GYNECOLOGIC CANCER

This study tests a combination of two drugs, cabozantinib and dostarlimab, in 37 women with recurrent gynecologic carcinosarcoma, a rare and aggressive cancer. The goal is to see if the combo can keep the cancer from growing for at least 6 months. Participants must have had at le…

This study looks at whether proton therapy can safely treat cancers that return after standard radiation. Proton beams are more targeted than traditional X-rays, so they may deliver stronger doses to the tumor while sparing healthy tissue. Researchers will track side effects and …

This study tests a new type of radiation called spatially fractionated radiation therapy for people with cervical cancer or pelvic cancer that has come back. It is for patients who cannot get the usual brachytherapy because of unusual anatomy or large tumors. The goal is to see i…

This early-phase study tests a new treatment called GC203 TIL for people with advanced solid tumors (cancers in organs like the breast, lung, or gut) that have not responded to standard therapies. The treatment uses a patient's own immune cells, which are modified in a lab to bet…

This study tests a drug called belzutifan in people with a rare, hard-to-treat type of gynecologic cancer called clear cell carcinoma. The goal is to see if the drug can shrink tumors or stop them from growing. About 32 participants will receive the drug, and researchers will mon…

This study tests the immunotherapy drug atezolizumab in 200 people with advanced solid tumors (breast, lung, GI, and others). Researchers use each person's tumor DNA to see if it predicts a response. Participants get the same dose every 3 weeks. The goal is to see if DNA analysis…

This phase 2 trial tests whether riluzole, a drug already approved for ALS, can prevent the cognitive problems (often called 'chemo brain') that many cancer patients face during chemotherapy. The study will enroll 24 adults with various cancers who are about to start chemotherapy…

This study tests a program called BOLSTER, which offers six telehealth sessions with a nurse to help patients with advanced gynecologic or gastrointestinal cancers and their care partners build skills, manage symptoms, and cope with challenges. Participants also get access to a w…

This study tests whether using cold wraps plus compression (cryocompression) on hands and feet during chemotherapy can reduce nerve damage (peripheral neuropathy) in people with gynecologic cancer. About 190 participants will be randomly assigned to receive either cryocompression…

This study tests whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can reduce nerve pain caused by chemotherapy in breast and gynecologic cancer survivors. About 19 women who have persistent pain after chemo will receive…

This pilot study tests whether brodalumab, a drug used for autoimmune conditions like psoriasis, can safely reduce immune-related side effects caused by cancer immunotherapy. About 11 adults with advanced solid tumors who developed these side effects will receive brodalumab injec…

This study tests if a special type of acupuncture (on the tongue area) can reduce taste problems caused by chemotherapy in people with gynecologic cancers. 75 participants will be randomly assigned to real acupuncture, fake acupuncture, or standard dietary advice. The goal is to …

This study tests whether a personalized activity coaching program can help women feel less tired during pelvic radiation therapy for endometrial cancer. Sixteen participants will be randomly assigned to receive coaching or usual care. The main goal is to see if the program is pra…

This study is testing a program called MyCarePulse and ASCENT to help cancer patients overcome food-related challenges. About 100 adults recently diagnosed with certain cancers will either receive the program or standard care. The goal is to see if the program improves food secur…

This study tests whether guided imagery—a relaxation technique using mental images—can reduce nausea, vomiting, and anxiety while improving quality of life in women receiving chemotherapy for gynecologic cancer. About 158 participants will be randomly assigned to either practice …

This phase 2 trial tests whether guarana, a natural supplement from the Amazon, can reduce fatigue in 86 people with neuroendocrine tumors or gynecologic cancers. Participants take either guarana or a placebo daily for up to 42 days, and researchers measure changes in fatigue usi…

This study tests whether a personalized digital exercise program, combined with a virtual support group, can help gynecologic cancer patients feel better during treatment. Researchers will enroll 60 patients at UCSF to see if the program is practical and acceptable. The goal is t…

This study tests whether a mobile cognitive training app can reduce 'chemobrain'—memory and thinking problems caused by chemotherapy—in people with gynecologic cancers. Sixty-four participants will use the app on their own phones while undergoing chemotherapy and complete thinkin…

This study tests a stress management program called Self-Help Plus for women with breast or gynecologic cancer in Vietnam. The goal is to see if it helps reduce anxiety and depression and improves quality of life. About 285 women will take part, with half receiving the program an…

This study is testing whether a 12-week virtual program of mind-body classes (like yoga, dance therapy, and tai chi) can reduce fatigue and improve quality of life for people with head and neck, thoracic, gynecologic, or other cancers. About 480 adults currently receiving cancer …

This study tests whether brief, audio-recorded guided meditation (10-15 minutes) during daily radiation therapy can lower anxiety in people with breast or gynecologic cancers. About 34 adults will be randomly assigned to either listen to meditation practices or receive standard c…

This study looks at whether using the Headspace mindfulness app before surgery or chemoradiation can help people with endometrial or cervical cancer use fewer opioid painkillers. About 120 participants will be randomly assigned to use the app or not. The goal is to see if mindful…

This study is testing a web-based tool called CARE that gives cancer patients information about treatment costs, health insurance, and financial resources. About 430 adults with gynecologic, prostate, lung, or colorectal cancer will use the tool to see if it helps them feel more …

This study compares a smartphone chatbot to usual care for collecting family history and identifying women at high risk for hereditary cancer syndromes. Participants are English-speaking gynecology patients aged 18 and older who have not had prior genetic testing. The goal is to …

This pilot study is testing whether a 7-day integrative oncology retreat called 'Via Shalva' is practical and helpful for women who have finished primary treatment for breast or gynecologic cancer. Thirty participants will either attend the retreat or receive usual follow-up care…

This study enrolls 7,000 people with various cancers who have had or will have treatment aimed at a cure. Researchers collect blood, tissue, urine, and saliva samples over time to look for tiny bits of cancer DNA left behind. The goal is to find any remaining cancer as early as p…

This study looks at how well different fluids (albumin and Ringer's solution) increase blood volume during laparoscopic surgery. About 60 adults having abdominal surgery will receive one of three fluid types. The goal is to see which fluid keeps the heart and blood vessels workin…

This study aims to gather and analyze detailed medical information from 10,000 people diagnosed with endometrial cancer in Italy. Researchers will look at how the cancer's molecular and immune features affect how long patients stay free of the disease and how long they live overa…

This study looks at how lung ultrasound can help find lung issues early in women who are critically ill due to pregnancy complications or gynecologic cancer. Researchers will check for different lung ultrasound patterns and see if they relate to patient outcomes like death or nee…

This study will analyze the genes of 25,000 adults who have cancer or are at risk for it. Researchers will use advanced testing to find genetic changes linked to cancer and track health records over time. The goal is to learn more about cancer biology and discover new ways to per…

This study is a large registry that will follow about 8,000 cancer patients who receive radiation therapy using a special machine called an MR-Linac, which combines an MRI scanner with a radiation beam. The goal is to learn how well this technology works for different cancers, in…

This study is testing a web-based application that lets cancer patients report side effects from radiation therapy in real time. The goal is to see if this tool helps doctors spot and address complications sooner. About 30 patients with gynecologic, urologic, or breast cancer wil…

This study tests whether 3D-printed custom applicators can deliver radiation more precisely than standard cylinder applicators for gynecologic cancers like endometrial, vaginal, and vulvar cancer. Ten participants will receive brachytherapy with a personalized 3D-printed mold. Th…

This study follows 500 adults with newly diagnosed gynecologic cancer to understand how frailty—a state of increased vulnerability—impacts their recovery and quality of life. Researchers will assess physical function, collect questionnaires, and review surgical outcomes. The goal…

This study looks at how steep head-down position and two types of anesthesia (total IV vs. balanced) change eye pressure in women having robotic surgery for gynecologic cancer. Researchers will measure eye pressure in 40 participants to see which anesthesia method causes less pre…

This pilot study looks at how often women experience posttraumatic stress disorder (PTSD) after gynecologic brachytherapy, a type of internal radiation. Researchers want to find better ways to keep patients comfortable and reduce psychological distress when the treatment applicat…

This study looks at whether a special hospital visit with a team of experts can help women who finished treatment for ovarian or endometrial cancer get more of the supportive care they need. About 268 women in remission will be split into groups: some get the extra hospital asses…

This study is collecting blood samples from 1,000 people with digestive, gynecologic, or breast cancers to see if pieces of tumor DNA floating in the blood (called ctDNA) can help doctors diagnose cancer, predict how the disease will progress, and check if treatments are working.…

This study aims to learn how gene and protein changes in gynecologic tumors affect cancer behavior and treatment response. Researchers will collect tumor tissue and blood samples from 1,000 people with ovarian, uterine, cervical, or other gynecologic cancers. The goal is to bette…

This study collects blood, tumor tissue, and other fluids from people with advanced ovarian cancer to find biological markers (biomarkers). Researchers will analyze these samples to understand why some patients live longer or respond better to treatment. Results may be shared wit…

This study looks at 120 women having laparoscopic gynecologic surgery. It compares two ways of using a breathing machine (volume-controlled vs. pressure-controlled ventilation) to see which one better protects lung function and brain oxygen levels during surgery. The goal is to f…

This study looks at cells and molecules collected from a gentle uterine wash during gynecologic surgery. Researchers aim to understand what types of cells are present and what they reveal about uterine health. Up to 50 participants will provide samples, which will be analyzed for…

This study tracks 125 cancer patients receiving standard chemotherapy and radiation to understand why they feel tired. Researchers will collect blood, stool, and survey data before, during, and after treatment. The goal is to find patterns that could help predict and manage fatig…