Pharmacy-Based hepatitis c testing could cure more people on opioid therapy

NCT ID NCT03935906

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 17, 2026 · Last updated Jul 17, 2026

Summary

This study tests whether offering hepatitis C testing right in community pharmacies—using a simple finger-prick device—helps more people on opioid therapy get diagnosed and cured compared to the usual approach of referring them to a clinic. Participants are adults on stable methadone or buprenorphine treatment who have a history of injecting drug use. Those who test positive receive a highly effective 8- to 24-week course of antiviral pills.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
direct-acting antiviral treatment (glecaprevir/pibrentasvir) for hepatitis C
What this could lead to
If successful, this approach could dramatically increase hepatitis C testing and cure rates among people on opioid therapy, helping eliminate the virus in a high-risk group.
What could go wrong
The trial focuses on a specific population and setting, so results may not apply broadly. Also, the intervention relies on nurse availability and patient willingness to engage.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

1,410 people

The number who actually took part.

Started

Oct 2019

Finished

Jan 2021

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Over 18 years of age. * Previous or current injecting drug user. * Stable OST dose for greater than 12 weeks prior to study enrolment. * Glecaprevir/pibrentasvir treatment naïve. * Able to voluntarily sign and date an informed consent form prior to initiation of any screening or study specific procedures. * Able to understand and adhere to study visit schedule and all other protocol requirements. Exclusion Criteria: * Female who is pregnant, planning to become pregnant or breastfeeding or unwilling/unable to take appropriate birth control. * Known current HIV infection. * Known current HBV infection. Serological: patients with a positive HBsAg or isolated positive anti-HBC will be excluded from the study and followed up in secondary care. * Previous treatment with glecaprevir/pibrentasvir. * Currently taking any concomitant medication that has a warning of'do not co-administer' with glecaprevir and/or pibrentasvir as defined by the Liverpool Hep drug interactions website and product SmPC. * Clinically significant abnormalities that make candidate unsuitable for this study in the opinion of the investigator including but not limited to: * Uncontrolled cardiac, respiratory, gastrointestinal, hematologic, neurologic, psychiatric or other medical disease or disorder, which is unrelated to existing HCV infection. * History of either current or previous decompensated liver disease or symptoms/signs of decompensation e.g. ascites noted on physical exam, use of beta-blockers for portal hypertension, hepatic encephalopathy or oesophageal variceal bleeding. * Candidate is deemed unsuitable to receive study drugs by the study investigator, for any reason according to clinical judgement. * Unable or unwilling to provide informed consent. * History of severe, life-threatening or other significant sensitivity to any excipients of the study drugs. * Drug-drug Interaction which may have safety concerns with any concomitant medication the patient is receiving including non-prescribed and/or recreational drugs.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • NHS Tayside

    Dundee, Scotland, United Kingdom

  • Public Health Wales

    Cardiff, Wales, United Kingdom

  • The Burnet Institute

    Melbourne, Australia

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