Exercise plus diet: the secret to lasting metabolic health?
NCT ID NCT05806801
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looks at what happens inside your fat tissue when you lose weight with or without exercise. 68 adults with obesity will lose 10% of their body weight through diet, with some also doing moderate exercise. Researchers will measure insulin sensitivity, fat breakdown, and changes in fat tissue structure. After weight loss, participants are followed for 6 months to see if exercise helps maintain health benefits even if weight returns.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Moderate intensity continuous exercise (MICT) vs. no exercise
What this could lead to
If successful, this could reveal why exercise plus diet is better for metabolic health than diet alone, even after some weight is regained.
What could go wrong
This is a small, early-stage observational study (68 participants) focused on mechanisms, not a treatment. Results may not apply to older or more diverse populations.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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University of Michigan
RECRUITINGAnn Arbor, Michigan, 48109, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••