METABOLIC SYNDROME

This study tests whether a strict diet (eating only within an 8-hour window), daily walking (10,000+ steps), and calorie cutting can help obese adults with metabolic syndrome lose weight and improve heart health. After 24 weeks, participants also receive one of two weight-loss me…

This study looks at whether treating Helicobacter pylori (Hp) infection can also help improve metabolic syndrome—a group of conditions like high blood sugar, unhealthy cholesterol, and excess belly fat. About 120 adults with both Hp infection and newly diagnosed metabolic syndrom…

This study tests whether empagliflozin, a drug used for diabetes, can reduce chronic inflammation in people with obesity and metabolic syndrome. Researchers will measure immune cells and blood vessel function in 74 adults to see if the drug helps control disease risk. The goal is…

This study is testing whether a daily capsule made from fermented fruits and vegetables (Rutazyme® lemon fermented product) can improve metabolic health in adults with obesity. Forty adults aged 18-65 with a BMI of 27 or higher will take either the active capsule or a placebo for…

This study tests a community program called LIGHTER-MetS for adults with metabolic syndrome. Participants use an AI-powered app and work with a health coach to improve eating habits, exercise, and emotional well-being. The goal is to see if this approach helps people better regul…

This study tests whether empagliflozin, a diabetes drug, can help people with HIV who are overweight or obese lose weight and improve their metabolism. About 66 adults with HIV on a specific antiretroviral therapy will receive either the drug or a placebo for 6 months. The main g…

This study tests a personalized, person-centered lifestyle program for 152 Chinese adults with metabolic syndrome. Participants will either receive the tailored program or standard brief advice. The goal is to see if the program can help reverse metabolic syndrome and improve hea…

This study tests whether a dietary supplement called resistant starch can improve heart health and gut bacteria in women with polycystic ovary syndrome (PCOS). About 100 women will take either resistant starch or a placebo for 12 weeks, alongside standard birth control pills. The…

This study looks at whether exercise, a drug called liraglutide, or both can improve blood flow to the heart and muscles and help the body use insulin better in adults with metabolic syndrome. About 80 people aged 21 to 60 will be placed into one of four groups: control, exercise…

This study tests whether breathing a special mix of low and high oxygen air (called IHHT) for 3 or 10 days can help control blood sugar in people with type 2 diabetes, including older adults. About 250 participants aged 50-74 will be randomly assigned to short or long treatment o…

This study looks at whether the speed of resistance exercises (like squats and bench presses) affects kidney function and metabolic health in people who have had a kidney transplant. About 12 adults, aged 18-50 and at least one year post-transplant, will do a 12-week training pro…

This study tests whether combining intermittent fasting, calorie restriction, and increased physical activity can improve key health markers in adults with metabolic syndrome. Researchers in Riyadh will enroll 140 participants to measure changes in blood sugar, cholesterol, blood…

This study looks at whether drinking cranberry juice can help improve blood sugar, insulin levels, and gut health in people who are overweight or have early signs of metabolic problems. About 73 adults will drink either a cranberry beverage or a placebo for 12 weeks, then switch …

This study looks at whether limiting when you eat (time-restricted eating) can help people with metabolic syndrome—a group of conditions like belly fat, high blood pressure, and high blood sugar. Researchers will test if adding a program that addresses eating habits, sleep, and s…

This study looks at whether continuing GLP-1 medications (like Ozempic or Wegovy) after bariatric surgery helps people lose more weight and control blood sugar better than stopping them. About 150 adults with severe obesity, some with diabetes, will be randomly assigned to keep o…

This study tests a new, non-surgical stomach procedure called Endoscopic Radial Compression Gastroplasty (ERCG) combined with lifestyle changes for weight loss in Chinese adults who are overweight or have mild-to-moderate obesity. About 216 participants will be randomly assigned …

This study tests whether a program combining a reduced-calorie Mediterranean diet with increased physical activity can help middle-aged adults (30-50 years old) with metabolic syndrome lose weight and maintain that loss for a year. Researchers will compare this lifestyle interven…

This study looks at whether time-restricted eating (eating all meals within a set daily window) can improve health markers like blood sugar and cholesterol in people with metabolic syndrome or pre-diabetes. About 140 adults who typically eat over 12 hours a day will be randomly a…

This study looks at how tiny air pollution particles and noise affect heart health in people aged 45-64 living in Kaunas City. It also tests if daily walks in green spaces or following a Mediterranean diet can improve health markers. About 180 participants will wear a wristband s…

This study compares three weight loss approaches—medication, surgery, and diet—to see which helps people with metabolic syndrome (obesity, diabetes, and high blood pressure) live longer and healthier. Researchers will track 220 adults aged 35-65 for 24 weeks, measuring weight, bl…

This study explores whether analyzing the chemicals in your breath can help doctors identify metabolic syndrome and metabolically healthy obesity without blood draws or invasive tests. Researchers will collect breath samples from 300 adults and use machine learning to find unique…

This study tests whether using a detailed heart scan (Cleerly CAD Staging) to guide treatment can prevent heart attacks, strokes, and other heart-related events better than the usual approach of managing risk factors like cholesterol and blood pressure. The trial will include 7,5…

This study is testing whether daily consumption of foods made with antioxidants, prebiotic fibers, and oat beta-glucans can improve health in 40 adults at risk for metabolic syndrome. Participants will eat these functional foods and attend clinic visits for blood tests and body m…

This study looks at whether using a sit-stand desk at work can help prevent type 2 diabetes in people who are overweight and sit most of the day. About 198 adults with prediabetes or other risk factors will be randomly assigned to stand 2 or 3 hours daily at their desk, or to a c…

This study tests whether taking part in racial justice activism can prevent depression and reduce physical stress in Black and Latinx youth aged 15-20. Researchers will measure mood, stress hormones, and health markers in 300 participants over two years. The goal is to see if act…

This study is testing whether a nutritional supplement containing inositol can improve symptoms of Polycystic Ovary Syndrome (PCOS), such as hair growth, acne, and irregular periods. Researchers will also check if it helps with metabolism, inflammation, and quality of life. The s…

This study looks at whether taking nattokinase, a natural enzyme from fermented soy, can help people with early signs of metabolic syndrome and poor sleep. About 80 adults will take either nattokinase or a placebo for 12 weeks, then switch. Researchers will check sleep quality, t…

This study tests whether limiting eating to a specific window each day can improve insulin sensitivity, weight, and other metabolic measures in postmenopausal women with metabolic syndrome. About 164 women aged 45-65 who are prediabetic or have at least two features of metabolic …

This study looks at whether adding aerobic exercise to cognitive behavioral therapy (talk therapy) can improve outcomes for heavy drinking men who also have impotence and metabolic syndrome. Researchers will measure erectile function, body mass index, waist size, and blood pressu…

This study tests whether adding transcutaneous electrical nerve stimulation (TENS) and isometric exercise to standard medication can improve blood pressure in people with resistant hypertension. Researchers will compare two groups of 25 adults aged 50-60: one doing TENS plus exer…

This study tests a non-invasive treatment called low-energy shock wave therapy for women with overactive bladder and metabolic syndrome. About 60 women will receive either real or sham treatment to see if it safely reduces urgency, frequent urination, and nighttime bathroom trips…

This study tests whether a time-saving, joint-friendly muscle stimulation technology (whole-body electromyostimulation) can lower resting blood pressure and improve other heart-related risk factors in people with mild high blood pressure and overweight. Researchers will compare t…

This study looks at how fasting insulin and insulin resistance (HOMA-IR) differ based on age, sex, race/ethnicity, body mass index (BMI), and whether someone has polycystic ovary syndrome (PCOS). Researchers will analyze data from 150 adults who recently had metabolic blood tests…

This study follows 1,500 twins aged 15 to 44 over five years to learn how metabolic syndrome and related conditions like fatty liver disease, heart problems, and diabetes start and progress. Researchers will track changes in the liver and other organs, and look at how genes, envi…

This study will follow 200 adults with overweight or obesity for up to 3 years to see if two blood inflammation markers (SII and SIRI) can predict metabolic problems like insulin resistance and fatty liver, and how well people respond to weight-loss treatments. Participants will …

This study is testing a new, radiation-free imaging technique called photoacoustic imaging to look at brown adipose tissue (brown fat), which helps burn energy. Researchers will compare brown fat activity in 100 healthy adults and people with metabolic syndrome, both at rest and …

This study looks at how being active or inactive changes your body's functions, like fitness, muscle strength, and brain health. Researchers will ask 40 adults aged 50-65 to either increase or decrease their physical activity for several months. The goal is to understand how acti…

This study is following 1,000 people who are having weight-loss (bariatric) surgery to see how their bodies change over two years. Researchers will measure weight, body fat, blood sugar, cholesterol, and other health markers before surgery and at several follow-up visits. The goa…

This study is following 2,500 adults aged 30-75 in Puerto Rico to learn how stress, diet, and where they live affect chronic diseases like heart disease, diabetes, and obesity. Researchers will collect health data and survey participants over two years, including before and after…

This study aims to understand how obesity and aging are connected by looking at blood-based aging markers in 650 adults. Participants include young (18-35) and older (60+) people who are either lean or overweight. The goal is to find clues that could lead to future treatments or …

This study looks at whether a protein called BNP, measured in babies and again in teenagers, can help identify teens at risk for metabolic syndrome (a cluster of conditions like obesity, high blood pressure, and diabetes). Researchers will follow 70 adolescents who were part of a…

This study looks at how one serving of red or white wine changes tiny particles called extracellular vesicles in the blood. These particles help cells talk to each other and may influence heart and brain health. Researchers will compare blood samples from 8 healthy adults before …

This study is looking at whether an infection with H. pylori bacteria in the stomach is linked to more severe insulin resistance in people with metabolic syndrome. Researchers will compare 50 people with the infection to 50 without it, measuring blood sugar control, inflammation,…

This study aims to find early warning signs of heart failure in people with type 2 diabetes and metabolic syndrome. Researchers will analyze blood cells from 175 participants to see if certain signals can predict heart problems before they become serious. The goal is to improve d…

This study looks at 8,000 obese young adults in China to find out how genes and other factors contribute to obesity and related health problems like metabolic syndrome. Participants must have a BMI of 30 or higher and be from eastern China. The goal is to learn more about the cau…

This study is for women with PCOS to see how the condition affects their heart and blood vessels. Researchers will measure changes in heart function after a sugar drink and after 6 months of different treatments. The goal is to find out which treatment best protects heart health …

This study follows 10,000 adults aged 18 and older for life to see if simple health measurements can predict how long and how well people age. Researchers will track deaths, diseases, and disabilities to find early warning signs. No treatments or drugs are tested—just observation…

This study looks at whether metabolic syndrome (a cluster of conditions like high blood pressure and belly fat) harms artery function differently in young men and women. Researchers will also test if a 30-minute bike ride can temporarily improve artery health. 48 adults with and …

This study looks at how fat tissue grows and changes when people gain weight over a short period. Researchers want to understand why some people develop health problems like metabolic syndrome or diabetes when they gain weight, while others do not. About 58 overweight adults will…

This study will follow 2,000 adults with metabolic syndrome or prediabetes for many years. Researchers will track their health, nutrition, and physical function to learn how these conditions progress and lead to complications. The goal is to find key factors that affect long-term…

This study looks at how different types of protein (animal vs. plant, whole foods vs. protein powders) affect blood sugar and insulin sensitivity in adults with metabolic syndrome. Researchers will measure how the body handles sugar over 24 hours and after meals. The goal is to u…

This study follows about 4,000 adults from Shanghai communities to see how heart, kidney, and metabolic diseases develop over time. Researchers will compare current health data with information collected between 2016 and 2017. The goal is to understand how risk factors change and…

This study looks at people with a rare brain condition called cerebral folate deficiency, where the brain lacks enough folate. Researchers want to find out if the problem is caused by a part of the brain called the choroid plexus not working properly. They will use brain scans an…

This study explores whether watching virtual reality (VR) scenes that simulate exercise can produce health benefits similar to actual physical activity. Researchers will test this on 48 sedentary adults with prediabetes, measuring changes in blood sugar, blood pressure, and walki…

This study looks at how adding exercise to a weight loss plan changes belly fat and metabolism in ways that may keep you healthier even if you regain some weight. Researchers will compare two groups of adults with obesity: one that loses weight through diet and exercise, and anot…

This study looks at how drinking whole-fat milk changes heart and metabolic risk factors in 40 adults with metabolic syndrome. Participants will have blood tests and artery function checks. The goal is to see if dairy can improve cholesterol, blood sugar, and blood vessel health.

This study looks at how the immune system's first response (innate immunity) reacts to certain environmental triggers. Researchers want to understand if these reactions are linked to long-term illnesses like asthma, heart disease, and cancer. Healthy volunteers aged 18 to 45 will…