Disease by developmental or physiological process

This early-stage trial tests a single intravenous infusion of NGGT002, a gene therapy designed to deliver a working copy of the PAH gene to adults with classic phenylketonuria (PKU). The goal is to see if this approach can safely lower phenylalanine levels in the blood, which cou…

This trial is testing an experimental therapy called CD22 CAR T cells in adults with certain types of B cell lymphomas that have come back or not responded to previous treatments. The therapy involves collecting a patient's own immune cells, modifying them to recognize and attack…

This study tests whether a vaccine can prevent C. difficile infection in adults 65 and older. About 32,000 participants will receive either the vaccine or a placebo shot. The study will track infections and side effects over up to three and a half years.

This trial tests whether matching cognitive training to a person's specific thinking deficits can improve real-world outcomes for incarcerated individuals with substance use disorders. Participants are assigned to one of two types of training—one targeting attention to context, t…

This phase 2 study tests an oral drug called nemtabrutinib in about 490 people with blood cancers like chronic lymphocytic leukemia, non-Hodgkin lymphoma, and Waldenstrom's macroglobulinemia. The goal is to see if the drug can shrink tumors and control the cancer, while also chec…

This trial tests whether a new transcatheter heart valve (Myval) works as safely and effectively as two existing valves (Sapien and Evolut) in people with severe aortic stenosis, a condition where the heart's main valve narrows. About 768 patients who are eligible for valve repla…

This study tests an investigational drug called KarXT to see if it can prevent the return of psychosis (like hallucinations or delusions) in people with Alzheimer's disease. About 410 participants aged 55-90 will receive either KarXT or a placebo for 38 weeks. The main goal is to…

This study tests an oral drug called nizubaglustat in children and teens aged 4 and older with Niemann-Pick type C disease, a rare genetic disorder that affects movement and thinking. Participants will take the drug or a placebo for 18 months to see if it slows the disease and im…

This early-stage trial tests an experimental drug called RO7663498, given as an injection into the eye, for people with diabetic retinopathy. The main goal is to check safety and how the drug moves through the body. About 30 participants will receive multiple doses to see if it i…

This study tests an experimental drug called ATV-1601 in people with moderate to severe HHT, a condition that causes frequent nosebleeds and anemia. The trial has two parts: first, participants receive either the drug or a placebo to check safety and effectiveness; then, all elig…

This phase 2 trial tests whether galvokimig, an experimental biologic drug, can reduce the number of moderate-to-severe COPD flare-ups in people with chronic bronchitis. About 400 adults aged 40 to 80 with moderate-to-severe COPD will receive either galvokimig or a placebo as an …

This Phase 2 trial tests whether combining pembrolizumab (an immunotherapy) with aldesleukin (IL-2) can shrink tumors in people with advanced melanoma or kidney cancer that hasn't responded to prior treatments. About 78 adults will receive two cycles of the combo in the hospital,…

This trial tests whether a smartphone app-guided rehabilitation program (MOKneeTOR) is as effective as traditional hospital-based physiotherapy for people with knee osteoarthritis. Participants will be randomly assigned to either use the app for 24 weeks or attend outpatient phys…

This early-stage study tests a new medicine called PF-08046033 in adults with advanced lung, esophageal, or skin cancers that have spread or can't be removed. The main goal is to check safety and find the right dose. Researchers will also look for early signs that the drug may he…

This early-phase trial is exploring whether a radioactive drug called [211At]MABG, given in several smaller doses, is safe and tolerable for children with neuroblastoma that has relapsed or not responded to treatment. The study will include about 10 participants aged 1 year and o…

This early-stage trial explores whether adding two experimental capsules, ND-12 and H-6, to standard mesalazine treatment can better control chronic inflammatory diarrhea in adults, including those with active ulcerative colitis. Participants will take the combination or a placeb…

This study tests a new medicine called HM15275 in people with type 2 diabetes. The goal is to see if it can lower blood sugar levels (HbA1c) safely over 36 weeks. About 180 adults who manage their diabetes with diet, exercise, or metformin will take part. Half will get the drug, …

This study tests a new drug called BMS-986340, alone or with other cancer treatments, in people with advanced solid tumors like lung, colon, or breast cancer. The goal is to find safe doses and check for side effects. About 1,100 adults with tumors that have worsened after standa…

This Phase 2 trial tests a personalized cell therapy called Descartes-08 for people with dermatomyositis or antisynthetase syndrome, two rare autoimmune diseases that cause muscle weakness and inflammation. The therapy uses a patient's own immune cells, modified to target and red…

This study looks at the long-term safety of a drug called zigakibart for adults with IgA nephropathy, a kidney disease. It is for people who have already finished a previous zigakibart study. Researchers will monitor side effects and check kidney function over 96 weeks.

This study looks at whether the diabetes drug pioglitazone can improve how the liver processes energy in people with nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes. Researchers will measure liver mitochondrial function using special tracers before and after 16 weeks…

This trial tests whether digital follow-up through a patient portal and exercise app can help people with mental disorders stick to a 12-week high-intensity interval training program. Participants will be randomly assigned to receive either digital follow-up or standard care, wit…

This study tests a once-monthly injection called berobenatide to help adults with overweight or obesity lose weight. About 954 participants will receive either the drug or a placebo for 20 months. The goal is to see if the drug is safe and effective for weight loss, including in …

This trial is testing whether an experimental oral medication called SEP-363856 (ulotaront) can reduce anxiety symptoms in adults with generalized anxiety disorder (GAD). About 384 participants will receive either the drug or a placebo daily for 8 weeks. The main goal is to see i…

This early-stage trial is testing a new drug called DNL952 in 32 adults with late-onset Pompe disease. The main goal is to check if the drug is safe and how the body processes it. Participants will receive the drug through an IV infusion at different doses.

This trial tests whether a silicone-based or a hydrocolloid patch placed under insulin pumps or glucose monitors can prevent contact dermatitis from coming back in children aged 2-18. Participants will use different patches and attend visits for skin exams, ultrasounds, and quest…

This study tests whether a virtual session with a peer recovery coach can help incarcerated adults with substance use disorders connect to addiction treatment and recovery resources. About 550 participants in jail will either get the coaching or just standard information. Researc…

This study tests whether adding a Chinese herbal formula (Si Miao Xiao Bi Tang) to standard rheumatoid arthritis medication can improve symptoms. About 132 adults with active RA will receive either the herbal medicine or a placebo for 12 weeks. The main goal is to see if more peo…

This study tests whether omega-3 fatty acid supplements from fish oil, combined with a healthy diet, can reduce disease activity in adults with dermatomyositis, a rare autoimmune disease causing muscle weakness and skin rashes. About 300 participants will take either fish oil cap…

This study tests whether exercise using electrical stimulation can improve muscle strength and endurance in people with lower limb paralysis from conditions like spinal cord injury, stroke, or multiple sclerosis. Participants will use devices that send electrical signals to their…

This early-stage trial is evaluating an investigational drug called ACT201, given as an injection, to see if it is safe and tolerable. The study first tests single and multiple doses in healthy volunteers, then moves to people with chronic hepatitis B whose virus is already suppr…

This Phase III trial tests whether giving radiation in three smaller doses (FSRS) works better than a single large dose (SRS) for cancer that has spread to the brain. About 269 adults with lung, breast, melanoma, kidney, or gastrointestinal cancers will be randomly assigned to on…

This study tests whether adding the drug dinutuximab to standard chemotherapy and other treatments helps children with high-risk neuroblastoma live longer without their cancer returning. About 478 children and young adults up to age 30 will be randomly assigned to receive either …

This 24-month study tests the long-term safety and effectiveness of abrocitinib, a liquid oral medication, in children aged 2 and older with moderate-to-severe atopic dermatitis (eczema). About 500 participants will receive the drug, with or without topical creams. The goal is to…

This phase 2 trial tests an experimental drug called vamifeport in 84 adults with HFE-related hereditary hemochromatosis, a genetic condition causing iron buildup. The drug aims to reduce liver iron levels, potentially offering an alternative to regular blood removal. Participant…

This phase 2 trial is testing a new treatment called FT819 for people with lupus nephritis, a serious kidney complication of lupus. FT819 is made from donor immune cells that are engineered to target and destroy faulty B cells. The study will enroll 53 participants and aims to se…

This Phase 3 study tests whether lebrikizumab, an injectable drug, can safely and effectively treat nummular eczema in adults who haven't gotten enough relief from topical steroids or can't use them. About 270 participants will receive either lebrikizumab or a placebo injection. …

This study tests whether listening to a specific 40 Hz sound for one hour a day, five days a week over 12 weeks, can improve memory, brain activity, sleep, and quality of life in older adults with mild cognitive impairment or mild dementia. Half of the participants will receive t…

This trial is testing whether huperzine A, given as a controlled-release tablet, can improve thinking and daily living skills in people with mild-to-moderate Alzheimer's dementia. Participants will receive either huperzine A, a placebo, or an existing Alzheimer's drug (donepezil)…

This trial tests whether an internet-based form of cognitive behavior therapy (CBT) can reduce symptoms of common mental disorders like anxiety, depression, and stress-related conditions in adults seeking primary care. About 500 participants will be randomly assigned to either th…

Cystinosis is a rare inherited disease that causes kidney failure and poor growth due to cystine buildup in cells. This study follows 330 patients taking cysteamine, a drug that lowers cystine levels, to track long-term effects, detect new complications, and support genetic resea…

This pilot study tests whether a non-invasive brain stimulation technique called tACS can help teens (ages 12-18) with major depression when added to their usual medication. Thirty participants will receive either real or sham stimulation daily for several weeks. The goal is to s…

This study tests a new medicine called ersodetug for people whose tumors cause dangerously low blood sugar that standard treatments can't control. About 16 adults with insulin-producing tumors will receive the drug alongside their usual care. The main goal is to see if ersodetug …

This study tests an experimental drug called senicapoc in people with mild Alzheimer's or mild cognitive impairment. The goal is to see if it can reduce brain inflammation and slow down memory loss. About 55 participants will take either the drug or a placebo for 52 weeks, with r…

This study tests whether abrocitinib, a liquid medicine, can improve moderate-to-severe eczema in children aged 6 to 12. About 150 kids will be randomly assigned to receive either the drug or a placebo for 16 weeks. The goal is to see if the medicine clears the skin and reduces i…

This early-phase trial is testing a new drug, FOG-001, in about 595 people with advanced or metastatic solid tumors, including colorectal, prostate, and liver cancers. The drug is given alone or with other cancer treatments to see if it is safe and shrinks tumors. The study is cu…

This study tests whether a non-invasive brain stimulation technique called rTMS, given before cognitive-behavioral therapy, can help adults with cocaine use disorder quit. Thirty participants will receive either real or sham rTMS daily for 3 weeks, followed by 12 weeks of weekly …

This phase IIa trial investigates whether obinutuzumab, a monoclonal antibody, can effectively treat adults with newly diagnosed minimal change disease, a kidney condition causing protein leakage and swelling. Participants receive either two doses of obinutuzumab or standard gluc…

This study tests whether adding a new drug (RO7268489) to the standard MS treatment ocrelizumab can slow disability progression in adults with progressive multiple sclerosis. About 360 participants will receive either the new drug or a placebo, and researchers will track walking …

This study is tracking 150 adults and teens with moderate-to-severe eczema who have already tried up to two biologic drugs without success. Researchers want to see how well the oral medication abrocitinib (Cibinqo) works in real-world settings. The main goals are to measure impro…

This trial tests whether using a diabetes-specific questionnaire during annual check-ups can improve the quality of care for people with type 2 diabetes. About 2,000 adults with type 2 diabetes from 30 general practices in Denmark will take part. Half of the practices will use th…

This study tests an experimental drug called AOC 1044 for boys with Duchenne muscular dystrophy (DMD) who have a specific genetic change (exon 44 skipping). About 70 boys aged 7 to 16 who can still walk will receive either the drug or a placebo. The main goal is to see if the dru…

This trial tests whether adding motivational interviewing—a counseling style that strengthens personal motivation—to a standard exercise program helps people with knee osteoarthritis feel more confident about exercising and managing pain. About 56 participants will be randomly as…

This study investigates whether a mobile app called reSET can help men who have sex with men, are living with HIV, and have a stimulant use disorder reduce their drug use and keep their HIV under control. Participants use the app for 12 weeks, completing modules on topics like ma…

This trial tests whether treating hepatitis C in primary care clinics, with non-specialist doctors, works as well as the standard specialist care in Brazil. It also evaluates the use of rapid tests and self-testing to find more people with the infection. The goal is to see if a s…

This study tests a drug called AGA2115 in 80 adults with osteogenesis imperfecta (brittle bone disease) types I, III, or IV. Participants receive either the drug or a placebo as a shot under the skin. The main goal is to see if the drug increases bone density in the spine after 1…

This trial asks whether giving children a low-dose ketamine infusion after heart surgery can protect their brains from damage. Children aged 1 to 60 months undergoing surgery for certain congenital heart defects will receive either ketamine at one of two doses or no ketamine. Res…

This early study tests baricitinib, a drug already approved for other immune conditions, in 20 people with Job syndrome who also have lupus-like disease or eczema. Participants take the pill daily for 6 months. The main goal is to see if it is safe and tolerable, while also check…

This study tests an experimental drug called ABBV-1758 in about 210 people with Alzheimer's disease. The drug is given by IV or injection every 4 weeks for 24 weeks. Researchers are checking if it is safe and whether it can reduce amyloid plaques in the brain, a hallmark of Alzhe…

This early-phase study tests a new drug called SV001 in 53 healthy Chinese adults to see if it is safe and how the body processes it. Participants receive a single dose of SV001 or a placebo. The goal is to check for side effects and measure drug levels in the blood. This is a fi…

This early-stage study tests a new drug called ALN-5288 in 50 adults with mild cognitive impairment or dementia caused by Alzheimer's disease. The drug is given via a spinal injection and aims to safely reduce tau protein levels in the brain. The main goal is to check safety and …

This Phase 3 trial is testing a new weekly injection called enicepatide for weight loss in 1600 people who are obese or overweight and also have type 2 diabetes. The drug works by mimicking natural hormones that help control appetite and blood sugar. Participants will receive eit…

This trial tests whether a structured six-month lifestyle modification program can improve penile blood flow and erectile function in men with metabolic syndrome-associated erectile dysfunction. Participants receive dietary counseling, exercise guidance, weight management, smokin…

This Phase 3 study tests a drug called nucresiran in 1250 people with ATTR amyloidosis, a rare disease where abnormal proteins damage the heart. Participants receive either nucresiran or a placebo every 6 months. The goal is to see if the drug reduces deaths and heart-related hos…

This Phase 3 trial tests whether privosegtor, a neuroprotective drug, can improve vision recovery in people having their first episode of optic neuritis. About 210 adults aged 18 to 50 will receive either privosegtor or a placebo, both alongside standard steroid treatment. The ma…

This study tests whether adding the drug pembrolizumab to a treatment that uses a patient's own immune cells (called TIL therapy) can shrink tumors in people with advanced melanoma. About 53 adults aged 18 to 72 who have already tried at least one other treatment will take part. …

This study tests whether psilocybin, a psychedelic substance, given with psychological support is safe and helps reduce symptoms of anorexia nervosa in young adults aged 16 to 35. Participants receive two doses of psilocybin (25 mg) four weeks apart, plus therapy before, during, …

This early-phase trial is testing an experimental oral drug called GIM-531, alone or with an immunotherapy (anti-PD-1), in 117 adults with advanced solid tumors that have stopped responding to standard treatments. The goal is to see if the drug is safe, tolerable, and can help th…

This study tests a program that delivers fresh produce to the homes of pregnant women with type 1 or 2 diabetes who also struggle to afford healthy food. Participants also get group classes on diabetes, nutrition, and cooking, plus help finding other resources. The goal is to see…

This study tests a one-time gene therapy called surabgene lomparvovec (Sura-vec) for diabetic retinopathy, a common eye problem from diabetes that can lead to blindness. About 576 adults with moderate-to-severe non-proliferative diabetic retinopathy will receive either the gene t…

This study follows 200 adults in Japan with moderate to severe ulcerative colitis who are already prescribed risankizumab by their doctor. Researchers will track how well the drug controls symptoms like diarrhea and rectal bleeding over up to 156 weeks. The goal is to see if the …

This early-phase trial is testing a new treatment called KITE-363 for people with certain autoimmune nerve diseases that have not responded to standard therapies. KITE-363 is a type of CAR T-cell therapy that uses a patient's own immune cells, modified to target and attack faulty…

This trial is testing an experimental once-daily pill called ASC30 in adults who are overweight or have obesity and also have type 2 diabetes. The study aims to see if ASC30 can help with long-term weight loss and improve blood sugar control compared to a placebo. Participants wi…

This Phase 3 trial tests a gene therapy called FLT201 for adults with Gaucher disease type 1. The goal is to see if a single dose can keep blood counts stable so patients can stop their regular enzyme replacement or substrate reduction therapy. The study will enroll 45 people who…

This trial compares two surgical approaches for treating furcation defects—bone loss where tooth roots split—in adults with periodontitis. One group receives a mix of advanced platelet-rich fibrin (A-PRF+) and bone graft material, while the other gets a collagen membrane with the…

This phase 3 trial tests a new antiviral pill, ibuzatrelvir, alone or with an IV drug (remdesivir) in 300 adults with weak immune systems who have mild-to-moderate COVID-19. The goal is to see if the combination prevents hospitalizations or worsening symptoms better than remdesiv…

This study tests whether adding an antibody drug called hu14.18K322A to standard chemotherapy helps children with high-risk neuroblastoma, a rare but aggressive childhood cancer. About 144 children and teens aged 18 months to 18 years will receive the combination over up to 12 cy…

This study tests whether a combination drug called OLZ/SAM (olanzapine plus samidorphan) causes less weight gain than olanzapine alone in teenagers with schizophrenia or bipolar I disorder. About 220 teens aged 10-17 will take either the combo or olanzapine for 52 weeks. The main…

This trial tests whether a daily 250 mg supplement of lactoferrin, a protein found in milk, can improve kidney health in people with type 2 diabetes and chronic kidney disease. The study will compare lactoferrin against a placebo, alongside standard diabetes care, to see if it re…

This study looks at how long adults with plaque psoriasis and a common liver condition called MASLD (fatty liver disease) continue taking the drug secukinumab. Researchers will review medical records from several Spanish hospitals to track treatment duration and changes in liver …

This early-stage trial tests an experimental drug called RO7823653, given as an eye injection alone or with an approved drug (faricimab), for people with diabetic macular edema—a condition where diabetes causes fluid buildup and vision loss in the center of the eye. The study wil…

This Phase 3 trial tests an oral drug called nizubaglustat (AZ-3102) in people aged 4 and older with Niemann-Pick type C disease, GM1 gangliosidosis, or GM2 gangliosidosis. The study lasts 18 months and compares the drug to a placebo to see if it is safe and can slow disease prog…

This early-stage study tests a new gene therapy called PBGENE-HBV in 45 adults with chronic hepatitis B who are already on antiviral medication. The goal is to see if the treatment is safe and can help control the virus. Participants must be in good health and have no liver scarr…

This study tests an oral medication called ibuzatrelvir in adults and teens with COVID-19 who are not hospitalized but have a high risk of becoming severely ill. Participants will receive either the drug or a placebo for 5 days, and researchers will track whether it reduces emerg…

This study is checking the long-term safety of a drug called avacopan for people with ANCA-associated vasculitis, a rare disease where the immune system attacks blood vessels. About 300 adults who need treatment for a new diagnosis or flare-up will take avacopan or a placebo. The…

This study is testing the safety and drug levels of glecaprevir/pibrentasvir, a hepatitis C treatment, in 30 pregnant women with or without HIV. The goal is to see how the drug works during pregnancy and to monitor the health of both mothers and their infants up to 10 weeks after…

This early-stage study tests a new drug called VV119 in healthy adults and people with schizophrenia. The main goal is to check if the drug is safe and how the body processes it. About 40 participants will take multiple doses to find the right amount for future studies.

This study tests a drug called nemolizumab in toddlers aged 6 to 23 months with moderate-to-severe atopic dermatitis (eczema) that hasn't improved with creams or ointments. The goal is to see how the drug moves through the body, if it is safe, and if it helps control the conditio…

This study tests a drug called zasocitinib in adults with nonsegmental vitiligo, an autoimmune condition that causes white patches on the skin. About 200 participants will take either the drug or a placebo for up to a year. The main goal is to see if the drug can improve skin col…

This Phase 3 trial tests whether a simple injection of frexalimab every 4 weeks works as well as the standard IV infusion for adults with relapsing or non-active progressive multiple sclerosis. About 160 participants will be randomly assigned to one of the two methods. The study …

This study tests whether suvorexant, a medicine used for sleep problems, can help people with alcohol use disorder (AUD) by changing how the brain's dopamine system works. About 180 adults (ages 18-75) with AUD and healthy volunteers will take either suvorexant or a placebo daily…

This trial tests whether transferring gut bacteria from a healthy donor (fecal microbiota transplantation, or FMT) can reduce disease activity in people with axial spondyloarthritis (axSpA) who haven't fully responded to biologic therapy. Participants receive a single enema with …

This study tests a new medicine called afimkibart in children aged 2 to 17 with moderate to severe ulcerative colitis, a disease that causes inflammation and sores in the colon. The goal is to see if the drug can safely help children feel better and achieve remission (no symptoms…

This early-stage trial tests two experimental pills (PF-07799544 and PF-07799933) taken twice daily at home by adults with advanced solid tumors that have a specific gene change called BRAF V600. The study aims to find safe doses and see if the drugs can shrink tumors. About 124 …

This study tests a new medicine called galvokimig in 160 adults with moderate-to-severe atopic dermatitis (eczema). The goal is to see if different doses can reduce skin redness, itching, and rash better than a placebo. Participants will receive injections and be monitored for 16…

This study compares two standard procedures—minimally invasive TAVR and open-heart surgery (SAVR)—for replacing a diseased aortic valve in people with a bicuspid aortic valve. About 1,200 participants aged 50 and older with severe aortic stenosis will be randomly assigned to one …

This study tracks 8 Korean patients with paroxysmal nocturnal hemoglobinuria (PNH) who are taking Danicopan alongside standard C5 inhibitors like eculizumab or ravulizumab. The goal is to monitor safety and check if the drug works as expected in everyday medical practice. It is a…

This trial asks whether adding a Mediterranean diet or a low-histamine diet to standard care can reduce disease activity and improve quality of life in teens aged 12-18 with chronic spontaneous urticaria (CSU), a condition causing persistent hives. Participants are randomly assig…

This study is testing the drug vedolizumab (Entyvio) in 400 adults with moderate to severe ulcerative colitis or Crohn's disease. Participants first receive the drug through an IV for 6 weeks, then switch to injections under the skin for the rest of the year. The main goal is to …

This Phase 2 trial tests whether adding ALE.F02 to standard therapy can protect kidney function in people with ANCA-associated vasculitis, an autoimmune disease that attacks small blood vessels, often damaging the kidneys. About 80 participants will receive either a low, high, or…

This phase 3 study tests the drug risankizumab in about 120 children aged 2 to 18 with moderate to severe ulcerative colitis. The trial has three parts: an initial 12-week IV treatment period, a 52-week maintenance phase where patients get one of two doses by injection, and a lon…

This Phase 3 trial tests a new drug called nucresiran in 125 people with a rare inherited condition that damages nerves (hATTR-PN). The drug is given as a shot under the skin every 6 months and aims to slow nerve damage and improve quality of life. Researchers will compare it to …

This study tests an experimental drug called MK-2214 in 340 people with early Alzheimer's disease. The goal is to see if it can slow the buildup of a harmful protein called tau in the brain, which damages brain cells. Participants will receive either the drug or a placebo, and re…

This Phase 3 trial tests whether mezagitamab, an injectable drug, can reduce protein in the urine and preserve kidney function in adults with IgA nephropathy, a condition where immune complexes damage the kidneys. About 347 participants will receive either mezagitamab or a placeb…

This phase 3 trial tests whether maridebart cafraglutide, a drug that may help with weight loss, can reduce sleep apnea episodes in 250 adults who are overweight or obese and not using a breathing machine. Participants receive either the drug or a placebo for 52 weeks. The main g…

This study is testing a shoulder replacement device in 300 people with shoulder arthritis, bone death, or rotator cuff tears. Participants receive the implant and are followed for 10 years to see how well it works and if it is safe. The goal is to improve pain and shoulder functi…

This study follows 550 patients whose first TAVI heart valve has failed. Researchers will compare a second TAVI procedure (redo TAVI) with open-heart surgery or medication alone. The goal is to see which approach works best and why, helping doctors make better decisions for futur…

This study tests a new oral medication, upadacitinib, in children aged 1 to 17 with active systemic juvenile idiopathic arthritis (sJIA), a rare and serious form of arthritis that can affect the whole body. About 90 participants will receive either upadacitinib or the standard in…

This study investigates whether inhaling the antibiotic amikacin can better treat pneumonia caused by gram-negative bacteria in patients on veno-arterial ECMO (a heart-lung bypass machine). Standard antibiotics often fail in these patients, possibly because the bypass reduces blo…

This trial is testing the safety of a medication called lumateperone in children and teenagers who have schizophrenia, bipolar disorder, or autism spectrum disorder. Participants take the drug once daily for 26 weeks, and researchers monitor for side effects. The goal is to see i…

This study looks at teenagers aged 12 to 17 who have severe atopic dermatitis (eczema) with intense itching but only a mild to moderate rash. They are being treated with dupilumab (Dupixent), a standard medication. The goal is to see how well dupilumab controls itching, improves …

This phase 3 trial is testing a once-weekly injection called enicepatide in 300 Chinese adults who are obese or overweight, with or without type 2 diabetes. The drug works by mimicking two gut hormones to reduce appetite and improve blood sugar control. Participants will receive …

This early-stage trial is testing two experimental drugs, vonsetamig and odronextamab, in people with lupus nephritis that has not responded to standard treatments. The main goal is to check safety and side effects over the long term. Researchers will also see if the drugs can he…

This study tests a new approach for teens (ages 10-17) recently diagnosed with type 1 diabetes. They will use an inhaled insulin called Afrezza along with a long-acting injected insulin. The goal is to see if this combination helps keep blood sugar in a healthy range and is safe …

This study looks at whether people with multiple sclerosis can safely switch from their current anti-CD20 therapy to a new under-the-skin version of ocrelizumab. About 100 participants will be followed for up to 48 weeks to see if brain lesions stay stable and if they are satisfi…

This early-stage trial tests a new type of cell therapy for children whose embryonal tumors (rhabdomyosarcoma, Ewing sarcoma, neuroblastoma, or Wilms tumor) have returned or not responded to standard treatments. The therapy uses the patient's own immune cells, engineered to bette…

This early-stage trial tests a new gene-editing approach for X-linked chronic granulomatous disease (X-CGD), a rare immune disorder. Researchers will collect stem cells from 10 adult male participants, use base editing to correct the genetic mutation, and return the cells after m…

This trial tests whether a new type of hip resurfacing implant, called the H1, can be as successful as a standard total hip replacement for people with hip arthritis. Participants will receive either the H1 implant or a traditional replacement, and researchers will compare their …

This early-phase trial tests the safety of CRD3874-SI, a drug that activates the STING pathway to boost the immune system against cancer. About 81 adults with advanced solid tumors (sarcoma, Merkel cell carcinoma, and others) will receive weekly IV infusions at increasing doses. …

This study tests a program called CONNECT Multilingual, designed to help Spanish and Cantonese speakers quit smoking while they undergo lung cancer screening. About 439 current smokers aged 50-80 will receive personalized video doctor messages, text support, and help getting nico…

This Phase 2 trial tests an experimental inhaled medication called LTI-03 in about 120 people with idiopathic pulmonary fibrosis (IPF), a progressive lung disease that causes scarring and breathing difficulty. Participants will inhale LTI-03 or a placebo twice daily for 24 weeks.…

This early-stage study tests an experimental drug called EXS73565 in about 50 adults with certain blood cancers (like lymphoma or leukemia) that returned or didn't respond to standard treatments. The main goal is to check safety and find the right dose, while also seeing if the d…

This study tests a computerized task where teens push or pull a joystick in response to images, aiming to change automatic habits around cannabis and alcohol. Fifty-two participants aged 13-17 who use both substances will be followed for three months. The goal is to see if this s…

This study is checking the long-term safety of a drug called KarXT in teenagers (13-17) with schizophrenia, and a combination of KarXT and KarX-EC in children (5-17) with irritability linked to autism. About 400 participants who completed earlier studies will take the drug for up…

This study tests whether a gentle electrical current applied to the scalp during reading lessons can improve reading skills in children aged 7 to 17 with dyslexia or reading difficulties. Half the participants receive active stimulation, while the other half receive a sham (place…

This study tests whether an AI app called SnapD, which recognizes Thai food and estimates nutrition, can help people with type 2 diabetes and overweight improve their blood sugar control. Some participants will also use a continuous glucose monitor (CGM) that tracks sugar levels …

This study tests whether the drug CardiolRx can prevent another episode of pericarditis (inflammation around the heart) in people who have had repeated attacks. About 110 adults who have been stable on an IL-1 blocker for at least a year will stop that medication and receive eith…

This early-stage trial tests a new drug called TRB-061 in healthy adults and people with moderate-to-severe atopic dermatitis (eczema). The study checks for safety, side effects, and how the drug moves through the body. Participants receive either TRB-061 or a placebo as injectio…

This Phase 2 trial tests IHL-42X, a combination of two drugs (dronabinol and acetazolamide), in people with obstructive sleep apnea. The study aims to see if the drug can reduce the number of breathing pauses during sleep and improve daytime symptoms. Participants will receive di…

This trial tests whether combining aerobic exercise with a targeted reading therapy, called Phono-Motor Therapy, can improve reading skills in people who have reading difficulties after a stroke. Participants will receive both interventions, and researchers will measure changes i…

This phase II trial is testing whether the combination of cabozantinib (a targeted therapy) and nivolumab (an immunotherapy) can shrink or stabilize advanced melanoma and head and neck cancers that have stopped responding to prior immunotherapy. Researchers are also checking if t…

This trial investigates whether giving standard combination immunotherapy (ipilimumab and nivolumab) in the early morning (before 10 AM) versus the afternoon (after 1 PM) improves tumor response in people with advanced melanoma. About 170 participants with metastatic or inoperabl…

This study tests a new treatment for adults with certain cancers (pancreatic, kidney, breast, melanoma, or ovarian) that have a protein called CD70. Doctors take a sample of your blood, modify your white blood cells in a lab to recognize and attack CD70, and then give them back t…

This pilot study tests whether intermittent use of a continuous glucose monitor (CGM), along with regular medical visits, diabetes education, and psychological support, can improve blood sugar control in children and adolescents with high-risk type 1 diabetes in the Dominican Rep…

This Phase 3 trial tests an oral drug called orelabrutinib against a placebo in about 990 people with non-active secondary progressive multiple sclerosis (MS). The goal is to see if the drug can delay worsening disability over 24 to 60 months. Participants are randomly assigned t…

This trial investigates different types of steroid injections for back, neck, and related pain to see which are most effective and safe. It compares various steroids, doses, and injection sites, including epidural and facet joint injections. The study measures pain relief and fun…

This Phase 3 trial is testing whether adding BDB-001 to standard treatments (cyclophosphamide, azathioprine, rituximab, or prednisone) helps more people with ANCA-associated vasculitis achieve remission. The study plans to enroll 300 adults with active GPA or MPA. Participants wi…

This phase 3 trial is testing whether the drug KarXT can safely and effectively treat schizophrenia in adolescents aged 13 to 17. About 166 teens will receive either KarXT or a placebo, and researchers will track changes in symptoms like delusions and social withdrawal. The goal …

This study is checking how well the Solo+ tympanostomy tube works in people with middle ear infections. Researchers will review doctor notes, monitor how the tubes function after surgery, and ask patients or their parents about their experience. The goal is to gather real-world i…

This study tests whether a low dose of glucagon, given before exercise, can prevent blood sugar drops in adults with type 1 diabetes who use an automated insulin pump. Eighteen participants will exercise after a meal, comparing glucagon to a standard glucose drink. The goal is to…

This trial tests whether a simpler dental procedure called pulpotomy works as well as the standard pulpectomy for treating severe tooth decay in children's baby molars. Pulpotomy removes only the infected part of the pulp and seals it, while pulpectomy removes the entire pulp and…

This trial is testing whether an integrated care pathway (ICP) can help reduce depressive symptoms in adolescents aged 13 to 18 who seek help at community mental health agencies. Participants will receive either the ICP or treatment as usual, and researchers will track changes in…

This study tests a program that sends personalized text messages and provides nicotine patches to help people with HIV in Cambodia stop smoking. Researchers will enroll 800 smokers and check if they quit after 6 months using self-reports and breath tests. The goal is to find a pr…

This program provides continued access to lucerastat for people with Fabry disease who were previously enrolled in a clinical trial of this drug. The goal is to allow these patients to keep receiving the treatment after the original study was stopped. It focuses on maintaining tr…

This early-stage study is testing a new drug called RO7121932 in 129 people with multiple sclerosis (MS). The goal is to check if the drug is safe and how the body handles it when given as a single or multiple doses, either through a vein or under the skin. Participants are not o…

This study tests if the drug vorinostat is safe and can help people with moderate-to-severe Crohn's disease by reducing gut inflammation. Participants who respond well may then receive a maintenance treatment with ustekinumab for up to two years. The goal is to control symptoms a…

This study follows 300 people with a specific type of knee injury called a displaced bucket-handle meniscus tear, which can lock the knee and damage the joint. Researchers will compare two surgical approaches: repairing the torn meniscus with stitches versus removing the damaged …

This study tests a new drug called AZD9793 in people with advanced liver cancer that has spread. The drug is an antibody designed to help the body's immune cells find and attack cancer cells. The main goals are to check if the drug is safe and if it can shrink tumors. About 304 a…

This trial tests whether giving far fewer opioid pills after hip arthroscopy, combined with gabapentin and extra-strength Tylenol, can control pain as well as the standard 30-pill opioid prescription. About 170 adults undergoing their first hip arthroscopy will be randomly assign…

This study is testing a new drug called ML-007C-MA for adults with schizophrenia. The goal is to see if it is safe and works well over a full year. About 500 people who have recently been in a related study or are new to the trial will take the drug twice daily. Researchers will …

This early-phase trial tests a gene therapy called AVB-101 for people with frontotemporal dementia caused by GRN gene mutations. The therapy delivers a working copy of the GRN gene directly into the brain during a one-time procedure. The study will enroll 18 adults aged 30-75 to …

This study tests how the drug rifaximin (Xifaxan) works in children aged 6 to 11 with acute diarrhea likely caused by bacteria. Half the children get the drug plus oral rehydration therapy, the other half get rehydration alone. Researchers want to see if adding the drug helps dia…

This study tests a new drug, atumelnant, in 150 adults with classic congenital adrenal hyperplasia (CAH). The goal is to see if it can safely control hormone levels and allow patients to take lower doses of their usual steroid medications. Participants will receive either atumeln…

This trial investigates whether using real-time ultrasound to guide shock wave therapy improves outcomes for people with calcific tendinitis of the shoulder, a painful condition where calcium deposits form in the rotator cuff tendons. Participants aged 20 to 70 with confirmed dep…

This trial tests whether a specific breathing exercise, the Buteyko technique, can improve oxygen levels, reduce breathlessness, and enhance exercise ability in patients with pneumonia caused by smog. It compares this approach to incentive spirometry, a standard device that encou…

This study tests whether a 12-week program of supervised foot and ankle exercises can help people with diabetes who have nerve damage in their feet. The exercises are done in groups at primary care clinics. Researchers will measure changes in symptoms, foot movement, and quality …

This study looks at whether helping clinics offer more take-home doses of methadone (instead of daily visits) helps people stay in treatment for opioid use disorder. Researchers will work with 36 clinics and about 318 patients to see if this approach reduces emergency visits and …

This phase II trial is testing whether adding the drug naxitamab (Danyelza) to standard chemotherapy improves outcomes for children newly diagnosed with high-risk neuroblastoma. About 93 participants will receive naxitamab during five cycles of induction chemo. The goal is to see…

This study tests whether starting inclisiran early during a hospital stay for a heart attack can lower bad cholesterol more than a placebo, when both are added to standard care. About 300 adults hospitalized for a heart attack will receive either inclisiran or a placebo shot at t…

This study tests two oral drugs, eflornithine (DFMO) and AMXT 1501, in children and young adults up to age 26 with certain cancers that have come back or not responded to treatment. The cancers include neuroblastoma, brain tumors, and sarcomas. The goal is to find a safe dose and…

This study tests whether changing treatment can help smokers who relapse early after trying to quit. 544 participants who want to quit smoking will receive free nicotine patches, lozenges, varenicline, or e-cigarettes for 12 weeks. All visits are remote, and the study lasts 6 mon…

This study tests a one-time gene therapy called ECUR-506 in baby boys under 9 months old with a severe form of OTC deficiency, a genetic disorder that prevents the body from breaking down ammonia. The goal is to see if the treatment is safe and can reduce dangerous ammonia levels…

This phase 2 trial tests whether dulaglutide, a drug used for type 2 diabetes, can improve small blood vessel function in adults with type 1 diabetes. The study involves 47 participants aged 18-40 with long-standing type 1 diabetes. Researchers measure blood flow and insulin sens…

This trial tests a 9-month program for women who had preeclampsia during their first pregnancy. The program includes online screening, group meetings, and a smartphone app to help monitor blood pressure and weight. Researchers want to see if it improves heart health and promotes …

This study tests whether a combination of two drugs, KarXT and KarX-EC, can improve cognitive impairment in people with mild to moderate Alzheimer's disease. About 586 participants will receive either the drug combo or a placebo. The trial measures changes in thinking, daily func…

This study tests whether combining two drugs—vedolizumab and tofacitinib—can quickly bring moderate to severe ulcerative colitis under control. About 65 adults will receive both drugs for 8 weeks, and those who respond will continue on vedolizumab alone for nearly a year. The goa…

This trial asks whether clamping the umbilical cord at 120 seconds after birth is better than clamping at 30 seconds for babies born with congenital heart disease. About 500 infants with a prenatal heart defect diagnosis will be randomly assigned to one of the two timings. Resear…

This study tests a single dose of a new drug, ALN-4324, to see if it improves how the body uses insulin in people with type 2 diabetes. About 40 adults who are on a stable dose of metformin will take part. The main goal is to measure changes in insulin sensitivity using a glucose…

This study tests a drug called mivelsiran in 58 adults with Down syndrome who have early-stage Alzheimer's. Participants receive either the drug or a placebo via injection into the spine every few months for two years. The goal is to see if the drug can reduce brain changes linke…

This phase 3 trial is testing whether an experimental oral medication called SEP-363856 (ulotaront) can reduce anxiety symptoms in adults with generalized anxiety disorder. Participants will receive one of two fixed doses of the drug or a placebo for 8 weeks. The main goal is to …

This study tests whether a chlorhexidine mouthwash with an anti-discoloration system (ADS) can prevent gum inflammation better than a placebo. Healthy volunteers will stop brushing for three weeks and use only the mouthwash to see how well it controls plaque and gingivitis. The g…

This study tests a new treatment called AZD0120 for people with severe lupus that hasn't improved with standard therapies. AZD0120 is a type of CAR T cell therapy that targets two proteins (CD19 and BCMA) on immune cells to calm the overactive immune system. The trial will enroll…

This study tests whether a simple esophageal string test (EST) can diagnose eosinophilic esophagitis (EoE) in people who have trouble swallowing. Participants swallow a capsule with a nylon string that collects fluid from the esophagus, which is then analyzed. The results will be…

This trial tests whether a single injection of [18F]-APN-1607, a radioactive tracer that binds to tau protein, can produce PET images that match the actual tau buildup found in the brain after death. It includes healthy volunteers and people with mild cognitive impairment or Alzh…

This phase III trial is evaluating whether an experimental PET imaging agent, [18F]Fluorbetazine, can accurately detect amyloid-beta plaques in the brain—a hallmark of Alzheimer's disease. The study will include about 400 adults aged 40 and older with normal cognitive function, m…

This study is testing a wearable sensor that measures oxygen levels in the brain and limbs of children with and without obstructive sleep apnea (OSA). The sensor, called near-infrared spectroscopy (NIRS), is compared to standard sleep study techniques. Researchers hope it could l…

This pilot study will enroll 150 pregnant individuals to see if a continuous glucose monitor (CGM) can accurately diagnose gestational diabetes. Participants will wear a small sensor on their arm that measures blood sugar continuously. The results will be compared to the standard…

This study is testing whether a diagnostic test called KidneyIntelX can help primary care doctors improve care for people with type 2 diabetes and chronic kidney disease. The test predicts the risk of kidney function worsening. Researchers will see if using this test leads to mor…

This phase IV trial will enroll 5,500 people with liver cirrhosis or chronic hepatitis B—conditions that raise liver cancer risk. Participants are randomly assigned to either standard ultrasound screening or a new blood test called GALAD, which measures three proteins. The goal i…

This study tests whether an online parenting program, eHealth Familias Unidas, can reduce symptoms of depression, anxiety, and suicidal behavior in Hispanic adolescents aged 12 to 16. The program involves 13 online sessions that aim to strengthen family communication and protecti…

This study tests whether taking progesterone early in pregnancy can prevent preeclampsia, a condition that causes high blood pressure and organ damage. Over 600 low-risk pregnant women will either receive nightly vaginal progesterone or standard care. Researchers will track who d…

This study explores whether visiting a museum can support the social and emotional well-being of autistic adults. Researchers plan to enroll 90 autistic adults aged 18 to 50 with average intellectual ability. Participants choose one of three options: a solo museum visit, five gui…

This phase II trial tests whether adding BMX-001 to standard symptom management can reduce severe mouth sores in head and neck cancer patients receiving chemoradiation. About 98 participants will receive either BMX-001 or a placebo alongside usual care. The goal is to see if BMX-…

This study tests if Dymista nasal spray safely eases allergy symptoms like sneezing, stuffy nose, and itchy eyes in Chinese teenagers aged 12 to 17. About 100 participants will use the spray twice daily for two weeks. The goal is to see if symptoms improve, not to cure allergies.

This study tests whether using shockwave therapy on the leg artery before a TAVR heart valve procedure can reduce bleeding and other complications. It involves 100 adults with severe aortic stenosis and heavily calcified arteries. The goal is to make the procedure safer by prepar…

This study tests whether a 12-week online ukulele learning program, called Music-4-MS, can improve cognitive function in people with multiple sclerosis (MS). Half the participants will learn to play the ukulele, while the other half will simply listen to music they enjoy. The goa…

This early-stage trial is testing a new injectable drug called ARQ-234 in healthy volunteers and people with moderate to severe eczema. The main goals are to check safety and how the body processes the drug, while also looking for early signs that it might improve eczema symptoms…

This pilot study tests a 12-week therapy called Integrated Suicide and Trauma Therapy (ISTT) in 20 adults with a history of childhood trauma and current suicidal thoughts. The therapy combines coping skills training with trauma-focused treatment to address both suicide risk and t…

This study is developing and testing a smartphone app called ACT to RECOVER, designed to help veterans receiving medication for opioid use disorder improve their daily functioning and quality of life. The app is based on Acceptance and Commitment Therapy (ACT), a well-supported a…

This Phase 2 trial will test whether adding selenium supplements to standard antidepressant medication (fluoxetine) can improve depression symptoms in 172 children and adolescents aged 12-18 with major depressive disorder. Participants will receive either selenium or a placebo fo…

This study looks at whether treating an extra nerve in the foot can improve pain relief for people with long-term heel pain. About 48 adults will receive a standard nerve treatment, with half also getting treatment on a second nerve. Researchers will measure pain and foot functio…

This study tests whether the experimental drug LAD328 can reduce symptoms of hidradenitis suppurativa, a chronic skin condition causing painful lumps. About 50 adults with moderate-to-severe disease will receive either LAD328 or a placebo. The main goal is to see if the drug lead…

This study tests whether real-time brain training (amygdala neurofeedback) can help people with borderline personality disorder (BPD) feel less intense negative emotions. Participants will either receive real feedback from their own brain activity or a fake (sham) signal while vi…

This trial tests whether photobiomodulation (PBM), a type of low-level laser therapy, can reduce pain and improve healing after endodontic microsurgery—a procedure to treat infections at the tip of a tooth root. About 90 adults needing this surgery will receive either real PBM or…

This study tests a program called Grow with Grit, where school nurses screen children aged 8-12 in rural Montana for anxiety using a standard questionnaire. Children who show signs of anxiety receive a brief, 3-5 minute coping-skills session during a regular nurse visit, along wi…

This study tests whether a ketogenic diet (high fat, low carb) can improve brain energy and reduce psychiatric symptoms in people with early bipolar disorder. Fifty participants will follow either the ketogenic diet or standard dietary guidelines for 12 weeks. Researchers will me…

This Phase 3 trial tests an investigational injection called SHR-1819 in adults aged 18 to 75 with seasonal allergic rhinitis (hay fever) who haven't gotten enough relief from standard treatments like nasal sprays or antihistamines. The study compares the drug to a placebo to see…

This trial tests whether an internet-based cognitive behavior therapy (CBT) program can reduce symptoms of anxiety, depression, and stress in adults with mild mental health issues who visit primary care. Participants are randomly assigned to either the online CBT program, which i…

This Phase 3 study tests whether CYB003, a psilocin analog (related to the active ingredient in magic mushrooms), can safely reduce depression symptoms in 330 adults with major depressive disorder. Participants receive either one of two doses of CYB003 or a placebo, along with ps…

This study tests whether a strict high-fat, low-carbohydrate (ketogenic) diet can help ease depression in people with bipolar disorder. Thirty adults aged 18 to 50 with bipolar I or II will follow the diet for 8 weeks while researchers track mood changes and heart health. The goa…

This study tests a new drug called SPT-300 in 360 adults with major depressive disorder, with or without anxiety. Participants will receive either the drug or a placebo for 6 weeks to see if it reduces depression symptoms. The goal is to find a safe and effective new treatment op…

This study compares injections of a patient's own processed fat tissue (MFAT) against standard steroid shots for shoulder osteoarthritis. Researchers will track pain, function, and quality of life in 48 adults aged 25-75. The goal is to see if the fat injection provides better or…

This Phase 3 study tests a once-weekly injection called NNC0487-0111 in 400 adults who are overweight or obese and have knee osteoarthritis. The goal is to see if it helps with weight loss and reduces knee pain compared to a placebo. Participants receive either the active drug or…

This study tests a drug called fezolinetant to see if it can reduce hot flashes in men with prostate cancer who are on hormone therapy (androgen deprivation therapy). About 60 men will take either the drug or a placebo daily for 4 weeks. Researchers will track hot flash frequency…

This study tests whether mentally practicing walking while watching videos of people walking can improve gait in people with multiple sclerosis. Twenty participants will either watch walking videos and imagine themselves walking, or watch nature scenes. Researchers will measure m…

This study tests an experimental daily tablet (PF-08049820) for adults with moderate to severe eczema (atopic dermatitis). About 165 participants will take either the study drug or a placebo for 12 weeks. Researchers will check skin improvement, itching, and safety through clinic…

This Phase 3 trial tests whether fenfluramine (Fintepla) can reduce behavioral and emotional symptoms in people with Rett syndrome. About 200 participants will receive either the drug or a placebo for 14 weeks. The study measures changes in behavior, sleep, and overall condition …

This pilot study tests whether engaging in enjoyable activities and virtual reality can reduce alcohol cravings and drinking in people with alcohol use disorder. About 44 adults will attend up to 10 visits, comparing active sessions (games, VR, crafts) with passive sessions (watc…

This trial tests whether a brief course of savoring meditation—a practice that generates positive emotions—can reduce pain and improve reward system function in people undergoing knee replacement for osteoarthritis. Half of the 150 participants will receive this meditation traini…

This study tests an experimental drug called ITI-1284 for people with generalized anxiety disorder (GAD) whose current treatment isn't working well enough. About 705 adults will receive either ITI-1284 or a placebo added to their usual therapy. The goal is to see if the drug safe…

This study tests a disposable silicone device that clips onto eyeglasses to trap moisture around the eyes. Thirty-five adults with mild to moderate dry eye will wear it for two hours. Researchers will measure tear film stability, tear volume, and symptom changes before and after …

This study tests a three-session training program to help older adults (65+) who use insulin learn to use a continuous glucose monitor (CGM). Participants will be randomly assigned to the program or standard training. The goal is to see if the program improves how often they wear…

This study tests whether a non-invasive earbud that gently stimulates a nerve in the ear can help adult survivors of childhood leukemia who have trouble sleeping. Forty participants will be randomly assigned to receive either active or sham stimulation nightly for 2 to 8 weeks. T…

This study tests whether Acceptance and Commitment Therapy (ACT), delivered through a smartphone app, can help caregivers of children with RASopathies (like Neurofibromatosis type 1 and Noonan syndrome) cope with parenting stress. The trial is fully remote and involves 70 adult c…

This study looks at whether over-the-counter hearing aids can improve communication for older adults with mild cognitive impairment and mild to moderate hearing loss. Fifty participants and their communication partners will be randomly assigned to try hearing aids first or receiv…

This trial tests whether a mild electric current applied to a brain area linked to memory can improve verbal recall in people with relapsing-remitting multiple sclerosis. Participants will receive either active or sham stimulation during cognitive tasks, and their performance wil…

This study tests whether an adapted questionnaire, called the Care Partner Hospital Assessment Tool (CHAT-AD), can help care partners of hospitalized people with Alzheimer's disease or related dementias feel more prepared to provide care after discharge. Participants are unpaid f…

This study explores whether hypnosis can help people with stroke, traumatic brain injury, or multiple sclerosis improve their attention and reduce fatigue. About 48 participants will receive hypnosis sessions alongside standard care, while researchers monitor brain activity with …

This trial tests whether daily music training—either piano practice or listening to music—can improve behavior and thinking in children with fetal alcohol spectrum disorder (FASD). Each child will do both activities for 12 weeks each, in a random order, with tests before and afte…

This trial tests two ways to bring nature to older adults stuck in the hospital for weeks: watching 360-degree nature videos through a virtual reality headset, or listening to audio guides that prompt them to imagine the same scenes. Both approaches use identical nature themes—me…

This pilot study will test whether a mobile phone app can help reduce depression symptoms in African American adults. Eight participants will attend six weekly 90-minute classes through the app and complete surveys over four months. The goal is to see if this approach is effectiv…

This trial explores whether wearing a bright light device for 60 minutes each morning for five weeks can help new mothers with postpartum depression. It focuses on whether the treatment is practical and acceptable to participants, and how it might be implemented in real-world set…

This study tests an experimental drug called icalcaprant for treating depression in people with bipolar I or II disorder. About 195 adults will take either the drug or a placebo daily for 6 weeks. Researchers will measure changes in depression symptoms and watch for side effects.

This study tests whether psilocybin, the active ingredient in magic mushrooms, can help veterans with depression that hasn't improved with at least two other treatments. 240 veterans will receive either psilocybin or a placebo in a controlled setting. The goal is to see if it red…

This trial tests a short virtual program designed to help older adults with early-stage dementia and their family caregivers work together on medication management. The program includes education about dementia, discussions about beliefs around independence and help, and creating…

This pilot study tests a bedtime routine called 'The Power Down' for autistic children aged 6 to 10 who have trouble settling down to sleep. The routine uses gentle massage and calming sounds to help children relax before bed. Caregivers will lead the routine each night for two w…

This phase II trial tests whether esomeprazole, a common acid-reducing drug, can lower the chance of severe esophagitis (inflammation of the food pipe) in people with stage III non-small cell lung cancer receiving radiation therapy. Participants take 40 mg of esomeprazole daily d…

This study tests if a noninvasive, at-home brain stimulation device (tDCS) can safely ease symptoms of major depression. Two hundred adults with depression will use the device themselves at home for 10 weeks, with video check-ins. The goal is to see if this approach reduces depre…

This trial tests whether using a weighted blanket at night and during the day can improve sleep in children aged 5-12 with ADHD who still have sleep problems despite standard care. Half the children will receive a weighted blanket, while the other half gets a non-weighted sham bl…

This study tests whether suvorexant, a sleep medication, can help people with opioid use disorder fall asleep and stay asleep. About 300 participants will receive either suvorexant or a placebo. The goal is to see if the drug improves total sleep time and is safe to use.

This study tests a computer-based therapy for adults with social anxiety disorder. Researchers want to see if it reduces anxiety and improves quality of life. About 80 people aged 18 to 60 with social anxiety will participate. The therapy is designed to be a new, accessible treat…

This study tests two experimental drugs, EXV-802 and EXV-801, to see if they can safely reduce agitation in people with Alzheimer's dementia. About 300 participants aged 55-90 with moderate to severe agitation will receive either the drug or a placebo twice daily for 6 weeks. The…

This study compares two brain-training programs for adults with ME/CFS who experience brain fog. Both programs include computer games and a mild nerve stimulation device, but one focuses on processing speed and daily tasks while the other emphasizes relaxation and healthy habits.…

This study looks at whether a store-bought weighted blanket can help children aged 5-12 with ADHD who have trouble sleeping. 100 kids will use the blanket every night for 4 weeks, and researchers will track their sleep with a wrist monitor. The goal is to see if the blanket incre…

This Mayo Clinic study tests a smartphone app called SleepWell24 to help people with obstructive sleep apnea use their CPAP machine for at least 6 hours a night, 6 nights a week. The app connects to a smart plug and a Fitbit to track CPAP usage, sleep time, and activity. Research…

This trial tests a structured, 8-session program designed to help adults who stutter feel less anxious and more confident in job interviews. The program uses techniques like cognitive restructuring, voluntary stuttering, and simulated interviews to gradually reduce fear of negati…

This study tests whether a nasal spray containing oxytocin (a natural hormone) can help adults with binge-eating disorder eat less often in binges. About 60 adults will receive either the oxytocin spray or a placebo for 8 weeks. Researchers will track changes in binge frequency a…

This study tests a new form of transcranial magnetic stimulation (TMS) for post-traumatic stress disorder (PTSD). Unlike standard TMS, which takes 6-7 weeks, this accelerated version delivers 10 sessions per day for 5 days. Researchers will enroll 40 adults with PTSD to see if ac…

This study tests a cream called roflumilast 0.15% for itching in people with mild to moderate atopic dermatitis (eczema). About 40 participants aged 12 and older will apply the cream once daily for 4 weeks. Researchers will track how patients describe their itch and other skin se…

This study tests whether psilocybin (the active ingredient in magic mushrooms) combined with therapy can help reduce depression, anxiety, and stress in adults whose parents survived genocide. One hundred participants will receive a single 25mg dose under supervision, followed by …

This pilot trial tests an adaptive stepped-care digital intervention to improve sleep in Chinese cancer survivors with mild-to-moderate insomnia. Participants first receive a self-guided web-based CBT-I program or a simple exercise program; those who don't improve may be stepped …

This study tests a combined treatment for older adults who wake up often to urinate and have trouble sleeping. The goal is to see if treating both problems together can reduce bathroom trips and improve sleep quality. Researchers will track changes over 4 months in 192 participan…

This early-stage study tests a drug called CX-011 for moderate to severe knee osteoarthritis pain. About 72 adults aged 18-75 with knee osteoarthritis will receive the drug via injection into the knee joint. The main goals are to check safety and tolerability, and to see if it re…

This study explores whether rhythmic auditory stimulation (like a metronome beat) can improve walking and brain function in people with Alzheimer's disease or mild cognitive impairment. Participants will walk while listening to rhythmic sounds, and researchers will measure change…

This large study tests a collaborative care model (COMPASS+) that adds a mental health care manager to regular obstetric care for pregnant and postpartum people. The care manager offers short-term therapy, tracks symptoms, and works with doctors and a psychiatrist to create perso…

This study investigates whether a single dose of psilocybin, the active compound in magic mushrooms, can reduce rumination—repetitive negative self-focused thinking—in people with major depressive disorder. Researchers will use brain scans to see how psilocybin changes activity i…

This study compares two robot-assisted knee replacement methods for people with severe knee arthritis. One method uses a CT scan to plan the surgery (image-based), while the other uses a simpler approach without a scan (imageless). The goal is to see if the imageless method works…

This study compares two types of stitches (NOVOSYN quick and MONOSYN quick) used in gum surgery to see if they heal equally well. About 84 adults having gum surgery will be randomly assigned one of the two stitches. The main goal is to check early healing signs like skin regrowth…

This study looks at whether teaching people with a colostomy or ileostomy how to care for their stoma helps them adjust better, feel better about their body, and manage their daily life. About 100 adults who had planned stoma surgery will take part. The goal is to see if educatio…

This study tests whether extra support—like personalized mask fitting, monthly phone calls, and a tracking app—helps stroke patients with sleep apnea use their CPAP machine more consistently during rehab. About 250 participants will be randomly assigned to either this intensive s…

This early-stage study tests a new drug called BBT001 in healthy volunteers and adults with moderate-to-severe atopic dermatitis (eczema). The main goal is to check safety and how the drug moves through the body. About 198 participants will receive either BBT001 or a placebo, wit…

This study tests whether a gamified education program can improve health literacy and quality of life in children aged 8-12 with type 1 diabetes. Half of the 52 participants will receive the gamified program plus standard education, while the other half gets standard education al…

This trial tests whether genicular artery embolization (GAE), a procedure that blocks certain blood vessels in the knee, can reduce persistent pain in people with severe knee osteoarthritis who haven't found relief from conservative treatments and may not be candidates for surger…

This trial tests whether a structured talk therapy called ConquerFear can help people with advanced cancer manage their fear of the disease progressing. It compares ConquerFear to a supportive-expressive approach, which focuses on emotional expression and support. The study invol…

This trial tests whether adding a structured patient education program to standard physical therapy helps people with chronic low back pain, knee osteoarthritis, or shoulder pain stick to their prescribed home exercises. Participants will be randomly assigned to receive either st…

This study tests an experimental drug called HBS-301 to see if it can reduce symptoms of idiopathic hypersomnia, a condition causing severe daytime sleepiness, trouble waking up, and fatigue. About 248 adults with moderate to very severe symptoms will receive either the drug or a…

This study tests whether adding a computer task called gaze-contingent music reward therapy (GCMRT) to standard cognitive behavioral therapy (CBT) helps reduce anxiety in children aged 8 to 17. In GCMRT, children look at faces on a screen while pleasant music plays or stops depen…

This study looks at whether a simple, non-needle ear acupressure technique can lower anxiety and pain in women having breast surgery after a first breast cancer diagnosis. About 66 women will either get standard care or standard care plus ear acupressure. The goal is to see if th…

This study tests an experimental oral medication (BMS-986368) to reduce agitation in people with Alzheimer's disease. About 120 participants will receive either a low dose, high dose, or placebo. The main goal is to see if the drug safely decreases agitated behaviors, such as pac…

This study tests if a spray made from ground cardamom seeds and a harmless skin bacteria (Roseomonas mucosa) can improve eczema symptoms in people aged 2 and older. Participants apply the spray 2-3 times a week for 14 weeks and are monitored remotely for about 7 months. Half rece…

This study tests whether a structured nursing program—including patient education, emotional support, and clear communication—can help men feel more resilient and less anxious when undergoing a transrectal prostate biopsy. Around 120 men scheduled for the procedure will receive t…

This study looks at two ways of giving the pain medicine ketorolac to children after heart surgery: as a steady drip or as shots every few hours. The goal is to see if the steady drip reduces the need for stronger opioid pain medicines. About 166 children aged 3 months to 5 years…

This trial tests three pain-relief approaches after a single-visit root canal in people with symptomatic irreversible pulpitis, a painful tooth condition. Participants receive either acetaminophen, an NSAID, or a combination of trypsin-chymotrypsin with acetaminophen for three da…

This trial tests whether kangaroo care—holding a diaper-clad baby skin-to-skin on the chest—can reduce pain during a routine heel-prick blood test in newborns receiving phototherapy for jaundice. It compares two approaches: kangaroo care given by the mother versus by a nurse. The…

This study tests whether the antidepressant duloxetine can help reduce opioid painkiller use after knee replacement surgery. About 150 adults with knee osteoarthritis will receive either duloxetine or a placebo before and after surgery. The goal is to see if duloxetine lowers opi…

This study tests whether low-intensity focused ultrasound (LIFU), a gentle sound wave technique, can safely improve speech fluency in people who stutter. Twenty adults who stutter will receive LIFU or a sham treatment, and researchers will measure changes in stuttering severity a…

This study tests whether adding a special breathing treatment called intrapulmonary percussive ventilation (IPV) to standard care helps patients with pneumonia who are on a breathing machine. About 96 adults will be randomly assigned to receive either standard therapy alone or st…

This study tests Mom-Net, an online cognitive behavioral therapy program with coaching, for low-income mothers with depression whose children are in Head Start. About 960 mothers will be assigned to Mom-Net or usual care, with coaching provided by Head Start staff. The goal is to…

This study tests whether two experimental antibodies, given alone or together, can reduce eye allergy symptoms caused by cat dander. About 570 adults and children aged 8 and older with confirmed cat allergy will receive either the antibodies or a placebo. The main goal is to see …

This study aims to learn more about insulin resistance and diabetes by collecting blood and skin samples from up to 1,200 participants, including patients with severe insulin resistance and their family members. Researchers will study genetics and how insulin works in the body to…

This study will test a new screening program for 3,000 people turning 50 in the Ascoli Piceno province of Italy. Participants will fill out questionnaires and get a blood test to check their risk of developing type 2 diabetes and cardiovascular disease. The goal is to see if this…

This long-term observational study uses MRI scans to track how multiple sclerosis (MS) changes over time in up to 3750 people. Researchers will compare brain images and immune system markers in untreated patients, those on approved therapies, and healthy volunteers. The goal is t…

This natural history study follows up to 4,000 people with inherited bone marrow failure syndromes (IBMFS) and their families to learn why they are prone to certain cancers. Researchers will track health over time, collect genetic samples, and look for clues that separate those w…

This large observational study in Mali is following up to 15,000 pregnant women and children to understand why some get malaria and others don't. Researchers are looking at immune responses, parasite features, and other factors that influence infection and disease severity. The g…

This study is building a large collection of blood, saliva, urine, stool, and tissue samples from people who are at increased risk of cancer, including those with genetic predispositions, survivors of childhood or adult cancer, or those with precancerous conditions. The goal is t…

This study is creating the first large database for Niemann-Pick type C (NPC), a rare disease that damages the brain, liver, and spleen. Researchers will collect blood samples and medical records from 100 people with NPC to link their genes with their symptoms. The goal is to und…

This study will follow 500 people with knee injuries or knee osteoarthritis who receive standard care at a hospital in China. Researchers will collect medical history, imaging, and function tests at the start and then again at 6, 12, and 24 months. The goal is to better understan…

This study looks at why some people with HIV develop Immune Reconstitution Inflammatory Syndrome (IRIS) after starting HIV medications. Researchers will use PET scans and lymph node biopsies to track inflammation and immune recovery in 300 adults. The goal is to better understand…

This study aims to learn more about the genetics and natural history of autoinflammatory diseases, which cause repeated fevers and inflammation. Researchers will study up to 5,000 people, including patients, their relatives, and healthy volunteers. Participants provide blood and …

This study follows 500 people with neurocysticercosis, a brain infection caused by the pork tapeworm. Participants receive standard antiparasitic drugs and anti-inflammatories. Researchers will track their health over many years to understand what factors lead to better or worse …

This study aims to collect cognitive performance data from 1,000 healthy adults aged 18 to 100 using a fully digital, voice-recognition-based testing platform. Participants complete a one-time, 30-45 minute online assessment covering memory, language, attention, and problem-solvi…

This study looks at how the brains of children with anxiety disorders work differently from healthy children. Researchers will use brain scans and thinking tasks to track changes over a year, before and after standard treatments like therapy or medication. The goal is to find pat…

This study looks at the tiny organisms living on our skin—like bacteria and fungi—and how they might differ in people with eczema (atopic dermatitis). Researchers will collect skin samples from healthy volunteers and patients aged 2 to 40 with moderate to severe eczema, as well a…

This study aims to understand what happens in the brain when someone thinks about or attempts suicide. Researchers will use brain scans, sleep monitoring, blood tests, and questionnaires to compare four groups: people with recent suicidal thoughts or attempts, those with past sui…

This study is testing whether a mobile app called Fabla-diabetesMM, which lets people record audio diaries, is easy and helpful for older adults with type 1 or 2 diabetes who also have other health conditions. Thirty participants will use the app and answer questions about their …

This study uses special PET scans to measure inflammation in the brains of people with Alzheimer's, Parkinson's, ALS, and other neurodegenerative diseases. Researchers will compare these scans to those from healthy volunteers to see if inflammation levels differ. The goal is to d…

This study looks at how social behaviors and feelings of connection impact treatment for opioid use disorder. Researchers will collect daily reports from 230 patients and a close friend or family member over several weeks. The goal is to find patterns that could lead to more pers…

This study aims to understand the genetic causes of brain development disorders, including Aicardi syndrome, polymicrogyria, and Dandy-Walker malformation. Researchers will analyze genetic data from 2000 participants with these conditions, all confirmed by MRI. The goal is to use…

This study aims to improve how doctors find and understand pheochromocytomas and paragangliomas, rare tumors that can cause dangerous high blood pressure. Researchers will use advanced imaging scans and genetic testing in up to 3,000 participants to learn more about these tumors.…

This natural history study is observing up to 250 people with Smith-Lemli-Opitz syndrome and related cholesterol disorders, as well as their relatives. Researchers will track symptoms, development, and lab results over several years to find better ways to measure disease progress…

This study looks at how people's immune systems react to infections from parasitic worms, which can cause serious health problems like swelling, blindness, or heart disease. Researchers will evaluate and treat up to 500 participants aged 3 to 100 using standard medical tests and …

This study is following children and adults with olfactory neuroblastoma, a rare cancer of the nasal cavity, to learn more about how the disease behaves over time. Researchers will collect medical records, blood samples, and survey responses from 525 participants to track symptom…

This study looks at whether a drug called fampridine, which blocks potassium channels in the brain, can improve working memory in people with cocaine use disorder. Forty chronic cocaine users will receive either the drug or a placebo and then take memory tests. The goal is to und…

This study looks at whether certain genes make some people more likely to develop eye damage from the drug Plaquenil, which is used for autoimmune diseases like lupus and rheumatoid arthritis. Researchers will compare people who have had eye damage from Plaquenil with those who h…

This study looks at how changing sleep schedules affects attention, mood, and the internal body clock in teens aged 13-17 with ADHD. Over three weeks, participants follow different sleep patterns—including a short-sleep week and a week with extended sleep timed either to match or…

This study at the National Institutes of Health looks at how infections can worsen symptoms in people with mitochondrial disease, a group of disorders that affect energy production in cells. Researchers will evaluate participants' immune systems through blood tests, physical exam…

This study aims to understand the genetic and biological causes of Proteus syndrome, a rare condition causing abnormal growth of bones, skin, and other tissues. Researchers will follow up to 1,500 participants over time, using medical exams, imaging, and blood tests to track how …

This study aims to create a large data repository by collecting smartphone data and daily surveys from 10,000 adults who use alcohol or drugs. Participants will use an app that tracks phone activity and location, and answer short surveys about mood and substance use. The goal is …

This study looks at proteins in lung fluid from 750 people with pneumonia to find biomarkers that could reveal what's causing the lung inflammation. Participants undergo a standard bronchoscopy with lung washings, plus a blood draw. The goal is to better understand different type…

This study aims to find the genetic causes of movement disorders and dementias by analyzing DNA from up to 12,000 participants, including patients and their family members. Researchers will collect blood or saliva samples and look for gene mutations linked to these conditions. Th…

This study aims to better understand why some people experience dangerously low blood sugar (hypoglycemia), especially after fasting. Researchers will admit 1,500 adults to the NIH Clinical Center for controlled fasting and a series of blood tests to measure insulin and other fac…

This study aims to see if people with major depressive disorder have lower levels of an enzyme called PDE4B in their brains compared to healthy volunteers. Researchers will use PET and MRI scans along with an experimental radioactive tracer to measure this enzyme. The study invol…

This observational study uses brain scans (MRI) and behavioral tasks to compare people with and without alcohol dependence. Researchers want to see if differences in brain structure and activity relate to personality, behavior, and genetics. Up to 1,000 adults will participate in…

This study aims to learn more about childhood-onset behavioral, psychiatric, and developmental disorders by observing people of all ages who have these conditions, along with their family members. Researchers will collect medical histories, perform psychiatric assessments, and ma…

This study follows 2,800 unpaid caregivers of people with chronic conditions like diabetes or inherited disorders. Researchers will survey and interview caregivers over up to 5 years to track changes in their health, stress, and social support. The goal is to understand how careg…

This study tests a new approach called RIGHTimeCPV, designed to help children with poor-prognosis cancer and their families talk more openly with doctors about the future. Participants choose a communication companion and attend a special visit to share their preferences. The goa…

This study enrolls people with endocrine tumors (such as thyroid, parathyroid, adrenal, or pancreatic tumors) who are scheduled for surgery or biopsy. Researchers collect samples of the tumor, nearby healthy tissue, blood, and urine to analyze genetic and molecular changes. The g…

This study looks at whether oral nicotine pouches (like ZYN) can be a good substitute for cigarettes or smokeless tobacco. Researchers will test different nicotine levels and forms to see which ones reduce cravings and appeal to users. 160 adult tobacco users will try the pouches…

This study aims to learn more about heart and blood vessel diseases by observing people who have them or are at risk. Researchers will collect samples and perform tests like imaging and stress tests on up to 5,000 participants, including healthy volunteers and relatives of affect…

This study follows up to 4,000 people with vasculitis (a group of diseases that cause blood vessel inflammation) and healthy volunteers over many years. Researchers collect blood, urine, imaging, and genetic samples to learn how the disease develops and changes. The goal is to fi…

This study is testing whether a continuous glucose monitor (CGM) can predict blood sugar problems in people who are at risk for type 1 diabetes but have no symptoms. Researchers will follow 75 people aged 5 to 39 who have diabetes-related autoantibodies. They will compare CGM dat…

This study looks at how common certain antibodies and inflammatory markers are in people with chronic granulomatous disease (CGD). Researchers will measure levels of adenovirus-fighting antibodies and inflammatory cytokines in blood samples from 60 adults and children with CGD. T…

This study tests a new radioactive tracer to see if it can measure brain inflammation in people with Alzheimer's disease or mild cognitive impairment. Researchers will compare scans from 90 volunteers (patients and healthy older adults) to understand how inflammation relates to m…

This pilot study will compare the Clubhouse Model—a structured, community-based program where members work together to run the clubhouse—to standard outpatient care for adults with schizophrenia. Researchers will measure changes in thinking, daily functioning, and brain activity …

This study looks at children and teens ages 7-17 who have severe mood problems like chronic anger, sadness, or irritability, along with extreme tantrums. Researchers will use interviews, tests, and brain imaging to understand what happens in the brain. Up to 2,350 participants wi…

This study aims to learn more about liver diseases like hepatitis B, C, and D by observing up to 8,050 participants over time. Participants will have yearly check-ups, blood and urine tests, and liver ultrasounds. Some may be offered experimental treatments if they qualify. The g…

This study looks at anxiety related to cancer screenings in adults with Fanconi anemia, a rare condition that raises cancer risk. Researchers will observe 20 participants during their regular screening visits, noting body language, worries, and the clinic environment. No treatmen…

This study aims to understand how genetics and environmental factors contribute to melanoma, a serious skin cancer. Researchers will enroll up to 3,000 people with a personal or family history of melanoma or related conditions. Participants will fill out questionnaires, provide b…

This study looks at how alcohol changes a brain protein called PDE4B, which may be linked to alcohol use disorder. Healthy social drinkers aged 21 to 70 will have brain scans before and after receiving alcohol. The goal is to understand how alcohol affects this protein, which cou…

This study looks at how the liver processes fat in people with alcohol use disorder who are quitting drinking. Researchers will take two small liver samples—one early in detox and one after four weeks—to compare gene activity. The goal is to understand how the liver clears fat wh…

This study aims to understand why some people are more prone to fungal infections, especially from Candida yeast. Researchers will collect blood, saliva, urine, and tissue samples from people with immune disorders, their family members, and healthy volunteers. No treatment is giv…

This study aims to uncover genetic changes that cause autoimmune diseases in people native to Peru. Researchers will collect blood, urine, and stool samples from 300 participants, including patients with conditions like lupus and rheumatoid arthritis, their family members, and he…

This study looks at how obesity and body fat affect heart disease risk in 2,000 healthy African American men and women. Researchers will measure body fat, blood fats, and insulin function to see if risk factors differ by sex. The goal is to understand why heart disease rates are …

This observational study is recruiting 2400 people with immune-related central nervous system diseases, such as multiple sclerosis, along with healthy volunteers for comparison. Researchers will use MRI scans, lumbar punctures, blood tests, and neurological exams to track disease…

This study looks at how ketamine affects the brain in people with major depression and healthy volunteers. Researchers use brain scans, blood tests, and other measures to understand why a single dose works quickly but briefly. The goal is to find biomarkers that could lead to bet…

This study aims to learn more about myositis, a group of diseases that cause muscle inflammation and damage. Researchers will observe up to 1,200 children and adults with myositis, along with healthy volunteers, to track changes in the immune system and other health problems over…

This NIH study aims to understand what causes depression in teenagers and how the brain changes with the condition. Researchers will compare depressed teens with healthy ones using interviews, computer tasks, and brain scans. Eligible participants may also receive free talk thera…

This study follows 600 people aged 55 to 85 with early, middle, or late-stage Alzheimer's disease for 12 months. Researchers will track changes in memory, daily activities, behavior, and traditional Chinese medicine symptom patterns. They will also observe whether those receiving…

This study looks at whether ultrasound measurements of thigh muscle and fat can predict how well patients with knee osteoarthritis respond to a genicular nerve block. Researchers will measure muscle thickness and fat under the skin before the procedure and check pain levels one m…

This study aims to understand what causes primary sclerosing cholangitis (PSC), a rare chronic liver disease. About 143 adults with PSC will provide blood, saliva, urine, stool, and tissue samples, plus undergo imaging and procedures like colonoscopy and liver biopsy. No treatmen…

This study looks at how your genes and your environment—like what you eat, breathe, and experience—work together to influence common diseases such as diabetes, heart disease, and asthma. Researchers are collecting health questionnaires, genetic data, and other information from 25…

This study collects blood stem cells and immune cells from healthy volunteers and patients with primary immune deficiencies or blood disorders. The cells are used in the lab to develop new gene and cell therapies. Up to 850 adults aged 18-70 will participate. The goal is to advan…

This study follows up to 30 children (up to age 16) with a rare genetic condition called methylmalonic acidemia (MMA), which affects how the body processes food. The goal is to observe how the disease progresses over time by tracking specific blood tests and health signs. This in…

This study follows 950 people with idiopathic CD4+ lymphocytopenia (ICL), a rare condition where low CD4+ white blood cells raise infection risk. Researchers will track participants for up to 10 years, collecting medical history, blood samples, and infection data. The goal is to …

This study aims to collect information and bone samples from up to 1,000 people with bone or mineral disorders, such as tumor-induced osteomalacia or familial tumoral calcinosis. Participants receive standard medical evaluations and may provide bone tissue from surgery or a biops…

This study uses yearly PET scans to track amyloid protein buildup in the brains of 400 adults aged 55 and older over 5 years. Participants are already part of the Baltimore Longitudinal Study of Aging. The goal is to see how these brain changes relate to memory loss and other thi…

This study tests four different HIV drug regimens in 120 healthy volunteers to see how they affect metabolism and weight. Participants take one of the drugs or a combination for four weeks, with blood tests, body scans, and optional fat biopsies. The goal is to understand why som…

This study aims to find differences between organic tics (related to diagnosed disorders) and functional tics (caused by problems in brain-body communication). Researchers will use sensors to measure muscle activity and brain waves in 75 adults with tics and healthy volunteers. P…

This study looks at whether tiny particles released by fat cells, called adiposomes, carry harmful fats that damage blood vessels in people with obesity and type 2 diabetes. Researchers will test if a 12-week aerobic exercise program or weight-loss surgery can reduce these harmfu…

This study is testing whether artificial intelligence can accurately classify skin pigment, sun sensitivity (phototype), and sun damage from standard photos of the arm. Researchers will enroll 1,500 adults from diverse backgrounds, combining objective color measurements, expert a…

This study looks at whether fungi moving from the gut into the blood can cause inflammation and worsen lung function in people with HIV. Researchers will measure a fungal marker called BDG in blood and urine, and track lung health over three years. The goal is to better understan…

This study looks at whether doulas with extra training in mental health support can help pregnant women in rural Montana feel more confident and less depressed. About 75 pregnant women will be split into three groups: one with a specially trained doula, one with a regular doula, …

This study looks at whether freezing ovarian tissue can help preserve fertility in people aged 2-21 with conditions like Turner syndrome, galactosemia, or premature ovarian insufficiency. Participants may have surgery to remove and freeze a gonad, with a small piece used for rese…

This study aims to create a simple, minimally invasive test to find pancreatic cancer at an early stage and track how well treatment is working. Researchers will study 700 people with pancreatic cancer, pancreatitis, or pancreatic cysts. The goal is to identify biological markers…

This study aims to develop a standardized questionnaire that lets patients with venous malformations report their own symptoms and treatment outcomes. Venous malformations are abnormal veins that can cause pain, swelling, and emotional distress, and current assessments may miss w…

This pilot study explores whether adding a digital health platform called Lōvu to standard prenatal care is practical and well-received by pregnant people. Participants use a Bluetooth scale, blood pressure cuff, and fetal Doppler that send data to their care team, alongside ment…

This study is creating a large collection of microbiome samples—like stool, saliva, and skin swabs—from 600 people of all ages, including healthy volunteers and those with various illnesses. The goal is to build a resource for future research on how the microbiome affects health …

This study looks at how medium-chain and long-chain fatty acids affect metabolism in people with Medium-Chain Acyl-CoA Dehydrogenase Deficiency (MCADD) and healthy individuals. Researchers will measure ketone bodies, resting metabolic rate, and other factors after participants co…

This study looks at whether liver function and blood clotting tests can help doctors better understand and monitor cardiac transthyretin amyloidosis (ATTR-CA), a condition where abnormal protein builds up in the heart. Researchers will compare these tests in people with ATTR-CA a…

This study follows 436 women undergoing hysterectomy for non-cancerous reasons to see if certain pre-surgery assessments can predict who will develop chronic pain lasting months after the operation. Researchers measure pain sensitivity using a pressure device on the shoulders, an…

This study aims to understand why bones weaken with age, leading to conditions like osteoporosis and osteoarthritis. Researchers will collect bone waste and blood samples from 2,000 people undergoing orthopedic surgery, including those with and without bone disease. By analyzing …

This study tests whether simple reminders—called nudges—sent to doctors and patients can increase the use of genetic testing for people with certain conditions like Parkinson's disease, ALS, or heart problems. The trial will compare different ways of prompting genetic testing, su…

This study looks at how chemotherapy for colon or rectal cancer affects thinking and memory. Researchers will track changes in brain function and blood proteins in 60 patients during and after treatment. The goal is to find tests that could identify who is at risk for 'chemo brai…

This study is developing questionnaires to measure how visible tumors in neurofibromatosis type 1 (NF1) affect patients' appearance concerns. About 110 participants, including children, adults, and caregivers, will complete surveys and join focus groups or interviews to give feed…

This study follows 500 adults already receiving care for depression, bipolar disorder, or suicide risk at the NIH. Researchers will conduct weekly interviews and optional tests like blood draws and brain scans to track symptoms and treatment responses. The goal is to better under…

This study tests whether showing an aphasia identification card helps healthy volunteers better understand a person with aphasia. 160 service workers will listen to sentences from a speaker with aphasia, with or without seeing the card first. Researchers will measure comprehensio…

This study investigates how Fabry disease damages the kidneys over time, even before routine tests show problems. Researchers will examine kidney biopsies and function in 50 patients, some of whom receive enzyme replacement therapy. They aim to see if starting treatment earlier o…

This study looks at the long-term health of people who were cured of Cushing disease before age 21. Researchers want to understand how past high cortisol levels affect the body and mind years later. Participants will complete surveys and have check-ups every 5 years. The goal is …

This study looks at how the rotator cuff muscles are doing one and two years after total shoulder replacement surgery. Researchers will use EMG and CT scans to check for nerve damage or tears in the muscles. About 30 adults who had shoulder replacement for osteoarthritis will tak…

This study looks at whether a rapid fingerstick test that gives results in 10-20 minutes can help more people get screened for HIV, hepatitis C, and syphilis during mobile clinic visits. About 200 patients of the WVU Street Medicine team can choose the rapid test, a traditional b…

This study uses advanced MRI (3T fMRI) to look at brain activity in people who have or will have deep brain stimulation (DBS) implants. DBS is a treatment for conditions like Parkinson's disease, tremor, and obsessive-compulsive disorder. The researchers will scan participants un…

This study aims to understand brain changes in people with mild cognitive impairment (MCI) and Alzheimer's disease. Researchers will use MRI, EEG, cognitive tests, and blood and stool samples to find differences between healthy individuals and those with cognitive impairment. The…

This study is testing whether a blood test measuring a protein called LRG can tell if the gut lining has healed in people with ulcerative colitis. Researchers will compare blood LRG levels with colonoscopy and tissue samples in 100 patients. If the blood test works, it could offe…

This study looks at whether a group support program is practical and helpful for female partners of men who have viewed child sexual abuse material. Researchers will check if 15-20 women can be recruited within a year and if they find the program useful. The goal is to understand…

This study looks at how physical activity, sleep, and light exposure relate to mood in people with bipolar disorder, major depression, or no mood disorder. Over two years, participants wear activity monitors and complete smartphone diaries for up to 20 days at a time. The goal is…

This study looks at whether measuring the heart's pumping and relaxing ability in fetuses with growth restriction can signal how well they are doing. Researchers will use a special ultrasound technique to assess heart function in pregnant women after 28 weeks. The goal is to see …

This study follows 842 people with multiple sclerosis who are starting a new under-the-skin injection of ocrelizumab. Researchers will ask participants how satisfied they are with the injection after 1, 6, and 12 months. The goal is to understand patient experience, not to test t…

This study is observing up to 3,500 people with immune system problems, including rare genetic conditions like chronic granulomatous disease and severe combined immunodeficiency. Researchers will track how these diseases change over time through blood tests, imaging, and checkups…

This study aims to learn more about RASopathies, a group of genetic conditions that can cause developmental issues, birth defects, and increased cancer risk. Researchers will follow up to 500 people of any age who have or may have a RASopathy, along with their family members, for…

This study investigates how people with hearing loss, including cochlear implant users, experience listening effort from moment to moment. Researchers will track eye movements and pupil dilation as participants repeat sentences that are manipulated to be harder to understand. The…

This study is gathering medical information and samples from up to 5,000 people with neurosurgical conditions like brain tumors, epilepsy, and Parkinson's disease. Participants receive standard care while their data is collected for future research. No new treatments are being te…

This international observational study will follow 50,000 people with Alzheimer's disease or related dementias for many years. Researchers will collect real-world data from routine doctor visits to track how the disease progresses and how treatments are used and tolerated. The go…

This trial asks whether a gentle electrical current applied to the scalp during language lessons can speed up and improve how adults learn a new language. Healthy adults who are learning or planning to learn a language are randomly assigned to receive either real or sham (placebo…

This study tests whether a single evening yoga session can improve sleep and heart health in adults aged 18–40, both those with insomnia and healthy sleepers. Participants will try a moderate-intensity vinyasa yoga session, a gentle yoga session, and a quiet rest period on separa…

This study explores whether dream yoga practices can improve sleep and reduce anxiety. About 70 healthy adults with mild anxiety will learn techniques using virtual reality and home sleep monitors. The goal is to understand how these practices affect brain activity and dreaming, …

This study aims to understand why people with Alzheimer's disease differ from each other and from healthy older adults. Researchers will use advanced brain imaging (7T MRI), brain wave recordings (EEG), and blood and stool samples to look for patterns that might reflect different…

This study looks at whether giving opioid treatment programs (OTPs) regular reports on how well they retain patients, plus a quality-improvement toolkit, can help more people stay in treatment for at least 90 days. Some clinics will also get extra help from an outside facilitator…

This study enrolls up to 15,000 children with known or suspected endocrine or metabolic disorders, along with their family members. Researchers will collect medical records, blood, saliva, and other samples to identify genetic changes linked to these conditions. The goal is to be…

This study collects blood samples from 10,000 healthy adults using both a fingerstick and a traditional needle draw from the arm. The goal is to compare lab results from the two methods and see how well fingerstick samples hold up after a few days of storage. The findings could h…

This study aims to find biological markers in spinal fluid and blood that could signal the start of prion disease before symptoms appear. Researchers will follow 150 people who carry a genetic mutation for prion disease, along with family members and healthy volunteers. Participa…

This study is tracking how adults with meningitis are treated in about 30 hospitals across Brazil. Researchers will follow 624 patients during their hospital stay and after discharge to see what treatments work best and how patients recover. The goal is to gather real-world evide…

This observational study looks at how the brain responds when watching others perform actions, focusing on the mirror neuron system. Researchers will measure brain activity in healthy adults and infants, including those at risk for developmental delays, using EEG and fNIRS. The g…

This study is testing whether low-intensity focused ultrasound (LIFUS) can safely change brain activity in people with conditions like Parkinson's disease, essential tremor, epilepsy, or substance abuse. Researchers will use brain recordings and movement tests to see if the ultra…

This study screens 360 adults with neurodegenerative disorders like ALS, frontotemporal dementia, and progressive supranuclear palsy. Researchers will use medical history, physical exams, memory tests, movement analysis, MRI scans, and other tests to find common features and diff…

This study follows 650 people aged 8 to 99 with androgen insensitivity syndrome (AIS) to better understand their long-term health. Researchers will track hormones, bone density, heart health, metabolism, and tumor risk through regular check-ups and scans. No treatments are being …

This study investigates how acetate, a substance produced when the body breaks down alcohol, is used by the brain in heavy drinkers. Researchers will use a special imaging technique to track acetate metabolism and measure stress hormone levels. The goal is to understand the link …

This study looks at how exercise changes the amount of sugar the liver makes in people with type 2 diabetes and fatty liver disease. Researchers will measure liver sugar production during rest and exercise in 12 adults aged 25-55. The goal is to better understand how exercise hel…

This study uses a special PET scan to measure amyloid plaques in the brains of 160 people with Alzheimer's disease. Researchers want to see how these plaques relate to race and heart health risks. Participants are already part of a larger Alzheimer's study at the University of Al…

This early-stage study will test how a hemp-based CBD lotion with a small amount of THC is absorbed by the body. Twenty healthy adults will use the lotion in a clean, controlled environment. Researchers will measure cannabinoid levels in saliva, blood, and urine over time to unde…

This early-stage trial is testing how the experimental drug repinatrabit interacts with several common medications, including birth control pills, metformin, and methotrexate. The study involves 48 healthy volunteers and will measure drug levels in the blood to see if combining t…

This study tests whether a short video-based training program, called the ICU Delirium Playbook, can improve how intensive care unit (ICU) nurses understand and recognize delirium—a sudden confusion that affects many critically ill patients. Nurses at one hospital will complete q…

This study tests a 9-session program called Changing Lives and Changing Outcomes-9 for people with serious mental illness who have been involved with the legal system. The program is designed to help participants understand their mental health better and reduce their chances of f…

This study uses an online questionnaire to understand how side effects from antifibrotic medications affect the emotional and social well-being of patients with idiopathic pulmonary fibrosis (IPF) or progressive pulmonary fibrosis (PPF) in Japan. Researchers will ask about patien…

This study will enroll 5,000 adults with chronic heart conditions like heart failure, high blood pressure, or aortic stenosis. Participants will wear a Prolaio digital health patch that monitors heart rate, breathing, and other vital signs. The goal is to observe how these condit…

This study uses a special PET scan to measure a harmful protein called tau in the brains of 160 people with Alzheimer's disease. Researchers want to see how tau buildup relates to a person's thinking abilities, race, and heart health risks. Participants are already part of a larg…

This registry is following 3,000 adults with idiopathic pulmonary fibrosis (IPF) or other chronic fibrosing interstitial lung diseases (ILDs) to understand how these conditions progress over time. Researchers collect information on symptoms, treatments, quality of life, and store…

This study is looking at whether a specific genetic variation, called SLC16A11, influences how well the common diabetes drug metformin lowers blood sugar. Adults with type 2 diabetes will be grouped by whether they carry this gene variant and will take extended-release metformin …

This study is a disease registry that will collect information from 200 people in Egypt who have neurofibromatosis type 1 (NF1), a genetic condition that causes tumors to grow on nerves. The goal is to understand how the disease progresses over time, what treatments patients rece…

This study looks at whether a condition called alexithymia—difficulty recognizing and describing emotions—affects pain levels and quality of life in people with chronic pain who use a spinal cord stimulator. Researchers will ask 20 participants to fill out questionnaires about em…

This Stanford study watches 20 young women for 28 days to see how sleep, body rhythms, and the menstrual cycle work together. Researchers track movement, heart rate, and other body signals. The goal is to learn how these cycles might affect injury risk, not to test a treatment.