Could family clinics cure hepatitis c as well as specialists?

NCT ID NCT06306300

NEW Recruiting now Disease control Sponsor: Oswaldo Cruz Foundation Source: ClinicalTrials.gov ↗

First seen Aug 17, 2026 · Last updated Aug 17, 2026

Summary

This trial tests whether treating hepatitis C in primary care clinics, with non-specialist doctors, works as well as the standard specialist care in Brazil. It also evaluates the use of rapid tests and self-testing to find more people with the infection. The goal is to see if a simpler, more accessible approach can help more people achieve a cure.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: sofosbuvir/velpatasvir (Epclusa) tablets, with or without specialist follow-up
What this could lead to: If simplified treatment works as well as specialist care, it could make hepatitis C cure accessible to many more people in Brazil and similar settings.
What could go wrong: The trial is large but still needs to show that non-specialist care is truly non-inferior; adherence and follow-up in primary care may be challenging, and results may not generalize beyond Brazil's health system.

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Conditions

The condition(s) this trial relates to.

hepatitis C virus infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEPATITIS C

Contacts and locations

Locations

Evandro Chagas National Institute of Infectious Diseases
RECRUITING

Rio de Janeiro, Rio de Janeiro/RJ, 21040-360, Brazil
Hugo Perazzo
RECRUITING

Rio de Janeiro, Rio de Janeiro, Brazil

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