Could baking soda fight fatigue in kidney disease?

NCT ID NCT04984226

Recruiting now Disease control Sponsor: University of California, Davis Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether taking sodium bicarbonate (baking soda) daily can improve muscle energy and physical endurance in people with chronic kidney disease and metabolic acidosis. About 80 adults with moderate-to-severe kidney disease will receive either sodium bicarbonate or a placebo for 8 weeks, then switch. Researchers will measure muscle metabolism, exercise capacity, and fatigue levels.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: sodium bicarbonate
What this could lead to: If it works, this could point toward a simple, cheap treatment to reduce fatigue and improve physical function in people with chronic kidney disease.
What could go wrong: This is a small, early-phase trial (80 people) testing a common substance, so the benefits may be modest or not confirmed in larger studies. Sodium bicarbonate can cause stomach upset or electrolyte imbalances.

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Conditions

The condition(s) this trial relates to.

Acidosis chronic kidney disease chronic renal failure syndrome diabetes mellitus Fatigue Insulin Resistance metabolic acidosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC KIDNEY DISEASES DIABETES FATIGUE INSULIN RESISTANCE METABOLIC ACIDOSIS MITOCHONDRIAL ENERGETICS PHYSICAL ENDURANCE

Contacts and locations

Locations

University of California Davis Health
RECRUITING

Sacramento, California, 95817, United States
Vanderbilt University Medical Center
NOT_YET_RECRUITING

Nashville, Tennessee, 37232, United States

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