DIABETES

This study compares the iLet Bionic Pancreas, an automated insulin delivery system, to usual care for adults with type 1 or type 2 diabetes who use insulin. About 240 participants will use the device or continue their routine care for 13 weeks to see if it improves blood sugar co…

This study compares three types of weight-loss surgery to the best medical care for helping people with type 2 diabetes achieve long-term remission. About 408 severely obese adults with diabetes will be followed to see which approach works best for controlling blood sugar and imp…

This study is testing a smartphone app designed to help adults aged 55 and older who have multiple chronic conditions like heart failure, diabetes, and kidney disease. The app provides fall prevention tips, a personalized after-hospital care plan, and tools to track symptoms and …

This study is testing how well the Omnipod 5, an automated insulin delivery system, works in real-world conditions for people with type 1 diabetes. About 304 participants aged 2 and older will use the system for the first time. Researchers will measure blood sugar control, qualit…

This study tests a diabetes program called Together Overcoming Diabetes (TOD) that is designed specifically for Lakota communities. It includes 140 adults with type 2 diabetes who are also caregivers to a young person aged 10-25. The program focuses on cultural factors and social…

This study looks at whether adding extra support from a pharmacist or a community health worker helps adults with type 2 diabetes better manage their blood sugar and medications. About 376 adults with uncontrolled diabetes will be placed into one of four groups: usual care, pharm…

This study tests a program that helps adults with uncontrolled high blood pressure plus diabetes or kidney disease. Participants use a home blood pressure monitor that sends readings to a care team, including a community health worker and a pharmacist. The goal is to see if this …

This study looks at whether wearing a continuous glucose monitor (CGM) for two weeks after leaving the hospital helps people with diabetes who are starting insulin for the first time. About 150 adults with type 1 or type 2 diabetes will be randomly assigned to use either a CGM or…

This study aims to help people with diabetes living in rural Kentucky by connecting them with community resources for needs like food, housing, and transportation. About 12,000 adults with diabetes will take part. The goal is to see if this approach improves health and well-being…

This study looks at how well the Omnipod 5 automated insulin delivery system works in daily life for people with type 1 diabetes. About 152 participants aged 2 and older will use the system for the first time. The goal is to see if it helps keep blood sugar in a healthy range and…

This study tests a program to improve telehealth access for 600 low-income adults with diabetes or high blood pressure. Participants will get digital health coaching and clinic support. The goal is to see if this helps lower blood sugar levels and increase use of online patient p…

This study is testing whether giving free fresh food boxes and nutrition education to 400 adults with diabetes or prediabetes can improve their diet, reduce food insecurity, and help control blood sugar levels. Participants receive food boxes twice a month for six months. The goa…

This pilot study gives free produce boxes to 20 Veterans with kidney disease who also struggle to get enough healthy food. Researchers will check if the boxes help lower blood pressure and improve kidney function. They will also interview participants to learn about their experie…

This study compares three different programs to help pregnant women maintain a healthy weight and avoid keeping on too much weight after giving birth. About 795 women who are early in pregnancy will join one of two special programs or receive standard care. The programs provide n…

This study tests whether a church-based program led by community health workers can help Black adults in New Orleans lower their risk of heart disease, high blood pressure, diabetes, and high cholesterol. About 800 participants aged 40 and older with at least three heart risk fac…

This study tests whether a program led by community health workers can help migrant farmworker women ages 18-45 reduce stress, feel less isolated, and improve heart health. Participants will either receive peer support and help finding community resources, or just basic health in…

This study tests a pharmacy-led program to help low-income patients with multiple chronic conditions take their medications correctly after leaving the hospital. The program provides free medications, bedside delivery, and health coaches to address common barriers like cost and t…

This study tests a new automated ultrasound system (EchoMark/EchoSure) to see if it can help arteriovenous fistulas mature faster in people with end-stage kidney disease and diabetes. About 304 adults will be randomly assigned to get biweekly automated scans or standard care. The…

This study tests whether a minimally invasive stomach-shrinking procedure (endoscopic sleeve gastroplasty) combined with lifestyle changes is better than lifestyle changes alone for treating a serious liver condition called MASH in people with obesity. The procedure reduces stoma…

This study tests whether a daily tablet (semaglutide) can safely control high blood sugar in people who recently had a kidney transplant. About 104 participants will receive either the tablet or a placebo for 14 weeks, alongside their usual care. The goal is to see if the tablet …

This study tests whether adding empagliflozin or semaglutide to insulin helps overweight adults with type 1 diabetes achieve better blood sugar control. About 105 participants will take one of these drugs for 3 months. The goal is to lower HbA1c without causing dangerous low bloo…

This study tests a program called Inspire HER, designed to help Black women improve their heart health through education, physical activity, and social support. Researchers will enroll 90 Black women aged 30-79 with heart, kidney, or metabolic conditions in the Birmingham, AL are…

This study looks at whether whole milk or nonfat milk is better for body composition and heart health in children ages 9 to 12 who have a higher BMI. Researchers will measure body fat, lean muscle, and other health markers over one year. The goal is to help guide healthy milk cho…

This study tests a new insulin called GZR4 against another insulin, Icodec, in 300 adults with type 2 diabetes who already use basal insulin. The goal is to see which one better controls blood sugar and has fewer side effects. Participants may also take other diabetes pills durin…

This study looks at whether continuous glucose monitors (CGMs) can help people with type 2 diabetes who are uninsured or on Medicaid better manage their blood sugar. About 50 adults who take daily insulin will either use a CGM or standard finger-stick testing for 6 months. Resear…

This pilot study explores whether eating Greek bottarga (grey mullet fish roe) daily can improve markers of metabolic health in adults with prediabetes, diabetes, high cholesterol, or obesity. Twenty participants will compare the effects of bottarga versus a calorie-matched dairy…

This study gives free continuous glucose monitors (CGMs) to 17 adults with poorly controlled type 2 diabetes. Researchers want to see if easier access to real-time blood sugar data helps lower A1c levels and improves quality of life. Participants wear the sensor for 14-day period…

This study tests whether a mobile health app that gives personalized, real-time tips can help older adults with diabetes better manage their condition. Researchers will enroll 184 people aged 60+ who already use a government health app. Participants will use the app to track bloo…

This study looks at whether adding occupational therapy and dietitian services to home-delivered meals can reduce fall risk in older adults who have trouble leaving home. About 750 people aged 60 and older will receive either meals alone, meals with dietitian support, meals with …

This early-phase trial tests whether transplanting insulin-producing cells into the front chamber of the eye can help control diabetes. Two participants with severe vision loss in one eye will receive the cells through a small incision, along with immunosuppressive eye drops to p…

This study compares a self-administered oral glucose tolerance test (OGTT) at home using a continuous glucose monitor (CGM) with the standard clinic-based OGTT. 75 adults with prediabetes will do both tests to see if the home version is accurate and practical. The goal is to make…

This study tests an AI software called iPredict-DR that analyzes eye photos to detect diabetic retinopathy, a leading cause of blindness, at an early stage. About 922 adults with diabetes will have their eyes photographed in primary care clinics, and the AI's accuracy will be com…

This study aims to find the most effective way to screen for diabetes in people who take glucocorticoids (steroids) for more than three months. Steroids can raise blood sugar and cause diabetes, but current screening methods vary. Researchers will compare three tests—fasting bloo…

This study tests whether a wearable breath sensor can detect high or low blood sugar in teens with type 1 diabetes. Thirty participants aged 12-19 will wear the device for 72 hours and provide breath samples while checking their blood sugar. The goal is to find a painless, noninv…

This study is testing a new device that uses a special light (Raman spectroscopy) to measure blood sugar without needing a finger prick. About 49 people with diabetes and healthy volunteers will have their blood sugar checked by both the new light-based method and the traditional…

This study tests two lifestyle programs in 400 older African American and non-Hispanic white adults who are at risk for dementia and diabetes. One program focuses on aerobic exercise, the other on a healthy diet called the MIND diet. The goal is to see if these programs can impro…

This study looks at how common thinking problems are in people aged 65+ with type 2 diabetes. It then tests a program that combines healthy habits, exercise, and mental activities to see if it can prevent or slow down memory and thinking decline. About 420 participants will be fo…

This study tests a family-oriented program to help Black families in Southwest Georgia lower their risk of type 2 diabetes. Parents with prediabetes and their children aged 8-15 will take part in healthy lifestyle activities over 20 months. The goal is to see if parents can lose …

This study tests whether a special adhesive patch (COVER PATCH) can help keep continuous glucose monitors (CGMs) attached to the skin for their full recommended wear time. About 194 people with type 1 or type 2 diabetes, aged 6 and older, will either use the patch or not for 4 mo…

This study tests a program called enCompass Humana, designed to support family caregivers of people with both cancer and diabetes. The program offers coaching and help finding resources to reduce stress and improve coping skills. About 162 caregivers will take part to see if the …

This study is testing whether a special type of talk therapy, delivered over video, can help young adults with type 1 diabetes who also struggle with anxiety or depression. The therapy includes reviewing blood sugar data from a continuous glucose monitor. Researchers will measure…

This study tests a new smart bandage called exciflex that delivers gentle electrical therapy to help heal chronic wounds that won't close on their own. The study involves 16 veterans with diabetes or spinal cord injury who have wounds on their lower legs. The bandage is designed …

This early-phase study tests whether a weight-loss drug called tirzepatide can help overweight or obese men with intermediate-risk prostate cancer lose weight before their prostate removal surgery. The goal is to see if the program is safe and feasible. About 30 men will take par…

This study tests a group counseling program combined with peer support to help adults with obesity, skin disease, cancer, HIV, diabetes, or chronic pain reduce the internal shame and worry caused by health-related stigma. Researchers want to see if this approach improves quality …

This study uses a special PET-MR scan to measure a protein called HDAC in the heart. Researchers will compare HDAC levels in people with aortic stenosis or diabetes to those in healthy volunteers. The goal is to better understand how HDAC relates to heart disease. About 96 partic…

This study looks at whether adding routine physical health checkups to mental health care helps find hidden diseases like diabetes, heart problems, and lung disease in people with serious mental illness. About 2,800 adults in Denmark will get these screenings, and their results w…

This study looks at how being an unpaid caregiver for someone with a long-term illness affects your health and well-being over time. Researchers will follow about 2,800 adult caregivers for up to 5 years using surveys, phone interviews, and diaries. The goal is to understand the …

This study examines whether using advanced automated insulin delivery systems soon after diagnosis can protect brain growth and thinking skills in children aged 5-7 with type 1 diabetes. Researchers will compare brain MRI scans and cognitive tests over 18 months in three groups: …

This study looks at how losing weight and improving diabetes after bariatric surgery changes brain function and thinking skills. Researchers will also test if a non-invasive nerve stimulation device, started 30 days after surgery, can further improve brain health. The study invol…

This study uses MRI scans to measure pancreas size in pregnant women and their babies. Researchers want to see how the pancreas changes during pregnancy and how diabetes might affect those changes. The study will follow 87 women from early pregnancy until one year after birth.

This study is creating a biobank of DNA samples and health information from 500 adults. Researchers will use this resource to study genetic links to heart disease, diabetes, and obesity. The goal is to support future studies, not to test a treatment directly.

This study collects genetic and health information from 3,000 people to help doctors choose safer and more effective medications. Participants have conditions like diabetes, high blood pressure, heart disease, or cancer, and take multiple medications. The goal is to learn how gen…

This study aims to find more accurate ways to measure metabolism (how your body uses food for energy) by looking at body size and shape. Researchers will study 2000 healthy people and those with conditions like diabetes, obesity, or cancer. Participants will stay in the hospital …

This study looks at how fat buildup in the pancreas (pancreatic steatosis) is linked to type 2 diabetes and metabolic syndrome. Researchers will use a special ultrasound technique to measure pancreatic fat in 100 adults aged 18–80. Participants will have one visit for blood tests…

This study aims to find out why people with diabetes often have lower vitamin C levels in their blood. Researchers will measure vitamin C in blood and urine from 5,000 adults with and without diabetes. They will also look at genes that control vitamin C transport. The goal is to …

This study looks at whether screening for social needs (like housing or food) with a focus on antiracism can help reduce chronic diseases such as high blood pressure, diabetes, and asthma. About 68,000 adults and children in primary care will take part. The goal is to see if this…

This study aims to find out how often people with cystic fibrosis-related diabetes (CFRD) develop eye, kidney, and nerve problems, as well as heart disease risks. Researchers will enroll 200 adolescents and adults with CFRD for at least 5 years. The goal is to better understand t…

This study follows 50 people who have had a stroke and at least one risk factor like high blood pressure or diabetes. Researchers use repeated MRI scans over 15 months to watch how small blood vessel damage in the brain gets worse. The goal is to learn more about how this damage …

This study tests a tele-education program for primary care providers at community health centers across the U.S. The goal is to help them better manage diabetes in their patients. Researchers will measure changes in blood sugar levels and use of diabetes technology like continuou…

This study looks at whether pregnant women with high-risk conditions like diabetes or high blood pressure can use a home device to monitor their baby's health instead of going to the clinic. Fifty participants will try the device for three 30-minute sessions each week starting at…

This study looks at whether ultrasound measurements of nerves in the legs can help explain walking and balance problems in people with type 2 diabetes who have nerve damage (diabetic polyneuropathy). Researchers will measure nerve size and appearance with ultrasound and test bala…

This study looks at whether certain proteins in the blood can help predict if older adults with diabetes will experience confusion (delirium) after surgery. Researchers will measure these proteins before surgery in 180 participants aged 65 and older. The goal is to find early war…

This study looks at how a person's genes and their environment (like pollution, diet, and lifestyle) work together to cause common diseases such as diabetes, heart disease, and asthma. Researchers are collecting health questionnaires and genetic data from 25,000 adults to build a…

This study tests whether a simple educational session can help hospital doctors feel more confident when adjusting diabetes and blood pressure medications for older adults (65+). About 150 clinicians will attend a one-time training and complete surveys before and after. Researche…

This study collects a one-time sample (skin, blood, or urine) from 100 people with and without diabetes. Researchers will try to turn those cells into stem cells and then into insulin-producing cells in the lab. The goal is to learn more about diabetes and pave the way for future…

This study will follow 2,000 adults with metabolic syndrome or prediabetes for many years. Researchers will track their health, nutrition, and physical function to learn how these conditions progress and lead to complications. The goal is to find key factors that affect long-term…

This study follows about 4,000 adults from Shanghai communities to see how heart, kidney, and metabolic diseases develop over time. Researchers will compare current health data with information collected between 2016 and 2017. The goal is to understand how risk factors change and…

This study aims to validate and check the reproducibility of laboratory tests, equipment, and techniques used in research on chronic diseases like obesity, diabetes, and heart disease. Researchers will compare old and new testing methods to ensure results are accurate and consist…

This study looks at how lactate, a fuel for brain cells, influences brain blood flow in people with and without obesity. Researchers will measure blood flow and lactate levels during exercise in 24 healthy adults. Only those with obesity will do short-term exercise training to se…

This study will enroll 5,000 adults with diabetes and open foot ulcers to test whether certain biomarkers can predict which wounds will heal. Researchers will collect blood, wound fluid, and tissue samples to measure healing, infections, and amputations over 52 weeks. The goal is…

This study looks at whether the anesthetic propofol can lower the risk of postoperative delirium (sudden confusion after surgery) compared to sevoflurane in diabetic patients aged 60 and older. About 450 people having non-cardiac surgery will be randomly assigned to receive one o…

This study is checking if a new version of a glucose sensor (the ROME GS) works just as well and is as safe as the current model (Eversense 365). About 60 adults with type 1 or type 2 diabetes will wear the sensor to see how accurately it measures blood sugar levels. The goal is …

This study partners with community organizations and trusted local members to improve health research participation among Black, Latino, and Native American communities in Colorado. It focuses on understanding and addressing health issues like mental health, high blood pressure, …

This study tracks muscle and fat changes in 50 adults starting semaglutide for type 2 diabetes or weight loss. Over 12 months, participants undergo MRI scans and physical tests to see how the drug affects muscle mass and function. The goal is to understand risks of muscle loss an…

This study aims to uncover the genetic and lifestyle factors that contribute to type 2 diabetes in African populations, particularly the Yoruba people in Nigeria. Researchers will compare 300 people with diabetes to 300 without, using blood samples and health data. The goal is to…

This study aims to see if stem cells from taste buds can be turned into insulin-producing cells, which could lead to new diabetes treatments. Researchers will take tiny tissue samples from the tongues of 250 healthy adults. The goal is to grow these cells in a lab and test if the…

This study aims to find biological markers in the blood that show when insulin-making beta cells are damaged or dying. By comparing people with type 1 diabetes, type 2 diabetes, prediabetes, and healthy volunteers, researchers hope to better understand how diabetes starts and get…

This study aims to develop better MRI techniques for imaging the heart and blood vessels, avoiding the radiation used in standard X-ray tests. Researchers will compare these new MRI methods with traditional angiography and CT scans in up to 4,000 adults, including healthy volunte…

This study looks at how obesity and body fat affect heart disease risk in 2,000 healthy African American men and women aged 18-70. Researchers will measure body fat, blood fats, and insulin function to find out why heart disease risk factors differ between African Americans and C…

This study uses high-resolution and high-speed cameras to take detailed pictures of the eye. The goal is to see tiny structures that regular eye exams miss, which could help doctors better understand diseases like glaucoma, macular degeneration, and diabetes-related eye problems.…

This study aims to understand how a person's weight and blood sugar levels influence the activity of genes in tissues that control sugar and fat metabolism. Researchers will collect biological samples from 20,000 adults undergoing abdominal surgery. The goal is to learn more abou…

This study is building a large collection of human biological samples and health data to help scientists understand diseases better. It will collect samples from up to 10,000 people, including both healthy individuals and those with conditions like cancer, heart disease, and diab…