University Of California, Davis

This study tests a two-step treatment for adults with a specific type of acute myeloid leukemia (AML) that has an IDH1 mutation. First, patients receive two drugs (olutasidenib and azacitidine) to kill cancer cells. Then, they take olutasidenib alone as maintenance therapy to try…

This study tests whether adding stem cells from the placenta to standard fetal surgery can improve how well babies with spina bifida can walk and control their bladder and bowels. About 55 pregnant women carrying babies with the condition will receive the stem cell-enhanced repai…

This early-phase study tests a new chemotherapy drug called TR-002 in people with advanced solid tumors or pancreatic cancer that has stopped responding to standard treatments. The main goals are to find the safest dose and understand side effects. About 52 adults will take part,…

This study tests a procedure called FETO for babies with a severe diaphragmatic hernia, where organs move into the chest and crowd the lungs. A tiny balloon is placed in the baby's windpipe while still in the womb to help the lungs grow. The study involves 10 pregnant women and f…

This early-phase study tests a new approach for people with metastatic non-small cell lung cancer that has worsened despite standard treatments. Participants receive a radioactive drug designed to seek out and attach to cancer cells, allowing doctors to see tumors on scans and de…

This early-stage study tests whether combining a precise laser treatment (LITT) with the chemotherapy drug lomustine is safe and feasible for adults whose glioblastoma has returned. About 20 participants will receive the laser procedure followed by chemotherapy within a week. The…

This early-stage study tests a two-part approach for people with advanced pancreatic cancer. First, a radioactive tracer helps doctors see tumors on a scan. Then, a related radioactive therapy is given to try to shrink those tumors. The study aims to find safe doses and see how w…

This early-phase trial tests whether combining a blood pressure drug (losartan) with immunotherapy (pembrolizumab) and precise radiation (SBRT) is safe and effective for head and neck cancer that has come back or spread. About 24 adults whose cancer cannot be surgically removed w…

This study tests whether using a protein-based test to guide treatment can help people with advanced non-small cell lung cancer live longer without their cancer getting worse. About 56 adults with stage IIIC or IV lung cancer will be randomly assigned to either standard therapy o…

This study tests whether eating grapes every day can improve gut health, reduce inflammation, and help blood vessels work better in healthy overweight adults aged 45 to 70. Participants will drink a grape powder or placebo drink twice daily for three weeks. Researchers will measu…

This early-phase study tests a pair of special molecules designed to find and treat metastatic cancers that have spread. One molecule helps doctors see tumors on a PET scan, while the other delivers targeted radiation to destroy them. The study involves 40 adults with certain adv…

This study tests whether a home monitoring program using text messages and a smartphone app can help people with heart disease recover better after a stent procedure. About 200 patients will either get standard care or extra digital support, including remote blood pressure checks…

This early-stage trial tests a new treatment called PPM for people with a type of bladder cancer that has returned or not responded to standard therapy. PPM uses tiny particles to deliver a chemotherapy drug directly to cancer cells in the bladder, aiming to kill them while reduc…

This early-stage trial tests a new vaccine (IO102-IO103) combined with the immunotherapy drug pembrolizumab in 30 adults with a type of bladder cancer that did not respond to or could not tolerate standard BCG treatment. The vaccine is designed to train the body's immune cells to…

This study tests whether a continuous glucose monitor (CGM) can help people who have had a kidney transplant and have type 2 diabetes better control their blood sugar. About 80 adults who received a kidney transplant in the past year and use insulin will wear a CGM device. The go…

This study looks at whether follow-up care for opioid use disorder works better through telehealth or in-person visits after starting treatment in the emergency department. About 528 adults who received buprenorphine in the ER will be assigned to either telehealth or in-person ou…

This study tests an experimental drug called senicapoc in people with mild or early Alzheimer's disease. The goal is to see if it can slow memory loss and reduce brain inflammation. About 55 participants will take either the drug or a placebo for one year. This is a small early-s…

This study tests a doctor-modified stent graft for people with complex aortic aneurysms who cannot use standard devices. The graft is custom-fitted to each patient's anatomy to seal the aneurysm and prevent rupture. Researchers will track safety and success in 40 high-risk partic…

This study looks at whether the Early Start Denver Model (ESDM), a therapy for young autistic children, works when used by community agencies. Researchers will work with 300 children ages 1-5 and their providers to see if the program improves language and daily living skills. The…

This study is testing a new single-port robotic system for colorectal surgeries, such as for cancer or rectal prolapse. The goal is to see if it is safe and effective compared to current multi-port robots. About 25 adults will take part, and researchers will track complications a…

This study is testing if a weekly pill called alendronate is safe and can help adults with sickle cell disease who have a painful bone condition called osteonecrosis. Researchers will give the pill to about 30 participants for 6 months to see if it reduces pain and improves bone …

This study is testing a new type of PET scan that uses a special tracer to find non-small cell lung cancer that has spread to the brain. About 20 adults with this condition will receive the tracer and then have a PET/CT scan. The goal is to see if this scan can detect cancer spot…

This early-phase study tests a new radioactive tracer called [68Ga]Ga DOTA-5G for PET/CT scans in 30 people with advanced invasive lobular breast cancer. The goal is to see if it can better detect where the cancer has spread compared to standard scans. Researchers will also check…

This study tests if short, documentary-style videos can motivate firefighters to take safety steps that lower their cancer risk. About 1,000 active California firefighters will watch one of five videos and answer surveys before and after. The goal is to see if the videos increase…

This study tests whether drinking tart cherry juice can prevent nerve pain caused by the chemotherapy drug paclitaxel in people with breast or ovarian cancer. About 86 participants will be randomly assigned to take either a high or low dose of the juice during their 12-week chemo…

This study tests two lifestyle programs in 400 older African American and white adults at risk for dementia and diabetes. One group does aerobic exercise classes; the other gets diet counseling to follow the MIND diet (rich in berries, greens, fish, and olive oil). The goal is to…

This study aims to design better breastfeeding support for women who had gestational diabetes, with the goal of preventing type 2 diabetes later in life. Researchers will work with patients, healthcare providers, and hospital leaders to create a practical support plan. Only 10 pa…

This study looks at whether giving magnesium sulfate through an IV can help manage pain and reduce the need for strong painkillers in trauma patients in the intensive care unit (ICU). About 156 adults with injuries will receive either magnesium or a saltwater solution. The goal i…

This study tests whether spraying a cooling liquid (ethyl chloride) on the skin before a numbing injection can reduce pain during Mohs surgery for skin cancer. About 80 adults will have half their surgical site pre-cooled and the other half not, then rate the pain of each injecti…

This study tests whether taking sodium bicarbonate (baking soda) can improve muscle energy and physical endurance in people with chronic kidney disease and metabolic acidosis. About 80 adults with moderate-to-severe kidney disease will take either sodium bicarbonate or a placebo …

This study compares two imaging techniques—fluoroscopy and ultrasound—used during a procedure called cooled radiofrequency ablation to treat knee pain from osteoarthritis. The goal is to see which method provides better pain relief and function. About 90 adults with knee osteoart…

This study compares two ways of giving steroid injections for De Quervain's tenosynovitis, a painful thumb tendon condition. 80 adults will receive either an injection inside or outside the tendon sheath. Their pain levels will be measured before and up to 6 months after the inje…

This study looks at two ways to heal wounds on the scalp after Mohs surgery for skin cancer. One method lets the wound heal naturally, which can take 8 weeks or more. The other uses a small skin graft from the groin to help the wound close faster. Researchers will track healing t…

This study tests whether a numbing injection inside the nose can better control severe headaches caused by a type of brain bleed called subarachnoid hemorrhage. About 40 adults with a secured aneurysm will receive either standard pain meds alone or plus the nerve block. The goal …

This study looks at whether giving children gabapentin before and after chest surgery can reduce the amount of strong painkillers (opioids) they need. About 60 children under 18 having heart or lung surgery will take part. If it works, this could mean fewer side effects and less …

This study looks at how a person's background and their clinic visit affect knee osteoarthritis pain relief using a topical gel called diclofenac. About 220 adults aged 50 and older with knee OA will use the gel for 8 weeks and answer questions about their pain. Researchers hope …

This study compares the side effects of two standard treatments for advanced prostate cancer: abiraterone with prednisone versus darolutamide alone. About 75 men with advanced prostate cancer will take one of these treatments, and researchers will track which causes fewer severe …

This study tests whether a natural supplement can increase collagen production in the body after eating collagen protein. Researchers will measure collagen markers in the blood of 20 healthy adults aged 18-30 and use their serum to treat lab-grown ligaments. The goal is to see if…

This study is testing a new deep brain stimulation (DBS) method for people with Parkinson's disease. The standard high-frequency stimulation helps with movement but can sometimes cause thinking or mood problems. Researchers want to see if adding low-frequency stimulation to a dif…

This study tests two different numbing injections for pain after kidney transplant surgery. One uses a continuous drip of medicine through small tubes, the other a single long-lasting shot. The goal is to see which method reduces the need for strong painkillers like opioids. Abou…

This study tests two medicines, dopamine and norepinephrine, in newborns with low blood pressure and lung problems. The goal is to see which one helps the heart and lungs work better. About 30 babies will take part, and doctors will check their oxygen levels and heart function.

This study tests a non-invasive brain stimulation treatment called TMS for adolescents and young adults (ages 15-25) with depression and suicidal thoughts. The treatment is given over 5 days and uses MRI to guide targeting. Researchers want to see if it reduces depression and sui…

This study tests two different ways to close a wound after skin surgery to see which one leaves a better-looking scar. About 73 adults will have their wound split in half, with each side closed using a different stitching method. Three months later, doctors and patients will rate…

This early-stage study tests if injecting cyclosporine directly into the scalp can safely regrow hair in people with alopecia areata, an autoimmune condition causing patchy hair loss. About 12 adults with mild to moderate hair loss will receive either the drug or a placebo over 1…

This study tests whether adding a small gauze pad (called a tie-over bolster) on top of regular stitches can reduce scarring after surgery on the head or neck. Sixty adults will have half of their wound treated with the bolster and the other half with stitches alone, so each pers…

This study tests whether applying almond oil to the face can reduce dark spots (pigmentation) as effectively as a common prescription cream called hydroquinone. Researchers will also check how each treatment affects the skin's natural bacteria (microbiome). The study involves 50 …

This study tests two different stitching techniques for closing surgical wounds on the head or neck. Half of each wound will be closed with a standard running stitch, and the other half with a running locking stitch. Researchers want to see if the locking stitch leads to less not…

This study compares a skin patch to pills for reducing bladder pain and urgency in children aged 4 to 8 after bladder surgery. About 100 participants will receive either the patch or oral medication to see which works better. The goal is to improve comfort and reduce the need for…

This study looks at whether adding bean smoothies to the diet can improve bowel and metabolic health in 25 overweight adults aged 30-80 who are scheduled for a colonoscopy. Participants will drink bean smoothies for two weeks, and researchers will measure changes in gut bacteria,…

This study looks at how certain dietary supplements change proteins in the immune system of healthy adults. Researchers will give supplements or a placebo to 44 volunteers aged 18-45 and take blood samples to measure changes. The goal is to understand, not to treat any disease.

This study looks at how eating kimchi, a fermented cabbage dish, affects the gut health of healthy adults. Researchers want to see if kimchi increases good bacteria in the gut and improves digestion. Participants will eat either kimchi or plain cabbage every day for 3 weeks and p…

This study looks at whether a stepped-care program can help identify and treat young people (ages 12-25) who are at high risk for psychosis. The program is being tested in six community mental health centers. Researchers will track how many youth join the program, how well it wor…

This study looks at how common topical medications—like antifungal creams, mild steroid ointments, and moisturizers—change the community of bacteria living on healthy skin. Researchers will track these changes over short-term use in 24 adults. The goal is to understand how these …

This study looks at how young women absorb zinc and iron from four types of common beans. Researchers want to see if natural compounds in beans, like phytate and polyphenols, affect how much of these minerals the body can use. Fifteen healthy women who eat beans regularly will pa…

This early study looks at whether products made from Chardonnay grape leftovers (marc) can improve heart and blood vessel health. Five adults with higher body weight and slightly reduced blood vessel function will take the products and have their vascular response, oxidative stre…

This study looks at how different kinds of rewards—like praise for effort versus rewards for good grades—affect whether children choose to do hard tasks. About 180 kids aged 9 to 13 will complete puzzles and thinking games, and their parents will answer questions about how they r…

This study looks at a small part of the brain called the locus coeruleus, which helps control attention. Researchers will use special MRI scans and a safe medication to see how this area works in 40 healthy adults aged 18-60. The goal is to better understand attention problems li…

This study is creating a registry to collect information about children with Antiphospholipid Syndrome (APS), a condition that causes abnormal blood clots. Researchers hope to learn more about what causes APS and how to treat it. The study will follow up to 50 participants who we…

This study aims to understand if women and men have different voice outcomes after total laryngectomy (removal of the voice box) when using a voice prosthesis called TEP. Researchers will survey 12 participants and measure voice quality, speech, and quality of life. The goal is t…

This study looks at how a person's beliefs about a treatment can change their mood, motivation, and reactions to rewards. Healthy volunteers aged 15-25 will receive a sham (fake) version of a brain stimulation therapy, meaning no actual stimulation is given. Researchers will trac…

This study looks at whether eating honey-flavored yogurt every day for 4 weeks can lower inflammation and improve gut health in overweight women aged 45 to 65. Participants will eat yogurt and have their blood and stool tested for signs of inflammation and healthy gut bacteria. T…

This study reviews medical records from 5,000 adults who had heart or blood vessel surgery at UC Davis Medical Center. Researchers want to find out which factors affect recovery and survival after surgery. The goal is to improve future care and reduce risks.

This study looks at whether eating mangoes every day for 4 weeks, instead of high-calorie snacks like cookies and chips, can improve gut health, reduce inflammation, and boost heart health in Hispanic/Latino teens. About 25 teens aged 12-19 with a higher BMI will participate. Res…

This study looks at how a gentle brain stimulation technique called tDCS affects attention and thinking. Researchers will test healthy adults and people with schizophrenia using computer tasks and brain wave recordings. The goal is to understand brain function better, not to trea…

This study looks at how a common sweetener, erythritol, affects blood clotting and blood vessel health. Twenty-four adults with a BMI of 27 or higher will drink beverages sweetened with either erythritol or aspartame for two weeks each. Researchers will measure markers of platele…

This study looks at whether a short 2-week program of exercise and nutrition advice is safe and practical for people about to have surgery for head and neck cancer. About 20 adults with a new diagnosis will take part. The goal is to see if patients can complete the program and fi…

This study tests whether a mild, non-invasive electrical current applied to the forehead (tDCS) can improve attention, learning, and memory in people with schizophrenia. Researchers will compare different stimulation methods and measure brain activity and neurotransmitter levels.…

This study is not testing a new treatment. Instead, it aims to understand why multiple myeloma affects African American, Latino, Asian American, and other groups differently. Researchers will survey 4,000 people in California who have been diagnosed with multiple myeloma in the l…

This study looks at how a 36-hour water-only fast changes the immune system in healthy adults aged 20-40. Researchers will measure immune cells and gene activity in blood samples. Only 4 men are being enrolled, so results will be very early and limited.

This study looks at whether it's possible to start feeding babies with gastroschisis (a birth defect where the intestines are outside the belly) soon after surgery. Researchers will enroll 20 newborns to see if parents agree to join and if the feeding plan can be followed. The go…

This study uses a special full-body PET/CT scan to look for signs of immune system activity and blood vessel changes in people with Long COVID. About 51 adults will be scanned and have blood tests to see how their immune system is working. The goal is to better understand what ca…

This study aims to uncover the genetic changes that cause moles (melanocytic nevi) to form. Researchers will collect skin biopsy samples and blood from 50 adults with moles and analyze the DNA to find mutations. The goal is to better understand mole biology, not to treat or cure …

This early-phase study at UC Davis aims to see if a single PET tracer (FDG) can measure both blood flow and sugar use in the heart at the same time. Researchers will compare these results with those from a separate tracer that only measures blood flow. 60 healthy adults and peopl…

This study looks at how much flavanols (natural compounds found in foods like apples, berries, and tea) people consume as part of their normal diet. Researchers will collect urine samples from 200 healthy adults aged 25-75 to measure specific breakdown products. The goal is to be…

This study follows teens aged 11 to 17 who come to the emergency room with a mild traumatic brain injury (mTBI). Researchers want to see if they can predict who will develop new or worse depression or anxiety in the months after the injury. Participants and their parents fill out…

This study aims to better understand heart failure by using advanced testing (like genetic and protein analysis) and remote monitoring. Researchers will track 100 people with heart failure to see if these tools can predict who is at risk for serious problems like hospitalization …

This study tests whether a new, standardized physical exam can reliably identify joint motion problems in adults who have had a stroke or mini-stroke (TIA), as well as in healthy volunteers. Researchers will compare exam results from different providers to see if the method is co…

This study tests a program called Individual Placement and Support for Autism (IPS-AUT) that helps autistic adults (ages 18-40) find and keep jobs. Researchers will work with employment agencies to train staff and track how well the program works. The goal is to see if this appro…

This study looks at whether eating pecans every day for 3 months can improve metabolism, blood fats, inflammation, blood pressure, thinking skills, and gut bacteria in healthy adults aged 45 to 75. Participants will follow two diet periods (with and without pecans) and provide bl…

This study looks at how young children's early experiences with waiting (like for a treat or a gift) might affect their behavior and success later in life. About 200 typically developing children will play games, answer questions, and be observed while waiting. Researchers will a…

This study looks at whether eating beef every day as part of a heart-healthy diet helps older adults (ages 55-70) absorb zinc better and improve blood vessel function. Researchers will measure zinc levels inside cells and how well blood vessels work. The goal is to understand how…

This study looks at whether fidgeting helps adults with ADHD pay attention and manage emotions better. Researchers will have participants use a fidget device in a lab while measuring thinking speed, memory, and heart rate. The goal is to understand how movement might help, not to…

This study looks at whether a quick bedside ultrasound (called FAST) can safely reduce the number of CT scans in children who have hurt their belly in an accident. CT scans are very good at finding internal injuries but expose kids to radiation. The trial will include over 4,000 …

This study aims to see if switching to a balanced diet for 6 weeks reduces body-wide inflammation in people with psoriasis. Researchers will use a new, full-body PET scanner to measure inflammation before and after the diet change in 5 participants. The goal is to understand if d…

This study aims to understand how well people with spleen injuries can build protection against pneumonia after receiving a vaccine. Researchers will compare the immune response in 75 adult trauma patients who receive one of three standard treatments for their injury: observation…