PANCREATIC CANCER

This study tests a personalized cancer vaccine (XH001) given after surgery for pancreatic cancer. The vaccine is combined with immunotherapy and chemotherapy to help prevent the cancer from coming back. About 28 adults who had their tumor fully or mostly removed will receive this…

This early-stage study tests a vaccine designed to train the immune system to attack cells with a specific mutation (mutant KRAS) that can lead to pancreatic cancer. The vaccine is given to people who are at high risk due to family history or pancreatic abnormalities. The main go…

This study tests whether adding the experimental drug QLS31905 to standard chemotherapy helps people with a specific type of advanced pancreatic cancer live longer. About 602 adults whose tumors have a protein called CLDN18.2 will receive either the drug combo or a placebo plus c…

This study tests a new drug called daraxonrasib to see if it can delay or prevent pancreatic cancer from returning after surgery and chemotherapy. About 500 adults who have had their pancreatic cancer removed will be randomly assigned to receive the drug or just be watched. The g…

This study tests a new drug called GI-108 in people with advanced or metastatic solid tumors (cancers that have spread). The drug is designed to help the immune system fight cancer. The trial has two parts: first, finding a safe dose, and then seeing if it shrinks tumors. About 7…

This study is testing whether combining an immunotherapy drug (atezolizumab), an immune-boosting agent (BDB001), and targeted radiation can help control advanced solid tumors. It includes people with pancreatic cancer, lung cancer, melanoma, bladder cancer, triple-negative breast…

This program provides an experimental drug called AVM0703 to people with various cancers, including brain tumors, breast cancer, and leukemia. It is available in the US when a doctor requests it. So far, 37 patients have received the treatment, and side effects have been mostly m…

This early-phase study tests a new drug called PT0511 in about 195 adults with advanced solid tumors that have a KRAS mutation or amplification, including colorectal, pancreatic, and lung cancers. The main goals are to check safety, find the best dose, and see how the drug works …

This study tests a new drug called ivonescimab, which targets the immune system and tumor blood vessels, combined with targeted radiation and chemotherapy for people with locally advanced pancreatic cancer that cannot be removed by surgery. The goal is to see if this combination …

This study looks at how well the drug T-DXd works in adults with advanced HER2-positive solid tumors that have spread and are not responding to other treatments. About 100 people will be followed to see if their tumors shrink and how long that lasts. The goal is to provide a trea…

This study tests whether adding two targeted drugs (defactinib and avutometinib) to a precise form of radiation therapy can help people with advanced pancreatic cancer live longer without their disease getting worse. About 36 adults whose cancer is locally advanced or borderline …

This study tests whether using a person's genetic makeup to decide the dose of chemotherapy can lower the risk of severe side effects. About 178 adults with colorectal or pancreatic cancer will be randomly assigned to either standard dosing or dosing based on their UGT1A1 gene ty…

This early-phase study tests a new treatment called GC203 TIL for people with pancreatic cancer that has not responded to standard therapies. The treatment uses a patient's own immune cells, which are collected from their tumor, genetically modified to fight cancer better, and th…

This study tests a new combination of drugs (QL1706, nab-paclitaxel, gemcitabine, with or without bevacizumab) as a first treatment for people with advanced pancreatic cancer that cannot be removed by surgery. About 58 adults aged 18-75 who have not had prior treatment for this s…

This study tests a new drug (HRS-4642) combined with standard chemotherapy and an immunotherapy for people with pancreatic cancer that can be surgically removed. The treatment is given before and after surgery to shrink tumors and prevent return. About 30 adults with resectable o…

This study tests an experimental drug called M9140 in people with advanced solid tumors (stomach, lung, or pancreatic cancer) that have a specific protein (CEACAM5). The drug is designed to deliver a powerful chemotherapy directly to cancer cells. The goal is to see if it can shr…

This early-stage study tests a new drug called PF-08046876 in people with advanced cancers of the bladder, lung, head and neck, esophagus, or pancreas. The drug is designed to stick to cancer cells and kill them directly. The main goals are to check safety, find the best dose, an…

This study tests a new treatment for people with advanced pancreatic cancer that cannot be removed by surgery or has spread. The treatment uses a patient's own immune cells, which are mixed with a special antibody to help them attack cancer cells. Up to 23 participants will recei…

This study tests a new drug called ODM-212 combined with other anti-cancer treatments in people with advanced solid tumors, including mesothelioma, pancreatic cancer, and non-small cell lung cancer. The trial has two parts: first finding a safe dose, then checking how well it wor…

This study tests an experimental drug called FMC-376 in people with advanced solid tumors that have a specific genetic change (KRAS G12C). The goal is to find a safe dose and see if the drug can shrink tumors. About 400 adults whose cancer has worsened after standard treatments w…

This early-phase study tests a new drug called BL-M17D1 in people with advanced HER2-positive or low-HER2 gastrointestinal cancers and other solid tumors. The main goals are to check safety, find the right dose, and see if the drug shrinks tumors. About 20 adults will take part, …

This early-phase trial tests whether adding the cholesterol-lowering drug pitavastatin to standard chemotherapy (gemcitabine and nab-paclitaxel) can safely help control advanced pancreatic cancer. About 18 adults whose cancer has not worsened on initial chemo will receive the com…

This study tests whether a higher dose of proton radiation, given alongside oral chemotherapy, can help people with pancreatic cancer that cannot be removed by surgery. The goal is to shrink tumors enough to allow surgery and improve survival. About 60 adults with inoperable or b…

This study tests a new treatment for people with certain cancers (pancreatic, kidney, breast, melanoma, or ovarian) that have a protein called CD70. Doctors take a sample of your blood, remove white blood cells, modify them in the lab to recognize and attack CD70, and then give t…

This early-phase study tests an experimental drug called MRG007 in people with advanced solid tumors (like colorectal, gastric, or pancreatic cancer) that have stopped responding to standard treatments. The main goals are to find a safe dose and see if the drug can shrink tumors.…

This early-stage study tests two drugs, ulixertinib and palbociclib, together in people with advanced solid tumors, including pancreatic cancer and certain melanomas. The main goal is to find the safest dose and check for side effects. About 45 adults whose cancer has not respond…

This study tests a tiny radiation device placed directly into pancreatic tumors, combined with standard chemotherapy. It aims to see if the treatment is safe and helps control pain. About 40 people with advanced or spread pancreatic cancer will take part.

This early-phase trial tests whether adding an experimental MK2 inhibitor (zunsemetinib) to standard chemotherapy (mFOLFIRINOX) can better control metastatic pancreatic cancer. About 51 adults who have not had prior treatment for advanced disease will participate. The main goal i…

This study tests a precise radiation technique for people with pancreatic cancer that cannot be removed by surgery. The goal is to see if this approach can control the tumor while causing fewer stomach and bowel side effects. About 134 participants will receive the treatment afte…

This early-phase study tests a new drug called RSC-1255, alone or with hydroxychloroquine, in people with advanced solid tumors (like lung, colon, pancreatic cancer, or glioblastoma) that have stopped responding to standard treatments. The goal is to find a safe dose and see if t…

This study tests a treatment plan for people with borderline resectable pancreatic cancer. Participants first receive chemotherapy, then proton radiation combined with more chemo, followed by surgery if possible. The goal is to see if this approach is safe and helps control the d…

This study tests new drug combinations (ADC drugs with or without other targeted therapy or immunotherapy) in 160 people with advanced pancreatic cancer that has spread or cannot be removed. The goal is to find the safest and most effective doses to shrink tumors and control the …

This study tests whether a combination of two drugs, AK130 and AK112, can help people with advanced pancreatic cancer that has not responded to up to two prior treatments. The trial will enroll 160 participants and measure how many patients see their tumors shrink or stop growing…

This study tests a combination of chemotherapy drugs (liposomal irinotecan, 5-fluorouracil, oxaliplatin), an immunotherapy (adebrelimab), and radiation therapy before surgery for people with pancreatic cancer that is either removable or borderline removable but has high-risk feat…

This study tests a new approach for advanced pancreatic cancer that cannot be removed by surgery. Doctors place tiny devices called Alpha DaRT seeds directly into the tumor to deliver a special type of radiation from the inside. The main goals are to see if the procedure is safe …

This study looks at adults whose platelet counts stayed low after finishing chemotherapy for gastrointestinal cancers (like stomach, pancreas, or colorectal). Participants get either a standard platelet-boosting drug alone or combined with another medicine (ATRA) for 12 weeks. Th…

This early-stage study tests if adding a heat-based treatment (radiofrequency ablation) to chemotherapy is safe for people with advanced pancreatic cancer that hasn't spread. About 15 participants will receive the combo therapy. The main goal is to check for serious side effects.

This study tests a new drug (NC410) combined with standard chemotherapy (FOLFIRINOX) and two immunotherapy drugs (nivolumab with or without ipilimumab) in people with metastatic pancreatic cancer who have not had prior treatment. The main goal is to check safety and find any unex…

This study tests whether adding low-dose radiation and an immunotherapy drug (pultelimab) to standard treatment can help control advanced pancreatic cancer. About 10 adults who have not had prior immunotherapy will receive the combination. The goal is to see if the treatment shri…

This study tests whether adding the experimental drug atebimetinib to standard chemotherapy helps people with metastatic pancreatic cancer live longer. About 510 adults who have not had prior treatment will be randomly assigned to receive either the new combination or standard ch…

This study tests two different cancer vaccines (GVAX and mKRASvax) combined with two immunotherapy drugs (balstilimab and AGEN2373) in people with pancreatic cancer that can be surgically removed. The goal is to find the safest dose and see if the treatment helps the immune syste…

This early-stage study tests a new drug called RMC-5127 in adults with advanced solid tumors that have a specific KRAS G12V gene change. The main goals are to check safety, find the right dose, and see if the drug can shrink tumors. About 574 people with lung, colorectal, or panc…

This early-phase trial tests a new drug called MDX2001 in people with advanced solid tumors that have spread. The main goals are to check the drug's safety and see if it can shrink tumors. About 285 adults with various cancers like lung, breast, or colon cancer will take part.

This study tests a new drug called AGX101 in people with advanced solid tumors that have not responded to standard treatments. The drug is given through a vein and aims to shrink or control tumors. The main goals are to find the safest dose and understand side effects. About 80 p…

This study tests a new drug called JAB-21822 (Glecirasib) in people with advanced pancreatic cancer or other solid tumors that have a specific KRAS G12C mutation. The goal is to see if the drug can shrink tumors and how safe it is. About 88 participants will take the drug daily, …

This study tests whether combining two drugs, pembrolizumab and olaparib, can shrink tumors in people with advanced pancreatic cancer that has certain genetic changes (high tumor mutation burden or mismatch repair deficiency). About 20 adults who have had no more than one prior t…

This study tests a new treatment for people with certain advanced cancers (like pancreatic, stomach, or colon cancer) that have a specific genetic change called KRAS G12V. The treatment involves taking a patient's own white blood cells, modifying them in a lab to better recognize…

This study offers expanded access to an experimental treatment called DNG64-CAR-V for people with advanced pancreatic cancer, sarcoma, or breast cancer. Up to 40 patients will receive the therapy intravenously or directly into tumors, alone or with other approved cancer drugs. Th…

This program provides ulixertinib, an experimental drug, to adults with advanced solid tumors that have specific genetic changes (MAPK pathway mutations) and who have run out of standard treatments. The goal is to control the cancer, not cure it. Participants may take ulixertinib…

This study looks at whether closely monitoring and controlling blood sugar levels can help people with pancreatic cancer who are receiving chemotherapy. About 50 participants will wear a continuous glucose monitor and be randomly assigned to either tight blood sugar control or st…

This early-phase study tests a new treatment called CAR-NK cells (CL-NK-003) in 9 people with advanced pancreatic cancer that has not responded to standard therapies. The treatment uses specially modified immune cells to target and attack cancer cells. The main goals are to check…

This study tests a new drug called LY4052031 in people with advanced or spreading solid tumors, including bladder, breast, lung, and other cancers. The goal is to see if the drug is safe and works against these cancers. About 420 participants will take part, and the study will la…

This study tests whether using a special surgical glue (Glubran® 2) during pancreas surgery can prevent dangerous fluid leaks. About 194 adults with pancreatic or related cancers who need surgery will be randomly assigned to receive the glue or standard care. The main goal is to …

This study tests whether adding the drugs ivonescimab and AK117 to standard chemotherapy helps people with metastatic pancreatic cancer live longer. About 999 adults aged 18-75 who have not had prior treatment for their advanced cancer will be randomly assigned to receive either …

This early-phase study tests a new treatment called IDOV-Immune, a virus designed to infect and kill cancer cells while boosting the immune system. It is for adults with advanced solid tumors (like colorectal, pancreatic, or lung cancer) that have not responded to standard treatm…

This early-phase study tests a new treatment for people with metastatic pancreatic or breast cancer that has stopped responding to standard therapies. The treatment combines two chemotherapy drugs with high-dose vitamins and a stem cell transplant to help the body recover. The ma…

This study tests a new treatment using specially engineered natural killer (NK) cells that target a protein called TROP2 found on cancer cells. The cells are given directly into the abdomen to people with ovarian or pancreatic cancer that has stopped responding to standard treatm…

This study tests an experimental drug called VMD-928, taken as a pill, either alone or with pembrolizumab (an immunotherapy), in adults with advanced solid tumors or lymphoma that have stopped responding to standard treatments. The goal is to find safe doses and see if the drug c…

This early-stage study tests a new drug called azirkitug, alone or with other medicines, in people with advanced solid tumors like lung, head/neck, and other cancers. The goal is to find safe doses and check side effects. About 694 adults will take part at sites worldwide.

This early-stage study tests a personalized cell therapy for 18 adults with advanced pancreatic cancer that has not responded to standard treatments. The therapy uses a patient's own immune cells, modified to recognize and attack cancer cells with a specific KRAS mutation. The ma…

This study tests a new drug called GAIA-102, given alone or with another drug (pembrolizumab), for people with advanced stomach or pancreatic cancer that has spread to the belly lining and causes fluid buildup (malignant ascites). The first part checks safety and the best dose; t…

This early-stage study tests a new drug called PHN-012 in people with advanced colon, pancreatic, or lung cancers that have stopped responding to standard treatments. The drug is an antibody-drug conjugate, designed to deliver a cancer-killing agent directly to tumor cells. The m…

This study tests a new drug called daraxonrasib, either alone or with standard chemotherapy, for people with metastatic pancreatic cancer that has spread. About 900 adults with a RAS gene mutation will be randomly assigned to one of three treatment groups. The goal is to see if t…

This study looks at whether removing the entire pancreas is better than removing just part of it for people with certain cancers in the head of the pancreas. The goal is to see if total removal helps patients live longer without making their quality of life worse. The trial invol…

This study tests a new drug called KIVU-107 in people with advanced solid tumors that have stopped responding to standard treatments. The drug is designed to target and kill cancer cells while limiting harm to healthy cells. The main goals are to find the safest dose and check fo…

This early-phase trial is testing a device called Suizenji that uses focused ultrasound waves to heat and destroy pancreatic cancer cells from outside the body. The study aims to see if the treatment is safe, tolerable, and effective for patients with advanced pancreatic cancer t…

This early-phase study tests a new treatment called PTC13, which uses a patient's own immune cells (T cells) engineered to target a protein called CEA found on certain cancer cells. The goal is to see if it is safe and tolerable for people with advanced solid tumors like colorect…

This study is testing a type of internal radiation called high-dose-rate brachytherapy for people with liver tumors that cannot be surgically removed. The treatment uses a tiny radioactive source placed directly into the tumor to kill cancer cells while sparing nearby healthy tis…

This study tests whether adjusting cancer treatment based on how the tumor responds can help more people with localized pancreatic cancer complete their full treatment plan and have surgery. About 125 adults with resectable or borderline resectable pancreatic cancer will receive …

This study compares two radiation approaches given before surgery for pancreatic cancer that can be removed or is locally advanced. About 102 participants will receive either stereotactic body radiation therapy (SBRT) or standard radiation with chemotherapy. The main goal is to s…

This study tests a new drug called BOLD-100 combined with standard chemotherapy (FOLFOX) in people with advanced solid tumors like colorectal, pancreatic, gastric, and bile duct cancers. The goal is to see if the combination is safe and can shrink or slow tumor growth. About 220 …

This study tests whether using a tumor's RNA profile (PurIST test) to choose chemotherapy before surgery improves outcomes for people with pancreatic cancer that can be removed. About 84 adults with resectable or borderline resectable disease will receive 12 weeks of personalized…

This early-stage study is testing a new drug, AOH1996, in adults with solid tumors (like lung, ovarian, or pancreatic cancer) that have stopped responding to standard treatments. The main goals are to find a safe dose and understand side effects. The drug works by blocking certai…

This early-stage study tests a new vaccine that targets a common cancer-driving protein (mutant KRAS) combined with two immunotherapy drugs (balstilimab and botensilimab) in people with advanced colorectal or pancreatic cancer that has not responded to standard chemotherapy. The …

This study tests whether adding the experimental drug setidegrasib to standard chemotherapy helps people with a specific genetic form of advanced pancreatic cancer (KRAS G12D mutation) live longer. About 614 adults whose cancer has spread and cannot be removed by surgery will rec…

This study tests a new treatment for people with advanced pancreatic cancer whose tumors have a specific genetic change (KRAS G12V) and a certain immune type (HLA-A*11:01). The treatment uses the patient's own immune cells, modified in a lab to recognize and attack cancer cells. …

This study is testing a new approach for people with advanced pancreatic cancer that cannot be removed by surgery. Doctors place tiny devices that release a special type of radiation directly into the tumor. The goal is to see if this is safe and possible to do, and to check if i…

This study tests a new vaccine made from engineered bacteria that targets KRAS mutations in colorectal and pancreatic cancer patients who have had surgery and chemotherapy but are at high risk of their cancer returning. The vaccine is designed to train the immune system to attack…

This early-phase trial tests a new drug called PTM-101 given alongside standard chemotherapy for people with pancreatic cancer that is either borderline resectable or locally advanced. The goal is to see if the combination is safe and can shrink tumors enough to allow surgery. Ab…

This study tests a device that uses sound waves (histotripsy) to break apart pancreatic tumors without surgery. It includes 50 adults with advanced pancreatic cancer that cannot be removed. The main goal is to check if the procedure is safe and to track any complications within 3…

This study tests a drug called zanidatamab in people with advanced solid tumors that have high levels of HER2 protein. Participants must have already tried at least one other cancer treatment. The goal is to see if the drug can shrink tumors or stop them from growing. This is not…

This early-phase study tests a new treatment called IX001 TCR-T for people with advanced pancreatic cancer that has a specific genetic change (KRAS G12V). The treatment uses the patient's own immune cells, which are modified in a lab to better recognize and attack the cancer. The…

This early-stage study is testing a new radioactive drug injection called 177Lu-CTR-FAPI in patients with advanced, metastatic cancers like pancreatic cancer. The main goals are to see if the treatment is safe, to measure how much radiation reaches the tumors, and to check if it …

This study is testing a new breath test to find pancreatic cancer earlier. Pancreatic cancer is hard to detect because its symptoms are similar to common illnesses. The test looks for tiny molecules in your breath that cancer cells produce. Researchers will check how accurate the…

This study is testing a new radioactive tracer that targets a protein called LRRC15, found on many cancers like pancreatic, breast, lung, and brain tumors. The tracer is used with PET scans to see if it can better detect and stage these cancers compared to standard scans. The stu…

This study is testing a new type of PET/CT imaging that uses special probes to target and highlight digestive system cancers, including cancers of the liver, stomach, colon, pancreas, and more. Researchers want to see how these probes spread in the body and how well they can find…

This study is testing a new test called NEO-Match® that uses nanomechanical profiling to analyze biopsy samples from people with suspected pancreatic cancer. The goal is to see if the test can predict how well patients will respond to treatment and help doctors make better decisi…

This study is testing whether a mixed meal test can accurately diagnose type 3c diabetes, a form of diabetes that occurs in people with pancreatic cancer or chronic pancreatitis. Researchers will enroll 775 adults aged 30 to 85 who have one of these conditions. The goal is to imp…

This study is testing a new type of PET scan that looks for a protein called CLDN18.2 on cancer cells. It includes about 56 adults with stomach, pancreatic, bile duct, or esophageal cancers, plus some healthy volunteers. The goal is to see if this scan can accurately find tumors …

This study is testing a small, portable device called the P4 that sits inside an MRI scanner to improve the accuracy of scans for pancreatic cancer. The goal is to see if the device can help doctors better measure how well cancer treatment is working by tracking blood flow change…

This early-phase study aims to develop a new blood test that detects cancer by measuring specific enzyme activity in plasma. Researchers will compare enzyme levels in 120 patients with localized breast, lung, or pancreatic cancer against 100 healthy volunteers. The goal is to see…

This study tests a new type of PET scan that uses a special tracer (FAPi) to find pancreatic cancer that standard CT scans might miss. About 60 adults with pancreatic cancer will get both a CT scan and this new scan so doctors can compare how well each detects the cancer's spread…

This study is testing a new imaging agent called 18F-T2, which targets a protein (CAIX) found on many solid tumors. About 200 adults with cancers like kidney, bladder, colorectal, or lung cancer will receive a PET/CT scan using this agent. The goal is to see if it can find tumors…

This study is testing a new blood test that looks for tiny particles called exosomes to find pancreatic cancer early. Researchers will study 2,000 people, including those with and without the disease, to see how accurate the test is. If successful, it could lead to earlier diagno…

This study tests an artificial intelligence model called PANDAPro that helps doctors find pancreatic cancer on regular CT scans. The goal is to catch cancers that might otherwise be missed, especially in early stages. The trial will involve 100,000 people aged 18-90 who have had …

This study is testing a blood test that looks for DNA signals from 20 different cancers, including breast, lung, and colon cancer. Researchers want to see if the test can find cancer early, detect any cancer left after treatment, and catch a relapse before symptoms appear. About …

This study is testing a new blood test that uses laser technology and artificial intelligence to find early signs of breast, colon, pancreatic, ovarian, and lung cancers. Researchers will collect blood samples from 1,400 people aged 45 and older who have or are suspected to have …

This study tests an artificial intelligence system that analyzes contrast-enhanced CT scans to help doctors decide the best next step for people with suspected pancreatic diseases. The AI will classify patients into three groups: immediate treatment, close monitoring, or routine …

This early-phase study is testing whether a special PET-CT scan using a tracer called PYLARIFY (piflufolastat F18) can better detect cancer that has spread in people with pancreatic cancer, liver cancer, or breast cancer. About 36 adults will receive the scan, and doctors will co…

This study looks at whether the things people buy at stores—like painkillers or indigestion remedies—could be early warning signs of cancer. Many cancers cause vague symptoms that people treat with over-the-counter products before seeing a doctor. Researchers will compare the sho…

This study aims to develop a simple breath test to detect pancreatic cancer earlier. Pancreatic cancer is often found late because early symptoms are vague. The test looks for tiny molecules in breath that may signal cancer. Researchers will collect breath and urine samples from …

This study is testing a new platform that uses advanced testing to better understand different types of cancer, including leukemia, myeloma, and solid tumors. The goal is to see if this platform can change the recommended treatment for patients, making it more personalized. About…

This study is testing a new imaging system that uses a special dye to make cancer cells glow, helping surgeons see and remove them more completely. About 66 adults with colorectal, pancreatic, esophageal, or gastric cancer will take part before their scheduled surgery. The goal i…

This pilot study tests if brodalumab, a drug approved for autoimmune diseases, can safely reduce severe side effects caused by cancer immunotherapy. About 11 adults with various solid tumors who have immune-related side effects will receive brodalumab. The goal is to see if it lo…

This study compares a new radiation technique called lattice radiation therapy (LRT) to standard stereotactic body radiation therapy (SBRT) for people with solid tumors that have spread to soft tissues. The goal is to see if LRT shrinks tumors better and helps immune cells attack…

This early-stage study is testing whether a low dose of oral ketamine can safely reduce anxiety in people with pancreatic cancer who are currently on or recently finished cancer treatment. About 20 participants will receive both ketamine and a placebo at different times to compar…

This study looks at a procedure called celiac plexus neurolysis, which uses alcohol to block pain nerves in people with pancreatic cancer. Doctors usually inject another drug, bupivacaine, first to prevent pain from the alcohol, but it's not clear if it helps or might even reduce…

This study tests whether a home-based, virtually supervised resistance exercise program combined with daily protein supplements can help people with pancreatic cancer maintain muscle mass while undergoing chemotherapy. About 45 participants will be randomly assigned to one of thr…

This study tests a program that gives extra nutrition help to people who had surgery for pancreatic cancer. Participants use a mobile app to log their meals and get support from a dietitian remotely. The goal is to see if the program is easy to use and helps patients stay nourish…

This study tests whether a remote exercise and nutrition program before surgery can help people with pancreatic cancer get stronger and recover better. About 26 adults with borderline resectable pancreatic cancer will take part. The program is done at home and focuses on improvin…

This study looks at whether a digital app can help cancer patients get genetic testing directly from their oncologist, instead of visiting a separate genetics clinic. The goal is to see if this approach reduces patient distress and improves care. About 180 adults with breast, pro…

This study is observing 3,000 Chinese patients with pancreatic cancer who are receiving a drug called irinotecan liposome. Researchers are collecting real-world data on side effects, survival, and how well the drug controls the cancer. The goal is to understand the drug's safety …

This study is testing a new type of ultrasound called multiparametric ultrasound (mpUS) to see if it can give more detailed information about tissue than standard ultrasound. Researchers will compare mpUS images to regular ultrasound and other tests in people at high risk for pan…

This study looks at how obesity may cause pancreatic cancer to grow differently in African American and White people. Researchers will compare genes, body fat, and tumor behavior in 125 adults. The goal is to find new drug targets and improve treatment for all groups.

This study collects tissue, blood, urine, and stool samples from 5,000 people undergoing colonoscopy or endoscopy, including those with GI cancers, polyps, or inflammatory bowel disease, as well as healthy volunteers. Researchers aim to find new biomarkers that could lead to earl…

This study enrolls 5,000 people at high risk for pancreatic cancer to collect blood, pancreatic juice, and medical images over 10 years. Researchers will use these samples to develop and validate tests for early detection, including AI-assisted analysis. Participants must be 18 o…

This study aims to create and improve educational materials about genetic testing for people with breast, ovarian, prostate, pancreatic, or colorectal cancer. Researchers will interview 445 participants from diverse cultural and language backgrounds to get their feedback. The goa…

This study is a registry that collects information from 1,500 people with advanced pancreatic cancer in Austria. Researchers will track which treatments patients receive and how they respond, including side effects. The goal is to learn from real-world experiences to help guide f…

This study explores whether bacteria in the mouth and gut can help detect pancreatic cancer earlier. Researchers will collect samples from 300 people with suspected pancreatic lesions. The goal is to find microbial patterns that improve diagnosis and treatment planning.

This pilot study aims to see if taking a blood sample from the vein that drains directly from a liver or pancreatic tumor can detect more cancer DNA than a standard blood draw from the arm. Fifteen adults scheduled for a tumor biopsy will provide both types of blood samples. The …

This study aims to learn more about what causes pancreatic cancer by collecting medical history, family history, and blood or urine samples from 10,000 participants. It includes people with pancreatic cancer, those at high risk, and those with other pancreas or liver conditions. …

This study looks at whether CT scans can help doctors predict how well chemotherapy works for people with pancreatic or liver cancer. About 259 adults with these cancers will get CT scans before and during treatment. The goal is to see if changes in the scan can tell if the tumor…

This study aims to find how often three specific BRCA gene mutations occur in Ashkenazi Jewish patients with pancreatic cancer. Researchers will test 100 participants to better understand the genetic links. The goal is to help relatives of patients get earlier screening and treat…

This study looks at tiny particles called exosomes, which carry important messages between cells in the blood and tissue. Researchers will compare samples from 181 people with pancreatic cancer and those with noncancerous pancreatic disease to understand how exosomes relate to ca…

This research study aims to discover new genes that may cause cancer to run in families. Researchers will collect blood samples and health information from 1,500 people in families where multiple members have had childhood cancers. Participants will not receive direct treatment o…

This study collects medical information, blood, tissue, and other samples from up to 20,000 people with pancreas diseases like pancreatic cancer or pancreatitis. The goal is to build a resource that helps researchers better understand these conditions and develop better screening…

This study follows 4,000 adults aged 30 and older who have at least one pancreatic cyst. The goal is to track which cysts turn into cancer and which stay harmless. By collecting data over time, researchers hope to create better guidelines to avoid unnecessary surgeries while catc…

This observational study collects tumor tissue and blood cells from 200 adults with advanced solid tumors like colorectal, lung, or pancreatic cancer. The goal is to understand how often tumors lose a specific marker (HLA) and to store participants' own T cells for possible futur…

This study looks at 800 people aged 50+ who recently developed diabetes or whose diabetes got worse. Researchers use MRI scans and blood samples to find early signs of pancreatic cancer. The goal is to see if changes in diabetes can lead to earlier detection of this cancer.

This study looks at whether watching a video before genetic testing helps people with certain cancers understand their hereditary risk better. About 1020 adults with breast, ovarian, pancreatic, prostate, colorectal, renal, melanoma, or sarcoma cancers will take part. Researchers…

This study collects samples from 320 people, including those with solid cancers and those undergoing lung cancer screening, to detect tumor cells and DNA in blood, urine, and bone marrow. The goal is to learn more about how cancer spreads and to improve early detection and person…

This study is testing whether a new, simple method of collecting rectal mucus can find DNA changes linked to lung, pancreatic, bladder, and colorectal cancers. Researchers will collect samples from 450 adults using a special device and analyze them for genetic and epigenetic mark…

This study enrolls 620 adults with solid cancers (lung, esophageal, stomach, pancreatic, liver, colorectal) to collect blood, urine, and bone marrow samples. Researchers will measure circulating tumor cells and DNA to see how they relate to cancer recurrence and survival. The goa…

This study is collecting information from 8,000 cancer patients treated with a special machine called the MR-Linac, which combines an MRI scanner with a radiation therapy device. The goal is to see how well this technology works for different cancers, including breast, prostate, …

This study looks at how pancreatic cancer changes over time in people receiving chemotherapy. Researchers will take small tissue samples from the tumor at two different times to see if the cancer's genetic type shifts. The goal is to better understand how the cancer evolves, not …

This study collects blood and leftover tissue samples from 9,600 adults with different types of cancer, such as breast, lung, and pancreatic cancer. Researchers will use these samples to improve tests that look for tiny bits of cancer DNA in the blood, which may help detect if ca…

This study is creating a large registry and collection of blood, tissue, and other samples from people with pancreatic disease or at high risk for pancreatic cancer. The goal is to gather information and biological materials for future research to better understand what causes pa…

This study looks at the genes of people with advanced pancreatic cancer to find patterns that might help choose better treatments in the future. Researchers will take a small sample of the tumor and analyze its DNA. They want to see if they can get the results back to doctors wit…

This study looks at whether regular screening with endoscopic ultrasound or MRI can find early signs of pancreatic cancer in people who have a high inherited risk due to BRCA1/2, ATM, or PALB2 gene mutations. About 200 adults with these mutations will be monitored over time. The …

This study is for people with stomach, pancreas, or bowel cancer who are having surgery, as well as some people without cancer for comparison. The goal is to understand why some patients lose muscle and weight (cachexia) and how it affects their recovery. Researchers will track c…

This study is collecting tissue and fluid samples from 160 people with suspected liver, bile duct, or pancreatic cancers. Researchers will analyze these samples to understand the cancers better and test new imaging and robotic tools for earlier, more accurate diagnosis. The goal …

This study looks at 250 people with pancreatic cancer whose stomach is blocked by the tumor. It compares three standard procedures—surgery, a stent placed by endoscopy, or a newer EUS-guided bypass—to see which one helps patients eat better, tolerate chemotherapy, and maintain nu…

This study looks at whether a wearable activity tracker can be used to collect heart rate data from people with pancreatic or breast cancer who are undergoing treatment. The goal is to see if patients find the device easy to use and if they will wear it consistently for 14 days. …

This study aims to create a simple, less invasive test to find pancreatic cancer at an early stage and monitor how well treatment is working. Researchers will study 700 people with pancreatic cancer, pancreatitis, or pancreatic cysts. The goal is to identify biological markers in…

This study tests whether a special MRI technique called 3D-MRE can measure the stiffness of pancreatic tumors and help predict how the disease will progress. Researchers will enroll 200 adults with pancreatic cancer and compare imaging results with actual tumor hardness and treat…

This study is testing whether a personalized nutrition plan can help people recover better after Whipple surgery for pancreatic or bile duct cancers. Twenty adults in Pakistan will receive tailored meals and supplements before and after surgery, and their recovery, weight, and la…

This study is for people with pancreatic cysts or other pancreas issues. Researchers will collect blood, tissue, and scan data from over 1,100 participants to create a tool that predicts which cysts may turn cancerous. The goal is to avoid unnecessary surgeries and catch cancer e…

This study is tracking 24,000 people with type 2 diabetes across seven European countries to see if those who started taking the drug exenatide have a higher risk of developing pancreatic cancer compared to those taking other diabetes medications. Researchers will analyze medical…

This study looks at whether adding a geriatrician (a doctor who specializes in care for older adults) to the cancer care team helps people aged 70 and older with gastrointestinal cancers. Researchers want to see if this approach is practical and if it reduces unplanned hospital v…

This study is creating a large database of medical information and biological samples from adults with or at risk for many types of cancer, as well as healthy volunteers. The goal is to help researchers better understand what causes cancer, how it progresses, and how to improve p…

This study looks at whether adding an MRI scan to the usual CT scan helps doctors choose the right treatment for people with pancreatic cancer. About 200 patients whose CT scans show no spread to the liver will be randomly assigned to get an MRI or not. The goal is to see if the …

This early-phase study tests a small implantable device that delivers tiny amounts of different cancer drugs directly into a pancreatic tumor during surgery. After about 4 hours, the device is removed with the tumor, and researchers check which drugs killed the most cancer cells.…

This study aims to understand how the tumor's surroundings change during chemoradiotherapy for locally advanced cervical and pancreatic cancers. Researchers will collect tissue samples, blood, and imaging data from 60 participants before, during, and after treatment. The goal is …

This study tests whether an app that collects patient-reported data (like pain, appetite, and weight) combined with artificial intelligence can better assess nutritional needs and improve recovery after pancreatic cancer surgery. Researchers will enroll 200 adults aged 18-80 who …

This study aims to test a new AI tool designed to spot severe, muscle-wasting weight loss (cachexia) early in people with pancreatic cancer. It will also check how practical and acceptable diet and exercise plans are for managing this condition. The research will involve about 12…