University Of California, Davis

This phase 2 trial is testing whether a targeted antibody-drug combination (loncastuximab tesirine plus rituximab) followed by standard chemotherapy can improve outcomes for people with high-risk diffuse large B-cell lymphoma. The study enrolls 24 adults with untreated double-exp…

This study tests whether adding the drug epcoritamab to standard chemotherapy and a stem cell transplant can help people with large B-cell lymphoma that has come back or not responded to treatment. About 25 adults will receive the combination, followed by more epcoritamab after t…

This trial tests whether focal ablation—using extreme cold (cryotherapy) or high-intensity ultrasound (HIFU)—can effectively destroy prostate tumors while leaving healthy tissue unharmed. It enrolls men with early-stage, localized prostate cancer that shows up on MRI. The goal is…

This study tests whether adding targeted radiation or heat-based ablation to ongoing drug therapy can control genitourinary cancers (prostate, bladder, or kidney) that have started growing in only a few new areas. Participants continue their current systemic treatment while recei…

This phase II trial tests whether combining brentuximab vedotin (a targeted antibody that delivers a toxin to cancer cells) with bendamustine (a chemotherapy drug) can shrink tumors in people with follicular lymphoma that has come back or not responded to prior treatment. The stu…

This study looks at whether follow-up care for opioid use disorder via telehealth works as well as in-person visits after starting treatment in the emergency department. About 528 adults who received buprenorphine in the ER will be assigned to either telehealth or in-person clini…

This study tests whether adding focused radiation or ablation to standard drug therapy can help people with lung cancer that has only a few new spots of growth. The goal is to see if this approach allows patients to stay on their current treatment longer without needing to switch…

This study tests whether adding the drug odronextamab before and after standard CAR-T cell therapy can help people with diffuse large B-cell lymphoma that has returned or not responded to prior treatments. About 34 adults who have already tried at least two other therapies will r…

This study tests whether adding a precise local treatment—like focused radiation or ablation—can help people whose cancer has a few new or growing spots while on standard therapy. Participants continue their usual medication while the resistant tumors are treated directly. The go…

This study tests new ways to help people with opioid use disorder continue their buprenorphine medication after starting it in the emergency department. About 3,500 adults will take part. The goal is to see if better coordination between the ER and outpatient clinics helps patien…

This study tests whether taking sodium bicarbonate (baking soda) daily can improve muscle energy and physical endurance in people with chronic kidney disease and metabolic acidosis. About 80 adults with moderate-to-severe kidney disease will receive either sodium bicarbonate or a…

This study tests a stent graft that doctors modify by hand to treat complex aortic aneurysms in patients who cannot use standard FDA-approved devices. About 40 high-risk adults will receive the custom graft and be followed for five years to check safety and effectiveness. The goa…

This early-phase study tests a two-part approach for people with advanced pancreatic cancer. First, a special scan identifies cancer cells. Then, a targeted radioactive treatment is given to destroy those cells. The goal is to check safety and find the right dose in 30 participan…

This early-stage study tests a two-part system to find and treat metastatic cancer. First, a radioactive tracer is used to spot tumors on a PET scan. Then, a similar radioactive drug is given to deliver radiation directly to the cancer cells. The goal is to see if this approach i…

This study tests whether alendronate, a drug used for osteoporosis, can help adults with sickle cell disease who have bone damage (osteonecrosis). Thirty participants will take a weekly pill for 24 weeks. The main goals are to see if the treatment is feasible and safe, and to mea…

This study tests whether eating grape powder daily for 3 weeks can improve gut health, reduce inflammation, and improve blood vessel function in 40 overweight adults aged 45-70. Participants will drink grape or placebo powder twice a day and provide blood and stool samples. The g…

This study looks at whether it is possible to start feeding breast milk early to newborns with gastroschisis, a condition where the intestines are outside the belly at birth. The goal is to see if parents agree to join the study and if doctors can follow the early feeding plan. T…

This early-stage trial tests a new treatment called PLZ4-coated paclitaxel-loaded micelles (PPM) for people with non-muscle invasive bladder cancer that has come back or not responded to standard therapy. PPM is a nanoparticle designed to deliver chemotherapy directly to tumor ce…

This early-phase trial tests whether adding a common blood pressure medication (losartan) to immunotherapy (pembrolizumab) and precise radiation (SBRT) is safe and effective for people with head and neck cancer that has returned, not responded to treatment, or spread to a few oth…

This early-stage trial is testing a new peptide vaccine (IO102-IO103) combined with the immunotherapy drug pembrolizumab (Keytruda) in 30 adults with high-risk non-muscle invasive bladder cancer that did not respond to or could not tolerate standard BCG therapy. The vaccine is de…

This phase 2 trial tests whether giving olutasidenib with azacitidine, followed by olutasidenib alone as maintenance, can keep acute myeloid leukemia (AML) with an IDH1 mutation from returning. The study enrolls 28 adults who have already achieved remission after initial treatmen…

This early-stage trial is testing a new chemotherapy drug called TR-002 in about 52 people with advanced solid tumors, including pancreatic cancer that has stopped responding to standard treatments. The main goals are to find a safe dose and check for side effects. Researchers wi…

This early-stage trial is testing a pair of radioactive drugs designed to find and attack non-small cell lung cancer that has spread. First, a scanning drug highlights tumors. Then, a therapeutic drug delivers radiation directly to those tumors. The study will enroll 40 adults wh…

This study tests whether a remote monitoring program can help people with coronary artery disease recover better after a heart procedure called PCI. About 200 participants will either get standard care or use a smartphone app with text follow-up and health coaching. The goal is t…

This phase 2 trial tests whether using a proteomic test (PROphet CB) and a toxicity assessment (CARG-TT) to guide first-line treatment can improve 12-month survival in people with advanced non-small cell lung cancer. About 56 participants will be randomly assigned to receive eith…

This pilot study tests two medicines, dopamine and norepinephrine, in 30 full-term or near-term newborns with low blood pressure and lung problems caused by pulmonary hypertension. The goal is to see which drug better improves blood flow and oxygen levels. Results could help doct…

This study looks at whether eating a mango every day for 4 weeks, instead of high-calorie snacks, can improve gut health, reduce inflammation, and boost heart health in Hispanic/Latino teens. Researchers will measure blood markers and blood vessel function in 25 participants. The…

This study tests an experimental drug called senicapoc in people with mild Alzheimer's or mild cognitive impairment. The goal is to see if it can reduce brain inflammation and slow down memory loss. About 55 participants will take either the drug or a placebo for 52 weeks, with r…

This study tests whether using a continuous glucose monitor (CGM) helps kidney transplant recipients with type 2 diabetes keep their blood sugar in a healthy range. Eighty adults who received a kidney transplant within the past year and use insulin will wear a Dexcom G6 sensor th…

This study is for pregnant women carrying a baby with spina bifida, a birth defect that can cause paralysis and other problems. Researchers are adding living stem cells from the placenta to the standard fetal surgery, hoping to protect the spinal cord and improve the child's abil…

This study tests a procedure called FETO for unborn babies with a severe diaphragmatic hernia, where organs move into the chest and harm lung growth. A tiny balloon is placed in the baby's windpipe around 27 weeks of pregnancy to help the lungs grow, then removed around 34 weeks.…

People without a working spleen are at high risk of severe infections from pneumococcus bacteria. This study looks at how well the pneumococcal vaccine works in adults aged 18-65 who have a spleen injury and are treated with monitoring, embolization, or spleen removal. Researcher…

This study tests whether the Early Start Denver Model (ESDM), a play-based behavioral therapy, helps young autistic children improve language and daily living skills when used in community programs. Researchers will enroll 600 participants, including 300 children aged 1-5, across…

This early-stage trial tests a two-step approach for glioblastoma that has come back after standard treatment. First, doctors use a laser guided by MRI to heat and destroy part of the tumor. Then, within a week, patients take the chemotherapy drug lomustine. The study will enroll…

This pilot study tests whether injecting cyclosporine directly into the scalp can safely regrow hair in people with alopecia areata, an autoimmune disease causing patchy hair loss. Twelve adults with mild to moderate hair loss will receive either cyclosporine or saline injections…

This study tests whether a machine learning algorithm can better detect critical congenital heart disease (CCHD) in newborns by combining standard oxygen saturation measurements with perfusion index data. Researchers will enroll up to 320 infants, including those with suspected o…

This early-stage trial tests a new radioactive tracer called [68Ga]Ga DOTA-5G for PET/CT scans in 30 people with metastatic lobular breast cancer. The goal is to see if it can find cancer lesions better than current methods and to check its safety. Participants receive one inject…

This early-phase study is testing a new radioactive tracer for PET scans that may better detect non-small cell lung cancer that has spread to the brain. About 20 adults with this type of lung cancer and brain metastases will receive the tracer and undergo imaging. The goal is to …

This study tests whether a bedside ultrasound (called FAST) can safely reduce the number of CT scans in children who have suffered a blunt injury to the belly. About 4,300 children will be randomly assigned to get either the FAST exam or standard care without it. The goal is to s…

This study looks at whether whole or low-fat (1%) milk is better for preventing obesity in toddlers. Researchers will give 625 children either whole or low-fat milk for one year and measure changes in waist size and body mass index. The goal is to find out which milk type support…

This study aims to develop a better system to support breastfeeding for women who had gestational diabetes, with the goal of preventing type 2 diabetes later. Researchers will work with patients, healthcare providers, and hospital leaders to design a practical strategy. Only 10 p…

This study tests whether short documentary-style videos can motivate California firefighters to adopt safety measures that reduce cancer risk. One thousand active firefighters will watch one of five videos and complete surveys before and after. The goal is to see if the videos in…

This phase 2 trial tests whether drinking tart cherry juice can prevent nerve damage (neuropathy) caused by the chemotherapy drug paclitaxel in breast and ovarian cancer patients. About 86 participants will be randomly assigned to receive either a high or low dose of the juice du…

This study tests two lifestyle programs in 400 older African American and non-Hispanic white adults at risk for dementia and diabetes. One group does aerobic exercise three times a week; the other learns to follow the MIND diet, which emphasizes berries, greens, and whole grains.…

This pilot study tests a wearable device called MedRhythms that uses shoe sensors and headphones to deliver real-time rhythmic cues (like a musical beat) to help people with incomplete spinal cord injury improve their walking. Fifteen participants will use the device during super…

This study tests two ways to guide a treatment called cooled radiofrequency ablation for knee osteoarthritis pain. The treatment uses heat to calm nerves around the knee. Researchers want to see if using ultrasound is better than the standard X-ray method for targeting the right …

This study tests whether a mobile app game can help impulsive 3-6 year olds learn to wait for bigger rewards. About 50 children with high impulsivity will either play the training game or be placed on a waitlist. The goal is to see if the app can improve self-control, which could…

This study tests whether adding a special gauze dressing (called a tie-over bolster) on top of regular stitches can reduce scarring after surgery on the head or neck. Sixty adults will have their wound closed normally, then half the wound gets the extra bolster. Doctors and patie…

This study looks at how a person's background and their clinic visit affect knee osteoarthritis pain relief using topical diclofenac gel. 220 adults aged 50+ with knee OA will apply the gel for 8 weeks and answer questions about their pain. Researchers will also analyze blood sam…

This study tests a new way to use deep brain stimulation (DBS) for Parkinson's disease. Standard DBS helps movement but can sometimes cause thinking or mood problems. The researchers will add low-frequency stimulation to a different part of the brain while keeping the usual high-…

This phase II trial compares the side effects of two standard treatments for advanced prostate cancer: abiraterone plus prednisone versus darolutamide alone. Researchers will track how many patients experience severe side effects (grade 3 or higher) over the course of treatment. …

This study tests a non-invasive brain stimulation treatment called TMS for teens and young adults (ages 15-25) with depression and suicidal thoughts. Over 5 days, participants receive 10 sessions of magnetic pulses per day, guided by MRI scans. Researchers want to see if this fas…

This study compares two types of nerve blocks for pain after kidney transplant surgery. One uses a single injection of long-lasting pain medicine, and the other uses a continuous drip through a small tube. The goal is to see which method reduces the need for opioid painkillers an…

This study tests whether injecting steroids just outside the tendon sheath works as well as injecting inside the sheath for De Quervain's tenosynovitis, a painful thumb condition. 80 adults with moderate to severe pain will receive one of the two injections and report their pain …

This study tests whether a skin patch that delivers oxybutynin works better than oral pills to reduce bladder pain and urgency in children after bladder surgery. About 100 children aged 4 to 8 will be enrolled. The goal is to see if the patch provides better relief and reduces th…

This study tests two different ways to close skin wounds after surgery: one stitch placed under the skin and one through the skin. About 73 adults having skin procedures on their head, neck, trunk, or limbs will have half their wound closed with each method. After three months, d…

This study tests whether a 2-week exercise and nutrition program is safe and doable for people about to have head and neck cancer surgery. About 20 adults with a new diagnosis will take part. The goal is to see if the program helps patients feel stronger before their operation.

This study tests whether a locking stitch or a standard stitch reduces scarring better after surgery on the head or neck. Fifty adults will have their surgical wound split in half, with each side closed using a different method. Blinded reviewers and patients will rate the scars …

This study tests a nerve block (sphenopalatine ganglion block) given through the nose to treat severe headaches after a type of brain bleed called subarachnoid hemorrhage. About 40 adults with a secured aneurysm will receive either the block plus standard pain meds or standard me…

This study tests whether a continuous intravenous infusion of magnesium sulfate can reduce pain and the need for narcotic painkillers in critically ill trauma patients admitted to the intensive care unit. Researchers will compare magnesium to a placebo (normal saline) in 156 adul…

This study looks at whether giving children gabapentin before and after chest surgery can reduce their need for strong painkillers like morphine. About 60 children under 18 having heart or lung surgery will take part. The goal is to see if gabapentin helps control pain with fewer…

This study tests whether spraying a cooling mist (ethyl chloride) on the skin before a numbing injection can reduce pain during Mohs surgery for skin cancer. Eighty adults will have half their surgical site pre-cooled and the other half not, then rate their pain. The goal is to f…

After Mohs surgery on the scalp, wounds are often left to heal on their own, which can take 8 weeks or more. This study tests whether a pinch graft—a thin piece of skin taken from the groin and placed in the wound—can help the wound heal faster. Researchers will compare healing t…

This study compares almond oil to hydroquinone cream for treating facial pigmentation in women with darker skin tones. Researchers will also check how each treatment affects the skin's microbiome. The goal is to see if almond oil is a safer, natural alternative to the standard tr…

This study uses ultra-high frequency ultrasound (UHFUS) and a green dye to map lymphatic channels in the arms of breast cancer patients scheduled for lymph node surgery. The goal is to better understand normal lymphatic anatomy, which could help reduce the risk of lymphedema (arm…

This study tests whether a natural supplement can increase collagen production in the body after exercise. Twenty healthy adults will take the supplement or a placebo for a week while doing weight-bearing exercise. Researchers will measure collagen markers in the blood and use th…

This study gives 25 depressed individuals aged 15-25 a fake version of accelerated transcranial magnetic stimulation (no real brain stimulation). The goal is to see how their beliefs and expectations about treatment change over time and whether those expectations influence mood, …

This study explores how a technique called Temporally Interfering Electric Fields Stimulation (TIEFS) affects brain activity and thinking. TIEFS uses electrodes on the scalp to send electrical currents that can reach deep brain areas without surgery. Researchers will test it in a…

This study is collecting tumor tissue and blood samples from 800 people with lung cancer to look for changes in a gene pathway called EGFR. The goal is to better understand the DNA mutations that drive the disease. No new treatment is being tested; instead, researchers hope to id…

This early-phase study tests a new way to use PET scans to measure inflammation in both the liver and brain at the same time. Researchers will scan 12 adults with fatty liver disease using two different tracers (18F-FDG and 18F-DPA-714) to see if the new method can reliably detec…

This study will test whether acupuncture can improve pain and function in people with chronic low back pain caused by myofascial pain syndrome. Sixty-four adults will receive either real acupuncture or sham (fake) acupuncture for eight weeks. Researchers will use full-body PET/CT…

This study looks at a small part of the brain called the locus coeruleus, which helps control attention. Researchers will use special MRI scans to measure its activity in 40 healthy adults. The goal is to better understand how this area works, which may help with conditions like …

This study will use a new, more sensitive total-body PET scanner to measure inflammation in the skin, joints, and blood vessels of people with psoriasis. Researchers want to see if switching from a typical Western diet to a more balanced diet for 6 weeks can reduce that inflammat…

This study is testing a new single-port robotic system for colorectal surgeries, such as for cancer or rectal prolapse. The goal is to see if it is safe and works as well as current multi-port robots. About 25 adults will take part, and researchers will track complications and re…

This study tests whether taking a monosaccharide powder (a type of sugar) can change how immune system proteins are modified in healthy adults. Researchers will analyze blood samples from 44 participants to look for changes in antibody structure. The study is placebo-controlled, …

This study uses a special full-body PET/CT scan to look for signs of immune system activity in people with Long COVID. Researchers will compare scans from 51 participants with and without Long COVID to see where the body might be inflamed. The goal is to better understand what ca…

This study looks at genetic and chemical markers in fat tissue from 500 people with severe obesity who are having weight-loss surgery. Researchers collect a small amount of belly fat during the operation and take blood samples afterward. The goal is to understand why some patient…

This study explores how the brain recognizes and remembers places, using virtual tours and brain recordings in people with epilepsy. Researchers aim to map the brain regions critical for spatial memory, so surgeons can avoid them during epilepsy surgery. Over 600 participants, in…

This study looks at how different types of rewards—like praise for effort versus rewards for good grades—affect children's desire to take on challenging tasks. Researchers will work with 180 children aged 9 to 13 to see if rewarding effort makes kids more likely to choose harder …

This study looks at how young children's experiences with waiting—like for a treat or a gift—relate to their behavior and life outcomes later on. About 200 typically developing children will complete tasks that measure self-control, flexibility, and academic readiness, and return…

This study looks at how eating kimchi, a fermented cabbage dish, affects the gut microbiome and overall health in healthy adults. Sixty participants will eat either kimchi or non-fermented cabbage daily for three weeks. Researchers will measure changes in gut bacteria, digestion-…

This study explores whether a gentle electrical current applied to the scalp (tDCS) can improve attention, learning, and memory in people with schizophrenia. Researchers will compare stimulation during a task versus rest, and front versus back of the head. They will also measure …

This study tests whether a single PET tracer (FDG) can measure both blood flow and sugar use in the heart, instead of needing two separate tracers. Researchers will compare results from FDG with a dedicated flow tracer in 60 healthy adults and people with heart disease. The goal …

This study looks at whether eating 2 ounces of pecans daily for 3 months can improve blood fats, inflammation, blood pressure, thinking skills, and gut bacteria in healthy adults aged 45 to 75. Participants will follow two diet periods—one with pecans and one without—and provide …

This study is testing whether two common topical medications—a steroid (desonide) and an antifungal (ketoconazole)—change the types and amounts of bacteria living on healthy skin. Twenty-four adults will apply the creams twice daily for two weeks, and researchers will compare ski…

This study looks at how well the body absorbs zinc and iron from four types of common beans that have different levels of natural compounds called phytate and polyphenols. Fifteen healthy young women will eat each bean variety in a random order, and researchers will measure miner…

This University of California, Davis study is testing whether chocolate made from chardonnay grape leftovers (called marc) can improve blood vessel function and reduce oxidative stress. Five adults with higher body weight and slightly reduced blood vessel flexibility will eat dif…

This study looks at whether fidgeting—specifically using a smart fidget ball—can help adults with ADHD pay better attention and manage emotions. Researchers will measure processing speed, memory, and heart rate in 109 adults with ADHD. The goal is to see if simple movements can b…

This study is reviewing medical records from 5,000 heart and blood vessel surgery patients to find factors that influence recovery and survival. Researchers are looking at data from 2001 to 2013 to identify what leads to complications or death after surgery. The goal is to improv…

This study looks at how men and women differ in voice quality after having their voice box removed (total laryngectomy) and using a special voice prosthesis. Researchers will ask 12 participants to complete surveys and voice tests. The goal is to understand if women have poorer s…

This study looks at whether eating beef every day as part of a heart-healthy diet helps older adults (ages 55-70) absorb zinc better and improves how their blood vessels work. Researchers will measure zinc levels in cells and blood vessel function in 20 participants. The goal is …

This study is for 100 people with heart failure. Researchers will use advanced blood tests and a home monitoring system to learn more about the disease and find better ways to manage treatment. The goal is to reduce hospital stays and improve outcomes.

This study is testing whether eating honey-flavored yogurt every day for 4 weeks can lower inflammation and improve gut health in overweight women aged 45 to 65. Twenty participants will eat both honey yogurt and sugar-sweetened yogurt at different times to compare effects. Resea…

This study tests a program called Individual Placement and Support for Autism (IPS-AUT) to help autistic adults ages 18-40 find and keep competitive jobs. Researchers will work with employment agencies to train staff and track job outcomes, satisfaction, and thinking skills. The …

This study is testing a stepped-care program to help identify and treat young people (ages 12-25) who are at clinical high risk for psychosis. The program is being rolled out in six community mental health clinics and includes steps like assessment, case management, stress manage…

This study looks at how the common sweetener erythritol affects blood clotting and blood vessel health compared to aspartame. Twenty-four adults with a BMI of 27 or higher will drink beverages sweetened with each sweetener for two weeks. Researchers will measure markers of platel…

This study looks at how adding beans to the diet affects bowel and metabolic health in 25 overweight adults aged 30-80 who are scheduled for a colonoscopy. Participants will drink a bean smoothie for two weeks, and researchers will measure changes in gut bacteria, blood markers, …

This study uses a weak electrical current applied to the scalp (tDCS) to see if it can improve attention and cognitive control in healthy adults and people with schizophrenia. Participants will perform thinking tasks while their brain activity is measured with EEG. The goal is to…

This study is creating a registry to collect information from children diagnosed with antiphospholipid syndrome (APS), a condition that causes abnormal blood clots. Researchers aim to better understand what causes APS and how it is treated, with a focus on long-term survival. The…

This study looks at how a 36-hour water-only fast changes immune cells in healthy young men. Four participants will have blood drawn before, during, and after fasting to measure immune markers. It's a very small, early-stage trial aimed at understanding, not treating, any conditi…

This study follows over 2,500 teens aged 11 to 17 who come to the emergency room with a mild traumatic brain injury (mTBI). Researchers want to see if they develop new or worsening depression or anxiety in the months after injury. Teens and their parents fill out questionnaires a…

This observational study tests a new physical exam method to reliably find joint motion problems in healthy adults and people hospitalized with stroke or TIA. Researchers will compare motion patterns between groups and see if motion issues relate to quality of life after stroke. …

This study aims to understand why multiple myeloma affects African American, Latino, Asian American, and White patients differently. Researchers will survey 4000 people diagnosed with multiple myeloma in California to learn about factors that may influence who gets the disease an…

This study collects moles and blood samples from 50 adults to analyze the genetic mutations that cause moles to form. Researchers will compare DNA from mole tissue with normal DNA from blood to find specific changes. No treatments or interventions are given—the goal is purely to …