Somatoform disorder

This trial tests whether an internet-based form of cognitive behavior therapy (CBT) can reduce symptoms of common mental disorders like anxiety, depression, and stress-related conditions in adults seeking primary care. About 500 participants will be randomly assigned to either th…

This early-stage trial is testing whether a single oral dose of ayahuasca can reduce the frequency of psychogenic non-epileptic seizures (PNES) in adults aged 18 to 60. Participants must have PNES confirmed by video-EEG and will taper off psychiatric medications before the dose. …

This study aims to train an artificial intelligence system to recognize rare genetic diseases by analyzing front and profile facial photographs. Researchers will collect photos from 22,000 patients with craniofacial features linked to rare conditions, as well as control subjects.…

This study tests a device called Cereset Research to see if it can improve how the body handles stress, anxiety, and insomnia. About 200 adults with these symptoms will use the device while researchers measure heart rate and blood pressure changes. The goal is to find a non-drug …

This study tests whether a type of talking therapy called neurobehavioral therapy (NBT) can help people with motor functional neurological disorder (mFND), a condition where the brain has trouble sending the right signals to the body, causing movement problems. The trial will com…

This study tests a group therapy program called the Unified Protocol for adults with emotional disorders such as anxiety, depression, and related conditions. The program teaches skills like emotional awareness, flexible thinking, and facing fears. Researchers want to see if it im…

This study tests whether sleeping with a weighted blanket (about 10% of your body weight) can help adults with chronic pain feel better. About 44 people will use the blanket every night for 5 weeks and report changes in pain, sleep, and daily activities. The goal is to see if thi…

This study explores whether listening to happy music or practicing cognitive reappraisal (thinking about symptoms in a more helpful way) can reduce the intensity and impairment of persistent physical symptoms in people with Somatic Symptom Disorder. Forty adults aged 18–65 will u…

This study tests a new type of talk therapy called ReACT for adults with functional seizures (also called psychogenic non-epileptic seizures). The therapy aims to help people regain control over their body by changing thoughts and behaviors that trigger seizures. Fifty participan…

This study tests whether a text message program that helps people reduce 'safety behaviors' (like checking mirrors or seeking reassurance) can lessen appearance anxiety, body dysmorphic symptoms, and related eating or social anxiety issues. About 300 adults with high appearance c…

This study tests whether adding dextromethorphan (a cough suppressant) to fluoxetine (an antidepressant) can safely reduce symptoms of obsessive-compulsive disorder (OCD) and related conditions like body dysmorphic disorder. About 60 adults in California will take the combination…

This study tests whether a therapist-guided online cognitive-behavioral therapy (CBT) program can reduce symptoms of body dysmorphic disorder (BDD) in children and teens aged 12-18. About 154 participants will receive the online treatment or a control, with follow-up at 6 months.…

This study tests whether a non-invasive brain stimulation technique called theta-burst rTMS can help people with motor functional neurological disorder (FND), a condition causing movement problems without a clear brain lesion. Twenty-two adults with FND will receive 40 sessions o…

This study tests whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can reduce physical distress and health anxiety in people with somatic symptom disorder. Thirty adults aged 20–70 will receive either real or sham rTMS i…

This study tests a new cognitive behavioral therapy called ReACT for teens aged 11-18 with psychogenic non-epileptic seizures (PNES) – episodes that look like seizures but are not caused by epilepsy. The therapy focuses on helping teens regain a sense of control over their body a…

This study tests a behavioral therapy called ReACT for teens aged 11-18 with functional seizures (non-epileptic). The therapy involves 12 sessions with a therapist to help manage seizures. Researchers want to see if a larger study is possible by checking how many teens join, stic…

This study tests whether a 24-week collaborative care program can improve quality of life for adults with epilepsy who also have anxiety or depression. The program includes regular check-in calls and expert recommendations from a psychiatrist and neurologist. Researchers will com…

This study tests whether adding amantadine or duloxetine to the standard painkiller pregabalin can prevent chronic pain after mastectomy. About 150 women undergoing breast cancer surgery will be randomly assigned to one of three drug combinations. The goal is to see if these add-…

This study tests whether a single clinic visit with a special attention exercise can help people with Functional Cognitive Disorder (FCD), a condition causing memory and thinking problems without a clear physical cause. About 30 adults aged 65 or younger will try the intervention…

This study tests whether a non-invasive brain stimulation technique called tACS can help people with severe constipation that hasn't improved with standard treatments, especially when they also have stress-related physical symptoms. About 60 adults will receive either real or sha…

This study tests a new therapy that combines cognitive-behavioral therapy (CBT) with biofeedback to help people with somatic symptom disorder—a condition where physical distress has no clear medical cause. Sixty adults will receive eight sessions over three months or be placed on…

This study compares two antidepressants, venlafaxine and dosulepin, in 84 adults with somatic symptom disorder where pain is the main complaint. Participants take one of the drugs for 8 weeks. Researchers will measure changes in pain and other symptoms, as well as levels of stres…

This early study tests whether an accelerated form of transcranial magnetic stimulation (TMS) is feasible and tolerable for people with functional seizures (also called psychogenic non-epileptic seizures). Thirty adults will receive up to 30 TMS sessions over 3–5 days, targeting …

This study tests a new cognitive behavioral therapy called ReACT for children aged 9-18 with psychogenic non-epileptic seizures (PNES) — episodes that look like seizures but have no physical cause. The therapy focuses on helping kids feel more in control and less afraid of their …

This study tests whether adding ozone therapy to standard care can reduce nerve pain caused by chemotherapy. 42 adults with cancer and persistent nerve pain will receive either ozone or oxygen gas via rectal insufflation for 16 weeks. The main goal is to see if pain and quality o…

This study aims to find differences between organic tics (related to diagnosed disorders) and functional tics (caused by problems in brain-body communication). Researchers will use sensors to measure muscle activity and brain waves in 75 adults with tics and healthy volunteers. P…

This study looks at the healthcare path of 36 young people aged 12 to 25 who have somatic symptom disorder—physical symptoms like pain or fatigue that doctors can't explain with a standard medical condition. Researchers will interview participants and their parents to map every d…

This study will create and test a team-based treatment program for people with Functional Neurological Disorder (FND), a condition that causes symptoms like seizures, dizziness, and tics without a clear physical cause. Researchers will enroll 1,100 adults and children at the Univ…

This study tests whether real-time brain scans (fMRI) can help young adults with anxiety learn to regulate their emotions better. Participants will practice reappraising negative thoughts while seeing their own brain activity. The goal is to understand which brain areas are invol…

This study is testing whether a small monitor worn on the thigh can reliably measure daily activity in people with Functional Neurologic Disorder (FND). The goal is to see if this remote tool gives a better picture of how symptoms affect real-world function than a single clinic v…

This study tests whether a structured, empathetic explanation of a functional neurological movement disorder diagnosis helps patients understand their illness better and feel more satisfied. About 35 adults with conditions like functional tremor or seizures will receive the speci…

This study looks at whether teenagers with scoliosis develop cyberchondria — excessive anxiety from searching health symptoms online. Researchers will compare 100 teens with scoliosis to a control group using questionnaires. The goal is to understand how internet use affects thei…

This study follows 5,000 adults with spinal conditions to track their pain, work status, and quality of life over time. Participants fill out questionnaires before and after treatment. The goal is to learn which treatments work best for different types of spinal disease.

This study looks at how often dissociative identity disorder (DID) occurs in adults who experienced childhood trauma and have borderline personality disorder, functional dissociative crises, or early psychosis. Researchers will use interviews and questionnaires with 350 participa…

This study looks at how a traumatic brain injury (TBI) can lead to heart problems like irregular heartbeat or heart failure. Researchers will use MRI scans to see if damage to certain brain areas disrupts the network that controls the heart. By studying 90 people with mild to mod…

This study reviews medical records of 1,000 patients who came to the hospital with sudden neurological symptoms like weakness, speech problems, or seizures. The goal is to find out how many are diagnosed with Functional Neurological Disorder (FND), a condition where the brain doe…

This study looks at how nomophobia—the fear of being without your smartphone—relates to stress, body image, and food addiction in university students aged 18 to 30. Researchers will use questionnaires and body measurements to find connections. The goal is to better understand the…

This study follows 1,000 adults in Lombardy, Italy, who have early memory complaints but no dementia. Researchers will use blood tests and annual check-ups over 5 years to see if certain biomarkers can predict who later develops Alzheimer's. The goal is to improve early detection…

This study aims to create and test a telehealth program to help veterans with psychogenic nonepileptic seizures (PNES) improve their thinking skills and daily functioning. About 47 veterans with PNES who report cognitive difficulties will give feedback to design a cognitive treat…

This study aims to understand why some people with social anxiety or body dysmorphic disorder respond fully to cognitive behavioral therapy while others do not. Researchers will use brain scans, thinking tests, and questionnaires to look for early signs of non-response. The study…

This study is testing whether a quick cold spray on specific ear points can change how the brain processes chronic low back pain. Sixty adults with back pain for at least 6 months will get either real or fake (sham) ear stimulation. Researchers will use brain scans (fNIRS and MRI…

This study tests whether a short, safe ear-water stimulation (caloric vestibular stimulation) can temporarily improve insight in people with obsessive-compulsive disorder, body dysmorphic disorder, or illness anxiety. Sixteen adults with strongly held beliefs will receive the sti…

This study follows 800 adults who spent at least 48 hours in the ICU to understand why some develop chronic pain. Researchers will call participants at 90 and 180 days after discharge to ask about pain, sleep, and quality of life. A smaller group will also have a detailed physica…

This study looks at how the brain and eyes work together when people with body dysmorphic disorder (BDD) view their own face. Researchers will use brain scans and eye-tracking to understand why people with BDD see their appearance differently. The goal is to learn more about thes…

This study looks at how searching for health information online affects stress and emotional well-being in women going through infertility treatment. Researchers will survey about 200 women to understand their online search habits, stress levels, and overall mental health. The go…

This pilot study is testing whether virtual reality motor tasks can help understand functional tremor, a type of movement disorder. Researchers will measure reaction time and brain activity in 48 people with functional tremor, essential tremor, or healthy controls. The goal is to…

This observational study at the Medical University of Graz will examine 216 people with movement disorders like Parkinson's, tremor, or dystonia to see how many also have functional neurological symptoms. Participants will undergo neurological exams, cognitive tests, and question…

This study looks at how emotional awareness, attachment style, and thinking skills relate to physical symptoms like stomach pain or headaches in children. Researchers will assess 300 children with somatic symptom disorder using questionnaires and tests. The goal is to understand …