METABOLIC SYNDROME

This pilot study tests a 3-month program that combines online education, music-paced brisk walking, group discussions, and phone follow-ups for 40 adults with both metabolic syndrome and chronic kidney disease. The goal is to see if the program can reduce waist circumference and …

This study tests whether a specially designed health behavior program can help people with metabolic syndrome and chronic kidney disease reduce their waist size and improve kidney function. Researchers will compare the program to usual care in 160 adults, measuring changes in wai…

This pilot study is testing whether galantamine, a drug already approved for Alzheimer's disease, can safely reduce inflammation and treat metabolic syndrome in people with chronic spinal cord injury. The study will enroll 60 adults who use wheelchairs and have obesity-related wa…

This study tests whether a daily fiber supplement (resistant starch, like Benefiber) can improve heart health markers and gut bacteria in women with polycystic ovary syndrome (PCOS). One hundred women will take either the fiber or a placebo for 12 weeks, alongside standard birth …

This study tests whether empagliflozin, a drug used for diabetes, can reduce chronic inflammation in people with obesity and metabolic syndrome. Researchers will measure immune cells and blood vessel function in 74 adults. The goal is to find a new way to lower heart disease risk…

This study tests whether breathing a special mix of low and high oxygen air (called intermittent hypoxic-hyperoxic training) can help lower blood sugar in people with type 2 diabetes. About 250 adults aged 50-74 will be split into groups receiving either a 3-day or 10-day course …

This study tests whether using a sit-stand desk at work can improve insulin sensitivity and reduce diabetes risk in 198 overweight, sedentary adults with prediabetes or other risk factors. Participants are randomly assigned to stand 2 or 3 hours per day at a sit-stand desk, or to…

This study looks at whether exercise training, the drug liraglutide, or both together can improve blood flow to the heart and muscles and help the body use insulin better in adults with metabolic syndrome. About 80 participants will be randomly assigned to one of four groups: con…

This study is testing whether a daily capsule made from fermented fruits and vegetables (Rutazyme®) can improve body fat, waist size, and blood markers in adults with obesity. Forty participants will take either the supplement or a placebo for 12 weeks. Researchers will measure c…

This study looks at how drinking whole-fat milk changes heart disease risk factors in adults with metabolic syndrome. Researchers will measure cholesterol, blood sugar, and blood vessel function in 40 participants. The goal is to see if whole-fat dairy is helpful or harmful for p…

This study is testing a fixed-dose combination of two cholesterol-lowering drugs (Pitavastatin and Ezetimibe) in 10,000 adults with high cholesterol and metabolic syndrome. Researchers will track how much LDL ('bad') cholesterol drops after 24 and 48 weeks of treatment in real-wo…

This study looks at whether treating Helicobacter pylori (Hp), a common stomach infection, can also help improve metabolic syndrome (high blood sugar, cholesterol, and weight). Researchers will give standard Hp treatment alone or with probiotics or berberine to 120 adults. They w…

This study tests whether a strict lifestyle program—eating only during an 8-hour window, walking 10,000 steps daily, and cutting 500 calories—can help obese adults with metabolic syndrome lose weight and improve heart health. After 24 weeks, participants also receive either Rybel…

This study tests a program called LIGHTER-MetS that combines health coaching with an AI-powered app to help people with metabolic syndrome eat better and lower their heart risk. About 316 adults aged 21-65 with metabolic syndrome will join. They will work with a health coach for …

This study tests whether daily consumption of special food blends—made from apple and grape by-products, prebiotic fibers, oat beta-glucans, and omega-3s—can improve blood sugar, weight, and cholesterol in 40 adults at risk for metabolic syndrome. Participants eat the foods daily…

This study tests whether a reduced-calorie Mediterranean diet plus regular exercise helps middle-aged adults (30-50 years) with metabolic syndrome lose weight and keep it off. About 106 participants will either follow this lifestyle program or receive standard care. Researchers w…

This study tests a new, non-surgical procedure called Endoscopic Radial Compression Gastroplasty (ERCG) that uses a clip-and-loop system to reduce stomach size, helping with weight loss. It is for Chinese adults aged 18-65 with a BMI of 24.0-37.4 who have not succeeded with diet …

This study looks at whether drinking cranberry juice for 12 weeks can help overweight or obese adults improve blood sugar, insulin levels, cholesterol, and gut health. About 73 participants will be randomly assigned to receive either a cranberry drink or a placebo, then switch af…

This study looks at whether limiting when you eat (to an 8- or 10-hour window each day) plus a special counseling program can improve health in people with metabolic syndrome. Researchers in Mexico will enroll 64 adults and track changes in waist size, blood pressure, blood sugar…

This study tests a nurse-led program called TOP-S that helps people with metabolic syndrome make lasting lifestyle changes. 152 Chinese adults in Hong Kong will either get the full program or brief advice. Researchers will check if the program helps reverse metabolic syndrome and…

This study tests whether limiting all eating to a consistent 10-hour window each day can improve blood sugar, cholesterol, and other health measures in people with metabolic syndrome or prediabetes. About 140 adults will either follow this eating schedule plus standard nutritiona…

This study tests whether combining transcutaneous electrical nerve stimulation (TENS) with isometric exercise can improve blood pressure in people with resistant hypertension. Resistant hypertension means blood pressure stays high despite taking three or more medications. The tri…

This study tests whether a 12-week supervised strength training program, done at different speeds, can improve kidney function and metabolic health in people who have received a kidney transplant. Twelve adults aged 18-50 with stable kidney function will be randomly assigned to o…

This study looks at whether people who take GLP-1 receptor agonists (like Ozempic or Wegovy) should continue them after having bariatric surgery. Researchers will compare weight loss, blood sugar control, gut health, and hunger in 150 adults who either keep taking the drug or sto…

This study tests whether empagliflozin, a diabetes drug, can help people with HIV who are overweight or obese lose weight and improve metabolic health. Researchers will enroll 66 adults with HIV who are on a specific antiretroviral therapy and have a BMI over 30. Participants wil…

This study tests whether watching virtual reality (VR) cycling videos can produce exercise-like benefits in 48 sedentary adults with prediabetes or high blood pressure. Participants will either do 20 minutes of real cycling or watch VR cycling, and researchers will measure change…

This study looks at three ways to lose weight—medication, surgery, or diet—to see which helps people with metabolic syndrome (a mix of diabetes, high blood pressure, and obesity) live longer and healthier. About 220 adults aged 35-65 will take part for 24 weeks. Researchers will …

This study tests whether eating only during a specific window each day (time-restricted feeding) can improve metabolic health in postmenopausal women who have metabolic syndrome or are prediabetic. Researchers will measure changes in insulin sensitivity, body weight, and blood fa…

This study tests whether a combination of intermittent fasting (16:8 method), a calorie-restricted diet, and increased physical activity can improve key health markers in adults with metabolic syndrome. Researchers in Riyadh, Saudi Arabia, will enroll 140 participants and measure…

This study is testing whether a breath test can identify metabolic syndrome and metabolically healthy obesity without needles or blood work. Researchers will analyze the air exhaled by 300 adults using a special mass spectrometry technique and teach a computer to recognize diseas…

This study is testing whether a special software that analyzes CT scans of the heart's arteries can better prevent heart attacks, strokes, and other cardiovascular events compared to usual care based on risk factors like cholesterol and blood pressure. The trial will enroll 7,500…

This study tests whether taking part in racial justice activism can prevent depression and reduce physical stress in Black and Latinx young people aged 15-20. Researchers will measure mood, stress hormones, and health markers over two years. The goal is to see if activism can be …

This study tests whether low-energy shock wave therapy, a non-invasive treatment, can improve overactive bladder symptoms in women who also have metabolic syndrome. Sixty women will receive either the real therapy or a sham procedure. Researchers will track symptom changes using …

This study looks at whether a special nutritional supplement (a mix of myo-inositol and D-chiro-inositol) can improve symptoms of Polycystic Ovary Syndrome (PCOS), like hair growth, acne, and irregular periods. Researchers will also check if it helps with metabolism, inflammation…

This study tests whether adding aerobic exercise (like walking on a treadmill) to cognitive behavioral therapy can improve erectile function in heavy drinking men who also have metabolic syndrome and impotence. Forty men will be split into two groups: one gets only talk therapy, …

This study tests whether taking nattokinase, a supplement made from fermented soybeans, can improve sleep quality, thinking skills, and heart health in people at risk for metabolic syndrome. About 80 adults will take either the supplement or a placebo for 12 weeks, then switch af…

This study tests whether a daily probiotic blend (called psychobiotics) can help ease depression and improve metabolic health in adults with pre-metabolic or metabolic syndrome. Sixty participants will take either the probiotic or a placebo for 12 weeks. Researchers will measure …

This study aims to find the best way to deliver preventive health screenings to people in underserved and rural areas. It will compare different methods, such as interactive health reports, mobile screening units, and even droid-assisted screenings, to see which improves health e…

This study looks at whether personality traits are linked to routine lab test results in 1,000 adults getting a health check-up. Participants fill out a personality questionnaire and provide blood samples. The goal is to see if certain personality types are more likely to have ab…

This observational study will enroll up to one million adults to understand how health, environment, and lifestyle affect aging and disease. Researchers will link participants' clinical data with information from public records, such as pollution and social factors, to create a d…

This study will follow 1,000,000 adults aged 18 and older for the rest of their lives. Researchers will collect health measurements and track who develops diseases, becomes frail, or dies. The goal is to find which tests best predict how well people age, so doctors can one day of…

This study looks at how the body's innate immune system responds to certain environmental exposures by measuring inflammation markers in blood. Researchers will collect blood samples from up to 725 healthy volunteers aged 18-45 to analyze how specific genes and proteins react. Th…

This study investigates how exercise affects the structure and function of fat tissue in adults aged 18-40 with obesity or metabolic syndrome. Participants are randomly assigned to either an exercise program or a sedentary control group. All undergo a 10% weight loss phase, then …

This study is recruiting 8,000 young Chinese adults with obesity (BMI 30 or higher) to investigate how genes and clinical features contribute to obesity and metabolic syndrome. Researchers aim to better understand the underlying causes, which could eventually lead to improved tre…

This study looks at two blood inflammation markers, SII and SIRI, to see if they can help predict metabolic problems like insulin resistance and fatty liver in people who are overweight or have obesity. Researchers will follow 200 adults for up to 3 years, tracking their diet, la…

This study looks at how different sources of protein (animal vs. plant, and whole foods vs. protein powders) affect blood sugar control and insulin sensitivity in people with metabolic syndrome. Researchers will measure blood sugar levels over 24 hours and use a special test to s…

This study follows 2,500 adults aged 30-75 in Puerto Rico to track chronic diseases like heart disease, diabetes, and obesity. Researchers will collect data on diet, stress, and lifestyle over two years to identify trends and risk factors. The goal is to guide public health prior…

This study looks at how fasting insulin and insulin resistance differ based on age, sex, race/ethnicity, body weight, and PCOS diagnosis. Researchers will analyze data from 150 adults to find patterns that may explain why some groups face higher metabolic risks. The goal is to be…

This study looks at what happens inside your fat tissue when you lose weight with or without exercise. 68 adults with obesity will lose 10% of their body weight through diet, with some also doing moderate exercise. Researchers will measure insulin sensitivity, fat breakdown, and …

This study follows 1,000 people who are having weight-loss (bariatric) surgery. Researchers will measure changes in weight, body fat, blood sugar, cholesterol, and other health markers before surgery and at several follow-up visits over two years. The goal is to better understand…

This study looks at how fat tissue changes when people gain weight from overeating. Researchers will ask 58 overweight adults to either maintain their weight or eat 30% more calories for a short time. By tracking fat cell growth and other changes, they hope to understand why some…

This study is looking at 100 adults with metabolic syndrome to see if those with an H. pylori infection in their stomach have worse insulin resistance (a key driver of diabetes). Researchers will compare blood tests, body measurements, and stomach inflammation between infected an…

This study aims to find early warning signs of heart failure in people with type 2 diabetes and metabolic syndrome by analyzing immune cells from a blood sample. Researchers will compare calcium and inflammation signals in these cells between patients with and without heart probl…

This study looks at whether young adults with metabolic syndrome have poorer artery function in the neck, and if a 30-minute bike ride can temporarily improve it. Researchers will compare 48 participants with and without metabolic syndrome. The goal is to understand sex differenc…

This study looks at how fat buildup in the pancreas (pancreatic steatosis) is connected to type 2 diabetes and metabolic syndrome. Researchers will use a special ultrasound technique to measure the fat and see how it relates to the cells that make insulin. The goal is to better u…

This study looks at people with a rare condition called cerebral folate deficiency, where the brain lacks enough folate. Researchers think the problem may be in the choroid plexus, a part of the brain that helps control what goes in and out of brain fluid. They will use MRI scans…

This study aims to understand how obesity and aging are connected by looking at blood markers in 650 young and older adults with or without obesity. Participants will provide blood samples and undergo imaging tests to measure biological age and fat distribution. The goal is to la…

This study looks at how moderate wine consumption changes tiny particles called extracellular vesicles, which help cells communicate. Eight healthy adults aged 35-65 will drink red wine, white wine, or water, and researchers will analyze their blood for changes in these particles…

This study is testing a new, safe imaging technique called photoacoustic imaging to look at brown adipose tissue (BAT), a type of body fat that burns energy. Researchers will compare BAT in healthy adults and people with metabolic syndrome to see if the imaging can spot differenc…

This study looks at how exercise improves blood vessel function in people with obesity. Researchers will measure oxidative stress and blood flow in the muscle before and after an 8-week interval training program. The goal is to understand the role of a specific enzyme (NADPH oxid…

This study looks at how increasing or decreasing physical activity changes the way your body works. Forty overweight adults aged 50-65 will either become less active for 3 months then retrain, or become more active for 6 months. Researchers will measure fitness, muscle strength, …

This study looks at how tiny air pollution particles and noise affect the heart and metabolism of adults aged 45-64 in Kaunas City. Researchers will test if daily walks in green spaces or following a Mediterranean diet can improve health markers. About 180 participants will wear …

This study will follow 2,000 adults with metabolic syndrome or prediabetes over time to understand how these conditions progress and lead to complications. Researchers will track health records, nutrition, and physical function to find key factors that affect long-term outcomes. …

This study looks at how different treatments for Polycystic Ovary Syndrome (PCOS) affect the heart and blood vessels. Researchers will compare four approaches: a GLP-1 receptor agonist, birth control pills, metformin, and lifestyle changes alone. They will measure changes in hear…

This study looks at whether a heart protein called BNP, measured in infancy and again in adolescence, can help identify teens at risk for metabolic syndrome—a cluster of conditions like obesity, high blood pressure, and diabetes. Researchers are following 70 teens who were part o…

This study follows 1,500 twins aged 15-44 in Poland over 5 years to learn how metabolic syndrome and related liver problems develop. Researchers will look at genetics, environment, and gut bacteria. Some twins will get an educational program to encourage healthy changes, while th…

This study follows 4,094 adults in Shanghai who were part of an earlier health survey. Researchers will track them for up to 10 years to see how heart disease, kidney problems, and metabolic conditions like diabetes and obesity develop and interact. The goal is to better understa…

This study aims to understand how fat buildup in the pancreas (pancreatic steatosis) is linked to type 2 diabetes and metabolic syndrome. Researchers will use a special ultrasound technique to measure pancreatic fat and compare it with blood sugar and other metabolic tests. 100 a…