University Of California, Davis

This trial tests a vaccine called LabVax 3(22)-23, designed to help the immune system recognize and attack a protein called labyrinthin found on adenocarcinoma tumor cells. The study includes adults with advanced or metastatic adenocarcinoma and will evaluate the vaccine alone or…

This study tests whether a combination of three drugs (obinutuzumab, ibrutinib, and venetoclax) can shrink tumors in people with untreated follicular lymphoma. The trial includes 40 adults with stage II to IV disease. The goal is to see if the combination works better than any si…

This study tests whether teaching kidney transplant recipients to eat a whole-food plant-based diet can improve their blood pressure, blood sugar, and weight, and reduce hospital visits and infections. About 49 adults who had a kidney transplant in the past 2–12 months and have h…

This Phase II trial tests whether high-dose vitamin D (4,000 IU daily) can correct deficiency and slow cognitive decline better than standard doses in 180 older adults aged 65-90. Participants include those with normal thinking, mild impairment, or early Alzheimer's. The study la…

This study looks at whether eating walnuts can improve cholesterol levels, reduce inflammation, and change gut bacteria in overweight adults aged 45-70 who are at risk for heart disease. Participants eat walnuts as part of their diet, and researchers measure blood lipids, blood p…

This early-stage trial is testing whether it is safe to inject a person's own bone marrow stem cells into their eye to treat vision loss from conditions like macular degeneration and diabetic retinopathy. Fifteen adults with severe vision loss will receive the injection and be mo…

This study tests if a person's own muscle cells, grown in a lab and injected into the tongue, can safely improve swallowing problems caused by head and neck cancer treatment. About 66 adults who finished cancer treatment at least 2 years ago and still have moderate swallowing tro…

This study tests whether adding a special stain called PRAME to standard tissue analysis helps surgeons remove early-stage melanoma more accurately. About 36 adults with stage 0 to IIc melanoma will have slow Mohs surgery, and their tissue will be checked both with and without PR…

This pilot study is testing the world's first total-body PET/CT scanner (EXPLORER) to see if it can improve cancer imaging. Researchers will scan 9 people with prostate cancer, breast cancer, or neuroendocrine tumors using FDA-approved radiotracers. The goal is to measure how wel…

This trial tests an online program to help women who had gestational diabetes get the recommended diabetes screening and lifestyle programs after giving birth. The program includes standard health information plus optional interactive components like values reflection and persona…

This study tests whether a brief 10-20 minute motivational interview given to injured patients who drink heavily can reduce future harm. Researchers will track hospital readmissions, DUIs, and drinking behavior over 12 months in 830 adults. The goal is to see if a simple conversa…

This pilot study tests whether gently massaging a newborn's belly can help prevent jaundice, a common condition that causes yellowing of the skin. Researchers at UC Davis will enroll 30 healthy newborns and ask some parents to perform the massage. The main goal is to see if paren…

This pilot study looks at whether following the DASH diet (a heart-healthy eating plan) can improve the health of people with heart failure. Researchers will track diet, blood pressure, and heart failure markers in 26 adults over time. The goal is to see if medical nutrition coun…

This study is testing a short, online mindfulness program for people still suffering from long COVID symptoms like brain fog, fatigue, and pain. The program includes four training sessions and daily 'microdoses' of mindfulness activities. Researchers want to see if this approach …

This study tests whether a nerve block (bilateral superficial cervical plexus block) plus local anesthetic can reduce pain, nausea, and opioid use after thyroid surgery. 74 adults having a partial or total thyroid removal are randomly assigned to receive either the nerve block or…

This study tests an online Emergency Preparedness Toolkit for caregivers of people with dementia. The toolkit helps caregivers find a backup caregiver so they can focus on their own health needs during an emergency. About 68 caregivers aged 55 and older who live with their partne…

This study tests a tablet-based app called the Digital Memory Notebook (DMN) to help older adults with mild memory problems or early Alzheimer's manage everyday tasks like appointments and medications. Twenty participants will learn to use the app over six weekly sessions, then c…

This pilot study tests whether a supplement called AHCC, made from cultured mushroom mycelia, can improve quality of life for ovarian cancer patients receiving standard chemotherapy. About 20 participants will take either AHCC or a placebo during their treatment. The main goal is…

This phase 3 trial tests whether injecting a fluid (tumescence) before harvesting a skin graft helps the graft heal better after head and neck cancer surgery. About 58 adults having reconstructive surgery will be randomly assigned to receive tumescence or standard care. The main …

This study looks at a way to possibly reduce scarring after surgery on the neck, trunk, arms, or legs. The technique, called "undermining," involves loosening the skin near the wound tips to reduce tension. Half of each wound will get this extra step, and the other half will not,…

This pilot study tests a telehealth-delivered training program for caregivers of infants (12-18 months old) who show early signs of ADHD, such as trouble with self-control or emotion regulation. The program teaches caregivers strategies to support their child's development throug…

This study looks at whether a set of thinking and memory tests can detect changes caused by a stimulant medication in children aged 6 to 17 who have both intellectual disability and ADHD. About 68 participants will receive either the medication or a placebo, then switch after a b…

This study compares two treatments for actinic keratosis, rough skin spots caused by sun exposure. About 73 adults with at least 10 spots on their head, neck, or limbs will receive both cryotherapy (freezing) and a 5-FU cream on different body areas. Researchers will track which …

This study looks at whether having a diabetes coach for 6 months can improve quality of life for families of children (16 or younger) recently diagnosed with type 1 diabetes. About 60 families will either get a coach or standard care. Researchers will check stress levels at 6, 12…

This study looks at two common ways to manage pain after ACL knee surgery: a nerve block (injection near the knee) versus oral pain medication. About 60 adults aged 18 to 45 having ACL reconstruction will take part. The goal is to see if both methods provide similar pain relief a…

This study looks at whether telehealth tools can help families concerned about autism in their infants. Researchers are testing an online assessment tool and a set of video modules that teach parents strategies to support their child's communication. 80 families will be randomly …

This study tests whether teaching memory strategies and promoting exercise, mental activities, and stress management can help older adults with memory concerns keep their thinking sharp. About 263 people aged 65 and older with normal cognition but subjective memory worries will j…

This study aims to create a network of clinics across California that use a mobile app to collect data from people with early psychosis and their families. The data will help doctors track symptoms and make better treatment decisions. Researchers will also develop a tool to measu…

This study looks at whether a fermented wheat germ supplement can help the immune system fight cancer better when taken with standard immunotherapy drugs. About 100 adults with advanced solid tumors (like lung, colon, or melanoma) will take the supplement alongside their usual tr…

This study looks at whether pulse oximeters, which measure oxygen levels, give less accurate readings for newborns with darker skin. Researchers will compare oxygen readings from the device with actual blood oxygen levels in 163 babies of different skin tones. The goal is to find…

This study looks at whether the immune system mistakenly makes antibodies that attack the body's own nerves and muscles in people with multiple sclerosis, myasthenia gravis, and similar conditions. Researchers will collect blood samples (and sometimes cheek swabs) from 120 adults…

This study aims to understand what factors help increase lung cancer screening in people aged 50-80 who smoke or have smoked. Researchers will track how many people get screened and interview staff and patients to learn what works. The goal is to improve screening rates and catch…

This study looks at flavanols, natural compounds found in foods like apples, berries, and tea. Researchers will collect urine samples from 200 healthy adults to measure flavanol metabolites and estimate how much flavanols people typically consume. The goal is to better understand…

This study looks at how eating corn bread made from either refined or whole grain maize flour, along with mung bean stew, affects nutrient levels in the blood and muscle protein synthesis. Twenty healthy, active adults aged 18-30 will eat the meal, and researchers will measure am…

This study looks at whether chicken raised using conventional or regenerative farming methods changes how your body processes nutrients and builds muscle. Nineteen healthy, active adults will eat a portion of chicken from each farming method, and researchers will measure blood nu…

This study tests whether an AI chatbot can help people with hip or knee osteoarthritis feel less conflicted and anxious about their treatment choices. About 100 adults with osteoarthritis will chat with the AI before seeing their surgeon. Researchers will measure changes in decis…

This study looks at how kangaroo care (holding your baby skin-to-skin) changes the nutrients and amount of breast milk in parents whose babies are in the NICU and can't breastfeed directly. About 25 parents will provide milk samples after holding their baby and after no contact, …

This study looks at how popular weight-loss drugs like semaglutide and tirzepatide affect food cravings and diet quality in people with obesity. Over 24 weeks, participants fill out surveys and food diaries to track changes. The goal is to understand whether these medications imp…

This study looks at two different oxygen level targets for newborns who have trouble breathing or a condition called pulmonary hypertension (high blood pressure in the lungs). About 54 babies born at 35 weeks or later are randomly assigned to one of two oxygen goals. Researchers …

This study follows 300 premature babies born before 33 weeks to see if the bacteria in their stool can predict life-threatening conditions like necrotizing enterocolitis, a severe gut infection. Researchers will also analyze the babies' DNA from saliva and look at small molecules…

This study looks at whether temporarily reducing immunosuppressive medication can help kidney transplant recipients mount a stronger immune response to a third dose of the COVID-19 mRNA vaccine. Fourteen participants with low or no antibodies will have their antimetabolite dose l…

This study looks at whether using sunscreen on a healing surgical scar improves how it looks. Fifty adults who had skin cancer surgery will have half of their scar treated with sunscreen and the other half left alone. After three months, doctors will compare the two sides to see …

This study looks at 30 people who have had a moderate to severe traumatic brain injury. Researchers use special PET scans to measure inflammation in the brain at two weeks and two months after the injury. The goal is to see if the amount of inflammation is linked to a higher risk…

This study uses a special total-body PET/CT scanner to take detailed images of muscles and tissues in people with chronic low back pain caused by myofascial pain. The goal is to find new ways to measure pain-related changes in the body, such as blood flow and tissue health. Fifty…

This study compares a new total-body PET/CT scanner (uEXPLORER) with a conventional PET/CT scanner in 180 adults with lung cancer, lymphoma, or melanoma. Each participant gets scanned on both machines to see if the new scanner can produce equally good images in a shorter time. Th…

This study looks at California's program that takes guns away from people who are no longer allowed to own them, such as those convicted of certain crimes or with severe mental illness. Researchers will track 20,000 people to see if the program lowers their risk of future violenc…

This study looks at how the antibiotic doxycycline changes the bacteria on the skin and in the gut of people with acne. Researchers will compare these changes between acne patients and healthy volunteers. The goal is to better understand the link between acne, antibiotics, and th…

This study tests whether showing digital educational materials about organ donation on social media can increase health awareness and organ donor registrations among Californians. Over 2 million Facebook users with California ZIP codes are included. The goal is to see if social n…

This study looks at whether the natural compounds in olive oil, called polyphenols, can improve heart health markers like cholesterol, inflammation, and gene activity. Researchers will give two types of olive oil to healthy, overweight, and obese adults aged 20-45. The goal is to…

This study looks at whether a supplement made from black rice extract can increase levels of BDNF, a protein important for memory and mood. Researchers will give 12 healthy adults either the supplement or a placebo and measure BDNF in their blood. The goal is to see if this natur…

This study looks at how dairy fat, especially a component called milk fat globule membrane, affects inflammation after a high-fat meal. Thirty-eight adults with metabolic syndrome or obesity will consume shakes with different fats, and researchers will measure inflammatory marker…

This study looks at how the sugars, fats, and proteins in breast milk change from mother to mother and over time. Researchers want to see how these differences, along with the mother's diet and health, affect the development of the baby's gut bacteria. About 395 pregnant women wh…

This study looks at how eating cheese, compared to a non-dairy cheese substitute, changes inflammation levels in the body over six hours. Researchers will measure inflammatory markers in the blood of 20 adults with metabolic syndrome or obesity. The goal is to understand the shor…

This study tracks 500 adults with conditions like acid reflux, achalasia, or complications after weight-loss surgery. Participants choose either a newer endoscopic procedure (done through a scope) or standard surgery. Researchers will compare how well each approach controls sympt…

This study checks if a non-invasive monitor (ClearSight) can predict low blood pressure during surgery as accurately as the standard method that uses a needle in the wrist. 50 adults having surgery with general anesthesia and an arterial line will be enrolled. The goal is to see …

This study looks at how weight-loss (bariatric) surgery might change memory and thinking skills in people with obesity who also have cognitive decline. Researchers will test memory and thinking before and after surgery in up to 9,500 participants. The goal is to understand if los…

This study tests whether special PET scans can accurately measure fat, swelling, and scarring in the liver of people with non-alcoholic fatty liver disease (NAFLD). Researchers will compare scan results with standard liver biopsies from 120 adults. If successful, this could lead …

This study looks at how introducing solid foods like sweet potato or pear changes the gut bacteria of breastfed babies. Researchers will track 102 infants and their mothers to see how these first foods affect digestion, health, and early brain development. The goal is to learn ho…

This study looks at whether giving a probiotic called B. infantis to healthy, breastfed infants for 21 days can increase the amount of good bacteria in their stool. Researchers will measure bacteria levels and track any stomach issues or other health changes. The study involves 1…

This study looks at whether a special training program called TEAMS helps therapists and teachers use proven autism therapies more effectively. Researchers will work with about 1206 people, including program leaders, providers, and parents of children with autism. The goal is to …

This study explores whether having college students write and perform a 10-minute play about diet and exercise can boost their knowledge, healthy habits, and overall well-being. Ten UC Davis students will create the play as part of a course, and researchers will measure changes i…

This study uses a safe, painless eye scan called OCT to look at support cells (glia) in the retina, which is part of the brain. Researchers want to see if these cells work differently in people with early signs of Alzheimer's compared to those without. If they find a difference, …

This study follows 1,000 people with stomach pre-cancer conditions like chronic gastritis and intestinal metaplasia. Researchers will track disease progression over time and analyze biospecimens to find biomarkers linked to cancer development. The goal is to better understand who…