Ozone gas may ease chemo nerve pain, small trial hopes

NCT ID NCT04299893

Recruiting now Symptom relief Sponsor: Bernardino Clavo, MD, PhD Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study tests whether adding ozone therapy to standard care can reduce nerve pain caused by chemotherapy. 42 adults with cancer and persistent nerve pain will receive either ozone or oxygen gas via rectal insufflation for 16 weeks. The main goal is to see if pain and quality of life improve, and whether the treatment is cost-effective.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ozone gas
What this could lead to: If it works, this could offer a new, low-cost way to reduce chronic nerve pain in cancer survivors.
What could go wrong: This is a small, early-phase trial with only 42 participants. The effect may be small or no better than the placebo (oxygen).

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Conditions

The condition(s) this trial relates to.

chemotherapy-induced neuropathy neuralgia Pain somatoform disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHEMOTHERAPY-INDUCED PERIPHERAL NEUROPATHY PAIN SYNDROME PAIN, NEUROPATHIC

Contacts and locations

Locations

Complejo Hospitalario Materno Insular
RECRUITING

Las Palmas de Gran Canaria, Las Palmas, 35016, Spain
Hospital Universitario de Gran Canaria Dr. Negrín
RECRUITING

Las Palmas de Gran Canaria, Las Palmas, 35019, Spain

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