Chill out chemo nerve pain: cold wraps plus compression tested in new trial

NCT ID NCT06139458

Recruiting now Symptom relief Sponsor: Duke University Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether using cold wraps plus compression (cryocompression) on hands and feet during chemotherapy can reduce nerve damage (peripheral neuropathy) in people with gynecologic cancer. About 190 participants will be randomly assigned to receive either cryocompression or cold wraps alone. The goal is to see if the combination is better at preventing numbness, tingling, and pain, and if it's tolerable for patients.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: cryocompression (cold wraps plus compression therapy)
What this could lead to: If it works, this could offer a simple, non-drug way to prevent or ease nerve pain from chemotherapy, improving quality of life during cancer treatment.
What could go wrong: This is a mid-sized trial testing a non-drug approach, so results may not be dramatic or apply to all patients. The benefit over cold therapy alone is uncertain, and tolerability varies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for CERVICAL CANCER are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

cervical cancer chemotherapy-induced neuropathy endometrial cancer female reproductive organ cancer ovarian cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHEMOTHERAPY-INDUCED PERIPHERAL NEUROPATHY GYNECOLOGIC CANCER

Contacts and locations

Locations

Carilion Clinic
RECRUITING

Roanoke, Virginia, 24016, United States
Duke University Medical Center
RECRUITING

Durham, North Carolina, 27710, United States
Hartford Healthcare Cancer Institute
NOT_YET_RECRUITING

Hartford, Connecticut, 06106, United States
Middlesex Health Cancer Center - Middletown
RECRUITING

Middletown, Connecticut, 06457, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.