Simple injection may boost skin graft success in head and neck cancer patients

NCT ID NCT04967391

Ongoing Symptom relief Sponsor: University of California, Davis Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 3 trial tests whether injecting a fluid (tumescence) before harvesting a skin graft helps the graft heal better after head and neck cancer surgery. About 58 adults having reconstructive surgery will be randomly assigned to receive tumescence or standard care. The main goal is to see if the technique improves graft take and reduces complications like infection or extra clinic visits.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: tumescence (fluid injection)
What this could lead to: If it works, this technique could improve skin graft healing, reduce infections, and cut down on extra clinic visits after head and neck cancer surgery.
What could go wrong: This is a small, single-center trial (58 people) testing a technique already standard in burn care. Results may not apply to all patients or settings.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

head and neck cancer Head and Neck Neoplasms

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GRAFT FAILURE HEAD AND NECK CANCER SURGERY COMPLICATIONS

Contacts and locations

Locations

UC Davis Health

Sacramento, California, 95817, United States

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