METABOLIC SYNDROME

This study tests whether spermidine, a natural substance found in foods like soy and aged cheese, can improve heart and muscle health in elderly people with coronary artery disease. 180 participants aged 65 and older will receive either spermidine capsules or a placebo for a peri…

This completed pilot study tested whether transferring gut bacteria from lean donors or from people who had gastric bypass surgery could improve metabolism in 29 obese adults with prediabetes or diabetes. Participants received fecal transplants, and researchers measured changes i…

This study tested whether bars made with polyunsaturated fatty acids could improve cholesterol and fat levels in people with metabolic syndrome. 60 adults aged 40-65 with high BMI and abnormal cholesterol took part. The goal was to see if these bars could help control dyslipidemi…

This study looked at whether a 16-week strength training program can prevent or reduce late effects like muscle loss, heart disease, and diabetes in adults who had a bone marrow transplant as children. 28 survivors and a matched control group participated. The goal was to see if …

This study tested whether eating a fermented pea-and-legume product for three weeks could improve gut health and reduce inflammation in people with metabolic syndrome. 56 adults with a large waist and at least one other risk factor (like high blood sugar or cholesterol) took part…

This study looked at whether eating only during a 10-hour window each day and doing high-intensity interval training three times a week can improve health in people with metabolic syndrome. Two hundred adults took part for 16 weeks. Researchers measured changes in metabolic syndr…

This study tested whether taking phytosterols (plant-based supplements) for 3 months can improve liver health, cholesterol, and insulin levels in people with nonalcoholic fatty liver disease (NAFLD). 27 participants took either phytosterol pills or a placebo. Researchers measured…

This study looked at 60 men with metabolic syndrome who also had erectile dysfunction and early signs of heart stiffness. Researchers compared three treatments: tadalafil (a common ED drug), an SGLT2 inhibitor (a diabetes drug), and a combination of both, given for three months. …

This study looked at 781 adults with moderate-to-severe plaque psoriasis and metabolic syndrome (a cluster of conditions like high blood pressure and obesity). Researchers wanted to see if adding a lifestyle intervention (diet and exercise) to the drug Secukinumab (Cosentyx) impr…

This study looked at whether a program of physical exercise combined with a daily supplement of leucine and arginine could help obese adults with metabolic syndrome lose body fat and improve their health. About 79 participants took part. The goal was to see if this approach could…

This study looked at whether omega-3 supplements from plants can improve blood vessel function in people with high blood pressure and metabolic syndrome. About 95 adults with treated hypertension and at least two signs of metabolic syndrome took part. Researchers measured artery …

This study tested a 'digi-physical' approach for families with children or teens living with obesity. Participants either received standard in-person care or a mix of digital tools (an app for tracking health and chatting with caregivers) plus fewer in-person visits. The goal was…

This study looked at 192 women with PCOS to see which treatment works best for improving insulin resistance and other symptoms. Participants were randomly assigned to take metformin, inositol, follow a calorie-restricted diet, or combine all three for 12 weeks. The goal was to fi…

This study tested whether the drug vericiguat can improve the function of small blood vessels in the heart for people with metabolic syndrome (a cluster of conditions like high blood pressure and belly fat). 45 adults took either vericiguat or a placebo for 6 weeks. Researchers u…

This study tested whether a special fiber supplement, combined with a healthy Mediterranean diet and lifestyle changes, could improve gut bacteria and metabolic health in children with obesity. 36 children aged 8-14 took part for 8 months. The goal was to see if this approach cou…

This study tested whether a structured, intensive lifestyle program could help overweight or obese people with metabolic syndrome achieve remission. 68 participants followed a program aiming for 15% weight loss. The goal was to see if this approach could reduce the number of meta…

This study tested a black seed extract (Nisatol®) in 50 perimenopausal women with metabolic syndrome, a cluster of conditions like high blood sugar and blood pressure. Over 4 months, researchers measured changes in blood sugar, cholesterol, blood pressure, and menopausal symptoms…

This study looked at whether drinking hydrogen-rich water every day for 12 weeks can improve body composition and metabolic health in adults with metabolic syndrome. 40 adults participated, and researchers measured changes in waist size, body fat, blood sugar, and cholesterol. Th…

This study tested whether a home exercise program using electrical stimulation to move the legs, combined with a personalized diet, could improve body composition and metabolism in adults with spinal cord injury. Twenty-six participants were assigned to either exercise plus diet …

This study tested whether taking green tea extract for one month could improve gut health and reduce inflammation in people with metabolic syndrome and in healthy adults. Participants took either the extract or a placebo for a month, then switched. The study measured markers of i…

This study tested whether providing medically tailored meals, with or without weekly group support sessions, helps Black adults with high blood pressure, type 2 diabetes, obesity, or metabolic syndrome improve their health. 75 participants received either meals alone, meals plus …

This study looked at whether a natural part of milk fat called milk fat globule membrane (MFGM) can lower harmful gut bacteria products in the blood and improve health markers in adults with metabolic syndrome. Thirty people with metabolic syndrome followed a controlled diet with…

This pilot study tested whether metformin, a common diabetes drug, can reduce blood vessel damage in the brain of people living with HIV who also have metabolic syndrome (a cluster of conditions like high blood pressure and cholesterol). The study enrolled 30 adults in South Afri…

This study tested whether taking moringa leaf powder capsules for 8 weeks could improve metabolic syndrome in Mexican adults. 36 participants were randomly assigned to receive either moringa or a placebo. Researchers measured changes in weight, blood pressure, waist size, and blo…

This completed study tested whether eplerenone, a drug that blocks a hormone called aldosterone, improves blood flow and reduces scarring in the heart more than another drug, chlorthalidone, in 79 people with obesity and high blood pressure. Participants took one of the two drugs…

This study looked at whether combining exercise with the diabetes drug metformin improves blood vessel function in adults with metabolic syndrome. 91 participants were assigned to different exercise intensities with or without metformin for 16 weeks. The goal was to see if the co…

This study looked at whether eating canola oil every day for 12 weeks can improve cholesterol, blood vessel function, and other risk factors in people with metabolic syndrome. Eighty adults with the condition were randomly assigned to consume either canola oil or a typical Wester…

This study tested a 12-week program combining exercise (stretching, resistance, and aerobic) with personalized nutrition and high-protein drinks in 168 older adults with sarcopenia and metabolic syndrome. The goal was to improve muscle strength, walking speed, and overall physica…

This study looked at whether drinking a strawberry beverage every day for four weeks could improve cholesterol, blood sugar, and other heart health markers in overweight or obese adults. Forty-eight participants with borderline-high cholesterol and normal to slightly elevated blo…

This study tested a 12-week program combining exercise (stretching, resistance, and aerobic) with personalized nutrition (including high-protein drinks) in 80 older adults aged 65-90 who have sarcopenia (muscle loss) and metabolic syndrome. The goal was to see if the program impr…

This study tested a 12-week diet and lifestyle program called the SWW Method in 85 women aged 35-75. The program included intermittent fasting, a high-protein diet, and other healthy habits. Researchers measured changes in blood sugar, weight, and other markers to see if it could…

This study tested whether a low-salt, heart-healthy diet (DASH diet) can prevent heart failure in veterans with high blood pressure and metabolic syndrome. 71 veterans received counseling and some also got tailored messages via smartphone or email. The goal was to see if the diet…

This study looked at whether taking Korean ginseng extract daily for eight weeks could reduce fatigue and improve exercise performance in healthy adults aged 20 to 50. Sixty participants were randomly assigned to receive either the ginseng extract or a placebo. The researchers me…

This study tested whether the sleep medication suvorexant (Belsomra) can reduce insomnia severity and improve metabolic health in midlife women who have both insomnia and signs of metabolic syndrome. Thirty-one healthy women aged 40-65 who were perimenopausal or postmenopausal to…

This study tested whether a special turmeric supplement (MERIVA®) could improve memory and thinking in older adults with metabolic syndrome. 85 people took either the supplement or a placebo for 6 months. Researchers measured changes in cognitive tests to see if turmeric helped p…

This study tested whether drinking VitalPLANT and Helichrysum italicum teas for one week could improve signs of metabolic syndrome in 30 overweight adults. Participants had at least two components of metabolic syndrome and were not taking any related medications. Researchers meas…

This study tested two types of time-restricted eating in 103 overweight adults with metabolic syndrome. One group ate all their food within an early 8-hour window, the other within a late 8-hour window. Researchers measured changes in body weight and belly fat to see which timing…

This study looked at how people with and without non-alcoholic fatty liver disease (NAFLD) process food. Researchers monitored 53 adults over two days, measuring metabolism, blood, and urine after meals. The goal was to find differences that might explain why fat builds up in the…

This study looks at how eating organically or conventionally grown fruits and vegetables affects the bacteria in your gut and your overall health. Researchers will compare two groups: healthy adults and those with metabolic syndrome (a condition linked to obesity and high blood s…

This study looked at health records from over 5,000 adults to see if having an H. pylori stomach infection is linked to metabolic syndrome—a cluster of conditions like high blood sugar, high blood pressure, and excess belly fat. Researchers compared people with and without the in…

This study looked at 88 women newly diagnosed with primary hypothyroidism (underactive thyroid) to see if taking levothyroxine to normalize thyroid hormones also improves metabolic health. Researchers measured special proteins called adipokines, which are linked to fat tissue and…

This study checks if a program called COPE helps Navajo people with diabetes and related health problems. The program uses community health workers to support patients and connect them with doctors. Researchers compared nearly 29,000 people who took part in COPE with those who di…

This completed pilot study in Yomitan Village, Okinawa tested three simple, low-cost approaches to reduce stress and encourage healthy habits in 45 adults with overweight or pre-metabolic syndrome. Participants were randomly assigned to receive health leaflets, wear functional cl…

This study looked at 90 children and teens (ages 7-18) taking antipsychotic medication to see how it affects their hormones, growth, and metabolism. Researchers measured prolactin levels and checked for links to sex hormones, metabolic health, and puberty development. The goal wa…

This study looked at two easy methods to measure hidden belly fat in 110 adults with type 2 diabetes. Researchers compared a simple waist measurement to a device that sends a mild electrical signal through the body. The goal was to see which method better relates to heart disease…

This small pilot study looked at whether combining walking with mindful attention is a practical and acceptable way to help people with metabolic syndrome become more active. 34 participants were assigned to a walking program, a mindfulness program, both, or neither. The goal was…

This study looked at whether a special drink called ketone ester can improve brain energy use and thinking skills in healthy adults aged 55 and older who have metabolic syndrome. Participants took the drink or a placebo for 28 days and had brain scans and memory tests. The goal w…

This study looked at 470 adults aged 18-75 with type 2 diabetes and metabolic syndrome to identify their Traditional Chinese Medicine (TCM) patterns. Researchers used a standard questionnaire and four TCM diagnostic methods to classify each person's syndrome. The goal was to bett…

This study looked at how two different nutritionally balanced diets affect insulin levels and other markers of metabolic health in 52 adults who are overweight or at risk for diabetes. Participants followed each diet while maintaining their weight, and researchers measured change…

This study tested whether a genetic score could predict how well adults with metabolic syndrome respond to a calorie-cutting diet. 115 Mexican adults followed a reduced-calorie diet for a period, and researchers measured changes in waist size, blood sugar, cholesterol, and blood …

This study followed 42 adults with spinal cord injury for one year after leaving rehab. Researchers tracked what they ate, how active they were, and their mood to understand why weight gain happens. The goal is to use this information to design better programs that help people wi…

This study looked at whether a 12-month lifestyle program could lower body fat and change certain gene markers in 26 adults with metabolic syndrome. Participants tracked their food and activity using a mobile app, and had blood tests and body scans at the start and end. The goal …

This study looked at how daily rhythms—like sleep and meal timing—affect fat cell genes and insulin response in 28 women with obesity scheduled for bariatric surgery. Researchers used timed lights and meals to align or disrupt the body's internal clock, then measured changes in f…

This study examined the relationship between metabolic syndrome and vitamin D levels in 549 older adults (65+). Researchers collected health questionnaires and blood samples to understand how these factors are connected. The goal was to gather knowledge, not to test a treatment.

This study looked at 320 people with HIV in Chile to understand why they often develop health problems like heart disease and diabetes, even when their HIV is controlled with medication. Researchers collected blood samples and used advanced techniques to measure inflammation and …

This study tested whether a special type of MRI (multiparametric MRI) can reliably measure kidney function in people with metabolic syndrome—a cluster of conditions like obesity, high blood pressure, and high blood sugar. Researchers compared MRI results between 46 healthy volunt…

This study followed 215 people newly diagnosed with HIV in Hong Kong to see how often they developed non-AIDS conditions like high blood pressure, diabetes, bone thinning, and kidney problems. Participants were on different anti-retroviral regimens, and researchers compared the r…

This study looked at 514 people with stable coronary artery disease to see if how their body processes fat after a meal (triglyceride tolerance) is linked to future heart attacks or death. Researchers also checked blood sugar tolerance. The goal was to find a better way to identi…

This study examined whether having metabolic syndrome (a cluster of conditions like high blood pressure and diabetes) changes how well a steroid injection works for people with chronic back pain from a herniated disc. Researchers treated 51 adults who had not improved with other …

This completed study looked at 332 adults with obesity to see if simple body measurements and blood tests could predict metabolic syndrome, a cluster of conditions that raise heart disease and diabetes risk. Participants were grouped by obesity severity, and researchers calculate…

This study looked at whether a blood marker called PTX3 can predict how well people do after gastric bypass surgery. Researchers followed 23 patients for 6 months after surgery, measuring weight loss, insulin resistance, and inflammation. The goal was to see if PTX3 levels before…

This small pilot study looked at whether people with major depression who eat a lot of ultra-processed foods could cut back on them. Twenty adults tried a personalized plan to reduce these foods. The goal was to see if it was possible and acceptable, not to measure mood changes. …

This study looked at how drinking orange juice compared to a sugar-sweetened beverage affects risk factors for heart disease and type 2 diabetes. Fifty-six adults drank either orange juice or a sugary drink for four weeks. Researchers measured changes in cholesterol, blood sugar,…

This study tested whether a personalized lifestyle program could be run in a family medicine clinic for people with insulin resistance and related conditions like obesity, diabetes, and high blood pressure. Forty participants were randomly assigned to start with either nutrition …

This completed study followed 1,100 adults with shoulder pain for up to five years to see how metabolic syndrome (a cluster of conditions like high blood pressure and diabetes) affects recovery. Participants received standard treatments like physiotherapy, injections, or surgery.…

This completed study looked at 357 healthy adults aged 35-65 to understand how excess belly fat relates to the buildup of fatty plaque in arteries, a key cause of heart attacks. Using MRI and CT scans, researchers measured abdominal fat and artery wall thickness. The goal was to …

This study looks at whether the body's ability to switch between burning fat and sugar (called metabolic flexibility) is linked to changes in metabolic health over 16 years. Researchers will re-examine 18 people who had their metabolic flexibility measured in 2008-2009. They will…

This completed study in Cameroon followed 406 adults with and without type 2 diabetes for one year. Researchers tested blood and stool samples at four time points to see if diabetes increases the risk of malaria and other parasitic infections. The goal is to understand how non-co…