Can a pill restore the Body's tumor suppressor to fight multiple cancers?

NCT ID NCT07752875

Not yet recruiting ⭐️ CURE ⭐️ Sponsor: LG Chem Source: ClinicalTrials.gov ↗

First seen Aug 07, 2026 · Last updated Aug 07, 2026

Summary

This trial is testing an experimental oral drug, LG00313112, in people with advanced solid tumors that carry a specific genetic change called TP53 Y220C. The drug aims to restore the function of the p53 protein, which normally helps stop cancer growth. The study includes adults with various cancer types, such as ovarian, lung, colorectal, and breast cancer, whose disease has progressed despite standard treatments. The goal is to see if the drug is safe, tolerable, and effective in shrinking or controlling these tumors.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: LG00313112, an oral drug designed to target tumors with a specific TP53 Y220C mutation
What this could lead to: If successful, this could lead to a new targeted treatment for several hard-to-treat cancers that share this specific genetic mutation.
What could go wrong: This is an early-stage trial, so the drug may not work as hoped or may cause side effects. Success in a small group may not translate to broader benefits.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm colorectal cancer colorectal neoplasm endometrial cancer endometrium neoplasm esophageal cancer Esophageal Neoplasms head and neck cancer Head and Neck Neoplasms malignant pancreatic neoplasm Neoplasm Metastasis non-small cell lung carcinoma ovarian cancer pancreatic neoplasm small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST CANCER COLORECTAL CANCER ENDOMETRIAL CANCER ESOPHAGEAL CANCER HEAD AND NECK CANCER LOCALLY ADVANCED UNRESECTABLE OR METASTATIC SOLID TUMOR NON-SMALL CELL LUNG CANCER OVARIAN CANCER PANCREATIC CANCER SMALL CELL LUNG CANCER

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