower blood pressure better than a placebo in 648 adults with hypertension who are also overweight or obese. Participants will take the drug or placebo for up to 48 weeks, and researchers will measure changes in blood pressur…

This study examines weight loss in adults who took semaglutide (a prescription weight management drug) as part of their routine care. Researchers will analyze medical records from about 35,000 people with overweight or obesity to see how much weight they lost and whether they ach…

This study looks at how obesity affects recovery from post-COVID conditions in older Veterans. Researchers will test if a weight loss program with diet and exercise can reduce inflammation and improve physical function and quality of life. The study involves 150 Veterans, some wi…

This study tests whether a structured cardiac rehabilitation program with exercise and lifestyle coaching, started after a standard catheter ablation procedure, can help obese patients with atrial fibrillation stay free from the heart rhythm disorder longer. Researchers will foll…

This early-stage trial tests a single dose of the experimental drug IBIO-600 in 32 overweight or obese adults. The main goal is to see if the drug is safe and tolerable, and to measure how it moves through the body. Researchers will also look at its effect on body composition. Th…

This study tests whether taking a probiotic for 3 months can improve how the body processes fats after a meal in adults aged 50-70 who are overweight or moderately obese but otherwise healthy. 66 participants will receive either the probiotic or a placebo. The main goal is to see…

This study tests a non-invasive brain stimulation method (temporal interference stimulation) aimed at improving metabolism in people with stable bipolar disorder who also have obesity. Researchers will measure changes in key metabolic molecules like GLP-1. The study enrolls 70 ad…

This Phase 3 trial tests a drug called IBI362 in people with mild to moderate high blood pressure who are also overweight or obese. Participants receive weekly injections of either the drug or a placebo for 48 weeks. The main goal is to see if IBI362 lowers blood pressure more th…

This study follows overweight and obese adults aged 45-65 to see if a tailored program of counseling, supervised exercise, and digital tools helps them lose weight and improve heart health over 18 months. Participants are compared to a group that only gets general written advice.…

This early-phase study aims to see if a natural substance called angiotensin-(1-7) can improve how the body uses insulin in people with obesity, insulin resistance, and high blood pressure. About 26 adults aged 18-60 will receive the peptide or a placebo infusion, and researchers…

This study looks at how well the drug tirzepatide works in everyday life for people with obesity (without diabetes) or type 2 diabetes (with or without obesity). About 160 adults in Paraguay will take the drug as part of their regular care and be followed for 52 weeks. Researcher…

This study compares two weight-loss surgeries—SASI bypass and sleeve gastrectomy—in 220 adults with severe obesity. The goal is to see which one leads to more weight loss and fewer problems like acid reflux. Participants will be randomly assigned to one of the two procedures and …

This study is testing whether e-cigarettes or nicotine replacement therapy (patches and lozenges) can help obese smokers quit or reduce smoking. Sixty participants will use one of the two products for 8 weeks, and researchers will track how many cigarettes they smoke, their carbo…

This study tests a 16-week behavioral program called T1DAL, designed specifically for teens with type 1 diabetes who have overweight or obesity. About 50 teens will be randomly assigned to either the program or usual care. The program includes virtual group sessions and one-on-on…

This study directly compares two popular weight-loss medications, tirzepatide and semaglutide, in 120 adults with obesity and metabolic syndrome. Participants will be randomly assigned to one drug and monitored for 12 months using advanced body scans, blood tests, and AI analysis…

This study tests whether a supervised, equipment-free high-intensity interval training (HIIT) program can improve heart and muscle fitness, body composition, and blood markers in adults aged 18-55 who are overweight or obese. Participants will do body-weight exercises in small gr…

This study tests a personalized program to help people who have lost weight keep it off. About 30 adults who lost at least 7% of their body weight in the past 6 months will receive weekly texts, surveys, and possibly health coaching over 26 weeks. The goal is to see if this appro…

This study looks at what happens to your body when you take anti-obesity medications like semaglutide or tirzepatide, and whether adding aerobic or resistance exercise helps preserve muscle and bone while losing fat. About 40 adults will be assigned to either standard care (medic…

This study tests whether eating 3 whole eggs every day for 4 weeks can improve metabolic health and choline levels in adults with obesity. Twenty participants aged 30-65 with a BMI over 30 will eat the eggs while continuing their normal lifestyle. Researchers will measure liver h…

This study tests a personalized diet and exercise program guided by a smartphone app in 140 obese adults with coronary heart disease. Participants receive custom meal plans and daily weight tracking to help them lose weight safely. The goal is to see if this approach improves wei…

This Phase 1 study looks at how CagriSema, semaglutide, and cagrilintide affect muscle health in 100 adults aged 50-70 with obesity and slightly high blood sugar. Participants will receive one of the drugs or a placebo for up to 15 months. The main goal is to measure how well mus…

This early study looks at whether taking tirzepatide (Mounjaro) after sleeve gastrectomy surgery helps people lose more weight and improve conditions like diabetes and high blood pressure. About 42 adults with obesity will be split into two groups: one gets surgery alone, the oth…

This study tests whether a supplement called Xanthigen helps overweight adults lose weight. About 180 people with a BMI between 27 and 30 will take either a low dose, high dose, or placebo for 16 weeks. Researchers will measure weight, BMI, and waist size to see if the supplement…

This study compares time-restricted eating (eating only within a 12-hour window each day) to standard calorie-restricted diets in 128 children aged 8-17 with obesity. Over 48 weeks, researchers will measure weight loss and how well children stick to the diet. The goal is to find …

This study tests a telehealth program to help cancer survivors quit smoking, lose weight, and get more active. About 1500 participants will either get coaching sessions or just information. The goal is to see which approach works better for improving long-term health.

This study tests a new surgical device (a metal clip) to create a second food pathway in the stomach for people with type 2 diabetes who are overweight or mildly obese (BMI 25-35). The goal is to improve blood sugar control without causing too much weight loss or needing lifelong…

The PROVE trial is testing whether a weight loss program combined with walking exercise can improve or maintain walking ability in people with peripheral artery disease (PAD) who are overweight. 212 participants will be randomly assigned to either weight loss plus exercise or exe…

This study tests whether adding a special light treatment (antimicrobial photodynamic therapy) to standard deep cleaning helps people with obesity and gum disease. 24 participants will receive either standard cleaning alone or cleaning plus the light therapy. Researchers will che…

This study tests whether using a sit-stand desk at work can improve insulin sensitivity and reduce diabetes risk in 198 overweight, sedentary adults with prediabetes or other risk factors. Participants are randomly assigned to stand 2 or 3 hours per day at a sit-stand desk, or to…

This study looks at whether a combination of physical exercise and a nutritional supplement (phenylcapsaicin) can improve body composition, metabolism, and overall health in adults aged 50-65 who are overweight but not obese. Participants must have at least two signs of mild meta…

This 12-week study tests whether replacing highly processed soy foods (like soy burgers) with less processed options (like tofu or edamame) can lower blood pressure and improve heart health in 300 adults with obesity, hypertension, and often type 2 diabetes. Participants use a di…

This study tests whether a dietary supplement called capsinoid, found in sweet peppers and chilies, can activate brown fat in obese adolescents. Brown fat is a type of body fat that burns calories to produce heat, which may help with weight control. The study will involve 38 teen…

This study tests whether semaglutide (Ozempic) helps people with HIV and obesity lose more weight than diet and exercise alone. About 80 participants will receive either semaglutide injections or standard lifestyle advice for 28 weeks. Researchers will also check how the drug aff…

This study tests two types of distal gastric bypass surgery for people who regained weight or didn't lose enough after an initial Roux-en-Y gastric bypass. About 150 participants will be randomly assigned to one of the two procedures and followed for three years. The main goals a…

This study tests whether resistance exercise and extra protein can help preserve muscle mass in people starting weight-loss drugs like semaglutide or tirzepatide. 232 adults with obesity will be randomly assigned to one of four groups: control, extra protein, exercise, or both. T…

This study is testing whether a daily capsule made from fermented fruits and vegetables (Rutazyme®) can improve body fat, waist size, and blood markers in adults with obesity. Forty participants will take either the supplement or a placebo for 12 weeks. Researchers will measure c…

This study tests if weight-loss surgery is better than standard medical treatment for making nonalcoholic steatohepatitis (NASH) with advanced liver scarring disappear without making the scarring worse. It involves 100 obese adults with NASH and significant liver fibrosis. Partic…

This study tests tirzepatide, a medication already used for obesity, in 60 adults who have both type 1 diabetes and obesity. Participants will receive either tirzepatide or standard care to see if it helps with weight loss and is safe. The goal is to understand if this drug can b…

This study tests whether a mango and chia-based drink can improve the gut bacteria of 100 obese children aged 8 to 16 in Paraguay. The children will drink the beverage for 6 weeks, and researchers will analyze their stool samples before and after to see if the drink changes their…

This study looks at whether a structured weight loss program, with or without added exercise, can improve physical function and emotional well-being in obese veterans who have had a stroke. Researchers will enroll 130 participants aged 35-85 who had a stroke at least 6 months ago…

This study compares a new weekly injection, HDM1005, to the existing drug tirzepatide for weight loss in 372 adults with obesity but without diabetes. Participants receive either HDM1005 or tirzepatide for 52 weeks, plus diet and exercise counseling. The main goal is to measure h…

This study tests whether a strict low-carbohydrate diet combined with lifestyle guidance can help obese men (BMI 30+) lose weight and improve their fertility. Researchers will track weight, semen quality, and reproductive outcomes in 98 men aged 22-40. The goal is to find a non-d…

This study tests a digital program for overweight teens aged 12-18 that uses AI coaching, games, and real-time feedback to encourage healthy eating and exercise. Two hundred participants will either use the digital program or receive standard health education for three months. Th…

This study looks at whether taking blood pressure medication in the morning or evening works better for obese people with high nighttime blood pressure. Obese individuals often have disrupted natural rhythms that raise their heart disease risk. Researchers will give 160 participa…

This study tests whether electro-acupuncture can improve insulin resistance in people with obesity. 60 participants will be randomly assigned to receive either real electro-acupuncture or a sham (fake) version. The main goal is to see if the treatment lowers a key measure of insu…

This study tests whether a low dose of the weight-loss drug mazdutide, an intensive lifestyle program, or both can help people with obesity maintain weight loss for a year after initially losing weight with a higher drug dose. About 420 adults with a BMI between 28 and 45 will ta…

This early-stage trial tests a new drug called DA-1726 in 139 people with obesity. The main goal is to check safety and side effects. Researchers will also measure how the drug moves through the body and its effect on weight. Participants receive either the drug or a placebo, and…

This early-stage trial tests a new drug called SYH9017 in 66 Chinese adults who are overweight or obese. The main goal is to check the drug's safety and how the body processes it after single and multiple doses. Participants will receive either the drug or a placebo, and research…

This study is testing a low-dose version of the drug semaglutide to help obese adults lose weight and improve heart health. The trial includes 60 Pakistani adults who are obese but do not have diabetes. Participants will receive weekly injections for 24 weeks, along with diet and…

This study tests a remote behavioral program for people who have regained at least 5% of their weight after bariatric surgery. 200 participants will be randomly assigned to either the program or a control group that receives standard dietary advice. The goal is to see if the prog…

This study looks at whether adding extra protein to the diet can help adults with obesity keep their muscle while losing weight with GLP-1 medications. About 130 people aged 30-65 with a BMI over 30 will take part. Half will get standard medication alone, and the other half will …

This study tests an investigational drug called MOTS-c in 120 adults with prediabetes and overweight or obesity. The goal is to see if 12 weeks of treatment can improve how the body uses insulin, compared to a placebo. All participants also receive standard lifestyle advice. The …

This study tests whether metformin, a diabetes drug, can help adults with intellectual disabilities who have gained weight from antipsychotic medications. One hundred participants will receive either metformin or a placebo for 24 weeks, along with lifestyle advice. The goal is to…

This study looks at whether adding whole-body vibration training to a standard 3-week weight-loss program helps obese teenage boys burn more calories while resting. About 28 boys aged 13-18 will either get the vibration sessions plus the usual rehab (diet, exercise, counseling) o…

This study tests whether adding an essential amino acid supplement (EAA-AC) to a low-calorie, low-protein diet helps people with severe obesity lose weight while keeping muscle mass. Sixty participants aged 45-65 with a BMI over 35 will be randomly assigned to receive either the …

This study is testing whether inviting friends, family, or coworkers to join a weight-loss program helps Black or Hispanic adults with obesity lose more weight. The program focuses on improving communication and problem-solving around eating and activity. Researchers will see if …

This study looks at whether adding aerobic or high-intensity interval exercise to a low-glycemic Mediterranean diet can lower inflammation better than diet alone. Researchers will enroll 90 adults aged 18-65 with obesity and non-alcoholic fatty liver disease. Participants will be…

This study tests whether a reduced-calorie Mediterranean diet plus regular exercise helps middle-aged adults (30-50 years) with metabolic syndrome lose weight and keep it off. About 106 participants will either follow this lifestyle program or receive standard care. Researchers w…

This study tests whether a probiotic (a mix of good bacteria) can help adults with obesity lose weight when combined with healthy lifestyle changes. About 100 people aged 18-50 with a BMI between 25 and 40 will take either the probiotic or a placebo for several weeks. Researchers…

This study tests whether a wearable device and AI app can help obese adults lose more weight than standard diet and exercise alone. About 120 participants will follow a 6-month program with coaching and tracking. The goal is to see if technology boosts weight loss and improves he…

This pilot study tests whether an 8-week whole foods diet (based on MyPlate, no calorie counting) can reduce body fat in 60 adolescents aged 10-18 with obesity. Participants will be randomly assigned to the diet or a control group. The study also looks at changes in diet quality …

This study tests a program called Regulation of Cues (ROC) in 30 Latina women with prediabetes and obesity. The program teaches awareness of eating triggers and coping strategies to reduce weight and prevent type 2 diabetes. Researchers are first checking if participants find the…

This study looks at whether adding protein supplements to a weight-loss plan (diet plus the drug semaglutide) helps overweight or obese adults lose more weight, keep muscle, and avoid gaining weight back. About 140 people will take part in a 3-month program and be followed for 6 …

This study looks at whether text messages and a program called Building Healthy Families can help lower-income families with a child who has obesity. About 600 families will be invited through their doctor's records and then offered the program, which teaches healthy eating, phys…

This study compares two non-drug approaches for helping obese children lose weight: ear acupressure (sticking tiny seeds on ear points) and an intermittent low-carbohydrate diet. Researchers will track changes in body weight and other health markers over three months in 240 child…

This study tests whether giving antibiotics to obese first-time mothers during labor induction can lower their chance of needing a C-section. About 787 women with a BMI of 30 or higher will be randomly assigned to receive either antibiotics or a placebo. The goal is to see if thi…

This study tests whether artificial intelligence can better predict difficult airway management in 340 obese patients undergoing bariatric surgery. Researchers will compare AI predictions using standard measurements like mouth opening and neck length against actual views during i…

LiverSeek is a study testing an automated screening program for advanced liver fibrosis in people aged 50-75 with risk factors like diabetes or obesity. When a routine blood test is done, the lab system automatically calculates a fibrosis score and, if needed, orders additional t…

This study tests a program called PINPOINT that helps women with obesity or diabetes get screened for cervical cancer. About 20 women who are behind on screening will be offered options like self-collection or a Pap smear. The goal is to see if the program is practical and well-l…

This study tests a 9-session group program for parents of children aged 6 months to 3 years, focusing on healthy eating, physical activity, and sleep. About 526 families from Spain will take part, with half receiving the program and half getting usual care. The goal is to see if …

This trial tests whether a personalized lifestyle medicine program can improve cardiometabolic health in Emirati adults aged 25-50 with obesity. Participants receive an 18-week program tailored to their individual health screening results, with follow-up over 24 weeks. The study …

This pilot study tests whether helping pregnant women quit smoking—through counseling, financial incentives, and support—can prevent rapid weight gain in their infants. About 48 smoking pregnant women will be randomly assigned to receive either the full program or education alone…

This study tests whether giving a fecal microbiota transplant to babies born by C-section can improve their gut bacteria and help prevent overweight or obesity later in life. Researchers will track the growth and gut health of 534 infants who receive the transplant shortly after …

This study adapts a diabetes prevention program for Hispanic adolescents aged 12-16 with obesity, delivering it via telehealth using a Fitbit, chatbot, and online lessons. The goal is to see if this approach is feasible and acceptable for reducing type 2 diabetes risk. Researcher…

This study looks at whether offering free center-based childcare during the summer can help prevent unhealthy weight gain in preschoolers from low-income households. Researchers will enroll 300 children who attend needs-based pre-K programs. The goal is to see if the structure an…

This study tests two parenting programs for families with newborns. One program teaches parents how to recognize baby hunger and fullness cues and offers nutrition advice. The other provides safety tips like safe sleep and car seat use. Researchers will track the babies' growth a…

This study tests a 9-month program to prevent obesity in 2,340 primary school children aged 6-12 in Pakistan. The program includes health education, daily physical activity, parent workshops, and regular feedback via WhatsApp. Half the schools will get the program, the other half…

This study is testing a mobile health platform designed to help children ages 8-12 who don't get enough sleep (less than 8.5 hours per night) sleep longer. The goal is to see if improving sleep can help prevent obesity. The study will enroll 5,000 children and track their sleep d…

This study looks at whether whole or low-fat (1%) milk is better for preventing obesity in toddlers. Researchers will give 625 children either whole or low-fat milk for one year and measure changes in waist size and body mass index. The goal is to find out which milk type support…

This study tests whether community health workers can help adults with chronic illnesses get up-to-date on COVID-19 and flu vaccines. Participants receive up to three counseling sessions in English or Spanish to address their vaccine concerns. The goal is to reduce health dispari…

This study tests whether playgroups or parent education classes can help toddlers develop healthy eating and activity habits. About 300 families with toddlers aged 18-36 months will be randomly assigned to one of three groups: a playgroup, a parent education class, or continuing …

This study tests a program called Healthy Family Foundations for military families expecting their first child. The program includes 10 online group classes (5 before birth, 5 after) to help parents support each other with healthy eating, activity, and parenting. Researchers will…

This study tests a program called Futuros Fuertes 2.0, which gives low-income Latino families health coaching and text messages during the first two years of a child's life. The goal is to promote healthy feeding, limit screen time, and improve sleep to prevent obesity. Half of t…

This study tests an online program called Families in Balance Online, designed to help parents of 2- to 5-year-olds build healthy routines around meals, sleep, and screen time. About 300 families with low income will be randomly assigned to either this interactive program or a se…

This study tests whether a daily powder containing fiber and plant compounds (inulin, resveratrol, quercetin) can reduce brain inflammation in 120 overweight women aged 35-60 who are going through menopause. Participants take the supplement or a placebo for 6 months, and research…

This study tests a 6-month lifestyle program designed to prevent obesity and eating disorders in transgender and gender-diverse adolescents aged 10-14. Participants attend monthly group sessions and receive weekly supportive messages. The goal is to improve quality of life and bo…

This Phase 3 study tests a once-weekly injection called NNC0487-0111 in 400 adults who are overweight or obese and have knee osteoarthritis. The goal is to see if it helps with weight loss and reduces knee pain compared to a placebo. Participants receive either the active drug or…

This study tests a once-daily pill called orforglipron in 800 adults with obesity or overweight who also have painful knee osteoarthritis. The goal is to see if the drug reduces knee pain and improves physical function over about 74 weeks. Participants will be randomly assigned t…

This study tests whether replacing sugary sodas with unsweetened sparkling water can reduce added sugar intake and improve health in Black/African American and Latine adolescents with obesity who love sweet drinks. For 4 weeks, participants swap their sodas for one of three optio…

This Phase 3 study tests a once-weekly injection called eloralintide in 900 adults with osteoarthritis of the knee who are also overweight or obese. The goal is to see if it reduces knee pain and helps with weight loss compared to a placebo. Participants will be in the study for …

This early-stage study tests whether a new drug called NNC0113-5840 is safe for people with overweight or obesity. About 48 adults aged 18-55 with a BMI between 25 and 35 will receive either the drug or a placebo. The main goal is to check for side effects and how the drug moves …

This study investigates whether a 12-week low-calorie diet can reduce tinnitus (ringing in the ears) in people who have both Behcet disease and obesity. Twenty participants will follow the diet, and researchers will measure changes in tinnitus severity, discomfort, and quality of…

This Phase 3 trial tests whether a once-weekly injection called NNC0487-0111 can help people with overweight or obesity and knee osteoarthritis lose weight and feel less pain. About 400 adults will receive either the drug or a placebo for several weeks. Researchers will measure c…

This trial compares two FDA-approved long-acting local anesthetics, Zynrelef and Exparel, for controlling pain after robotic sleeve gastrectomy. About 130 adults aged 18-65 scheduled for this surgery will receive one of the two drugs injected at the surgical site. Researchers wil…

This study tests whether a flexible, symptom-guided dosing plan for tirzepatide can reduce nausea and vomiting compared to the standard dosing plan in adults with obesity who do not have diabetes. Participants will be randomly assigned to one of two dosing strategies and followed…

This study tests whether adding dramatherapy—using role play, improvisation, and creative exercises—to a standard exercise program improves quality of life for adults with obesity and eating disorders. Participants are in medical or bariatric care and will be randomly assigned to…

This study tests whether a program that addresses chronic pain can help teens with obesity stay in weight management treatment. Fifty adolescents aged 12-18 with both obesity and musculoskeletal pain will either receive the Pain and Weight Treatment (PAW) plus standard care, or p…

This study tests whether online group education and lifestyle coaching can improve quality of life and health markers in women with PCOS and obesity. Forty non-pregnant women aged 18-49 will be assigned to either the virtual program or usual care. Researchers will measure changes…

This study tests whether early time-restricted eating (eating only during a set morning window) helps postpartum women with overweight lose weight and improve heart health. Sixty women 6-16 weeks after a healthy pregnancy will either follow this eating schedule or eat normally fo…

This study tests whether cagrilintide, a new injectable drug, causes fewer stomach side effects than a placebo in people with obesity who previously quit GLP-1 medications due to nausea, vomiting, or diarrhea. About 114 participants will receive either cagrilintide or a dummy sho…

This study is testing whether a time-restricted eating plan (eating only during an 8-10 hour window each day) combined with a healthy plant-based diet is safe and doable for people with liver cancer, cirrhosis, or fatty liver disease. Fifty overweight or obese adults will either …

This study tests whether 10 minutes of daily brain games on a phone can help teens aged 14-17 with overweight improve their self-control around food. Over three weeks, participants play games designed to strengthen inhibitory control and receive a short nutrition lesson. The goal…

This study tests whether a 16-week hydration program can reduce side effects like nausea and dehydration in people starting GLP-1 medications (such as Ozempic or Wegovy). Researchers will track 30 adults aged 18-60 who recently started the drug, measuring hydration levels and sid…

This study tests whether giving lidocaine through a stomach tube can reduce nausea and vomiting after weight-loss surgery. About 100 obese adults having laparoscopic sleeve gastrectomy will receive either lidocaine or a saltwater placebo right after surgery. Researchers will trac…

This study looks at whether adding pork protein to the diet can help middle-aged women with overweight or obesity who are taking GLP-1 medications (like Ozempic or Wegovy) maintain muscle and improve well-being. Over 12 weeks, 75 women will continue their medication and eat prote…

This study tests if a mild electrical patch placed on the skin (called TENS) can prevent breathing problems after weight-loss surgery in people with severe obesity. About 70 participants will be randomly assigned to receive either TENS or a fake device. The main goal is to see if…

This study looks at whether adding a special whey protein supplement to a high-fat meal can improve markers of heart and brain health in postmenopausal women who are overweight and at moderate risk for heart disease. Sixteen women will each try the supplement and a placebo on sep…

This study tests whether starting gentle, supervised movement soon after bariatric surgery and continuing it at home can help manage pain and improve recovery. Researchers will track pain levels, physical function, and quality of life in 112 participants. The goal is to find a si…

This study tests a medicine called cagrilintide to see how it affects appetite and how much people eat. About 120 adults with overweight or obesity will receive either the drug or a placebo for around 30 weeks. The goal is to measure changes in total energy intake from meals and …

This study is testing a weight loss program that uses a smartphone app and a coach to help teens and young adults who are overweight after a stem cell transplant. The goal is to see if the program can help them lose weight and build healthy eating habits. About 20 people who are …

This study looks at whether blowing balloons can improve lung function and reduce shortness of breath in obese children aged 6 to 12. Thirty-eight children will be split into two groups: one will blow balloons, the other will do a simple running exercise. Researchers will measure…

This study tests whether adding very short, intense exercise bursts (called 'exercise-snacks') to a standard weight-management program can improve physical fitness in obese adolescents. Forty-eight teens will either do six mini-exercise sessions daily for three weeks or just rece…

This early-stage study tests whether a once-weekly injection called NNC0487-0111 can lower how much people with obesity eat and reduce their appetite. About 120 adults will receive either the drug or a placebo for several months. The goal is to see if the treatment changes energy…

This pilot study tests whether semaglutide (Ozempic), a drug used for diabetes and obesity, is safe and tolerable for weight loss in people with advanced lung disease. Eight participants with conditions like COPD or pulmonary fibrosis will take weekly injections for 12 weeks. Res…

This early-stage study tests a new drug called RT-114 in 60 healthy volunteers to see if it is safe and how the body processes it. Some participants will get the drug as a shot or pill, while others will get a placebo. The goal is to gather initial safety data before testing in p…

This study tests whether a single 40-minute infrared sauna session, done before a meal, can lower blood sugar spikes in overweight adults. Fifteen participants at risk for metabolic issues will wear a continuous glucose monitor and compare sauna versus rest. The goal is to see if…

This study tests whether a gentle brain stimulation technique called tDCS, combined with cognitive training, can help veterans with obesity reduce impulsive behavior and lose weight. About 124 veterans will be randomly assigned to receive either real or fake stimulation during tr…

This study compares three volumes of a nerve block (M-TAPA) to see which provides the best pain relief after laparoscopic sleeve gastrectomy. Sixty adults undergoing this weight-loss surgery will receive one of three volumes of bupivacaine. The goal is to find the optimal volume …

This study aims to describe the physical and behavioral traits of overweight and obese adults compared to lean individuals. Researchers will measure hormones, metabolism, food preferences, fitness, sleep, and thinking patterns in 2,000 participants. The goal is to better understa…

This study aims to learn more about heart and blood vessel diseases by observing people who have them or are at risk. Researchers will collect samples and perform tests like imaging and stress tests on up to 5,000 participants, including healthy volunteers and relatives of affect…

This study looks at how obesity and body fat affect heart disease risk in 2,000 healthy African American men and women. Researchers will measure body fat, blood fats, and insulin function to see if risk factors differ by sex. The goal is to understand why heart disease rates are …

This study looks at whether tiny particles released by fat cells, called adiposomes, carry harmful fats that damage blood vessels in people with obesity and type 2 diabetes. Researchers will test if a 12-week aerobic exercise program or weight-loss surgery can reduce these harmfu…

This study compares two video laryngoscopes (GlideScope and Airway Scope) to see which one helps doctors place a breathing tube faster and more safely in severely obese patients (BMI 40 or higher). About 70 adults will take part. The goal is to find the best tool to reduce compli…

This study investigates whether bariatric surgery, such as gastric bypass or sleeve gastrectomy, changes how the body absorbs the common blood-pressure medication metoprolol. Researchers will measure drug levels in the blood of 12 patients before and after surgery. The goal is to…

This study looks at how bariatric surgery, such as gastric bypass or sleeve gastrectomy, affects the way the body absorbs lamotrigine, a medication used for epilepsy and bipolar disorder. Researchers will measure the drug's concentration in the blood of 12 patients before and aft…

This study asks whether weight-loss surgeries like gastric bypass or sleeve gastrectomy change how the body absorbs paracetamol, a common painkiller. Researchers will measure paracetamol levels in the blood of 12 people before and after surgery. The goal is to understand if these…

This study looks at whether weight-loss surgeries like gastric bypass or sleeve gastrectomy change how the body absorbs and processes the blood pressure medication losartan. Researchers will measure losartan levels in the blood of 12 people before and after surgery. The goal is t…

This study looks at how bariatric surgery, such as gastric bypass or sleeve gastrectomy, affects the way the body absorbs the blood pressure medication valsartan. Researchers will measure drug levels in the blood of 12 patients before and after surgery to see if the operation cha…

This study explores whether changing gut bacteria with antibiotics can help people keep weight off after losing at least 10% of their body weight. 200 adults with a BMI between 28 and 35 will take either antibiotics or a placebo for 10 days. Researchers will track weight, microbi…

This study investigates whether a key channel in insulin-producing cells becomes less active as type 2 diabetes progresses. Researchers will give a single 10 mg dose of glipizide, a drug that blocks this channel, to people with and without type 2 diabetes and measure their insuli…

This study looks at two different training programs for doctors and health workers at community health centers. The goal is to see which training helps patients lose weight better and get more people to use weight management services. About 6,200 adults and youth on Medicaid will…

This trial is developing and testing a system that uses ultrasound to automatically identify spinal landmarks, helping doctors find the right spot for spinal anesthesia. The study includes people who need spinal anesthesia for surgery, with a focus on obese patients, where tradit…

This study works with Black churches in Washington, D.C. to understand heart health risks like obesity, high blood pressure, and diabetes. About 200 adults will get a health exam, wear an activity monitor for a month, and answer health questions. The results will help design a fu…

This study looks at two ways of giving a standard liquid meal to measure how the body handles sugar. One method gives everyone the same number of calories, while the other adjusts the calories based on a person's size. Researchers want to find out which method gives more consiste…

This study follows 1,500 pregnant women and their children for up to 18 years to understand how a mother's health, lifestyle, and environment affect her child's growth and risk for obesity, diabetes, and fatty liver. Mothers attend visits during pregnancy and after birth, while c…

This study is investigating how immune cells called macrophages in fat tissue handle fat and influence metabolism. Researchers will compare people with obesity and related metabolic issues to lean individuals, using imaging, blood tests, and tissue biopsies. The goal is to unders…

This study investigates how immune cells in fat tissue, called macrophages, handle fats and whether this affects metabolism in people with obesity. Researchers will compare adults with obesity and type 2 diabetes or fatty liver to lean individuals, using imaging, blood tests, and…

This study looks at how fat tissue in the upper body reacts after a meal, comparing people with obesity to those at a healthy weight. Researchers will measure blood flow and tiny particles called exosomes released by fat cells. The goal is to better understand how fat tissue work…

This study aims to learn how type 2 diabetes and obesity in young people affect heart and blood vessel health over time. About 930 participants aged 12 to 25, including those with diabetes, overweight but not diabetic, and healthy lean individuals, will be followed for up to 25 y…

This study is testing new magnetic resonance imaging (MRI) techniques to get clearer pictures of the heart and blood vessels without using radiation. Researchers will compare these new MRI methods to standard tests like angiography and CT scans. Up to 4,000 adults—including healt…

This natural history study will look at how metabolism relates to body size and composition in 2,000 people aged 2 and older, including healthy volunteers and those with conditions like diabetes, obesity, or cancer. Participants will stay in the hospital for two days to undergo v…

This study looks at whether taking GLP-1 weight-loss medications before pregnancy influences how much weight a woman gains during pregnancy and her pregnancy outcomes. Researchers will compare pregnant women who used these medications before conception with those who did not. Par…

This study aims to validate the accuracy and reproducibility of laboratory assays and research techniques used in metabolism research. It will involve up to 100 adults aged 18-75 with a BMI between 18.5 and 45. Participants may undergo various tests, including blood sampling, ora…

This study compares robot-assisted bariatric surgery to standard laparoscopic surgery for obesity. About 482 adults aged 18-70 who qualify for weight-loss surgery will be randomly assigned to one of the two methods. The goal is to see if the robot's higher upfront cost is offset …

This study examines whether sex and obesity influence how blood vessels widen in response to low oxygen levels. Researchers will infuse several drugs into the forearm artery of 72 healthy volunteers to block or stimulate specific nerve signals, measuring changes in blood flow. Th…

This study tests whether an 8-week very-low-calorie diet (600-800 kcal/day) can alter bone marrow fat, bone health, and stem cell function in obese premenopausal women. Researchers will use MRI and biopsies to measure changes in vertebral bone marrow fat and the behavior of bone …

This study investigates whether semaglutide, a GLP-1 drug used for weight loss, alters dopamine activity in the brain when people with obesity and food addiction see, smell, and taste food. Thirty adults will receive semaglutide for 8 weeks and undergo PET brain scans to measure …

This study looks at whether a special digital follow-up system plus nurse-led education can help people feel better and stay active after weight-loss surgery. About 52 adults who have had bariatric surgery will take part. Half will get the extra digital support and exercise progr…

This study investigates whether genetic differences influence how people respond to semaglutide, a GLP-1 drug used for weight loss and diabetes. Overweight or obese volunteers of Amish descent will receive weekly semaglutide injections for six weeks. Before and after treatment, r…

This study surveys adults taking GLP-1 medications (like semaglutide or tirzepatide) for diabetes or weight loss to understand their resistance training habits before and after starting the drug. The goal is to learn how often people strength train, what their workouts look like,…

This study investigates whether differences in taste and smell perceptions affect food choices and eating behaviors in people with and without obesity. Researchers will compare measures of taste, smell, and eating habits between the two groups, along with genetic, inflammatory, a…

This study investigates why women with obesity often have trouble ovulating. Researchers will give estradiol patches to 20 women with regular cycles and measure how their pituitary gland responds. The goal is to see if obesity dampens the brain's ability to trigger the hormone su…

This study follows 80 adults before and after bariatric surgery to see how their muscle mass, strength, and physical function change over time. Researchers use ultrasound to measure thigh muscle thickness and simple tests like handgrip strength and walking speed. The goal is to b…

This study investigates why some people with obesity develop insulin resistance and related diseases while others remain metabolically healthy. Researchers are examining tiny particles called exosomes, released from fat tissue, which may carry signals that affect how cells respon…

This study investigates whether proteins released by muscles, called myokines, can serve as early warning signs or even causes of muscle loss (sarcopenia) in people with metabolic or endocrine conditions like diabetes, obesity, and Cushing syndrome. Researchers will measure myoki…

This study looks at how certain immune cells, called meta-inflammatory monocytes, along with body composition and diet, may contribute to insulin resistance in adolescents. Researchers will collect blood samples and health information from 175 teens aged 14-18, including those wi…

This study looks at whether a person's genetic makeup can predict how much weight they will lose on the drugs semaglutide or tirzepatide. Researchers will follow 220 adults with obesity who are starting one of these medications for six months. By analyzing genetic risk scores and…

This study investigates what happens inside the body after an 84-hour fast. Researchers will measure peak fat oxidation (how well the body burns fat during exercise), mitochondrial coupling (energy efficiency in cells), and changes in the extracellular matrix (the scaffold around…

This study investigates how gastric bypass or sleeve gastrectomy changes the way the body processes ramipril, a drug used to treat high blood pressure. Researchers will measure ramipril levels in the blood of 12 patients before and after surgery. The goal is to understand whether…

This study looks at how gastric bypass or sleeve gastrectomy affects the way the body handles hydrochlorothiazide, a common blood pressure medication. Researchers will measure drug levels in the blood of 12 people before and after surgery. The goal is to understand whether weight…

This study investigates how gastric bypass or sleeve gastrectomy alters the absorption of irbesartan, a common blood pressure medication. Researchers will measure drug levels in the blood of 12 people with morbid obesity before and after surgery. The goal is to understand whether…

This study looks at how two common weight-loss surgeries — gastric bypass and sleeve gastrectomy — change the way the body processes the antidepressant fluoxetine (Prozac). Researchers will measure drug levels in the blood of 12 participants before and after surgery. The goal is …

This study looks at how gastric bypass and sleeve gastrectomy — two types of weight-loss surgery — change the way the body absorbs enalapril, a common blood pressure medication. Researchers will measure drug levels in the blood of 12 people with severe obesity before and after su…

This study investigates how two common weight-loss surgeries—gastric bypass and sleeve gastrectomy—change the way the body absorbs the blood thinner apixaban. Researchers will measure apixaban levels in the blood of 12 participants before and after surgery. The goal is to underst…

This study investigates how gastric bypass and sleeve gastrectomy—two common weight-loss surgeries—affect the absorption of gabapentin, a drug used for nerve pain and seizures. Researchers measure gabapentin levels in the blood of 12 participants before and after surgery. The goa…

This study looks at how gastric bypass or sleeve gastrectomy changes the way the body processes the antipsychotic medication chlorprothixene. Researchers will measure drug levels in the blood of 12 people with severe obesity before and after surgery. The goal is to understand whe…

This study looks at how two common weight-loss surgeries — gastric bypass and sleeve gastrectomy — affect the way the body absorbs the medication quetiapine. Quetiapine is a prescription drug used for mental health conditions. Researchers will measure quetiapine levels in the blo…

This study investigates how the body processes glucose after a high-sugar meal in lean individuals and those with obesity. Participants drink a tiny, safe amount of radioactive glucose so researchers can trace exactly where the sugar goes—into breath, urine, or stool—and measure …

This study investigates how gastric bypass and sleeve gastrectomy—two common weight-loss surgeries—alter the way the body processes ibuprofen. Researchers will measure ibuprofen levels in the blood of 12 participants before and after surgery. The goal is to understand whether the…

This study investigates how bariatric surgery (gastric bypass or sleeve gastrectomy) changes the way the body absorbs candesartan, a drug used to treat high blood pressure. Researchers will measure candesartan levels in the blood of 12 people with severe obesity before and after …

This study looks at how bariatric surgery (gastric bypass or sleeve gastrectomy) affects the levels of the blood pressure drug lercanidipine in the blood. Researchers will measure drug concentrations before and after surgery in 12 people with severe obesity. The goal is to unders…

This study tests whether showing health warnings, tasty-sounding labels, or both can encourage 1,000 Chinese college students to pick sugar-free drinks over sugary ones. Participants will make drink choices on a platform, and researchers will track which options they select. The …

This study looks at how common and severe gum disease is in people with obesity. Researchers will check dental health, analyze saliva for signs of inflammation, and look at genes linked to obesity. They will also study the bacteria in dental plaque to understand the connection be…

This study looks at whether childhood trauma is linked to changes in stress hormones and inflammation in obese women. Researchers will measure cortisol levels in saliva and urine, along with other markers, in 102 women. The goal is to better understand how past experiences might …

This study looks at whether a program to reduce sitting time and increase light activity before bariatric surgery helps women with obesity achieve better weight loss and health. Seventy-two women scheduled for surgery will be guided to replace sedentary behavior with movement. Re…

This study follows 200 obese Chinese patients undergoing weight-loss surgery to understand how nonalcoholic fatty liver disease (NAFLD) progresses. Researchers will take liver biopsies during surgery and track health markers over time. The goal is to find better ways to predict a…

This observational study will follow 10,000 adults with obesity or overweight to understand how the disease progresses and what factors predict treatment success. Researchers will analyze medical records from 2000 onward, looking at heart and metabolic complications over 5 to 10 …

This study is tracking 2,000 adults over time to understand how obesity and disruptions to the body's internal clock (circadian rhythm) influence aging and heart health. Participants will provide health data, questionnaires, and biological samples during annual check-ups. The goa…

This early-stage study looks at how ZT002, a long-acting experimental drug for weight management, affects the way the body processes four common medications (metformin, warfarin, rosuvastatin, and digoxin). About 60 overweight or obese but otherwise healthy adults aged 18-45 will…

This study follows 750 severely or morbidly obese patients who have undergone bariatric surgery at a single hospital in France. Researchers aim to track long-term weight loss and improvements in related health issues such as diabetes and high blood pressure. By observing real-wor…

This study is testing whether mixed reality (MR) versions of common mobility tests, like the Timed Up and Go test, are as accurate and reliable as the traditional versions for overweight and obese adults. About 119 participants will perform both MR and conventional tests using a …

This study looks at whether raising the head and torso 25 degrees helps people with severe obesity (BMI over 40) breathe better through a facemask while under general anesthesia. Fifty adults scheduled for elective surgery will be placed in both a flat and a head-elevated positio…

This study compares how natural sugar (sucrose) and the artificial sweetener sucralose affect blood sugar control and metabolism in 120 adults with normal weight, overweight, or obesity. Participants will consume low or high doses of each sweetener in solid or liquid form over 12…

This study will enroll 20 adults with severe obesity who are scheduled for weight-loss surgery. Researchers want to see if advanced tools like MRI and 3D body scans give a clearer picture of health changes than just measuring weight or waist size. Participants will be followed fo…

This study looks at how a person's genetics, gut microbiome, and behaviors influence how well they tolerate and respond to the weight-loss drug tirzepatide. Researchers will follow 200 overweight or obese adults for up to 12 months, tracking weight changes, side effects, and whet…

This study follows 100 obese patients starting dialysis to understand why they are less likely to receive a kidney transplant. Researchers will track health changes over two years and compare them to non-obese patients. The goal is to identify barriers and improve access to trans…

This study tracks 800 obese patients at Nîmes University Hospital to see if they develop alcohol or other addictions during obesity treatment, especially after bariatric surgery. Researchers will use questionnaires and blood tests to understand these behaviors. The goal is to imp…

This study looks at why people with obesity often regain weight after losing it through a behavioral weight loss program. About 205 adults aged 25-59 will first lose at least 7% of their body weight, then be followed for a year to track how much weight they regain. The goal is to…

This study follows 165 adults undergoing bariatric surgery to see if certain pre-surgery traits—like anxiety, depression, eating behaviors, and weight-related quality of life—can predict how their quality of life changes over the two years after surgery. Participants complete que…

This study compares two common anesthesia methods—intravenous drugs and inhaled gases—to see how they affect thinking skills after sleeve gastrectomy (weight-loss surgery). Researchers will measure how quickly patients wake up and follow commands, and test their memory and attent…

This study looks at how the body absorbs esomeprazole (a stomach acid reducer) when taken as a tablet or dissolved in water, in people who had gastric bypass surgery a year ago. Fifty participants will have a small device placed in their stomach pouch to measure acid levels, and …

This study follows 30 people aged 16–80 with obesity who are starting weight-loss medication. Researchers will track changes in hunger, fullness, cravings, and portion size using questionnaires and interviews at 0, 3, 12, and 18 months. The goal is to understand how eating behavi…

This study investigates how exercise affects the structure and function of fat tissue in adults aged 18-40 with obesity or metabolic syndrome. Participants are randomly assigned to either an exercise program or a sedentary control group. All undergo a 10% weight loss phase, then …

This study is looking at whether GLP-1 receptor agonists—drugs used for type 2 diabetes and obesity—can also improve dry eye disease. Researchers will measure changes in tear stability and eye surface health in 100 patients who have not taken these drugs before. The goal is to un…

This study looks at why teens with obesity often regain weight after losing it. Researchers think hormones that control appetite might be involved. Over 35 weeks, 260 teens will follow a meal replacement plan and then be monitored for weight regain. The goal is to understand the …

This study looks at how obesity impacts the physical abilities and daily activities of people over 65. Researchers will compare obese and normal-weight seniors using fitness tests and questionnaires. The goal is to understand how excess fat, combined with age-related muscle loss,…

This study compares two common anesthetics—propofol and sevoflurane—in 70 obese patients undergoing back surgery. Researchers will measure inflammation markers in blood samples taken before and after surgery to see which anesthetic causes less immune system disruption. The goal i…

This study tests whether a cone-shaped blood pressure cuff placed on the forearm gives more accurate readings than the standard cuff on the upper arm in pregnant women. High blood pressure during pregnancy can lead to serious decisions like early delivery or C-section, so better …

This study looks at 100 adults with severe obesity to see if the type of weight-loss surgery—sleeve gastrectomy or gastric bypass—changes binge eating, depression, and anxiety differently. Participants fill out questionnaires before surgery and for 12 months after. The goal is to…

This study looks at why some children are less affected by food advertising than others. Researchers will use brain scans and eating tests in 200 kids aged 7-9 to find traits that protect against overeating. The goal is to understand what makes certain children resilient to food-…

This study looks at what happens when people sleep only a few hours on weekdays but catch up on weekends. Researchers want to see if this pattern harms blood sugar, blood pressure, and body fat compared to getting enough sleep every night. The study involves 72 adults aged 18 to …

This study looks at genetic and chemical markers in fat tissue from 500 people with severe obesity who are having weight-loss surgery. Researchers collect a small amount of belly fat during the operation and take blood samples afterward. The goal is to understand why some patient…

This study tracks 420 people to see how bariatric surgery affects drinking behavior using a special device called a drinkometer. It measures things like sip size and speed, and looks at how gut hormones and sex differences play a role. The goal is to better understand why surgery…

This study is testing whether a substance in the blood called 1,5-anhydroglucitol can serve as a marker for how well the pancreas is working in obese children, with or without type 2 diabetes. Researchers will measure levels of this marker in 50 children aged 12 to 16 and compare…

This observational study will follow 100 adults starting anti-obesity medications like semaglutide or tirzepatide. Researchers will track changes in body fat, lean muscle, bone density, handgrip strength, and nutrition over time. The goal is to understand the real-world effects o…

This study looks at how losing weight changes the fat stored inside your muscles, called intermuscular adipose tissue (IMAT). Researchers want to see if weight loss reduces inflammation and improves how your muscles respond to insulin. Seventy adults with obesity will follow a 12…

This study looks at whether eating peanuts every day can improve bone health, metabolism, and physical function in overweight or obese adults aged 50-75 during a 6-month weight loss program. Participants will be randomly assigned to eat either a daily peanut snack or a nut-free s…

This study aims to see if a short, interval fitness test (the IFT 30-15) can reliably measure heart and lung fitness in both healthy people and those with high blood pressure or obesity. Researchers will compare results from this test with a standard treadmill test and a six-minu…

This study is recruiting 8,000 young Chinese adults with obesity (BMI 30 or higher) to investigate how genes and clinical features contribute to obesity and metabolic syndrome. Researchers aim to better understand the underlying causes, which could eventually lead to improved tre…

This study looks at how growth hormone affects beta-cells, which make insulin, in people with a family history of type 2 diabetes. Researchers will compare 30 obese adults with and without a family history of diabetes. The goal is to better understand why some people develop diab…

This study collects data from 500 children with severe, early-onset obesity to find genetic causes. Researchers will track how many kids have genetic variants linked to obesity and monitor changes in their BMI over time. The goal is to better understand the role of genetics in se…

This study looks at 240 adults aged 40-60 to see if being overweight or obese in midlife is linked to early signs of Alzheimer's in the brain. Participants will have metabolic tests and brain scans (MRI and PET) to measure inflammation, brain shrinkage, and protein buildup. The g…

This study looks at why some children become overweight or obese by examining their eating habits, brain activity, and family history. Researchers will measure how kids' brains respond to food and how well they control their eating. The goal is to find early clues that could lead…

This study uses advanced heart MRI to see how bariatric surgery and cardiac rehabilitation change the heart's structure and function. Researchers will scan 150 adults before and 6-12 months after these metabolic treatments. The goal is to understand how the heart adapts to these …

This study looks at whether the amount of lean (fat-free) body mass before surgery can predict how much weight people lose in the two years after Roux-en-Y gastric bypass. Researchers will follow 91 adults with severe obesity who are scheduled for the procedure, measuring body co…

This observational study looks at the bacteria in dental plaque of 170 people with obesity (BMI 30+) who are scheduled for bariatric surgery. Researchers want to see if the types and amounts of mouth bacteria differ between those with obesity (BMI 30-35) and those with morbid obe…

This study looks at how being overweight affects insulin sensitivity and heart-lung fitness in people with type 1 diabetes. Researchers will compare participants with and without diabetes, before and after a 15-week high-intensity interval training program. The goal is to underst…

This study looks at whether breathing a low-density helium-oxygen gas mixture can reduce breathlessness and improve exercise capacity in people with heart failure with preserved ejection fraction (HFpEF) and obesity. Researchers will measure how much oxygen the body uses during b…

This study collects blood and tissue samples from 270 severely obese patients during bariatric surgery to uncover new biological factors that lead to type 2 diabetes. Participants are grouped by their metabolic status: those with diabetes, insulin resistance, or normal insulin se…

This study looks at how obesity affects the heart and blood vessels, and how these change after bariatric surgery. Researchers will collect blood, urine, stool, and fat tissue samples from 85 adults before and after surgery. They aim to understand how fat tissue and gut bacteria …

This trial tests two types of opioid-free anesthesia in 70 people having weight-loss surgery. One method uses a gas called desflurane, the other uses intravenous drugs. Researchers will measure stress hormones in the blood to see which approach causes less stress on the body. The…

This early-phase study tests whether a natural odor, when inhaled, can be detected in the cerebrospinal fluid (the fluid around the brain and spine) within 30 minutes. 32 lean and obese adults who are already scheduled for a spinal tap will sniff either the odor or a placebo. The…

This study follows 2,500 adults aged 30-75 in Puerto Rico to track chronic diseases like heart disease, diabetes, and obesity. Researchers will collect data on diet, stress, and lifestyle over two years to identify trends and risk factors. The goal is to guide public health prior…

This study is looking at how the timing of meals, along with genetics, affects weight loss in a Mediterranean population. Researchers will track nearly 6,000 overweight adults to see if eating lunch later makes it harder to lose weight. The goal is to understand if when we eat is…

This study looks at how fasting insulin and insulin resistance differ based on age, sex, race/ethnicity, body weight, and PCOS diagnosis. Researchers will analyze data from 150 adults to find patterns that may explain why some groups face higher metabolic risks. The goal is to be…

This study looks at tiny particles released from fat cells, called extracellular vesicles, and how they relate to blood vessel function in people with obesity. Researchers will compare normal-weight and obese adults, then have obese participants follow a 12-week weight loss diet.…

This early-phase study tests the safety and how the body handles a new injection called HEC-007. It involves 126 healthy adults and overweight or obese individuals. Researchers will monitor side effects, measure drug levels in the blood, and check changes in weight and other heal…

This study will track 1,200 adults in semi-rural Tanzania to find out how common chronic kidney disease (CKD) is and what factors increase the risk. Participants will have blood and urine tests at the start, after 90 days, and again after one year. The goal is to create better wa…

This study tests whether dosing the anesthetic propofol based on adjusted body weight is better than total body weight for obese patients. Using a computer-controlled system, researchers will monitor brain activity to maintain the right depth of anesthesia. The goal is to avoid o…

This study looks at how a high-protein drink versus a high-carbohydrate drink influences what people choose to eat afterward. Researchers will test 45 adults with normal weight, overweight, or obesity to see if the type of meal changes their 'food memory' and calorie intake. The …

This study looks at how different types of exercise—moderate, vigorous, or short bursts—change inflammation levels in the body. Researchers want to see if exercise can help reduce the low-grade inflammation linked to obesity and heart disease. The study is recruiting 33 overweigh…

This early-stage study is testing whether a new weekly injection called NNC0662-0419 changes how the body processes birth control pills and a common painkiller. Researchers will measure drug levels in the blood of 45 women who cannot become pregnant and have overweight or obesity…

This study looks at whether losing weight and breathing low-oxygen air (like at high altitude) can help people with obesity absorb more iron. Iron deficiency is common in obesity, possibly due to inflammation. The study will measure iron absorption before and after a 6-week progr…

This study collects information from medical records and patient visits to see how well endoscopic bariatric therapies (EBTs) work for weight loss and if they are safe. It includes adults who have had or plan to have an EBT within six months. The goal is to track weight changes a…

This study looks at how limiting eating to an 8-hour window each day (time-restricted feeding) affects the immune system of women with severe obesity. Researchers will compare two groups of women with obesity—one following the 8-hour eating schedule and one eating normally—and al…

This study tests whether using a special tube to measure pressure inside the chest can help doctors set breathing machines better for severely obese patients with acute lung injury. About 40 adults with a BMI over 40 and moderate to severe ARDS will take part. The goal is to see …

This study will check how often muscle loss (sarcopenia) happens in 300 adults with obesity. Researchers will measure muscle mass, strength, and physical function, and look at factors like age, diet, and activity. The goal is to help doctors better identify and manage this condit…

This study looks at how severe obesity can lead to a type of heart failure called HFpEF, where the heart becomes stiff and has trouble filling with blood. Researchers will study 250 people with obesity using heart ultrasounds and blood tests to find early signs of heart problems.…

This study looks at whether a community program rooted in Native Hawaiian values can improve the well-being of young people aged 12-25 who have health issues like asthma, obesity, or mental health concerns. About 100 youth from the Wai'anae area will take part in cultural activit…

This study looks at what happens inside your fat tissue when you lose weight with or without exercise. 68 adults with obesity will lose 10% of their body weight through diet, with some also doing moderate exercise. Researchers will measure insulin sensitivity, fat breakdown, and …

This study follows 1,000 people who are having weight-loss (bariatric) surgery. Researchers will measure changes in weight, body fat, blood sugar, cholesterol, and other health markers before surgery and at several follow-up visits over two years. The goal is to better understand…

This study looks at how the body's internal clock affects fat tissue in people with and without obesity. Researchers want to see if eating around the clock changes these rhythms. The goal is to better understand obesity, not to test a treatment. 40 healthy, sedentary adults are n…

This study looks at how resistance training (like lifting weights) affects fat breakdown in obese postmenopausal women who also have prediabetes. Researchers want to see if this type of exercise can improve how the body uses fat, which might help prevent type 2 diabetes. The stud…

This study looks at whether eating dinner earlier in the evening, in sync with your body's internal clock, helps burn more fat and control blood sugar. Researchers will compare early versus late dinner in 32 adults—some healthy weight, some with obesity and prediabetes. Participa…

This study looks at why adults who carry extra weight around their belly don't respond to insulin the same way lean people do. Researchers will measure how fat is released from different parts of the body in 48 overweight and lean volunteers. The goal is to better understand how …

This study looks at how fat tissue changes when people gain weight from overeating. Researchers will ask 58 overweight adults to either maintain their weight or eat 30% more calories for a short time. By tracking fat cell growth and other changes, they hope to understand why some…

This study looks at how a heart hormone called atrial natriuretic peptide (ANP) affects metabolism and heart health. Researchers will test 200 adults with different genetic versions of ANP to see how their bodies respond to exercise and sugar. The goal is to understand why some p…

This study looks at 150 adults with obesity to see if there are differences in fat, muscle, and metabolism between those who were obese as children and those who became obese as adults. Participants will provide tissue samples, blood, and urine, and undergo a weight loss program.…

This study will screen blood pressure in over 22,000 children aged 5-18 across South Africa. The goal is to create the country's first reference charts for normal blood pressure, since current charts are based on US and European data. This will help doctors correctly diagnose and…

This study looks at whether bariatric surgery can change a person's biological age—a measure of how well their body is aging. Researchers will track 300 adults with obesity before and one year after surgery, checking blood markers, fat cell health, gut bacteria, and daily rhythms…

This study looks at how two natural hormones—amylin and pancreatic polypeptide—work together to control appetite and food intake. Eighteen healthy men will receive infusions of these hormones, alone or combined, and then eat a meal to see how much they consume. The goal is to bet…

This study aims to understand how people with obesity feel about their quality of life after undergoing endoscopic vertical gastroplasty (GVE), a less invasive alternative to traditional weight-loss surgery. Researchers will interview 20 Italian adults who had the procedure at le…

This study looks at how 12 weeks of endurance exercise affects fat tissue quality and insulin sensitivity in 70 men and women with obesity. Researchers will take small samples of fat and muscle, and use a glucose test to measure insulin response. The goal is to understand how exe…

This study looks at how GLP-1 medications (like Ozempic) affect fat tissue in people with severe obesity who are scheduled for weight-loss surgery. Researchers will compare fat samples from 40 patients—half taking a GLP-1 drug and half not—to see changes in oxytocin and other mar…

This study looks at the best dose of a green fluorescent dye (indocyanine green) used during repeat weight-loss surgery to see blood flow. About 108 people with obesity scheduled for this surgery will get different doses of the dye. The goal is to find the smallest dose that stil…

This study looks at how well young women with overweight or obesity absorb iron from their diet compared to women at a healthy weight. Researchers will track iron levels and losses over time in 70 South African women. The goal is to understand why obesity raises the risk of iron …

This study looks at whether using ultrasound before and after surgery can help predict difficult breathing tube placement in obese patients. It will compare standard checks with ultrasound measurements and test different types of laryngoscopes. The goal is to improve safety and r…

This study aims to find out how many adults in rural Bangladesh have metabolic fatty liver disease (MAFLD) and how it relates to their diet and metabolic health. Researchers will check 1,000 participants with physical exams, blood tests, and ultrasound. The goal is to gather basi…