CHEMOTHERAPY-INDUCED PERIPHERAL NEUROPATHY

This study tracks how chemotherapy causes nerve pain (peripheral neuropathy) in breast cancer patients. It also tests a brain-computer interface that stimulates the brain to see if it can prevent this pain. The goal is to understand and stop nerve damage early.

This study tests whether wearing a compression stocking on one foot during antibody-drug conjugate (ADC) infusions can prevent nerve damage (peripheral neuropathy). About 58 adults with advanced cancers like bladder cancer will take part. Each person will wear a stocking on their…

This study tests a special cooling sleeve worn on the arms and legs during chemotherapy to prevent nerve damage, a common side effect. About 80 cancer patients receiving weekly paclitaxel will try the device. Researchers will check for side effects and ask patients about numbness…

This study tests whether cannabis-based compounds (CBD and THC) can reduce chronic nerve pain, tingling, and numbness caused by chemotherapy in breast and colon cancer survivors. About 120 participants will receive different types of phytocannabinoids and report their symptoms ov…

This study looks at whether a spinal cord stimulator can help people with long-term nerve pain caused by chemotherapy. About 20 adults who still have pain at least six months after finishing chemo will try this device. The goal is to see if it cuts pain by half or more and improv…

This study looks at whether ozone therapy can improve quality of life for people with long-lasting pain or side effects from cancer treatments like radiation and chemotherapy. About 105 adults who have not found relief from standard treatments will receive ozone therapy as an add…

This study tests if a capsaicin patch (made from chili peppers) works better than the drug duloxetine for nerve pain caused by chemotherapy. About 274 adults with ongoing pain in their hands and feet will receive either a one-time patch or daily pills for 5 weeks. The goal is to …

This study tests whether acupuncture can ease nerve pain and numbness caused by chemotherapy in people with gynecologic, urologic, or rectal cancers. About 75 participants will be randomly assigned to receive real acupuncture, sham acupuncture, or no extra treatment. The goal is …

This study tests an experimental gel called VMD-3866 for people with nerve pain from chemotherapy (CIPN). The gel is applied to the skin and works by calming overactive nerves without entering the brain, so it's not addictive. Researchers will compare the gel to a placebo in 16 a…

This study tests whether a device that cools and squeezes the arms and legs during chemotherapy can help prevent or reduce nerve damage (numbness, tingling, pain) caused by taxane drugs. About 50 adults with breast or gynecologic cancer will wear the device during their first rou…

This study tests whether adding ozone therapy to standard care can reduce nerve pain caused by chemotherapy. About 42 adults with cancer who have had pain for at least 3 months will receive either ozone or a placebo. The goal is to see if ozone helps with pain and quality of life…

This early study is testing whether a commercially available CBG/CBD oil is safe and can reduce nerve pain, numbness, and tingling caused by chemotherapy in people who have finished treatment for gastrointestinal cancers. Twelve adults will take the oil under their tongue twice d…

This study tests whether a mobile app can teach family caregivers safe massage techniques to help cancer survivors with long-term nerve damage from chemotherapy. About 300 people (survivors and their caregivers) will use the app at home to see if it reduces pain, numbness, and ti…

This study tests whether a virtual diet program (low added sugar, high fiber, and omega-3s) can help cancer survivors manage nerve pain, numbness, and tingling caused by chemotherapy. About 50 adults who finished chemo at least three months ago and still have moderate nerve sympt…

This study tests a new way to help people with nerve damage caused by chemotherapy. Participants report their symptoms daily via website, app, or phone for 12 weeks. One group gets standard care, while the other receives a prompt call from a nurse practitioner who uses a treatmen…

This study tests whether combining a nerve pain drug (duloxetine) with neurofeedback—a therapy that teaches you to change your own brain waves—can better relieve chemotherapy-induced nerve damage than either treatment alone. About 380 adults with nerve pain from past chemo will b…

This study tests a new approach to help breast cancer survivors with nerve pain caused by chemotherapy. Instead of real needles, participants watch guided acupuncture videos at home. The study is small (20 people) and focuses on whether this method is practical and satisfying, no…

This early study tests whether a small device that sends gentle electrical pulses to nerves in the leg can relieve long-lasting pain caused by chemotherapy. Ten cancer survivors with moderate to severe pain will try the treatment. The main goal is to see if it is safe and if it h…

This study tests whether Scrambler Therapy, a device that sends mild electrical signals to the skin, can reduce pain, numbness, and tingling caused by chemotherapy. About 90 adults with persistent nerve pain after chemo will receive either real or sham treatment for 10 sessions. …

This study tests whether using cold wraps with compression (cryocompression) is better than cold wraps alone at preventing or reducing nerve damage caused by chemotherapy in people with gynecologic cancers. About 190 participants will wear the wraps during chemo sessions and repo…

This study is testing whether tiny particles in the blood, called extracellular vesicles, can predict nerve damage caused by chemotherapy. Researchers will follow 120 adults with various cancers who are receiving specific chemotherapy drugs. Participants will give blood samples a…

This study aims to create a simple, objective tool to detect nerve damage caused by the chemotherapy drug vincristine in children and teens. Researchers will test a new device on 40 patients aged 6-18 who have received vincristine for leukemia. The goal is to catch nerve problems…

This study looks at how cinnamon and chili extracts affect blood flow in the skin of people with nerve pain caused by chemotherapy. Researchers will compare healthy volunteers and patients to better understand this pain. The goal is to learn more, not to test a new treatment.

This study aims to find out if a simple blood test can identify breast cancer patients at higher risk of nerve damage from the chemotherapy drug paclitaxel. Researchers will measure a protein called NFL in the blood after the first treatment cycle to see if it predicts who will n…