Pharmacy-Based hepatitis c testing could cure more people on opioid therapy
NCT ID NCT03935906
First seen Jul 17, 2026 · Last updated Jul 17, 2026
Summary
This study tests whether offering hepatitis C testing right in community pharmacies—using a simple finger-prick device—helps more people on opioid therapy get diagnosed and cured compared to the usual approach of referring them to a clinic. Participants are adults on stable methadone or buprenorphine treatment who have a history of injecting drug use. Those who test positive receive a highly effective 8- to 24-week course of antiviral pills.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- direct-acting antiviral treatment (glecaprevir/pibrentasvir) for hepatitis C
- What this could lead to
- If successful, this approach could dramatically increase hepatitis C testing and cure rates among people on opioid therapy, helping eliminate the virus in a high-risk group.
- What could go wrong
- The trial focuses on a specific population and setting, so results may not apply broadly. Also, the intervention relies on nurse availability and patient willingness to engage.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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1,410 people
The number who actually took part.
- Started
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Oct 2019
- Finished
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Jan 2021
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Over 18 years of age. * Previous or current injecting drug user. * Stable OST dose for greater than 12 weeks prior to study enrolment. * Glecaprevir/pibrentasvir treatment naïve. * Able to voluntarily sign and date an informed consent form prior to initiation of any screening or study specific procedures. * Able to understand and adhere to study visit schedule and all other protocol requirements. Exclusion Criteria: * Female who is pregnant, planning to become pregnant or breastfeeding or unwilling/unable to take appropriate birth control. * Known current HIV infection. * Known current HBV infection. Serological: patients with a positive HBsAg or isolated positive anti-HBC will be excluded from the study and followed up in secondary care. * Previous treatment with glecaprevir/pibrentasvir. * Currently taking any concomitant medication that has a warning of'do not co-administer' with glecaprevir and/or pibrentasvir as defined by the Liverpool Hep drug interactions website and product SmPC. * Clinically significant abnormalities that make candidate unsuitable for this study in the opinion of the investigator including but not limited to: * Uncontrolled cardiac, respiratory, gastrointestinal, hematologic, neurologic, psychiatric or other medical disease or disorder, which is unrelated to existing HCV infection. * History of either current or previous decompensated liver disease or symptoms/signs of decompensation e.g. ascites noted on physical exam, use of beta-blockers for portal hypertension, hepatic encephalopathy or oesophageal variceal bleeding. * Candidate is deemed unsuitable to receive study drugs by the study investigator, for any reason according to clinical judgement. * Unable or unwilling to provide informed consent. * History of severe, life-threatening or other significant sensitivity to any excipients of the study drugs. * Drug-drug Interaction which may have safety concerns with any concomitant medication the patient is receiving including non-prescribed and/or recreational drugs.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
NHS Tayside
Dundee, Scotland, United Kingdom
-
Public Health Wales
Cardiff, Wales, United Kingdom
-
The Burnet Institute
Melbourne, Australia
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