8,000-Patient study aims to sharpen cancer radiation with Real-Time MRI

NCT ID NCT04075305

Recruiting now Knowledge-focused Sponsor: UMC Utrecht Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is a large registry that will follow about 8,000 cancer patients who receive radiation therapy using a special machine called an MR-Linac, which combines an MRI scanner with a radiation beam. The goal is to learn how well this technology works for different cancers, including breast, prostate, lung, and brain tumors. Researchers will track survival, tumor control, side effects, and quality of life to improve future treatments.

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Conditions

The condition(s) this trial relates to.

brain cancer brain neoplasm breast cancer breast neoplasm esophageal cancer Esophageal Neoplasms female reproductive organ cancer female reproductive system neoplasm head and neck cancer head and neck neoplasm Head and Neck Neoplasms liver and intrahepatic bile duct neoplasm liver cancer Liver Neoplasms lung cancer lung neoplasm malignant pancreatic neoplasm neoplasm neoplasm of esophagus pancreatic neoplasm prostate cancer prostate neoplasm radiation injury rectal cancer rectal neoplasm urinary bladder carcinoma urinary bladder neoplasm Urinary Bladder Neoplasms

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BLADDER CANCER BLADDER NEOPLASM BRAIN CANCER BRAIN TUMOR BREAST CANCER BREAST TUMOR ESOPHAGEAL CANCER ESOPHAGEAL NEOPLASM ESOPHAGEAL TUMOR ESOPHAGUS CANCER ESOPHAGUS NEOPLASM ESOPHAGUS TUMOR GYNECOLOGIC CANCER GYNECOLOGIC TUMOR HEAD AND NECK CANCER HEAD AND NECK NEOPLASMS HEAD AND NECK TUMOR LIVER CANCER LIVER METASTASES LIVER NEOPLASMS LUNG CANCER LUNG NEOPLASM LUNG TUMOR NEOPLASMS OLIGOMETASTASES ONCOLOGY PANCREATIC CANCER PANCREATIC NEOPLASMS PANCREATIC TUMOR PROSTATE CANCER PROSTATE NEOPLASM PROSTATE TUMOR QUALITY OF LIFE RADIATION TOXICITY RECTAL CANCER RECTAL NEOPLASMS RECTAL TUMOR TUMOR

Contacts and locations

Locations

Allegheny Health Network
RECRUITING

Pittsburgh, Pennsylvania, 15212, United States
Austin Health - Olivia Newton-John Cancer Wellness and Research Centre
NOT_YET_RECRUITING

Melbourne, Australia
IRCCS Ospedale Sacro Cuore Don Calabria
RECRUITING

Negrar, Italy
Insitut Jules Bordet
NOT_YET_RECRUITING

Brussels, Belgium
Md Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
Medical College of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States
Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital
RECRUITING

Amsterdam, Netherlands
Odense Universitetshospital
RECRUITING

Odense, Funen, 5000, Denmark
Radboud UMC
RECRUITING

Nijmegen, Netherlands
Radiotherapeutisch Instituut Friesland (RIF)
NOT_YET_RECRUITING

Leeuwarden, Netherlands
Radiotherapiegroep
RECRUITING

Deventer, Netherlands
Sunnybrook Health Sciences Centre/Odette Cancer Centre
RECRUITING

Toronto, Ontario, Canada
The Christie National Health Service Foundation Trust
RECRUITING

Manchester, United Kingdom
The Royal Marsden and The Institute of Cancer Research National Institute for Health Research Biomedical Research Centre
RECRUITING

London, United Kingdom
University Health Network - Princess Margaret Cancer Center
RECRUITING

Toronto, Canada
University Medical Center Utrecht
RECRUITING

Utrecht, 3508GA, Netherlands
Università degli Studi di Brescia
NOT_YET_RECRUITING

Brescia, Italy
Universitätsklinikum Tübingen
RECRUITING

Tübingen, Germany

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