DIABETES

This study tests whether semaglutide, a diabetes drug, is safe and tolerable for people with type 2 diabetes who are on dialysis. About 100 participants will either receive weekly semaglutide injections or standard care for 26 weeks. The goal is to see if patients can stick with …

This study tests whether a minimally invasive procedure called endoscopic sleeve gastroplasty (ESG), which reduces stomach size by 70%, can help reverse fatty liver disease (MASH) in people with obesity. Researchers will compare ESG plus lifestyle changes to lifestyle changes alo…

This study tests a device called ReCET that delivers gentle electric pulses to the first part of the small intestine. The goal is to trigger cell regeneration and improve blood sugar control in people with type 2 diabetes who are not on insulin. Participants are randomly assigned…

This study will test if a 'produce prescription' program, called Eat Well, helps veterans with high blood pressure and food insecurity. About 1,500 veterans in North Carolina will either get money for fruits and vegetables for 6 or 12 months, or standard care. Researchers will tr…

This study compares the iLet Bionic Pancreas, an automated insulin delivery system, to standard care for adults with type 1 or type 2 diabetes who use insulin. About 240 participants will use the device for 13 weeks or continue their usual routine. The goal is to see if the devic…

This study tests whether a program called Sisters for Heart Health can help farmworker women ages 18-50 reduce stress, feel less isolated, and improve their heart health. Participants will join weekly peer support groups led by trained community health workers for 10 weeks. The s…

This study looks at how well the Omnipod 5 Automated Insulin Delivery System works in real-world settings for people with type 1 diabetes. About 152 participants aged 2 and older will use the system for the first time. The goal is to see if it helps keep blood sugar levels in a h…

This study looks at whether adding support from a pharmacist or a community health worker helps adults with type 2 diabetes better manage their blood sugar. About 376 people will be placed into one of four groups: usual care, pharmacist help, community health worker help, or both…

This study is testing the Omnipod 5, a tubeless insulin pump that automatically adjusts insulin delivery, in real-world settings for people with type 1 diabetes. About 304 participants aged 2 and older will use the system for the first time. Researchers will track blood sugar con…

This study tests whether screening for social needs like housing and food access, combined with referrals to community resources, can improve chronic disease outcomes for patients of color. Researchers will track blood pressure, cholesterol, blood sugar, depression, and asthma co…

This study compares two ways to place heart stents in people with diabetes: one using special imaging (IVUS or OCT) and the other using standard X-ray. The goal is to see if the imaging method reduces heart-related deaths, heart attacks, or the need for repeat procedures. About 1…

This study tests whether a weekly injection of dulaglutide, a GLP-1 drug used for diabetes, can improve early insulin release in adults with cystic fibrosis who have trouble processing sugar. About 30 participants will receive the drug or no drug in a crossover design. The goal i…

This study tests a computer program that alerts doctors and nurses when hospital patients have dangerously high or low blood sugar. The tool suggests care steps to improve glucose control. Researchers will track over 15,000 adults across multiple hospitals to see if the tool redu…

This study is testing whether taking an antibiotic pill for 7 days after surgery to fix a broken leg, ankle, or foot can lower the chance of wound infection in adults with poorly controlled diabetes. About 40 participants will either receive the antibiotic or standard care (no ex…

This study tests whether taking sodium bicarbonate (baking soda) daily can improve muscle energy and physical endurance in people with chronic kidney disease and metabolic acidosis. About 80 adults with moderate-to-severe kidney disease will receive either sodium bicarbonate or a…

This pilot study is testing whether providing free produce boxes and nutrition education can improve health outcomes for Veterans with kidney disease and food insecurity. The study will enroll 20 participants and measure changes in blood pressure and kidney function. Researchers …

This study tests whether continuous glucose monitors (CGMs) can improve blood sugar control in underserved people with type 2 diabetes who are uninsured or on Medicaid. Fifty participants will wear a CGM replaced every 14 days for 6 months. The goal is to see if this technology h…

This study is testing a new continuous glucose monitoring system called ROME GS in 60 adults with type 1 or type 2 diabetes. The goal is to see if it measures blood sugar accurately and is safe to use. Participants will wear the sensor and have their glucose levels checked agains…

This study looks at how fat cells work differently in normal-weight people with type 2 diabetes compared to those without diabetes. Researchers will test two drugs, pioglitazone and tirzepatide, to see if they improve insulin resistance and fat storage. About 104 adults aged 30-7…

This study is testing whether adding registered dietitian counseling or occupational therapy home safety tips to regular home-delivered meals can reduce fall risk in older adults. Researchers will compare four groups: meals alone, meals plus dietitian, meals plus occupational the…

This study tests a device called EchoMark/EchoSure that is implanted during fistula surgery for dialysis patients. The device uses automated ultrasound to monitor healing every two weeks. The goal is to see if it helps the fistula mature faster and reduces the need for additional…

This study tests whether screening diabetes patients for unmet social needs (like food, housing, or transportation) and connecting them to community resources can improve their health. It will involve 12,000 adults with diabetes in rural Kentucky. The goal is to see if this appro…

This study tests whether a special adhesive patch (COVER PATCH) can help keep continuous glucose monitors (CGMs) stuck to the skin for their full recommended wear time. About 194 people with type 1 or type 2 diabetes, aged 6 and older, will either use the patch or not for 4 month…

This study tests whether adding empagliflozin or semaglutide to insulin can improve blood sugar control in overweight or obese adults with type 1 diabetes. About 105 participants will take one of the two drugs or a placebo for 3 months. The goal is to see if these drugs help lowe…

This early-phase trial tests transplanting insulin-producing cells into the front chamber of the eye in legally blind people with diabetes. The goal is to see if the cells survive and work safely using only eye drops for immune suppression. Only 2 participants are enrolled, so th…

This study compares three approaches to help pregnant women and new mothers maintain a healthy weight. About 795 participants will receive either self-management support via mobile app or mail, community-based help from health workers, or usual care. The goal is to see which meth…

This small pilot study is testing whether eating Greek bottarga (grey mullet fish roe) every day can improve blood sugar, cholesterol, and inflammation in adults with prediabetes, diabetes, or obesity. About 20 participants will compare the effects of bottarga against a dairy pro…

This study tests a pharmacy-led program for low-income patients with multiple chronic conditions like diabetes, heart disease, and depression. After leaving the hospital, participants get their medications with no copay, delivery to their bedside and home, and help from a pharmac…

This study tests a diabetes program called Together Overcoming Diabetes (TOD), designed specifically for Lakota and other American Indian/Alaska Native communities. About 140 adults with type 2 diabetes who care for a young person aged 10-25 will take part. The program focuses on…

This study is testing whether whole milk or nonfat milk is better for body composition and health in 200 children aged 9-12 who have a higher BMI. Families receive weekly milk deliveries and monthly check-ins. The goal is to see which milk type helps reduce fat mass and improve m…

This study looks at whether a program that combines digital health coaching for patients and support for clinics can help low-income people with diabetes better manage their condition. Researchers will enroll 600 adults with uncontrolled diabetes or high blood pressure. The goal …

This study tests whether oral semaglutide (Rybelsus) can safely control high blood sugar in people who recently had a kidney transplant. About 104 participants will receive either the drug or a placebo for 14 weeks, alongside standard care. The goal is to see if it works as well …

This study tests a 24-week community-based lifestyle program called Inspire HER for Black women aged 30-79 with heart, kidney, or metabolic conditions. The program provides health education, physical activity, and social support to improve heart health. Researchers will also comp…

This study compares three types of weight-loss surgery (sleeve gastrectomy, gastric bypass, and duodenal switch) with standard medical care for people with type 2 diabetes and a BMI of 35 or higher. The goal is to see which approach leads to long-term diabetes remission and impro…

This study tests a new insulin drug, GZR4, against another insulin (Insulin Icodec) in 300 adults with type 2 diabetes who already use basal insulin. The goal is to see which one controls blood sugar better and causes fewer side effects like low blood sugar. Participants may also…

This study tests a program that helps people with high blood pressure, diabetes, or kidney disease manage their health at home. Participants use a blood pressure monitor that sends readings to their care team, and they get support from community health workers and pharmacists. Th…

This study tests whether adding a structured self-management program (DECIDE) to standard community health worker support helps 500 Philadelphia residents aged 35-75 better manage heart disease risks and meet their social needs. Participants will either receive the enhanced progr…

This study looks at whether wearing a continuous glucose monitor (CGM) for two weeks after leaving the hospital helps people with diabetes who are starting insulin for the first time. About 150 adults with type 1 or type 2 diabetes will be randomly assigned to use either a CGM or…

This study provides 400 adults with diabetes or prediabetes who struggle to afford food with free fresh food boxes and nutrition classes twice a month for six months. Researchers will check if this program helps lower blood sugar levels and reduces food insecurity. The goal is to…

This study tests a mobile app that sends personalized reminders to help older adults with diabetes manage their blood sugar, diet, and medications. 184 participants will either use the app or receive standard nurse consultations. The goal is to see if the app can improve diabetes…

This study is testing a new laser-based blood test that uses nanoparticles to detect pancreatic cancer early. Researchers will enroll 400 people, including those with diabetes, pancreatic cysts, or pancreatic cancer, to see if the test can accurately identify cancer. The goal is …

This study tests whether a device that shines light through the toe (photoplethysmography) can quickly detect peripheral artery disease in people with diabetes. The new method measures how long it takes blood to refill the toe after a heartbeat, and researchers compare it to the …

This study compares a self-administered oral glucose tolerance test (OGTT) at home using a continuous glucose monitor (CGM) with the standard clinic-based OGTT. 75 adults with prediabetes will undergo both tests to see if the home version accurately diagnoses blood sugar problems…

This study tests whether a wearable breath sensor can detect high or low blood sugar in teens with type 1 diabetes. Participants wear the device for 72 hours and provide breath samples while checking blood sugar with a finger prick. The goal is to see if breath chemicals can repl…

This study will enroll nearly 3,000 people with type 2 diabetes to improve how diabetic retinopathy (an eye disease) is diagnosed and managed. Researchers will use eye exams, blood tests, and continuous glucose monitors to build better models for predicting and treating the condi…

This study compares three common blood tests—fasting blood sugar, sugar load test, and HbA1c—to see which one is best at detecting diabetes caused by long-term steroid use. Researchers will enroll 75 non-diabetic adults who need steroids for more than three months. The goal is to…

This study is testing a new device that uses light (Raman spectroscopy) to measure blood sugar without needing a finger prick. Researchers will compare the device's readings to traditional blood tests in 49 people with diabetes. The goal is to see if this painless method is accur…

This study tests an artificial intelligence system called iPredict-DR that analyzes retinal photos to detect diabetic retinopathy, a leading cause of blindness. Researchers will enroll 922 adults with diabetes at primary care and endocrinology clinics. The AI's accuracy will be c…

This study tests a program called PINPOINT that helps women with obesity or diabetes get screened for cervical cancer. About 20 women who are behind on screening will be offered options like self-collection or a Pap smear. The goal is to see if the program is practical and well-l…

This study tests a family-oriented version of the Diabetes Prevention Program for Black families in Southwest Georgia. Parents with prediabetes and their children aged 8-15 will learn healthy eating and exercise habits together. The goal is to help parents lose weight and lower t…

This study tests if special sensor-equipped insoles can help prevent foot ulcers from coming back in people with diabetes and nerve damage. About 400 high-risk participants will use the insoles alongside standard care or just standard care alone. The goal is to see if the insoles…

This study tests whether community health workers can help adults with chronic illnesses get up-to-date on COVID-19 and flu vaccines. Participants receive up to three counseling sessions in English or Spanish to address their vaccine concerns. The goal is to reduce health dispari…

This study tests two lifestyle programs in 400 older African American and non-Hispanic white adults at risk for dementia and diabetes. One group does aerobic exercise three times a week; the other learns to follow the MIND diet, which emphasizes berries, greens, and whole grains.…

This study tests whether ear acupuncture, led by village doctors and supported by telemedicine, can improve sleep in adults aged 65 and older who have both diabetes and high blood pressure. Participants will receive either real or sham ear acupuncture for 6 weeks. The goal is to …

This study compares two common anesthetics—propofol and sevoflurane—to see which one causes less confusion (delirium) after surgery in older diabetic patients. Researchers will enroll 450 people aged 60 and older undergoing non-cardiac surgery. The goal is to find the best anesth…

This study tests a program called enCompass Humana, which provides coaching and resources to unpaid caregivers of adults with both cancer and diabetes. The goal is to see if the program is practical and helpful for caregivers, improving their coping skills and reducing loneliness…

This early-phase study tests whether a weight-loss drug called tirzepatide can help overweight or obese men with intermediate-risk prostate cancer lose weight before their prostate removal surgery. The study will enroll 30 participants and focus on safety and how well the program…

This study tests a group counseling program called Healing HEARTS to help people with conditions like obesity, skin disease, cancer, HIV, diabetes, or chronic pain deal with internalized stigma. Participants will either join the counseling program or a peer support group. The goa…

This study provides free continuous glucose monitors (CGMs) to 17 adults with poorly controlled type 2 diabetes. Researchers will track changes in blood sugar levels and quality of life over time. The goal is to see if easier access to CGM technology helps patients manage their d…

This study tests whether a special type of talk therapy, delivered via video calls, can reduce anxiety and depression in young adults (ages 18-64) with type 1 diabetes. The therapy also includes reviewing continuous glucose monitor data to help link emotions and blood sugar level…

This pilot study tests a new flexible bandage called exciflex that delivers mild electrical stimulation to chronic wounds that won't heal normally. The study includes 16 veterans with diabetes or spinal cord injury who have lower leg wounds. The bandage is designed to work for up…

This natural history study will look at how metabolism relates to body size and composition in 2,000 people aged 2 and older, including healthy volunteers and those with conditions like diabetes, obesity, or cancer. Participants will stay in the hospital for two days to undergo v…

This study looks at how your genes and your environment—like what you eat, breathe, and experience—work together to influence common diseases such as diabetes, heart disease, and asthma. Researchers are collecting health questionnaires, genetic data, and other information from 25…

This study explores whether stem cells from taste buds can be turned into insulin-making cells. Researchers will take tiny tissue samples from the tongues of 250 healthy adults to isolate and grow these stem cells in a lab. The goal is to see if this is possible in humans, which …

This study follows 2,800 unpaid caregivers of people with chronic conditions like diabetes or inherited disorders. Researchers will survey and interview caregivers over up to 5 years to track changes in their health, stress, and social support. The goal is to understand how careg…

This study is looking for biological markers (biomarkers) in blood, saliva, and urine that signal damage to insulin-producing beta cells in the pancreas. Researchers will compare samples from people with type 1 diabetes, type 2 diabetes, prediabetes, and healthy volunteers. The g…

This study looks at how a 12-week lifestyle change affects inflammation and stress markers in 60 overweight adults with type 2 diabetes and moderate chronic kidney disease. Participants will follow a modified diet and exercise plan. The goal is to see if these changes can reduce …

This study aims to find out why people with diabetes often have lower vitamin C levels in their blood. Researchers will measure vitamin C in blood, urine, and cells from 5,000 adults with and without diabetes. They will also look at genes that control vitamin C transport. The goa…

This study looks at how obesity and body fat affect heart disease risk in 2,000 healthy African American men and women. Researchers will measure body fat, blood fats, and insulin function to see if risk factors differ by sex. The goal is to understand why heart disease rates are …

This study is testing new magnetic resonance imaging (MRI) techniques to get clearer pictures of the heart and blood vessels without using radiation. Researchers will compare these new MRI methods to standard tests like angiography and CT scans. Up to 4,000 adults—including healt…

This study is not testing a new drug or treatment. Instead, researchers want to make sure their lab tests and equipment give accurate and repeatable results when studying conditions like obesity, diabetes, heart disease, and bone loss. Up to 100 healthy volunteers and people with…

This study tests a digital tool called CGM ASSIST that combines a continuous glucose monitor with easy-to-read displays. The goal is to help people with Alzheimer's or dementia and diabetes, along with their caregivers, better understand blood sugar levels and make informed decis…

This study tests whether an AI tool called EchoGo can help doctors spot early signs of heart failure in people with type 2 diabetes who have no symptoms. Researchers will send alerts to doctors about patients at risk, and see if this leads to more prescriptions of heart-protectin…

This study surveys up to 900 adults with type 1 diabetes who use a closed-loop insulin system for at least 4 months. The goal is to understand how satisfied they are with the special 'physical activity mode' designed to prevent low blood sugar during exercise. Participants fill o…

This study is a large registry that will follow 20,000 people with type 1 diabetes across China. It aims to track changes in blood sugar, kidney function, heart health, and emotional well-being over many years. The goal is to better understand how the disease progresses and impro…

This study uses advanced MRI scans to track changes in muscle and fat in the body and heart over 12 months in 50 adults starting semaglutide for type 2 diabetes or weight loss. Participants will undergo MRI scans, physical tests, blood samples, and questionnaires. The goal is to …

This study tests whether a clinical decision framework helps hospital doctors feel more confident when prescribing medications for older adults (65+) with chronic conditions like diabetes and high blood pressure. About 150 doctors will attend an educational session and complete s…

People with serious mental illness often have undiagnosed physical conditions like heart disease, diabetes, and cancer. This study tests whether adding routine physical health checks to psychiatric care helps find and treat these hidden illnesses. About 2,800 adults in Denmark wi…

This study takes a small sample of skin, blood, or urine from people with diabetes and healthy volunteers. Scientists will turn those cells into stem cells and then into insulin-producing cells in the lab. The goal is to learn more about diabetes and pave the way for future cell-…

This study collects blood, tissue, and other samples from up to 10,000 people to create a biobank for research. The goal is to help scientists study the causes of diseases like cancer, heart disease, and diabetes. Participants provide samples and basic health data, but no treatme…

This study tests whether a simple fetal ECG monitor worn at home can effectively track the health of babies in high-risk pregnancies. Fifty pregnant women who need weekly fetal testing will use the device for 30-minute sessions, three times a week, starting at 32 weeks. The goal …

This study at Johns Hopkins University will follow 50 people who have had a stroke and have risk factors like high blood pressure, high cholesterol, or diabetes. Researchers will use repeated MRI scans over about 15 months to track changes in the brain's white matter. The goal is…

This study partners with community organizations to improve participation in health research among Black, Latino, and Native American communities in Colorado. Researchers will track changes in diet, transportation access, and social support over time. The goal is to build lasting…

This study tests a tele-education program called ECHO Diabetes for primary care providers at 18 federally qualified health centers across the U.S. Providers attend twice-monthly online sessions for 6 months, led by a team at the University of Florida. The goal is to see if this t…

This study is building a biobank of DNA samples and health information from 500 adults. Researchers will use this resource to explore how genetic variations relate to heart disease, high blood pressure, diabetes, and obesity. Participants provide samples and data, but no experime…

This study looks at how losing weight and improving diabetes after bariatric surgery changes brain function and thinking skills. Researchers will also test if a non-invasive nerve stimulation device, started 30 days after surgery, can further improve brain health. The study invol…

This study looks at how often people with cystic fibrosis and diabetes develop complications like eye, kidney, and nerve problems. Researchers will also check blood pressure and cholesterol. The goal is to better understand these risks in a diverse group of 200 adolescents and ad…

This study tests a new imaging tracer called 11C-Martinostat that lights up a specific enzyme (histone deacetylase) in the heart during a PET-MRI scan. Researchers will compare enzyme activity in people with aortic stenosis or diabetes to healthy volunteers. The goal is to see if…

This study aims to understand how a person's weight and blood sugar levels influence the activity of genes in tissues that process sugar and fat. Researchers will collect tissue samples from 20,000 adults undergoing abdominal surgery. The goal is to learn more about the link betw…

This study looks at how common memory problems are in older adults (65+) with type 2 diabetes. It then tests a program that combines several lifestyle changes to see if it can prevent or slow down memory loss. About 420 people will take part, and their thinking skills will be com…

This study looks at how a substance called lactate affects blood flow to the brain in people with and without obesity. Researchers will measure brain blood flow and lactate levels during rest and exercise. The goal is to understand if short-term exercise training can improve lact…

This study will follow 2,000 adults with metabolic syndrome or prediabetes over time to understand how these conditions progress and lead to complications. Researchers will track health records, nutrition, and physical function to find key factors that affect long-term outcomes. …

This study tests a high-resolution imaging system to see tiny structures in the eye that routine tools cannot detect. Researchers will scan 1,200 people with various eye conditions and healthy volunteers. The goal is to better understand diseases like glaucoma, diabetes, and reti…

This study is testing a smartphone app designed to help older adults (55+) with conditions like heart failure, diabetes, and kidney disease manage their health after leaving the hospital. The app provides fall prevention tips, a personalized care plan, and a way to track symptoms…

This study tests whether wearing noise-canceling earplugs can lower stress and reduce heart disease risk in people annoyed by traffic noise. Researchers will use brain and blood vessel scans to measure changes over 6 months in 26 adults with heart risk factors. The goal is to see…

This study uses MRI to measure pancreas size in pregnant women and their babies, since smaller pancreases are linked to diabetes. Researchers will follow 87 women from early pregnancy to one year after birth. The goal is to see how pancreas changes relate to diabetes, which could…

This study examines whether using advanced automated insulin pumps soon after diagnosis can protect brain growth and thinking skills in children aged 5-7 with type 1 diabetes. Researchers will compare brain scans and cognitive tests over 18 months between children using standard …

This study looks at whether certain proteins in the blood can predict postoperative delirium (sudden confusion after surgery) in elderly patients with diabetes. Researchers will measure levels of TGF-β, ADNP, MAP6, and PGC-1α in 180 participants before surgery and track who devel…

This study aims to find biological markers (biomarkers) that can predict whether a diabetic foot ulcer will heal or not. Researchers will collect samples like blood and wound fluid from 5,000 adults with diabetes and open foot ulcers. The goal is to develop a tool that helps doct…

This study is building a registry of genetic and health information from 3,000 people with conditions like diabetes, high cholesterol, cancer, and heart disease. The goal is to help doctors choose the safest and most effective medications based on a person's genetic makeup. Parti…

This study uses ultrasound to measure the size and appearance of leg nerves in people with type 2 diabetes who have nerve damage (diabetic polyneuropathy). Researchers will then test how these nerve measurements relate to balance, walking, and daily life. The goal is to better un…

This study follows 4,094 adults in Shanghai who were part of an earlier health survey. Researchers will track them for up to 10 years to see how heart disease, kidney problems, and metabolic conditions like diabetes and obesity develop and interact. The goal is to better understa…

This study aims to understand how fat buildup in the pancreas (pancreatic steatosis) is linked to type 2 diabetes and metabolic syndrome. Researchers will use a special ultrasound technique to measure pancreatic fat and compare it with blood sugar and other metabolic tests. 100 a…