GYNECOLOGIC CANCER

This early-phase study tests a new treatment called GC203 TIL for people with advanced solid tumors (cancers in organs like the breast, lung, or gut) that have not responded to standard therapies. The treatment uses a patient's own immune cells, which are modified in a lab to bet…

This study tests the drug atezolizumab in about 200 adults with different incurable solid tumors. Researchers use each person's tumor DNA and RNA to see if their cancer might respond to the drug. Participants receive the same dose every 3 weeks, and the study checks if the geneti…

This study looks at whether proton therapy can safely treat tumors that have come back after standard radiation. Proton beams are more precise than X-rays, so they may deliver a stronger dose to the tumor while sparing healthy tissue. The study will enroll 1,800 adults with vario…

This study tests a combination of two drugs, cabozantinib and dostarlimab, in 37 women whose gynecologic carcinosarcoma has returned after at least one prior chemotherapy. The goal is to see if the combination can keep the cancer from growing for at least 6 months. Participants w…

This study tests a new radiation method for people with cervical cancer or pelvic cancer that has come back. It is for those who cannot get standard brachytherapy because of unusual anatomy or large tumors. The goal is to see if this technique can control the cancer in the treate…

This study tests whether the drug belzutifan can shrink or control certain gynecologic cancers (like ovarian, endometrial, cervical, vaginal, or vulvar) that have come back or not gone away. About 32 adults with clear cell carcinoma will receive belzutifan pills. The main goal is…

This study is testing whether a headband with special semiconductors can help with memory and thinking problems (often called 'chemo brain') that some people have after chemotherapy. About 50 adults with breast or gynecologic cancer who finished chemo within the last 90 days will…

This study tests a program called MyCarePulse and ASCENT that helps cancer patients overcome food-related challenges. About 100 adults recently diagnosed with certain cancers will either get the program or standard care. Researchers will check if the program improves food securit…

This study tests a program called BOLSTER designed to support people with advanced gynecologic or gastrointestinal cancers and their caregivers. Participants will receive extra help managing complex care needs like ostomies or feeding tubes. The goal is to see if the program impr…

This study tests whether guided imagery—a relaxation technique using mental images—can reduce nausea, vomiting, and anxiety while improving quality of life in women receiving chemotherapy for gynecologic cancer. About 158 participants will be randomly assigned to either practice …

This study tests whether the drug riluzole can prevent memory and thinking problems (often called 'chemo brain') in people receiving chemotherapy for various cancers. About 24 adults with breast, lung, or other cancers will receive either riluzole or a placebo during their chemo.…

This pilot study tests if brodalumab, a drug approved for autoimmune diseases, can safely reduce severe side effects caused by cancer immunotherapy. About 11 adults with various solid tumors who have immune-related side effects will receive brodalumab. The goal is to see if it lo…

This study is testing whether a personalized digital exercise program and virtual support group can help people with gynecologic cancer feel better during treatment. About 60 patients will participate. The goal is to see if the program is practical and helpful for improving well-…

This study tests whether a brief guided meditation during daily radiation therapy can lower anxiety for people with breast or gynecologic cancer. About 34 adults will either listen to a meditation or receive standard care. Researchers will measure anxiety right before and after e…

This study tests whether a mobile app can reduce memory and thinking problems (often called 'chemobrain') caused by chemotherapy in women with gynecologic cancers. About 64 participants will use the app and have their brain function tested. The goal is to see if this simple, at-h…

This study tests a treatment called repetitive transcranial magnetic stimulation (rTMS) for nerve pain caused by chemotherapy in breast and gynecologic cancer survivors. The goal is to see if this non-invasive brain stimulation can reduce pain scores. About 19 women with persiste…

This study tests a stress management program called Vietnamese Self Help Plus (vSH+) for women with breast or gynecologic cancer in Vietnam. The goal is to see if it helps reduce anxiety and depression and improves quality of life. About 285 participants will be randomly assigned…

This study looks at whether a special hospital visit with a team of experts can help women who have finished treatment for ovarian or endometrial cancer get the supportive care they need. About 268 women in remission will either receive a personalized care plan with a day-hospita…

This study tests whether a personalized activity coaching program can help women with endometrial cancer feel less tired during pelvic radiation therapy. Sixteen participants will receive coaching sessions to boost their energy and daily function. The goal is to see if this appro…

This study looks at whether a special retreat program called 'Via Shalva' is helpful and practical for people who have finished treatment for breast or gynecologic cancer. About 30 survivors will take part, and researchers will measure changes in quality of life, stress, and othe…

This study looks at whether using the Headspace mindfulness app before surgery or chemoradiation can help people with endometrial or cervical cancer use fewer opioid painkillers. About 120 participants will be randomly assigned to use the app or not. The goal is to see if mindful…

This study tests whether guarana, a natural plant extract, can improve fatigue in people with neuroendocrine tumors or gynecologic cancers. About 86 adults will take guarana or a placebo for up to 42 days, and researchers will measure changes in fatigue and quality of life. The g…

This study is testing whether a virtual mind-body program called Integrative Medicine at Home (IM@Home) can help people with head and neck, thoracic, gynecologic, or other cancers feel less tired and have a better quality of life while receiving treatments like chemotherapy or ra…

This study tests whether using cold wraps with compression (cryocompression) is better than cold wraps alone at preventing or reducing nerve damage caused by chemotherapy in people with gynecologic cancers. About 190 participants will wear the wraps during chemo sessions and repo…

This study looks at whether a simple bedside lung ultrasound can help identify serious lung problems early in women admitted to the intensive care unit for pregnancy complications or gynecologic cancer. Researchers will track different ultrasound patterns and see if they are link…

This study enrolls 7,000 people with various cancers who have had or will have treatment aimed at curing their disease. Researchers collect blood, tissue, urine, and saliva samples over time to look for tiny bits of cancer DNA that might remain after treatment. The goal is to lea…

This study looks at which type of fluid given through an IV during laparoscopic surgery best helps maintain blood volume and heart function. About 60 adults having abdominal surgery will receive either a salt-based solution or albumin. The goal is to find the safest and most effe…

This study is collecting blood samples from 1,000 people with digestive, gynecologic, or breast cancer to study tiny bits of tumor DNA and particles called exosomes floating in the blood. Researchers want to see if these markers can help predict how the cancer will behave, whethe…

This study follows 500 adults with newly diagnosed gynecologic cancer to understand how frailty—being more vulnerable to stress—affects their recovery and quality of life. Researchers will measure physical frailty using five criteria like weight loss and slow walking. The goal is…

This study aims to gather and analyze medical information from 10,000 people diagnosed with endometrial cancer in Italy. Researchers will look at how the cancer's molecular and immune features affect how long patients live without the disease coming back. The goal is to build a d…

This study aims to see if a new method of collecting fluid from the uterus (uterine lavage) can provide useful information about gynecologic diseases, including cancer. Researchers will analyze the cells and molecules in these samples from 50 women having gynecologic surgery. The…

This study tests whether 3D-printed custom applicators can deliver radiation more precisely than standard cylinder applicators for gynecologic cancers like endometrial, vaginal, and vulvar cancers. Ten participants will receive brachytherapy using a personalized 3D-printed mold d…

This study looks at two ways of using a breathing machine during laparoscopic gynecologic surgery. It compares volume-controlled and pressure-controlled ventilation to see which one better protects lung function and brain oxygen levels. About 120 women aged 18-70 will take part. …

This study is testing a web-based tool called CARE that gives cancer patients information about treatment costs, health insurance, and financial help. About 430 adults with gynecologic, prostate, lung, or colorectal cancer will use the tool to see if it reduces financial stress a…

This study looks at why cancer patients feel very tired during chemotherapy and radiation. Researchers will collect blood and stool samples from 125 adults with different cancers before, during, and after treatment. They aim to find links between fatigue and changes in genes and …

This study is collecting information from 8,000 cancer patients treated with a special machine called the MR-Linac, which combines an MRI scanner with a radiation therapy device. The goal is to see how well this technology works for different cancers, including breast, prostate, …

This study aims to collect and analyze genetic information from 25,000 adults who either have cancer or are at risk of developing it. Researchers will look at tumor DNA and other health records to better understand what drives different cancers. The goal is to find new ways to de…

This study aims to learn more about gene and protein changes in gynecologic cancers (ovarian, uterine, cervical, and others) by collecting tissue and blood samples from 1,000 participants. Researchers will analyze these samples to understand why some people respond differently to…

This study is testing a web-based app that lets cancer patients report side effects from radiation therapy in real time. The goal is to catch problems early and improve care. About 30 adults with gynecologic, urologic, or breast cancer will use the app to answer simple questionna…

This study collects blood, tumor tissue, and other fluids from 510 people with advanced ovarian cancer to find biological markers (biomarkers). Researchers will analyze these samples to understand why some patients respond well to treatment while others do not. Results may be sha…