University Of California, Davis

This phase 2 trial tested a combination of two drugs, ibrutinib and blinatumomab, in 19 adults with B-cell acute lymphoblastic leukemia that had come back or wasn't responding to treatment. The goal was to see how many patients achieved complete remission. The study is completed,…

This early-stage trial tested the safety and best dose of adding niclosamide (a drug used for tapeworm infections) to standard hormone therapy (enzalutamide) in 6 men with advanced prostate cancer that no longer responds to hormone treatment. The goal was to see if the combinatio…

This early-phase trial tested a combination of two drugs, ibrutinib and lenalidomide, in 4 patients with myelodysplastic syndrome (MDS) who had not responded to or could not tolerate standard treatments. The main goal was to find the safest dose and identify side effects. While t…

This pilot study tested a special PET scan method to see if it could detect early signs that targeted therapy is working for genitourinary cancer. Eleven patients had scans before and two weeks after starting treatment. The goal was to see if changes in tumor blood flow could pre…

This study tested whether a device called Endocuff Vision, which attaches to the tip of a colonoscope and has soft projections to flatten folds in the colon, can help doctors find more sessile serrated adenomas—a type of precancerous polyp. Over 400 adults undergoing routine scre…

This study tests whether spraying a cooling mist (ethyl chloride) on the skin before a numbing injection can reduce pain during Mohs surgery for skin cancer. Eighty adults will have half their surgical site pre-cooled and the other half not, then rate their pain. The goal is to f…

This study tested whether aromatherapy can reduce pain, anxiety, and nausea in adults staying in an acute care hospital unit. 94 patients used an aromatherapy tab that releases a scent to inhale. Researchers measured changes in their symptoms and satisfaction. The goal is to see …

This study tested whether a negative pressure suction device placed in the throat could reduce aspiration (food or liquid entering the airway) during swallowing exams in people with severe swallowing problems. Only one person participated, and the device was inserted through an e…

This study looked at whether placing deep stitches 1 centimeter apart or 2 centimeters apart leads to a better-looking scar after skin surgery on the trunk or limbs. Fifty adults had their wounds closed with both spacing methods on different parts of the same wound. Blinded revie…

This study tested whether qigong, a gentle practice of slow movements and meditation, could improve quality of life for people with Long COVID. Forty adults with symptoms lasting over 12 weeks attended six weekly group sessions. Researchers measured changes in physical and mental…

This trial tests whether a communication training program for primary care doctors can improve how they discuss pain with patients and manage opioid prescriptions. Doctors are randomly assigned to receive the training or standard guidelines. Researchers then record patient visits…

This study looked at two methods for healing skin wounds below the knee after surgery: closing the wound with stitches (complex linear closure) or letting it heal naturally (second intention). The goal was to see which method gives a better-looking scar and improves quality of li…

This study looked for markers in blood and urine that show what fruits and vegetables people eat. 300 adults provided samples before and after eating different amounts of produce. The goal is to create an accurate, objective way to measure diet, replacing unreliable food question…

This study tested whether eating certain dietary fats can boost the production of beneficial fats (called cyclopropane fatty acids) by gut bacteria. Ten healthy adults ate specific foods, and researchers measured these fats in their blood, urine, and stool. The goal was to see if…

This study looked at whether protein from insects (like mealworms) can turn on muscle-building processes as well as whey protein. Twenty healthy adults drank a single dose of insect or whey protein, and researchers measured their blood's effect on muscle cells in a lab. The goal …

This study looked at how different collagen supplements with vitamin C affect collagen production after exercise. Twenty healthy adults took either hydrolyzed collagen, a vegan collagen (PrimaColl), whey protein, or a placebo before doing short jump rope sessions three times in 2…

This completed pilot study used a new, FDA-cleared total-body PET/CT scanner called EXPLORER to collect imaging data from 20 healthy volunteers who are members of racial or ethnic minority groups. The goal was to gather preliminary information on how the body absorbs a standard i…

This study looked at how two types of sweet oranges—one rich in certain nutrients called carotenoids and one without—affect inflammation and oxidative stress in healthy adults. Twenty healthy people ate one of the two orange varieties daily for four weeks. Researchers measured ch…

This completed phase 1 trial measured how much lidocaine, a common pain reliever, reaches the tumor and blood in 12 adults undergoing surgery for glioblastoma. Researchers collected blood and tumor samples at multiple times to understand the drug's levels. The goal was to gather …

This study used advanced total-body PET scans to look at how COVID-19 affects the lungs' blood-air barrier. Thirteen adults who had COVID-19 and healthy volunteers each had two scans, one at the start and one four months later. The goal was to measure changes in lung function ove…

This completed study used a total-body PET scanner to track how a radioactive sugar (FDG) behaves in head and neck cancer and inflammation right after injection and many hours later. Seven adults with stage II-IVa oral cancer who were scheduled for radiotherapy took part. The goa…

This early-phase study tested a radioactive tracer called 18F-αvβ6-BP in 5 people who had recovered from COVID-19. The goal was to see if the tracer could highlight lung damage on PET/CT scans. Participants received the tracer intravenously and underwent imaging. The study only a…

This study tested whether a personalized, home-based exercise program done via video calls could improve muscle function in people with moderate-to-severe chronic kidney disease (CKD) who are not on dialysis. Thirty-two sedentary adults aged 30-75 with CKD took part. They did com…

This study looked at whether sending text messages to smokers could get them to sign up for free quitline services. Over 4,000 patients from a large health system were sent texts offering either free counseling or free nicotine patches. The goal was to see which offer led more pe…

This study tested a program for adults aged 65-90 who had breast, colorectal, or prostate cancer. A community health worker assessed their health and provided coaching to address issues often missed after cancer treatment. The goal was to see if the program was feasible and could…

This study looked at how drinking orange juice compared to a sugar-sweetened beverage affects risk factors for heart disease and type 2 diabetes. Fifty-six adults drank either orange juice or a sugary drink for four weeks. Researchers measured changes in cholesterol, blood sugar,…

This completed study observed 150 adults undergoing elective surgery with general anesthesia. Researchers used an esophageal balloon to measure how changes in ventilator settings (tidal volume and PEEP) affect pressure inside the lungs and chest. The goal was to better understand…

This study looked at 43 adults having heart surgery to see if a simple blood pressure reading can accurately measure how well the heart contracts, compared to the standard ultrasound method. The goal was to test a new software tool that analyzes the blood pressure wave. This is a…

This study looked at whether using telemedicine (video or phone consultations) can help people in rural communities with leg wounds get specialist care more quickly. Researchers compared the time from when a wound was found to when a specialist saw the patient, either through tel…