Blood-Derived clot may regrow bone in gum disease
NCT ID NCT07764029
First seen Aug 13, 2026 · Last updated Aug 14, 2026 · Updated 1 time
Summary
This trial compares two surgical approaches for treating furcation defects—bone loss where tooth roots split—in adults with periodontitis. One group receives a mix of advanced platelet-rich fibrin (A-PRF+) and bone graft material, while the other gets a collagen membrane with the same graft. The study measures gum healing, bone regrowth via 3D imaging, and patient comfort over six months to see if the blood-derived fibrin offers an advantage.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Advanced platelet-rich fibrin (A-PRF+) combined with bovine xenograft, compared to collagen membrane with xenograft, during periodontal flap surgery.
- What this could lead to
- If effective, this approach could improve bone and gum healing around molars with furcation defects, potentially saving teeth that might otherwise be lost.
- What could go wrong
- This is a small early-stage trial, so results may not apply broadly. Surgery carries risks like infection, pain, or incomplete healing, and the A-PRF+ may not outperform the standard collagen membrane.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Faculty of Dentistry, University of Medicine and Pharmacy at Ho Chi Minh City
RECRUITINGHo Chi Minh City, Ho Chi Minh City (HCMC), 700000, Vietnam
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