New MRI scan could predict jaw bone damage in cancer patients

NCT ID NCT03145077

Recruiting now Diagnosis Sponsor: M.D. Anderson Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is testing whether a special type of MRI (called DCE-MRI) can predict jaw bone damage (osteoradionecrosis) in head and neck cancer patients who have had radiation therapy. Researchers will scan up to 1,400 participants before, during, and after radiation to see if changes in the jaw bone and soft tissue can be detected early. The goal is to find a way to identify patients at risk for this serious side effect before it happens.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI)
What this could lead to: If successful, this could help doctors predict and prevent jaw bone damage in head and neck cancer patients receiving radiation therapy.
What could go wrong: This is an observational study, not a treatment trial. It may not lead to a direct benefit for participants, and the MRI technique might not prove accurate enough for routine use.

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Conditions

The condition(s) this trial relates to.

head and neck cancer Head and Neck Neoplasms osteoradionecrosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEAD AND NECK CANCER

Contacts and locations

Locations

M D Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States

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