Ozone gas may ease chemo nerve pain, small trial hopes

NCT ID NCT04299893

First seen Jun 26, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study tests whether adding ozone therapy to standard care can reduce nerve pain caused by chemotherapy. 42 adults with cancer and persistent nerve pain will receive either ozone or oxygen gas via rectal insufflation for 16 weeks. The main goal is to see if pain and quality of life improve, and whether the treatment is cost-effective.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

ozone gas

What this could lead to

If it works, this could offer a new, low-cost way to reduce chronic nerve pain in cancer survivors.

What could go wrong

This is a small, early-phase trial with only 42 participants. The effect may be small or no better than the placebo (oxygen).

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for CHEMOTHERAPY-INDUCED PERIPHERAL NEUROPATHY are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

chemotherapy-induced neuropathy neuralgia Pain somatoform disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Complejo Hospitalario Materno Insular

    RECRUITING

    Las Palmas de Gran Canaria, Las Palmas, 35016, Spain

    Contact Email: •••••@•••••

  • Hospital Universitario de Gran Canaria Dr. Negrín

    RECRUITING

    Las Palmas de Gran Canaria, Las Palmas, 35019, Spain

    Contact Email: •••••@•••••

    Contact

    Contact