Can a DNA-Enriched mouthwash tame gum disease biofilm?
NCT ID NCT06028867
First seen Aug 07, 2026 · Last updated Aug 12, 2026 · Updated 2 times
Summary
This trial tests whether a mouthwash containing chlorhexidine and sodium DNA can better control bacterial biofilm in people with advanced periodontitis (stage III or IV). Participants will receive standard non-surgical gum treatment plus one of two mouthwashes or a placebo, and researchers will compare their effects on subgingival biofilm after two weeks. The goal is to see if the sodium DNA formulation offers extra antimicrobial benefits over chlorhexidine alone.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Chlorhexidine 0.12% + Sodium DNA mouthwash
- What this could lead to
- If effective, this mouthwash could become a simple at-home addition to gum disease treatment, helping to control bacterial biofilm and improve outcomes.
- What could go wrong
- This is a small, early-stage trial, so results may not be conclusive or widely applicable. The mouthwash may not outperform standard care, and side effects like tooth staining are possible with chlorhexidine.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
AOU Policlinico G. Rodolico
Catania, Italy, 95124, Italy
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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