University Of California, Davis

This study looks at whether eating grapes every day can improve gut health, reduce inflammation, and help blood vessels work better in overweight adults aged 45 to 70. Participants will take a grape powder or a placebo powder twice a day for three weeks. Researchers will measure …

This early-stage trial tests a new treatment called PPM for people with non-muscle invasive bladder cancer that has returned or not responded to standard therapy. PPM uses tiny particles coated with a targeting molecule to deliver a chemotherapy drug directly to cancer cells in t…

This study tests a specially modified stent graft for people with complex aortic aneurysms who cannot use standard devices. The graft is designed to seal the aneurysm and keep blood flowing properly. Researchers will check safety and success in 40 high-risk patients over five yea…

This early-phase trial tests a new vaccine (IO102-IO103) combined with the immunotherapy drug pembrolizumab in 30 adults with high-risk bladder cancer that did not respond to or could not tolerate standard BCG treatment. The vaccine is designed to train the body's immune cells to…

This study tests a two-step approach for adults with a specific type of acute myeloid leukemia (IDH1-mutated AML) who have already responded to initial therapy. First, patients receive a combination of two drugs (olutasidenib and azacitidine) to target cancer cells. Then, they co…

This study tests whether using a continuous glucose monitor (CGM) helps people who have had a kidney transplant and have type 2 diabetes better control their blood sugar. About 80 adults who received a kidney transplant in the past year will wear a CGM device to track glucose lev…

This study tests whether taking sodium bicarbonate (baking soda) can improve muscle energy and physical endurance in people with chronic kidney disease and metabolic acidosis. About 80 adults with moderate-to-severe kidney disease will be randomly assigned to receive either sodiu…

This early-stage study tests whether combining laser interstitial thermal therapy (LITT) with the chemotherapy drug lomustine is safe and feasible for adults with recurrent glioblastoma, an aggressive brain cancer. About 20 participants will receive the laser treatment followed b…

This study tests an experimental drug called senicapoc in people with early Alzheimer's or mild cognitive impairment. The goal is to see if it can reduce inflammation in the brain and slow down memory loss. About 55 participants will take either the drug or a placebo for 52 weeks…

This study tests whether a home monitoring program using text messages and a smartphone app can help people who just had a stent placed in their heart artery. About 200 patients will either get standard care or extra digital support, including blood pressure checks and health coa…

This study tests whether alendronate, a drug used for osteoporosis, can help treat bone damage (osteonecrosis) in adults with sickle cell disease. About 30 participants will take the drug for 6 months to see if it reduces pain and is safe. The goal is to find a new way to manage …

This study tests a procedure called FETO for babies with a severe birth defect where the diaphragm has a hole, causing organs to crowd the lungs. A tiny balloon is placed in the baby's windpipe while still in the womb to help the lungs grow. The study involves 10 pregnant women a…

This study looks at whether follow-up care for opioid use disorder works better through telehealth or in-person visits after starting treatment in the emergency department. About 528 adults who received buprenorphine in the ER will be assigned to either telehealth or in-person ou…

This study tests whether using a protein-based test to choose treatment can help people with advanced non-small cell lung cancer live longer without their cancer getting worse. About 56 adults with stage IIIC or IV lung cancer will be randomly assigned to either standard therapy …

This early-phase study tests a new chemotherapy drug called TR-002 in about 52 adults with advanced solid tumors, including pancreatic cancer, that have not responded to standard treatments. The main goals are to find the safest dose and understand side effects. Researchers will …

This early-stage study tests a two-part system to find and treat metastatic cancer. First, a radioactive tracer is used to spot tumors on a PET scan. Then, a similar radioactive drug is given to deliver radiation directly to the cancer cells. The goal is to see if this approach i…

This early-phase study tests a two-part system: one radioactive substance helps doctors see pancreatic cancer tumors on scans, and another delivers targeted radiation therapy. The goal is to check safety and find the right dose in 30 adults with advanced pancreatic cancer that ha…

This study tests whether adding stem cells from the placenta to fetal surgery can help babies with spina bifida walk better and have better bowel and bladder control. About 55 pregnant women carrying babies with spina bifida will receive the stem cell-enhanced surgery. The goal i…

This early-phase study tests whether combining a blood pressure drug (losartan), an immunotherapy (pembrolizumab), and precise radiation (SBRT) is safe and effective for people with head and neck cancer that has come back or spread. About 24 adults with limited metastatic disease…

This early-stage study tests a new approach to treat metastatic non-small cell lung cancer. A special radioactive compound is designed to seek out and deliver radiation directly to cancer cells, while a companion imaging agent helps see where the cancer is. The goal is to check s…

This early-stage study tests whether injecting cyclosporine directly into bald patches can safely regrow hair in people with alopecia areata, an autoimmune condition causing patchy hair loss. About 12 adults with mild to moderate hair loss will receive either the drug or a placeb…

This study tests two medicines, dopamine and norepinephrine, in newborns with lung and heart failure who also have low blood pressure. The goal is to see which medicine raises blood pressure without making lung problems worse. About 30 babies born at 35 weeks or later will take p…

This early-phase study tests a new radioactive imaging agent called [68Ga]Ga DOTA-5G to see if it can better detect cancer spread in people with advanced invasive lobular breast cancer. About 30 participants will receive the agent and have PET/CT scans at 1 and 2 hours. The goal …

This early-phase study tests a new radioactive imaging agent called [18F]-αvβ6-BP to see if it can better detect and monitor non-small cell lung cancer that has spread to the brain. About 20 adults with this condition will receive a PET/CT scan using the new agent, and the result…

This study tests whether short documentary-style videos can teach firefighters about cancer risks and motivate them to take safety measures. About 1,000 California firefighters will watch one of five videos and answer surveys before and after. The goal is to see if the videos inc…

This study tests two lifestyle programs in 400 older African American and non-Hispanic white adults who are at risk for memory loss and diabetes. One group will do aerobic exercise classes, and the other will get dietary counseling to follow the MIND diet, which emphasizes berrie…

This study aims to create better breastfeeding support for women who had gestational diabetes, with the goal of preventing type 2 diabetes later in life. Researchers will work with patients, healthcare providers, and hospital leaders to design a practical support plan. The study …

This study tests whether drinking tart cherry juice can prevent nerve damage (neuropathy) caused by the chemotherapy drug paclitaxel in people with breast or ovarian cancer. About 86 participants will be randomly assigned to take either a high or low dose of the juice during thei…

This study tests whether a numbing injection through the nose can better relieve severe headaches caused by a brain bleed (subarachnoid hemorrhage). About 40 adults with a secured aneurysm will receive either the nerve block plus standard pain meds or standard meds alone. The goa…

This study tests a non-invasive brain stimulation treatment called TMS for teens and young adults (ages 15-25) with depression and recent suicidal thoughts. The treatment is given over 5 days and uses MRI to target the right brain area. Researchers want to see if it reduces depre…

This study tests two methods of numbing the belly area after a kidney transplant to see which provides better pain relief and reduces the need for strong painkillers. About 200 adult kidney transplant patients will receive either a continuous numbing medicine drip or a single lon…

This study is testing a 2-week program of exercise and nutrition before head and neck cancer surgery. The goal is to see if the program is safe, acceptable, and practical for patients. About 20 adults with a new head and neck cancer diagnosis will take part. The program aims to i…

This study tests a new deep brain stimulation (DBS) approach for 10 people with Parkinson's disease who already have a DBS device. Standard high-frequency stimulation helps movement but can harm thinking. The new method adds low-frequency stimulation to a different brain area, ai…

This study looks at two ways to heal scalp wounds after Mohs surgery for skin cancer. One method lets the wound heal naturally, which can take 8 weeks or more. The other uses a small skin graft from the groin to help the wound close faster. Researchers will track healing time and…

This study compares two methods of closing skin wounds after surgery to see which leads to a better-looking scar. About 73 adults having skin procedures on their head, neck, trunk, or limbs will have half their wound closed with one method and the other half with the other. Resea…

This study compares the side effects of two standard treatments for advanced prostate cancer: abiraterone plus prednisone versus darolutamide alone. Researchers want to see which drug causes fewer severe side effects in 75 adult patients. The goal is to help doctors and patients …

This study tests two different stitching techniques for closing surgical wounds on the head or neck. Half of each wound will be closed with a standard running stitch, and the other half with a locking running stitch. Researchers want to see which method leads to less scarring. Th…

This study tests whether spraying a cooling liquid (ethyl chloride) on the skin before a numbing injection can reduce pain during Mohs surgery for skin cancer. About 80 adults will have half of their surgical site pre-cooled and the other half not, then rate the pain of each inje…

This study tests if injecting steroids outside the tendon sheath works as well as injecting inside it for De Quervain's tenosynovitis, a painful thumb condition. About 80 adults will receive one injection and report their pain levels before and after. The goal is to find a simple…

This study tests whether a natural supplement can increase collagen production in the body when taken with collagen protein. Researchers will measure collagen markers in the blood of 20 healthy young adults after exercise. They will also use participants' blood to see if it stren…

This study looks at whether giving magnesium sulfate through an IV can help manage pain and reduce the need for strong painkillers in trauma patients in the intensive care unit (ICU). About 156 adults with injuries will receive either magnesium or a saltwater solution. The goal i…

This study tests which imaging method—fluoroscopy (X-ray) or ultrasound—works better for a procedure called cooled radiofrequency ablation that targets nerves around the knee to reduce pain. The goal is to improve pain relief and function in people with knee osteoarthritis who ha…

This study tests whether adding a special gauze dressing (called a tie-over bolster) on top of regular stitches can reduce scarring after surgery on the head or neck. Half of each wound will get the extra dressing, and the other half will not, so doctors can compare the results. …

This study tests whether almond oil can improve facial pigmentation as well as the standard treatment hydroquinone. Researchers will also check how each treatment affects the skin's natural bacteria. The study involves 50 premenopausal women with darker skin tones (Fitzpatrick ty…

This study looks at why some people with knee osteoarthritis get more pain relief from a topical gel (diclofenac) than others. Researchers will track 220 adults aged 50+ over 8 weeks, collecting questionnaires and blood samples. The goal is to see if patient traits, clinic visit …

This study looks at whether giving gabapentin before and after chest surgery can reduce the amount of strong painkillers (opioids) that children need. About 60 children under 18 having heart or lung surgery will take part. The goal is to manage pain with fewer opioids, which can …

This study compares a skin patch to standard pills for treating bladder pain and urgency in children aged 4-8 after bladder surgery. About 100 participants will be assigned to either the patch or pill form of the drug oxybutynin. The goal is to see which method better reduces pai…

This study looks at whether eating beef daily as part of a heart-healthy diet helps older adults (ages 55-70) absorb more zinc into their cells and improve blood vessel function. Researchers will measure zinc levels and blood vessel health in 20 participants. The goal is to under…

This study looks at how a person's beliefs about a treatment can change their mood, motivation, and reactions to rewards. Healthy volunteers aged 15-25 will receive a fake (sham) version of brain stimulation, with no active treatment. Researchers will track changes in expectation…

This study looks at how well the pneumonia vaccine works in people who have injured their spleen. The spleen helps fight infections, so people without a working spleen are at higher risk. The study compares three treatments for the injured spleen to see which one allows the best …

This study looks at how certain dietary supplements might change proteins in the immune system of healthy adults. Researchers will give volunteers either a supplement or a placebo and then analyze their blood to see if there are any changes. The goal is to understand how these su…

This study looks at how young women absorb zinc and iron from four types of common beans. Researchers want to understand how natural compounds in beans, like phytate and polyphenols, affect nutrient absorption. Fifteen healthy women who eat beans regularly will participate in thi…

This study looks at how a gentle brain stimulation technique called tDCS affects attention and thinking. Researchers will test healthy adults and people with schizophrenia using cognitive tasks and brain wave recordings. The goal is to understand brain function, not to treat any …

This study looks at how people with epilepsy remember places and scenes, using a virtual tour task. Researchers will map brain areas involved in spatial memory to help predict and prevent memory problems after epilepsy surgery. About 620 adults with epilepsy or healthy volunteers…

This study aims to understand why multiple myeloma affects people of different races and ethnicities differently. Researchers will survey 4000 patients in California, including African Americans, Latinos, Asian Americans, and non-Hispanic Whites, to learn about factors that may i…

This study looks at how young children's experiences with waiting (like for a treat or a gift) are linked to their future behavior and life outcomes. About 200 typically developing children will complete tasks measuring self-control, thinking skills, and social rules, and return …

This small study looks at how a 36-hour water-only fast affects the immune system in healthy men aged 20-40. Researchers will measure changes in immune cells and gene activity. The goal is to understand, not treat, so no direct health benefit is expected for participants.

This observational study aims to test if a new, standardized physical exam can reliably identify joint motion problems in adults who have had a stroke or mini-stroke (TIA), as well as in healthy volunteers. Researchers will compare exam results between the groups and see if motio…

This study looks at how eating kimchi (fermented cabbage) affects the gut health of healthy adults. Researchers will compare people who eat kimchi daily with those who eat non-fermented cabbage. Participants will provide blood and stool samples to measure changes in gut bacteria …

This study is looking at how men and women differ in their speech after having their voice box removed (total laryngectomy) and using a special voice prosthesis. Researchers want to find out if women have poorer voice quality and lower satisfaction compared to men. The goal is to…

This study looks at how common topical medications like antifungal creams, mild steroid ointments, and moisturizers change the community of bacteria living on healthy skin. Researchers will track these changes over a short period in 24 adults. The goal is to understand whether th…

This study looks at whether fidgeting can help adults with ADHD pay attention and manage emotions better. About 109 adults with ADHD who fidget will do thinking and reaction tests in a lab, some while using a fidget device. Researchers will measure their speed, memory, and heart …

This study is testing a new single-port robotic system for colorectal surgeries, such as for cancer or rectal prolapse. It involves 25 adults and aims to see if the robot is safe and effective compared to current multi-port robots. The focus is on measuring complications and reco…

This study looks at whether eating pecans every day for three months can improve metabolism, blood fats, inflammation, blood pressure, thinking skills, and gut bacteria in healthy adults aged 45 to 75. Participants will eat pecans daily for one period and avoid them for another, …

This study looks at a small part of the brain called the locus coeruleus, which helps control attention. Researchers will use special MRI scans and a safe medication to see how this area works. Forty healthy adults aged 18-60 will take part. The goal is to better understand atten…

This study collects information from children diagnosed with Antiphospholipid Syndrome (APS) to better understand what causes it and how to treat it. Researchers will follow about 50 participants over time to track long-term survival. The goal is to improve care for young patient…

This study tests whether a 6-week balanced diet can lower inflammation in people with psoriasis, using a new total-body PET scanner. Five adults with psoriasis who eat a typical Western diet will have scans before and after the diet change. The goal is to see if the diet reduces …

This study looks at whether whole milk or low-fat (1%) milk is better for preventing obesity in toddlers. Researchers will track 625 children aged 1-2 years for one year, measuring changes in waist size and body mass index. The goal is to find out which milk type supports healthy…

This study looks at 100 people with heart failure to see if combining genetic and other health data can identify those at higher risk for serious problems like hospitalization or death. It also tests whether remote monitoring through a smartphone can help doctors adjust medicatio…

This study looks at whether eating honey-flavored yogurt every day for 4 weeks can reduce low-grade inflammation and improve gut health in overweight women aged 45 to 65. Researchers will measure markers of inflammation and gut bacteria changes. The goal is to understand how diet…

This study tests whether a quick bedside ultrasound (FAST) can safely lower the number of CT scans in children with blunt belly injuries. About 4,300 children will be randomly assigned to get either a FAST exam or standard care. The goal is to see if the ultrasound can identify l…

This study looks back at 5,000 adults who had heart or blood vessel surgery at UC Davis Medical Center. Researchers want to find out what factors lead to complications or death after surgery. The goal is to use this information to make future surgeries safer and improve patient o…

This study tests a program called Individual Placement and Support for Autism (IPS-AUT) to help autistic adults ages 18-40 find and keep jobs. Researchers will work with employment agencies to train staff and track job outcomes, satisfaction, and thinking skills. The goal is to s…

This study looks at whether adding beans to the diet can improve metabolic and bowel health in overweight adults aged 30-80 who are scheduled for a colonoscopy. Participants will drink a bean smoothie daily for two weeks, and researchers will measure changes in gut bacteria, bloo…

This study looks at whether eating mango every day for 4 weeks, instead of high-calorie snacks like cookies and chips, can improve gut health, reduce inflammation, and support heart health in Hispanic/Latino teens ages 12-19 with a higher BMI. Researchers will measure blood marke…

This study looks at genetic and biochemical markers in fat tissue from 500 people with severe obesity who are having bariatric surgery. Researchers want to compare tissue from healthy obese patients (no diabetes or other major issues) with tissue from those who have type 2 diabet…

This study looks at how different types of rewards—like praise for effort versus rewards for good grades—affect children's interest in taking on challenging tasks. About 180 children aged 9 to 13 will complete puzzles and games, and their parents will answer questions about how t…

This study looks at how two common sweeteners, erythritol and aspartame, affect blood clotting and blood vessel inflammation. Twenty-four adults with a BMI of 27 or higher will drink beverages sweetened with each sweetener for two weeks, in a random order. The goal is to see if e…

This study looks at whether a safe, non-invasive technique called transcranial direct current stimulation (tDCS) can help with attention, learning, and memory problems in people with schizophrenia. Researchers will test 160 participants to see if applying a tiny electrical curren…

This study tests a new way to use a standard PET scan tracer (FDG) to measure both blood flow and sugar use in the heart at the same time. Researchers will compare these measurements to those from a separate tracer that only measures blood flow. The goal is to simplify heart imag…

This early study looks at whether products made from Chardonnay grape leftovers (marc) can improve heart and blood vessel health. Five adults with higher body weight and slightly reduced blood vessel function will take these products. Researchers will measure blood vessel flexibi…

This study is for teens aged 11 to 17 who come to the emergency room with a mild traumatic brain injury (concussion). Researchers want to see if they can predict which teens will develop new or worse depression or anxiety in the months after their injury. Participants and their p…

This study uses a special full-body PET/CT scan to look at immune activity and blood vessel changes in people with Long COVID (PASC). About 51 adults will get scans and blood tests to see where the body's immune system is out of balance. The goal is to better understand Long COVI…

This study looks at whether a stepped-care program can help identify and treat young people (ages 12-25) who are at high risk for psychosis in community mental health centers. The program starts with simple steps and increases support as needed. Researchers will track how many yo…

This study tests whether the Early Start Denver Model (ESDM), a therapy for young autistic children, works well in community programs. Researchers will work with 600 participants, including 300 children ages 1-5 with autism, their families, and staff from community agencies acros…

This study aims to find the genetic changes that cause moles (melanocytic nevi) to form. Researchers will analyze DNA from skin biopsy samples and blood from 50 adults. The goal is to better understand mole biology, not to test a treatment.

This study looks at whether it is possible to start feeding newborn babies with gastroschisis (a condition where the intestines are outside the belly) soon after surgery. Researchers will enroll 20 infants to see if parents agree to the study and if the feeding plan can be follow…