HEAD AND NECK CANCER

This study tests a personalized vaccine created from a patient's own immune cells (dendritic cells) that are trained to attack unique markers on their tumor. It is for people with advanced solid tumors who have not responded to standard treatments. The main goal is to check safet…

This study is testing whether combining radiation therapy (proton or X-ray) with the immunotherapy drug pembrolizumab before surgery is safe and effective for people with recurrent head and neck cancer. The trial has two phases: the first checks safety and the right dose, and the…

This study is testing the drug T-DXd (Enhertu) in 100 adults with advanced HER2-positive solid tumors who have already tried other treatments and have no good options left. The goal is to see how well the drug works in real-world settings, including how many patients respond and …

This study tests a new drug called rezatapopt (PC14586) in people with advanced solid tumors that have a specific TP53 Y220C mutation. The drug is designed to reactivate the p53 protein, which normally helps stop cancer growth. The trial will also test rezatapopt combined with th…

This trial investigates whether combining two drugs, camrelizumab and famitinib, can help people with rare head and neck cancers that have spread or cannot be removed by surgery. The study includes four types of these cancers and aims to see how safe and effective the treatment i…

This phase 2 trial is testing a special form of the chemotherapy drug paclitaxel, called polymeric micelles, combined with carboplatin in 29 people with recurrent or metastatic head and neck squamous cell carcinoma. The goal is to see how well the treatment shrinks tumors and to …

This early-stage trial tests a new therapy made from cord blood immune cells that are engineered to better target and attack head and neck cancer cells. Up to 33 patients with advanced disease that has not responded to standard treatments will receive these cells along with low-d…

This phase 2 trial tests whether giving the immunotherapy drug pembrolizumab along with chemotherapy before surgery, followed by pembrolizumab alone for about a year after surgery, can improve outcomes for people with recurrent head and neck cancer. The study aims to see if this …

This study tests whether adding a precise local treatment—like focused radiation or ablation—can help people whose cancer has a few new or growing spots while on standard therapy. Participants continue their usual medication while the resistant tumors are treated directly. The go…

This phase 2 trial is testing a combination of three therapies—modified immune cells (PD-L1 t-haNK), an immune-boosting protein (NAI/Anktiva), and a targeted antibody (cetuximab)—in 25 people with recurrent or metastatic head and neck cancer that has not responded to prior immuno…

This early-phase trial is testing a new treatment called MEM-288, a virus designed to infect and kill cancer cells while also boosting the immune system. The study involves 40 adults with advanced solid tumors, including lung, skin, and breast cancers, who have not responded to s…

This early-phase study tests a new drug called EPI-326 in about 110 people with advanced lung or head & neck cancers that have specific EGFR mutations. The drug is a bispecific antibody designed to target cancer cells more precisely. The main goals are to check safety, find the r…

This Phase II trial tests whether giving a combination of two drugs—Becotatug Vedotin (a targeted chemotherapy) and Pucotenlimab (an immunotherapy)—before and after surgery can improve outcomes for people with recurrent head and neck cancer that can still be removed. About 102 pa…

This study tests a new drug that delivers a tiny dose of radiation directly to cancer cells that have a specific marker called FAP. The trial involves 112 adults with advanced cancers of the pancreas, stomach, esophagus, colon, ovary, head/neck, sarcoma, or mesothelioma. First, a…

This study is testing whether taking the antibiotic metronidazole and using a chlorhexidine mouth rinse for 10 days before surgery can lower the amount of bacteria living inside oral cancer tumors. The researchers will compare bacteria levels before and after treatment in 30 adul…

This program provides the experimental drug ulixertinib to people with advanced solid tumors that have certain gene mutations (MAPK pathway). It is for patients who have not responded well to or have run out of standard treatments. The goal is to control the disease and possibly …

This early-stage study tests a new treatment called ZI-MA4-1, made from specially engineered immune cells, in people with advanced ovarian, lung, sarcoma, or head and neck cancers that have not responded to other therapies. The treatment aims to help the body's immune system atta…

This phase 2 trial is testing an experimental drug called patritumab deruxtecan (HER3-DXd) in 740 people with advanced solid tumors, including melanoma, lung, breast, and other cancers. The drug is given by IV every three weeks. The main goal is to see if the drug shrinks tumors.…

This early-stage study is testing a new drug called ALX2004 in people with advanced lung, head and neck, esophageal, or colorectal cancers that have not responded to standard treatments. ALX2004 is an antibody-drug conjugate designed to deliver a cancer-killing payload directly t…

This phase 2 study tests whether adding occasional chemotherapy to the immunotherapy drug pembrolizumab (Keytruda) can improve outcomes for people with recurrent or metastatic head and neck cancer. A blood test that measures tumor DNA helps doctors decide when to give the chemo. …

This study is testing whether taking three oral chemotherapy drugs together is safe and practical for patients with head and neck cancer that has returned or spread. The trial focuses on people living in rural Midwest areas, making it easier for them to participate from home. The…

This early-stage study tests an experimental drug called IMGS-001 in about 105 people with advanced solid tumors that have come back or not improved after standard treatments. The goal is to find a safe dose and see if the drug can shrink tumors. The study has two parts: first, t…

This study tests whether it is safe to skip radiation to the lymph nodes in the neck after surgery for early-stage oral cancer. About 396 adults aged 18-70 with certain high-risk features will be randomly assigned to receive or not receive this radiation. The goal is to see if sk…

This study tests a new drug called MDX2001 in people with advanced solid tumors that have spread. The main goals are to check the drug's safety and see if it can shrink tumors. About 285 adults with various cancers like lung, breast, or colon cancer will take part. This is an ear…

This phase II trial tests whether a personalized, reduced-volume radiation plan can safely lower side effects after surgery for head and neck cancer. About 50 patients will receive radiation only to high-risk areas, skipping some traditionally treated zones. The goal is to see if…

This study is testing a new way to give chemotherapy and immunotherapy for people with advanced lung or head and neck cancers. Instead of giving both treatments together every time, the plan alternates cycles of chemo plus immunotherapy with immunotherapy alone. The goal is to se…

This early-phase trial is testing a new radioactive drug that seeks out a protein called Nectin-4 found on many cancer cells. The drug delivers a dose of radiation directly to the tumor, aiming to destroy it while sparing healthy tissue. About 150 adults with advanced bladder, br…

This study tests giving chemotherapy and immunotherapy before standard surgery for head and neck cancer. The goal is to shrink tumors enough so that surgeons can perform less extensive, function-preserving operations, reducing damage to swallowing, speech, and vision. The trial e…

This study is for people with head and neck cancer. It compares two types of radiation therapy: one that treats only the cancer and nearby lymph nodes (INRT) and one that treats a larger area (ENI). The goal is to see if the smaller treatment area works just as well and causes fe…

This study looks at whether proton therapy can safely treat cancers that return after standard radiation. Proton beams are more targeted than traditional X-rays, so they may deliver stronger doses to the tumor while sparing healthy tissue. Researchers will track side effects and …

This early-phase study tests an experimental drug called PF-08046876 in about 310 adults with advanced cancers of the bladder, lung, head and neck, esophagus, or pancreas that have not responded to standard treatments. The drug is a type of 'antibody drug conjugate' designed to s…

This phase 2 trial is testing whether using MRI scans to adjust radiation therapy can better protect healthy organs in people with head and neck cancer. The study will enroll 35 patients who will receive standard intensity-modulated radiotherapy, but with a personalized boost gui…

This early study tests whether using ultrasound and microbubbles can help the immunotherapy drug pembrolizumab (Keytruda) work better in people with head and neck cancer that has come back or spread. Only 6 participants will receive three rounds of treatment. The main goal is to …

This early-stage study is testing whether adding the immunotherapy drug cemiplimab to standard chemotherapy and cetuximab before surgery is safe for people with advanced head and neck cancer. The goal is to see if this combination can control the cancer well enough that patients …

This early-stage trial tests whether a stool transplant (FMT) can help cancer patients who develop severe diarrhea or colon inflammation from immune-checkpoint inhibitor drugs. About 40 patients with various cancers will receive the transplant via colonoscopy. The main goal is to…

This early-phase trial tests CPO301, a drug designed to seek out and attack cancer cells that have a protein called EGFR on their surface. About 132 adults with advanced solid tumors (including lung, breast, and head & neck cancers) will receive the drug by IV every three weeks. …

This study is for people with HPV-related throat cancer who have had surgery. It tests whether a lower, personalized dose of radiation (and sometimes chemo) can control the cancer while causing fewer side effects and improving quality of life. About 111 adults whose cancer was re…

This early-phase trial tests a combination of two newer drugs (tislelizumab and pamiparib) plus standard chemotherapy and re-radiation in 30 people whose head and neck cancer has come back. The main goal is to find a safe dose and check for side effects. Participants will be foll…

This study tests a new drug called volrustomig combined with standard chemotherapy (paclitaxel and carboplatin) in people with advanced head and neck cancer that is not caused by HPV. The goal is to see if this combination shrinks tumors before further treatment is tailored based…

This study tests whether giving additional immune therapy after surgery can help prevent head and neck cancer from coming back. It includes 268 adults who already had a good response to initial treatment. The goal is to see if this approach improves survival and is safe.

This phase 2 trial tests whether adding two immunotherapy drugs (iparomlimab and tuvonralimab) to standard chemoradiotherapy can improve outcomes for people with locally advanced head and neck cancer. The study will enroll 27 participants and track how many remain cancer-free aft…

This study tests whether giving lower doses of radiation to certain head and neck cancer patients can still effectively treat the cancer while causing fewer side effects. Participants receive chemotherapy and radiation, and doctors use a special PET scan to decide who can get the…

This study tests a new treatment called iC9-CAR.CSPG4 T cells for people with head and neck cancer that has come back after standard treatments. The therapy uses a patient's own immune cells, modified in a lab to better recognize and attack cancer cells. The main goals are to fin…

This trial tests an experimental drug called CP-383 in people with advanced solid tumors (like lung, colon, or pancreatic cancer) that have not responded to standard treatments. The drug is taken daily by mouth and works by blocking a process cancer cells need to grow. The study …

This study is testing an experimental drug called MCLA-129 in people with advanced solid tumors, including non-small cell lung cancer, head and neck cancer, and colorectal cancer. The drug is a bispecific antibody designed to attach to two cancer-related proteins (EGFR and c-Met)…

This early-phase trial is testing an experimental oral drug called OCT-598 in 51 adults with advanced solid tumors, including breast, lung, and prostate cancers. The study aims to find the safest dose and see if the drug works alone or with standard chemotherapy. It is too early …

This early-stage trial tests a new treatment called VLPONC-01, which is injected directly into head and neck tumors. It delivers a substance (IL-12) that may help the immune system attack the cancer. Some participants will also receive the immunotherapy drug pembrolizumab. The ma…

This study compares two radiotherapy schedules for people with head and neck cancer who begin radiation more than 6 weeks after surgery. One group gets standard treatment (5 days a week), the other gets an accelerated schedule (6 days a week). The goal is to see if the faster sch…

This study tests a combination of three drugs (carboplatin, paclitaxel, and cetuximab) in people with advanced head and neck cancer that has returned or spread. Participants must have already tried the immunotherapy drug pembrolizumab (with or without chemotherapy) and it stopped…

This trial tests a program called ENDURE that helps head and neck cancer patients start radiation therapy within 6 weeks after surgery. The program provides education, social support, and better coordination among doctors. Researchers will compare it to usual care in 532 adults w…

This study tests whether apixaban (a pill taken twice a day) is a safe and more satisfying alternative to enoxaparin (a daily shot) for preventing blood clots after head and neck cancer surgery. About 76 adults will take one of the two medicines for 10 days after surgery. Researc…

This study tests the immunotherapy drug atezolizumab in 200 people with advanced solid tumors (breast, lung, GI, and others). Researchers use each person's tumor DNA to see if it predicts a response. Participants get the same dose every 3 weeks. The goal is to see if DNA analysis…

This study tests a new surgical technique using a thin skin flap from the groin area to rebuild the mouth or throat after cancer removal. The goal is to see if it causes fewer problems at the donor site compared to standard flaps. Forty adults with head and neck cancer will be fo…

This early-phase trial is testing a new therapy called Meta10-TIL for people with advanced solid tumors that have not responded to at least one prior treatment. The therapy uses a patient's own tumor-fighting immune cells, which are modified in the lab to work better, and then gi…

This study is testing a new type of PET scan that uses special radioactive tracers to find and map solid tumors in the body. The tracers target a protein called Trop2, which is often found on cancer cells. Researchers will enroll 400 people with various cancers (including bladder…

This study is testing a new imaging agent called 18F-T2, which is designed to highlight tumors that produce a protein called CAIX. About 200 adults with various cancers (like kidney, lung, or breast cancer) will receive an injection of 18F-T2 and then undergo a PET/CT scan. The g…

This study is testing whether a special type of MRI (called DCE-MRI) can predict jaw bone damage (osteoradionecrosis) in head and neck cancer patients who have had radiation therapy. Researchers will scan up to 1,400 participants before, during, and after radiation to see if chan…

This study tests a dye called pegsitacianine that makes cancer cells glow during surgery. It is for 120 adults with head and neck cancer, including those with an unknown primary tumor. The goal is to see if the dye helps surgeons find and remove all cancer tissue safely.

This study is testing a special camera that uses a laser to take microscopic pictures of suspicious spots inside the mouth. The goal is to see if these images can help doctors diagnose oral cancers and guide surgery. About 140 people with oral cancer will have their lesions image…

This study is testing a blood test that looks for DNA signals from 20 different cancers, including lung, breast, and colon cancer. Researchers will see if the test can find cancer early, detect any cancer left after treatment, and catch a relapse before it shows up on scans. The …

This study tests a new imaging agent called FL-091, which targets a protein (NTSR1) found on some cancer cells. Researchers will use it with PET or SPECT scans to see if it can better detect and stage cancers like head and neck, colorectal, and pancreatic cancer. About 100 adults…

This study tests whether a dye called panitumumab-IRDye800 can make head and neck cancer cells glow during surgery, helping surgeons see and remove all cancer while sparing healthy tissue. About 25 adults with head and neck cancer scheduled for surgery will receive the dye before…

This study tests whether a special PET-CT scan (micro-PET-CT) can accurately show where head and neck cancer ends, compared to standard lab tests. Ten adults with operable head and neck tumors will have their surgical specimens scanned and then checked under a microscope. If succ…

This study tests whether a special dye (indocyanine green) and a near-infrared camera can help surgeons see tiny bits of cancer left behind during head and neck cancer surgery. About 65 adults with oral or throat cancer will receive the dye before surgery. The camera will scan th…

This early-stage trial tests a cream made from inactivated Akkermansia muciniphila bacteria to prevent skin injury in 40 breast or head/neck cancer patients receiving radiation. The cream is applied three times daily to the radiation area. The main goal is to see if it is safe an…

This study tests two ways to prevent dry mouth caused by radiation therapy in head and neck cancer patients. One method uses a tiny camera to clean saliva ducts, and the other uses low-level laser light to boost saliva gland function. 42 patients will be randomly assigned to one …

This study tests a liquid made from cockroach extract (Meilian Fuxin) to prevent severe skin damage in head and neck cancer patients receiving radiation therapy. About 60 participants will apply the solution to their skin during treatment. The goal is to see if it reduces the ris…

This study tests whether a zinc-based spray (Gel X) can prevent painful mouth sores caused by radiation therapy for head and neck cancer. About 130 adults receiving radiation will use either the zinc spray or a sodium bicarbonate rinse. The goal is to see if the spray reduces how…

This phase 2 trial tests whether riluzole, a drug already approved for ALS, can prevent the cognitive problems (often called 'chemo brain') that many cancer patients face during chemotherapy. The study will enroll 24 adults with various cancers who are about to start chemotherapy…

This study tests whether injecting a special gel (sodium thiosulfate) into the ear before each round of cisplatin chemotherapy can prevent hearing loss. About 100 adults with head and neck cancer will receive the gel in one ear only, so the treated ear can be compared to the untr…

This study tests whether cancer patients can complete a supervised exercise program from home using video calls. The program includes resistance training with dumbbells and aerobic exercise. Researchers want to see if this approach is practical and helps patients maintain functio…

This study tests high-dose steroids (methylprednisolone or prednisone) in 35 head and neck cancer survivors who have nerve damage from past radiation. The goal is to find the best dose that improves symptoms like tongue weakness while limiting side effects. Participants must be a…

This study tests whether starting tongue strengthening exercises early, using a device called the Tongueometer, can improve speech and swallowing in people who have had part of their tongue removed due to cancer. The device uses a small air-filled bulb and a mobile app to guide e…

This study tests a light-based treatment (photobiomodulation) to reduce long-term swelling in the head and neck area caused by cancer therapy. It involves 150 adult survivors who have had head and neck cancer and still have swelling for at least 6 months. Participants will receiv…

This study looks at whether offering nutritional counseling and exercise programs before and during radiation or chemoradiation is helpful for head and neck cancer patients. Researchers want to see if patients are willing to join and attend these sessions. The goal is to improve …

This study tests a drug called Pedmark (sodium thiosulfate) to see if it can prevent hearing loss in adults receiving cisplatin chemotherapy for cancers like testicular, head and neck, or thoracic cancer. About 25 adults will take Pedmark alongside their chemo. The drug is alread…

This study tests a program called SNAP that helps head and neck cancer survivors and their caregivers after radiation treatment. The program includes a needs assessment, a personalized care plan, and a mobile app. Researchers want to see if it reduces symptoms for survivors and e…

This study tests whether atorvastatin, a widely used cholesterol medication, can reduce hearing loss caused by cisplatin chemotherapy in people with head and neck cancer. About 224 adults will be randomly assigned to take atorvastatin or a placebo daily during and for three month…

This study tests whether a specially trained nurse-led team can help people recover better after head and neck cancer surgery. The team includes nurses, doctors, dietitians, and counselors who create a personalized care plan. Researchers will compare 80 patients who get this extr…

This study looks at whether starting speech and swallowing therapy early — before and just after surgery — can help people with head and neck cancer recover better. Forty patients will either get early therapy sessions with a speech-language pathologist or the usual care. The mai…

This study tests whether using RECELL® — a device that creates a spray from a patient's own skin cells — can improve skin color matching after head and neck reconstructive surgery. Twenty adults who need this surgery will receive the treatment, and their color match, healing, and…

This study tests whether doing breathing exercises at home can help reduce heart and lung side effects in people being treated for breast, head/neck, or lung cancer. The exercises are designed to strengthen breathing muscles and may be easier than regular aerobic exercise for pat…

This study tests whether wearing a virtual reality (VR) headset during daily radiation therapy can help manage anxiety in people with prostate, breast, lung, or head and neck cancer. About 54 patients will use a Meta Quest 2 headset during their treatments, and researchers will t…

This study tests whether extra nutritional counseling helps head and neck cancer patients maintain their weight after surgery. 60 adults having surgery for head and neck cancer will be split into two groups: one gets standard care, the other gets extra support from a dietitian an…

This pilot study tests whether brodalumab, a drug used for autoimmune conditions like psoriasis, can safely reduce immune-related side effects caused by cancer immunotherapy. About 11 adults with advanced solid tumors who developed these side effects will receive brodalumab injec…

This study tests whether a personalized 12-week speech, swallowing, and voice rehabilitation program can help preserve swallowing function in head and neck cancer patients after minimally invasive robotic surgery. About 53 participants will be enrolled, including those having sur…

Some head and neck cancer survivors develop velopharyngeal dysfunction (VPD), where the soft palate doesn't close properly, causing nasal-sounding speech and trouble swallowing. This study tests a simple injection that plumps up the back of the throat to improve closure. Research…

This study tests whether a daily physical activity routine, started before and continued during radiotherapy, can improve physical function and quality of life for head and neck cancer patients. 80 patients with tumors of the oropharynx, larynx, or hypopharynx will be randomly as…

This study tests a website called Project Prepare that helps head and neck cancer patients stick with swallowing exercises and coping strategies during radiation therapy. The goal is to reduce long-term swallowing problems and improve quality of life. About 300 patients receiving…

This study tests a new cream made from Prussian blue nanoparticles, combined with a special light therapy, to heal severe (grade III) radiation skin burns in head and neck cancer patients. The cream works by mopping up harmful molecules and, when activated by light, produces gent…

This phase 2 trial is testing a topical gel and mouthwash made from olive oil, betaine, and xylitol (XCM-OM118) to see if it can reduce severe oral mucositis (painful mouth sores) in head & neck cancer patients receiving radiation. The study will enroll 63 adults and track how ma…

This study tests whether a special spa therapy can improve skin-related quality of life in people who have skin hardening (fibrosis) after radiation for breast or head/neck cancer. About 110 adults who finished radiation at least 6 months ago will be randomly assigned to receive …

This study tests whether closely watching jaw movement and starting physical therapy early can prevent or reduce trismus (jaw tightness) in people receiving radiation for head and neck cancer. Thirty adults will be checked weekly during treatment and given jaw exercises if their …

This study tests whether a special light therapy called photobiomodulation (PBM) can reduce swelling and tissue hardening caused by radiation treatment in head and neck cancer survivors. Sixty participants who completed radiation at least 3 months ago will be randomly assigned to…

This study tests a nurse-led program that helps head and neck cancer patients manage symptoms early during radiation therapy. The goal is to see if this approach reduces the number of patients who need to pause treatment. About 170 adults with head and neck cancer will take part,…

This phase 2 trial tests whether a traditional Chinese medicine oral liquid and mouthwash can prevent or reduce severe mouth sores caused by radiation therapy in head and neck cancer patients. About 118 adults aged 18-65 will receive either the herbal treatment or a placebo along…

This study tests whether a structured physical activity program can reduce how much time head and neck cancer patients spend sitting or lying down. Researchers will track 96 patients over 18 months, measuring their movement, quality of life, and fatigue. Half the patients will fo…

This study looks at whether nerve transfer surgery can improve facial movement and quality of life for cancer patients who have facial paralysis after treatment. About 40 adults who are scheduled for this surgery will take part. Researchers will track side effects and measure cha…

This study tests a chatbot called Digi-Coach to see if it can reduce physical and emotional distress in people receiving radiotherapy for head and neck cancer. About 138 adults will either use the chatbot alongside standard nursing care or receive usual care alone. The goal is to…

This study tests whether a visual communication tool called MyCareGorithm helps newly diagnosed cancer patients understand their treatment options. About 86 patients with breast or head and neck cancer, along with their caregivers, will use the tool during consultations. The main…

This early-stage study tests a non-invasive procedure that uses focused ultrasound to create a tiny lesion in the brain's pain center. It is for 20 adults with head, neck, or brachial cancer whose pain is not controlled by opioids. The goal is to see if it is safe and can reduce …

This study tests whether a heavy lifting strength training program is safe and helpful for people who have finished treatment for head and neck cancer at least one year ago. Researchers want to see if it improves muscle strength, physical function, fatigue, and quality of life co…

This study tests a personalized radiation therapy called PULSAR for people with head and neck cancer who cannot have or choose not to have standard treatment. The goal is to see if giving fewer, larger doses of radiation that adapt to changes in the body can better control tumors…

This study tests a program called CARES that provides nurse navigators and counselors to rural cancer patients. The goal is to see if this support helps patients start and finish treatment more quickly and improves their quality of care. About 320 adults with solid tumors like lu…

This Phase 2 trial tests whether using MRI to map saliva ducts before radiation therapy can reduce dry mouth in people with oropharyngeal cancer. About 98 participants will be randomly assigned to standard radiation planning or a new approach that spares the parotid ducts. The ma…

This study compares standard radiation therapy to a newer method called dose painting for people with head and neck cancer. The goal is to see if dose painting causes fewer severe mouth ulcers one year after treatment. About 100 participants will be randomly assigned to receive e…

This study tests a cooling device placed inside the mouth during radiation therapy for larynx cancer. The goal is to see if cooling can protect taste buds from radiation damage and prevent loss of taste. About 15 adults with advanced larynx cancer will try the device and report t…

This study tests whether a 2-week exercise and nutrition program is safe and doable for people about to have head and neck cancer surgery. About 20 adults with a new diagnosis will take part. The goal is to see if the program helps patients feel stronger before their operation.

This study tests whether a special light therapy (photobiomodulation) combined with a mobile health app can improve dry mouth and quality of life in people who have had head and neck cancer and completed radiation. Sixty participants will receive either real light therapy or a sh…

This study tests whether special training for caregivers of head and neck cancer patients can reduce the stress of caregiving and help patients recover better at home. About 76 caregivers will be split into two groups: one gets standard care, the other gets hands-on training from…

This study tests whether gargling with olive oil can reduce painful mouth sores caused by radiation or chemotherapy in head and neck cancer patients. About 120 adults will either use olive oil mouthwash or receive standard care for 12 weeks. Researchers will track soreness, dry m…

This study tests whether using a 3D mindfulness virtual reality headset can improve depression, anxiety, pain, and stress in head and neck cancer patients undergoing radiation or chemoradiation. Forty patients will be randomly assigned to either a 3D VR or a 2D non-immersive expe…

This study tests a 6-week program called PAfitME that uses motion-controlled exergames (like Nintendo Switch) to help head and neck cancer survivors manage fatigue and pain after finishing treatment. 150 participants will be randomly assigned to either the exergaming program or a…

This study is testing whether a 12-week virtual program of mind-body classes (like yoga, dance therapy, and tai chi) can reduce fatigue and improve quality of life for people with head and neck, thoracic, gynecologic, or other cancers. About 480 adults currently receiving cancer …

This study is testing whether acupuncture can help reduce the painful side effects of radiation therapy in people with head and neck cancer. Sixty participants will receive either acupuncture plus standard care or standard care alone. The goal is to see if acupuncture can lower t…

This study tests a brief video-based cognitive behavioral therapy (BRIGHT) to reduce body image distress in 180 head and neck cancer survivors. Participants are randomly assigned to either BRIGHT or a supportive care control group. The goal is to see if BRIGHT can help survivors …

This study tests whether a non-invasive electrical therapy, similar to acupuncture but without needles, can help relieve dry mouth in people who had radiation for head and neck cancer. Researchers will treat 75 participants twice a week for 12 weeks and measure changes in dry mou…

This study tests whether a 20-week program of nutrition counseling, home-based exercise, and wellness education can reduce side effects and improve quality of life in 30 adults with head and neck cancer undergoing chemoradiation. The program includes weekly group sessions with a …

This study investigates clonal hematopoiesis (CH) — small mutations in blood cells that can arise naturally or after cancer treatment — in adults receiving chemotherapy or radiation for solid tumors like breast, lung, or colorectal cancer. Researchers will collect blood, saliva, …

This study collects blood and tumor tissue samples from people with head and neck or lung cancers to find biological markers that indicate low oxygen levels within tumors. Low-oxygen tumors tend to be more aggressive and resistant to standard treatments like radiation and chemoth…

This study explores whether planning radiation therapy to avoid key brain regions can reduce thinking and learning problems in children with brain or head and neck tumors. Participants include children receiving radiation, survivors who completed radiation at least two years ago,…

This study is collecting live tumor samples from 2,000 cancer patients undergoing standard biopsies. Researchers will analyze these samples to understand how tumors respond to immunotherapy drugs outside the body. The goal is to develop a method to predict which patients will res…

This study is testing a new PET-CT scanner that takes high-resolution images of tissue removed during cancer surgery. Researchers want to see if these images match lab results and help surgeons make better decisions. The study will include 850 people with prostate, breast, head a…

This study tracks 770 adults with advanced solid cancers (like lung, head and neck, melanoma, or bladder cancer) who are receiving immunotherapy. Researchers collect tumor and blood samples over time to find biological markers that predict how well the treatment works or causes s…

This study is collecting detailed genetic and health information from 500 people with various cancers, including breast, lung, and leukemia. The goal is to create a shared database that helps researchers develop more personalized treatments. Participants provide samples and data,…

This study tests a new program called Financial Compass that helps head and neck cancer patients deal with money problems caused by their illness. About 50 patients who are struggling financially will either get the program or usual care. The goal is to see if the program is prac…

This study is collecting blood and tumor samples from 60 people with recurrent or metastatic head and neck cancer who are receiving standard anti-PD1 immunotherapy. The goal is to find biological markers that can predict whether the immunotherapy will work. Researchers will analy…

This study aims to collect and analyze tumor samples from 10,000 adults with advanced solid cancers (like breast, lung, or colon cancer) to create a province-wide gene database. The goal is to help doctors identify which targeted drugs or clinical trials might work best for each …

This study is looking at how radiation therapy for head and neck cancer might affect thinking skills like memory and attention. Researchers will ask 60 newly diagnosed patients to complete thinking tests and questionnaires three times over one year. The goal is to learn more abou…

This study looks at whether eating more fiber can help head and neck cancer patients avoid muscle loss (sarcopenia). Researchers will track 59 adults from diagnosis for six months, measuring their fiber intake, muscle mass, and inflammation. The goal is to understand the link bet…

This study is developing an AI system that tracks tumors and organs during radiation therapy without needing physical markers. Researchers will use existing patient data to train and test the AI. If it works, it could help doctors target radiation more accurately. The study invol…

This study aims to grow miniature versions of head and neck tumors, called organoids, from patient samples. Researchers will test different cancer drugs on these organoids to see which ones work best. The goal is to eventually use this approach to tailor treatments to each patien…

This study enrolls 7,000 people with various cancers who have had or will have treatment aimed at a cure. Researchers collect blood, tissue, urine, and saliva samples over time to look for tiny bits of cancer DNA left behind. The goal is to find any remaining cancer as early as p…

This study follows 57 head and neck cancer patients during radiotherapy to monitor their nutritional health. Researchers regularly check body composition, muscle strength, food intake, and quality of life using simple tests and questionnaires. The goal is to spot early signs of m…

This study is testing whether tiny particles in the blood, called extracellular vesicles, can predict nerve damage caused by chemotherapy. Researchers will follow 120 adults with various cancers who are receiving specific chemo drugs. Participants give blood samples and answer qu…

This study looks at cells and biomarkers to understand why some head and neck cancers are more aggressive. Researchers will follow 50 newly diagnosed adults who have not yet received treatment. The goal is to learn more about how the cancer behaves, not to test a new treatment.

This study looks at how aware Hispanic/Latinx head and neck cancer survivors are about their risk of developing a second lung cancer and the recommended screening. Researchers will provide tailored education and conduct interviews to understand barriers to screening. The goal is …

This study is testing new MRI techniques to get more detailed images of head and neck and thyroid cancers. About 200 adults will have extra MRI scans before, during, or after treatment. The goal is to see if these scans can provide early clues about how well a treatment is workin…

This study is testing whether advanced PET/MR imaging can help doctors personalize radiotherapy for head and neck cancer. Researchers will scan 390 patients before, during, and after treatment to see if imaging details can predict survival and response. The goal is to improve out…

This study looks at why people with head and neck cancer follow (or don't follow) swallowing exercises after radiation. Researchers will use blood tests and questionnaires to see if immune system proteins or feelings about the disease affect exercise habits. The goal is to find w…

This large observational registry aims to collect data from over 13,000 adults across Europe with rare head and neck cancers, including cancers of the nasopharynx, nasal cavity, salivary glands, and middle ear. Researchers will track patient outcomes like survival, treatment resp…

This study is testing a new tool designed to predict side effects from cancer treatment in elderly patients (70+) with advanced head and neck cancer. The goal is to see if the tool can help doctors choose safer treatments. Only 3 participants are being enrolled, making this a ver…

This study follows 800 head and neck cancer patients who have had radiation therapy to see how often they develop blood vessel narrowing, strokes, or brain changes. Researchers will compare patients with nasopharyngeal cancer to those with other head and neck cancers. The goal is…

This study is a large registry that will follow about 8,000 cancer patients who receive radiation therapy using a special machine called an MR-Linac, which combines an MRI scanner with a radiation beam. The goal is to learn how well this technology works for different cancers, in…

This study will test whether special MRI scans can accurately detect and track damage to the mouth and jaw caused by radiation therapy for head and neck cancers. Researchers will enroll 300 adults undergoing radiation, with some receiving additional MRI scans before and after tre…

This study looks at whether changes in the bacteria living in your mouth and gut (the microbiome) are linked to head and neck cancer. Researchers will collect stool and saliva samples from 60 people—half with cancer and half without—to compare their microbial makeup. The goal is …

This study is testing whether a blood test that looks for tumor DNA (ctDNA) can find cancer returning earlier than standard scans. About 100 people with different solid tumors will give blood samples after treatment. The goal is to see if early detection can lead to better treatm…

This study looks at how well the IGEL laryngeal mask airway works in patients who have had radiation therapy to the neck. These patients are at higher risk of breathing difficulties during anesthesia. Researchers will measure how quickly and successfully the device can be inserte…

The RESCUE study is looking at 400 adults who have salvage surgery for head and neck cancer that came back after radiation. Researchers will track how long patients live without the cancer returning and how well they function after surgery. They will also analyze tumor tissue, bl…

This study looks at how head and neck cancer cells change after radiation treatment. Researchers will collect tissue and blood samples from 20 adults who had radiation before and are now having robotic surgery for new or returning tumors. The goal is to understand why some cancer…

This study collects tumor and blood samples from over 1,000 people with certain cancers (ovarian, breast, head and neck, cervical, vulva, and sarcoma). Researchers will analyze the samples to find links between genetic changes, the immune system, and how the cancer behaves. Parti…

This study collects blood, tumor, and other tissue samples from up to 1,250 people with head and neck, lung, or gastrointestinal cancers. Researchers want to understand how the immune system changes during cancer treatments, especially immunotherapies. Participants donate samples…

This early-phase study is testing a small implantable device that delivers tiny amounts of different drugs directly into head and neck tumors. The goal is to see which drugs are most effective for each person before they undergo full treatment. The study involves 30 adults with c…

This study looks at whether giving written, guideline-based information to head and neck cancer patients and their dentists can improve their knowledge and decisions about dental care. About 132 participants will fill out surveys before and after reading the materials. The goal i…

This study collects blood and leftover tissue samples from 9,600 people with various cancers, including breast, lung, and pancreatic cancer. Researchers will use these samples to improve tests that look for cancer DNA in the blood. The goal is to better detect if cancer returns o…

This study aims to learn how patients rate their symptoms during or after radiation therapy using different questionnaires. Researchers want to see if different rating scales give similar or different results. The study involves 300 adults with head and neck cancer who are curren…

This study aims to uncover the genes and proteins that drive head and neck cancer. Researchers at Stanford will analyze tissue from 500 patients undergoing surgery to better understand how the disease develops and progresses. The goal is to lay the groundwork for future diagnosti…

This study looks at whether a blood test that finds circulating tumor cells (CTCs) can help decide if oral cancer patients need extra chemotherapy after standard treatment. About 100 patients who have completed surgery and chemoradiotherapy will be tested. If their CTC count is h…

This study looks at whether patients who have head and neck reconstructive surgery with a tissue flap recover just as well on a regular hospital ward as in the intensive care unit (ICU). About 192 adults will be randomly assigned to either the ICU or a specialty ear-nose-throat w…

This study tests whether a prehabilitation program—combining physical exercise, nutritional support, and psychological counseling—can help head and neck cancer patients before and during their main treatment (surgery or chemoradiotherapy). About 60 adults will start the program a…

This study aims to create a large collection of blood samples from 2,500 people with or at high risk for cancer. Researchers will use these samples to study liquid biopsies, which are blood tests that may help detect cancer, track treatment response, and spot recurrence. Particip…

This study looks at how the natural bacteria in your mouth might influence the effectiveness of radiation therapy for head and neck cancer. Researchers will collect saliva samples from 100 patients before, during, and after treatment to analyze the bacteria and viruses present. T…

This study tests whether giving head and neck cancer survivors a personalized care plan and a counseling session helps them get better follow-up care. Researchers will compare this group to those receiving usual care. The goal is to see if the plan leads to more doctors following…

This study is for people with HPV-related throat cancer who have surgery to remove their tumor. Researchers are testing whether a blood test that looks for leftover tumor DNA can safely identify patients who do not need additional radiation. The goal is to reduce side effects by …

This study looks at how cancer treatment impacts the work life and overall well-being of 400 men, ages 21 to 70, who have been newly diagnosed with solid tumors like colorectal, lung, or head and neck cancer. Participants will fill out questionnaires about their work hours, finan…

This study collects tissue, blood, and saliva samples from up to 8,000 people with head and neck cancer and healthy volunteers. Researchers also gather medical and lifestyle information to build a detailed database. The goal is to provide a resource for future cancer research, no…

This study is analyzing blood and tumor samples from 30 people with advanced head and neck cancer who are receiving standard immunotherapy plus chemotherapy. The goal is to find biological markers that can predict who will respond well to treatment. By understanding changes in th…

The HOPE study is a long-term research project at Samsung Medical Center that will follow about 350 head and neck cancer patients each year. Researchers will collect medical information, tumor tissue, and blood samples to understand how the disease progresses and why some patient…

This research study collects sputum and tissue samples from 700 people with precancerous changes or certain cancers (lung, head and neck, esophageal). The goal is to find biomarkers—biological signs—that could help understand or detect these cancers earlier. Participants include …

This study tracks 125 cancer patients receiving standard chemotherapy and radiation to understand why they feel tired. Researchers will collect blood, stool, and survey data before, during, and after treatment. The goal is to find patterns that could help predict and manage fatig…

This study will collect blood and tumor samples from 1,100 people with various cancers, including head and neck, ovarian, cervical, lung, and brain cancers. Researchers want to learn how immune cells called T cells behave in these tumors. The goal is to better understand why some…