Can a tailored diet and exercise program help with insulin resistance? small study tests feasibility

NCT ID NCT04392284

Completed Knowledge-focused Sponsor: University of Alabama at Birmingham Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether a personalized lifestyle program could be run in a family medicine clinic for people with insulin resistance and related conditions like obesity, diabetes, and high blood pressure. Forty participants were randomly assigned to start with either nutrition counseling or exercise counseling. After 8 weeks, those who did not improve were given additional options, like weight-loss counseling or a prescription for metformin. The main goal was to see if such a program is feasible and acceptable to patients, not to prove it works.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: diet counseling and exercise counseling
What this could lead to: If successful, this could lead to a practical, adaptable lifestyle program that doctors can use in family medicine clinics to help patients improve insulin resistance and metabolic health.
What could go wrong: This is a very small, early feasibility study with only 40 participants. It is not designed to prove the program works, only to see if it can be done. Results may not apply to everyone.

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Conditions

The condition(s) this trial relates to.

abdominal obesity-metabolic syndrome diabetes mellitus Dyslipidemias hyperlipidemia hypertensive disorder inherited lipid metabolism disorder Insulin Resistance metabolic dysfunction-associated steatotic liver disease metabolic syndrome X Obesity obesity disorder prediabetes syndrome type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIABETES DYSLIPIDEMIAS HYPERTENSION INSULIN RESISTANCE METABOLIC SYNDROME OBESITY

Contacts and locations

Locations

UAB Highlands Family and Community Medicine Clinic

Birmingham, Alabama, 35205, United States

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