Pepper patch takes on pills for chemo nerve pain

NCT ID NCT05840562

Recruiting now Symptom relief Sponsor: Institut Cancerologie de l'Ouest Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 3 trial compares a capsaicin patch (applied once) to the daily pill duloxetine for treating painful nerve damage caused by chemotherapy. About 274 people whose nerve pain persists at least a month after chemo will be randomly assigned to one treatment. The goal is to see if the patch can reduce pain by 30% or more after six weeks, offering a potential alternative to daily medication.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: capsaicin patch (Qutenza) and duloxetine (Cymbalta)
What this could lead to: If it works, this could offer a new, non-pill option to ease nerve pain from chemotherapy, potentially with fewer side effects than daily oral medication.
What could go wrong: This is an open-label study, so both patients and doctors know which treatment is given, which can bias results. Also, capsaicin patches can cause burning or skin irritation, and the trial is still recruiting, so results are not yet available.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

chemotherapy-induced neuropathy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHEMOTHERAPY-INDUCED PERIPHERAL NEUROPATHY

Contacts and locations

Locations

"L'Hôpital Privé du Confluent "
RECRUITING

Nantes, 44200, France
CHU Bordeaux
RECRUITING

Bordeaux, 33075, France
CHU Grenoble
RECRUITING

Grenoble, 38043, France
Centre Antoine Lacassagne
RECRUITING

Nice, 06189, France
Centre François Baclesse
RECRUITING

Caen, 14076, France
Centre Léon Bérard
RECRUITING

Lyon, 69373, France
Institut Claudius Regaud -IUCT-O
RECRUITING

Toulouse, 31059, France
Institut de Cancérologie Strasbourg Europe
RECRUITING

Strasbourg, 67033, France
Institut de Cancérologie de l'Ouest
RECRUITING

Angers, 49055, France
Institut de Cancérologie de l'Ouest
RECRUITING

Saint-Herblain, 44805, France
Polyclinique Chenieux
RECRUITING

Limoges, 87039, France

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