University Of California, Davis

This study is testing a custom-modified stent graft to treat dangerous, complex aortic aneurysms in high-risk patients who have no other approved, minimally invasive options. Doctors will physically modify an existing stent graft on a surgical table to fit each patient's unique a…

This study is testing an oral drug called Senicapoc to see if it can slow down the progression of Alzheimer's disease in people with early memory problems. About 55 participants will take either the drug or a placebo daily for one year. Researchers will measure changes in memory,…

This study is testing a new community-based program designed to identify and support young people who show early signs of being at risk for psychosis. The program uses a 'stepped-care' approach, starting with basic support in local clinics and offering more specialized care if ne…

This early-stage trial is testing a new targeted treatment for bladder cancer that has returned or hasn't responded to standard therapy. Researchers are using microscopic particles designed to deliver cancer-killing medication directly to tumor cells in the bladder. The study wil…

This study is testing whether continuous glucose monitors (CGMs) help kidney transplant patients with diabetes better control their blood sugar. Researchers will track 80 patients who recently received transplants to see if wearing a CGM device improves their time in the healthy …

This study is comparing two common blood pressure medications, dopamine and norepinephrine, in newborns with a serious condition that causes low blood pressure and breathing failure. The goal is to see which drug better stabilizes blood pressure without potentially worsening the …

This is the first human study of a new chemotherapy drug called TR-002. It aims to find the safest dose and understand side effects for people with advanced solid tumors, including pancreatic cancer, that have stopped responding to standard treatments. The study will enroll 52 pa…

This early-stage study is testing a new two-part treatment for metastatic lung cancer. First, a special scan finds tumors that have a specific marker. Then, a radioactive treatment targets and delivers radiation directly to those cancer cells. The study aims to see if this approa…

This pilot study is testing a specialized fetal surgery to help babies with severe congenital diaphragmatic hernia (CDH) survive. During pregnancy, doctors temporarily place a tiny balloon in the baby's windpipe to help the lungs grow. The study is enrolling pregnant women who me…

This study aims to find out if follow-up care via video or phone (telehealth) works better than traditional in-person clinic visits for people starting medication for opioid addiction in the emergency room. Researchers will track over 500 patients to see which method helps people…

This study is testing whether a specific, play-based therapy for young autistic children works as well in everyday community clinics as it has in research settings. It will involve 600 children aged 1-5 and their therapists across the US. The goal is to see if this approach impro…

This study is testing whether a short, home-based program of exercise and high-protein nutrition is safe and practical for patients to do in the two weeks before head or neck cancer surgery. Researchers want to see if patients can complete the program and if it causes any problem…

This early-stage study is testing a new way to deliver a medication called cyclosporine directly into bald patches caused by alopecia areata, an autoimmune hair loss condition. The goal is to see if localized injections are safe and can help regrow hair while avoiding the side ef…

This early-stage study is testing whether a new vaccine (IO102-IO103) combined with an existing immunotherapy drug (pembrolizumab) is safe and effective for patients with high-risk bladder cancer that hasn't responded to standard BCG treatment. The vaccine is designed to teach th…

This early-stage trial is testing whether adding living stem cells from placenta to fetal surgery can improve walking ability in babies with spina bifida. The study will enroll 55 pregnant women whose babies have been diagnosed with this spinal cord defect. Researchers hope the s…

This study compares how well patients tolerate two different drug treatments for advanced prostate cancer. Researchers will follow 75 men taking either abiraterone with prednisone or darolutamide alone for one year. The main goal is to see which treatment causes fewer serious sid…

This early-stage study is testing if a three-part treatment is safe and effective for people with head and neck cancer that has come back, spread a little, or hasn't responded to other treatments. The treatment combines a common blood pressure drug (losartan), an immunotherapy dr…

This early-stage study is testing the safety of a two-part treatment for adults whose glioblastoma, a fast-growing brain cancer, has returned. First, doctors use a laser to heat and destroy the tumor. About a week later, patients take a chemotherapy pill called lomustine. The mai…

This study tests whether a drug combination can help control acute myeloid leukemia (AML) in patients with a specific genetic mutation (IDH1) who have already received standard treatment. The trial involves 28 adults who responded to prior therapy but need additional treatment. P…

This study is testing whether a remote monitoring program can help people better manage their health after a heart procedure like a stent placement. 200 patients will be split into two groups: one gets standard care, and the other gets devices to track their health at home along …

This early-stage study is testing a new two-step method for patients whose cancer has spread. First, a special imaging scan helps find tumors that might respond to a new targeted radiation treatment. Then, a single dose of that treatment is given to see if it's safe and if it hel…

This study is testing if using a special protein test to guide treatment choices helps people with advanced lung cancer live longer without their cancer getting worse, compared to standard treatment selection. It will involve 56 adults with newly diagnosed, advanced non-small cel…

This study is testing if a weekly pill called alendronate is safe and tolerable for adults with sickle cell disease who have a painful bone condition called osteonecrosis (bone death). Researchers will enroll about 30 participants to take the pill for 6 months to see if it helps …

This study is testing if a fast, bedside ultrasound can help doctors decide which injured children really need a CT scan. It involves over 4,300 children who come to the emergency room after a blunt injury to the belly. The goal is to safely reduce the number of CT scans, which e…

This study is testing a new type of PET scan to see if it can better detect and track the spread of non-small cell lung cancer, especially when it has reached the brain. Researchers will compare this new scan to standard imaging methods in about 20 patients. The goal is to see if…

This study is testing if adding a special lab stain called PRAME to a precise skin cancer removal technique helps surgeons better see the edges of the tumor. The goal is to remove all the cancer cells while saving as much healthy skin as possible. The study will enroll 36 adults …

This study is testing a new imaging agent called [68Ga]Ga DOTA-5G to see if it can better detect where metastatic lobular breast cancer has spread in the body. Researchers will enroll 30 patients to compare this new PET/CT scan against the standard FDG PET/CT scan. The main goals…

This study is testing whether two different lifestyle programs can help prevent dementia and diabetes in older adults who are at risk. It will enroll 400 African American and non-Hispanic white adults over 60 in the San Francisco Bay Area. One program focuses on aerobic exercise,…

This study is testing an online toolkit designed to help people caring for a spouse with dementia prepare for their own unexpected health problems. The goal is to give caregivers a clear plan to arrange backup care, so they can focus on their own health without worrying about the…

This study aims to find out if a specific stitching technique called a 'running locking suture' leads to less noticeable scars than the standard 'running suture' method after surgery on the head or neck. Researchers will test this by using both methods on different halves of the …

This study is testing if giving a continuous magnesium drip through an IV can help manage pain in adults who are critically injured and in the ICU. The goal is to see if this common mineral can safely reduce patients' pain scores and their need for strong opioid painkillers. Rese…

This study tests whether a 5-day brain stimulation treatment called TMS can help reduce depression and suicidal thoughts in teens and young adults. The non-invasive treatment uses MRI scans to target specific brain areas and aims to provide a fast-acting alternative to traditiona…

This study is testing if spraying a cooling substance (ethyl chloride) on the skin can reduce the pain of the numbing injections given before a common skin cancer surgery. It involves 80 patients having the surgery. Each patient will have the spray used on one half of their surgi…

This study compares two methods for healing wounds on the scalp after skin cancer removal surgery. One method lets the wound heal naturally over many weeks. The other uses a small skin patch (a 'pinch graft') taken from another area to cover the wound. Researchers want to see whi…

This study is testing if a special gauze dressing, called a tie-over bolster, can help reduce scarring after surgery on the head or face. Researchers will stitch a wound normally, then apply the dressing over only half of it to compare the results. The goal is to see if the side …

This study is testing if giving children the medication gabapentin around the time of chest surgery can safely reduce their need for strong opioid painkillers afterward. Researchers will compare 60 children who receive gabapentin to those who receive a placebo, measuring pain lev…

This study is testing if a medicine for bladder pain and urgency works better and with fewer side effects when given through a skin patch instead of a pill. It involves about 100 children, aged 4 to 8, who are having bladder surgery. The goal is to see if the patch provides bette…

This study is testing if a special nasal spray that numbs a nerve cluster can help reduce the severe headaches people get after a type of brain bleed called a subarachnoid hemorrhage. Researchers want to see if adding this spray to standard pain medication works better than medic…

This study is testing whether applying almond oil nightly works as well as a prescription cream (hydroquinone) to reduce the appearance of facial dark spots. It will involve 50 women with darker skin tones and will also check if either treatment changes the balance of bacteria on…

This study is testing whether drinking tart cherry juice can prevent nerve pain (neuropathy) caused by a common chemotherapy drug called paclitaxel. It will enroll 86 people with breast or ovarian cancer who are starting this type of chemo. Participants will be randomly assigned …

This study compares two different methods for managing pain after kidney transplant surgery. Researchers want to see which approach works better to reduce pain and limit the need for opioid painkillers. The trial involves 200 adult patients who are receiving kidney transplants. O…

This study aims to find out which of two common stitching techniques leads to a better-looking scar after skin surgery. Researchers will compare two methods on the same wound in 73 adult participants. They will measure scar appearance and any complications three months after surg…

This study is testing if a simpler steroid injection method works as well as the current standard for De Quervain's tenosynovitis, a painful wrist condition. 80 patients with this condition will be randomly assigned to receive an injection either directly into the tendon sheath o…

This study is comparing two different ways to guide a procedure that uses heat to quiet nerves causing knee osteoarthritis pain. Researchers want to see if using ultrasound imaging is more effective than the standard X-ray (fluoroscopy) method. They will measure changes in pain a…

This study is testing a job support program designed to help autistic adults find and keep competitive jobs in their community. Researchers will work with 60 unemployed autistic adults aged 18-40 and their employment agencies to see if the program is practical, well-liked, and ef…

This research study is exploring whether a mild, painless electrical current applied to the forehead (called tDCS) can improve thinking, memory, and attention problems in people with schizophrenia. It will compare different ways of delivering the stimulation and measure brain act…

This study aims to create a tool to help doctors predict which teenagers who suffer a mild traumatic brain injury (like a concussion) are at higher risk for developing new or worsening anxiety or depression in the months that follow. Researchers will enroll over 2,500 adolescents…

This study aims to understand how everyday skin treatments like antifungal creams and mild steroid ointments change the mix of bacteria and other microbes living on healthy skin. Researchers will apply these creams to small areas on the arms of 24 healthy adult volunteers and the…

This study aims to understand how well young women absorb zinc and iron from different varieties of common beans. Researchers will measure mineral absorption in 15 healthy women who regularly eat beans. The study compares beans with different natural compounds that might affect h…

This early-stage study aims to understand how taking sugar-based dietary supplements affects certain proteins in the immune system of healthy people. Researchers will give supplements or a placebo to 44 healthy adults and analyze their blood to see if the supplements change how i…

This study uses a special type of full-body PET/CT scan to look for signs of ongoing immune system activity and blood vessel changes in people with Long COVID. Researchers will compare scans from 34 people with Long COVID to 17 people who recovered fully, and track some participa…

This study aims to understand how well people with spleen injuries can build protection against pneumonia after receiving a vaccine. Researchers will compare the immune response in 75 adult trauma patients who receive different treatments for their spleen injury: observation only…

This study aims to test how reliable a new, standardized physical exam method is for identifying joint motion problems. Researchers will compare joint motion in healthy volunteers, people who had a mini-stroke (TIA), and people who had a recent stroke. The goal is to see if this …

This study is investigating whether eating beef daily as part of a healthy diet helps the body absorb zinc better, which might improve blood vessel function. Researchers are recruiting 20 adults aged 55-70 to compare two healthy diets—one with beef and one with other protein sour…

This study aims to see if switching to a balanced diet for six weeks can reduce body-wide inflammation in people with psoriasis. Researchers will use a new, highly sensitive full-body PET scanner to measure inflammation in the skin and body before and after the diet change in fiv…

This study aims to develop better methods for measuring activity in a small brain area called the locus coeruleus, which is thought to control attention. Researchers will use high-resolution brain scans and test a medication (modafinil) to see how it affects this brain area in 40…

This study aims to understand what makes a doctor's visit effective for knee arthritis pain. Researchers will observe 220 adults with knee osteoarthritis as they use a standard pain-relief gel for 8 weeks. They will measure things like patient-clinician rapport, body language, an…

This study aims to learn if eating pecans daily improves overall health in middle-aged and older adults. For about 7 months, 40 healthy participants will alternate between eating pecans and avoiding them. Researchers will measure changes in heart health, gut bacteria, blood marke…

This study aims to understand the genetic changes that cause moles to form. Researchers will analyze DNA from mole tissue and a participant's blood sample to identify specific mutations. The goal is to build knowledge about mole development, not to provide direct treatment.

This study aims to better understand how much of certain healthy plant compounds, called flavanols, people are eating in their normal diets. Researchers will collect urine samples from 200 healthy adults to measure specific markers that show flavanol intake from foods like apples…

This UC Davis study explores whether young children's experiences with waiting and delaying gratification connect to their later school readiness, behavior, and thinking skills. Researchers will observe 200 typically developing children aged 4-6 through games and tasks that measu…

This study aims to understand how a mild, non-invasive form of brain stimulation (tDCS) affects thinking skills like focus and self-control in healthy adults. Researchers will measure brain activity and performance on computer tasks to see if stimulating the forehead area improve…

This study aims to see if eating honey-flavored yogurt daily for 4 weeks can reduce low-level inflammation and improve gut health in overweight, postmenopausal women. Researchers will compare the effects of honey yogurt to sugar-sweetened yogurt in 20 participants. The goal is to…

This study is creating an international registry to collect information about children with antiphospholipid syndrome (APS), a rare blood clotting disorder. Researchers aim to gather data on what causes APS and how it's treated in pediatric patients. The registry will follow 50 c…

This study aims to understand how a short period of fasting changes the immune system in healthy people. Researchers at UC Davis will have a small group of healthy young men complete a 36-hour water-only fast. They will collect blood and other samples to see how fasting affects i…

This study aims to understand what factors influence patient recovery and survival after major heart and blood vessel surgeries. Researchers will look back at the medical records of 5,000 adults who had these surgeries at UC Davis between 2001 and 2013. The goal is to identify pa…

This study is testing a new, less invasive robotic surgery system that uses just one small opening instead of several. Researchers at UC Davis will perform colorectal surgeries on 25 patients using this single-port robot and compare their recovery and safety results to patients w…

This study aims to better understand why some heart failure patients do worse than others by analyzing their detailed molecular profiles over time. Researchers will collect blood samples and health data from 100 participants to identify patterns that predict who is at highest ris…

This study aims to understand if fidgeting or using a special fidget device can help adults with ADHD pay attention and regulate their emotions better. Researchers will measure focus, memory, and physical responses like heart rate in a controlled lab setting. The goal is to gathe…

This small study aims to see if it's possible and safe to start feeding babies with gastroschisis earlier than usual. Gastroschisis is a birth defect where a baby's intestines are outside the body. Researchers will enroll 20 stable, full-term babies to test if parents agree to th…

This early study from UC Davis is testing whether products made from Chardonnay grape skins can improve blood vessel function and metabolic health. Five participants will try different products in a single-day test, with measurements taken over 6 hours to see how their bodies res…

This study aims to understand why multiple myeloma affects different racial and ethnic groups differently. Researchers will survey 4,000 patients in California who were diagnosed within the last five years to learn about their risk factors, treatment, and quality of life. The goa…

This study is exploring whether drinking a bean smoothie for two weeks can improve gut and metabolic health. Researchers will compare adults who add the smoothie to their usual diet with those who don't. The goal is to gather information on how beans might influence the body to h…

This study is looking at whether eating mangos daily for 4 weeks, instead of typical high-calorie snacks like chips and cookies, can improve gut health and markers for heart health in Hispanic/Latino teenagers. Researchers will enroll 25 teens to compare their health before and a…

This study aims to see if a new natural supplement can help the body make more collagen, a key protein for skin, joints, and ligaments, especially after taking collagen protein and exercising. Researchers will enroll 20 healthy young adults to test this. They will measure collage…

This study aims to understand if women experience worse speech outcomes than men after having their voice box (larynx) removed due to cancer. Researchers will enroll 12 men and women who use a voice prosthesis to speak after this surgery. They will compare surveys and voice measu…

This early-stage study is testing a new PET scan method that aims to measure both blood flow and how much sugar tissues use from a single injection. Researchers want to see if this works as well as using two separate scans. The goal is to create a simpler tool to help doctors und…

This study aims to understand how two types of corn bread affect the body. Researchers will feed healthy volunteers a traditional meal with corn bread made from either whole grain or refined maize flour. They will then measure nutrients in the blood and test how well the meal sig…

This study aims to find out if consuming the sugar substitute erythritol increases markers in the blood linked to clotting and inflammation, which could raise heart risks. It will enroll 24 adults with a higher body weight. Participants will drink beverages sweetened with either …