Can a new drug shield nerves from Chemotherapy's side effects?
NCT ID NCT07765446
First seen Aug 14, 2026 · Last updated Aug 14, 2026
Summary
This phase 2 trial is testing an experimental drug called SIR2501 in adults with solid tumors who are about to receive paclitaxel-based chemotherapy. The goal is to see if SIR2501 is safe, tolerable, and might reduce the development of chemotherapy-induced peripheral neuropathy—a common side effect causing pain, numbness, and tingling. Participants will receive one of three doses of SIR2501, and researchers will monitor side effects and drug levels in the body.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- SIR2501
- What this could lead to
- If successful, SIR2501 could offer a way to prevent or reduce the nerve pain and numbness caused by paclitaxel chemotherapy, improving quality of life for cancer patients.
- What could go wrong
- This is a small, early-phase study focused on safety and dosing, so it may not prove effective. The drug could also have side effects or fail to show a clear benefit in preventing neuropathy.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Study site
Baltimore, Maryland, 21287, United States
-
Study site
East Brunswick, New Jersey, 08816, United States
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