Magic Mushroom-Derived drug enters final trial for depression

NCT ID NCT06793397

Recruiting now Symptom relief Sponsor: Cybin IRL Limited Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Aug 14, 2026 · Updated 8 times

Summary

This Phase 3 study tests whether CYB003, a psilocin analog (related to the active ingredient in magic mushrooms), can safely reduce depression symptoms in 330 adults with major depressive disorder. Participants receive either one of two doses of CYB003 or a placebo, along with psychological support. The main goal is to see if the drug improves depression scores over time.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: CYB003 (a psilocin analog)
What this could lead to: If successful, this could provide a new treatment option for people with major depression who haven't responded well to standard antidepressants.
What could go wrong: This is a Phase 3 trial, but results are not yet known. The drug may not work better than placebo, and side effects (including psychological effects) are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Depression depressive disorder major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEPRESSION DEPRESSION - MAJOR DEPRESSIVE DISORDER DEPRESSION DISORDER DEPRESSION DISORDERS DEPRESSION IN ADULTS MAJOR DEPRESSIVE DISORDER (MDD)

Contacts and locations

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Locations

A-SHINE s.r.o.
NOT_YET_RECRUITING

Předměstí, Czechia
ATP Clinical Research
RECRUITING

Orange, California, 92866, United States
Accel Research Sites - Maitland
RECRUITING

Maitland, Florida, 32751, United States
Adams Clinical Philadelphia
RECRUITING

Philadelphia, Pennsylvania, 19104, United States

Contact Email: •••••@•••••
Aqualane Clinical Research
RECRUITING

Naples, Florida, 34105, United States
Ascend Clinical Research
RECRUITING

Reading, RG7 8PA, United Kingdom
Atlas Psychiatry
RECRUITING

New Orleans, Louisiana, 70115, United States
Attikon University Hospital
RECRUITING

Athens, 12462, Greece
Austin Clinical Trial Partners
NOT_YET_RECRUITING

Austin, Texas, 78737, United States

Contact Email: •••••@•••••
Behavioral Research Specialists, LLC
RECRUITING

Glendale, California, 91206, United States
Bio Behavioral Health
RECRUITING

Toms River, New Jersey, 08755, United States
Brain Health Consultants and TMS Center
RECRUITING

Houston, Texas, 77046, United States

Contact Email: •••••@•••••
CNS Healthcare
RECRUITING

Jacksonville, Florida, 32256, United States
CalNeuro Research Group
RECRUITING

Los Angeles, California, 90025, United States

Contact Email: •••••@•••••
Cambridge University Hospital NHS
RECRUITING

Cambridge, CB1 2EU, United Kingdom
Central Institute of Mental Health
NOT_YET_RECRUITING

Mannheim, 68159, Germany
Centrum Badan Klinicznych PI-House Sp. z o.o
RECRUITING

Gdansk, 80-546, Poland
Charité Universitaetsmedizin Berlin
NOT_YET_RECRUITING

Berlin, 10117, Germany
Clerkenwell Health - Baker Street
RECRUITING

London, W1U 6RP, United Kingdom
Clerkenwell Health - Doncaster
RECRUITING

Doncaster, DN4 8QN, United Kingdom
Clerkenwell Health - Welbeck Street
WITHDRAWN

London, W1G 8DR, United Kingdom
Core Clinical Research
NOT_YET_RECRUITING

Everett, Washington, 98201, United States
Department of Pharmacology and Physiology of CNS
NOT_YET_RECRUITING

Warsaw, 02-957, Poland
Edwardson Building - Campus for Ageing and Vitality
RECRUITING

Newcastle upon Tyne, NE4 5PL, United Kingdom
Eginitio Hospital
RECRUITING

Athens, 11528, Greece
Emory University Dept of Psychiatry and Behavioral Studies
NOT_YET_RECRUITING

Atlanta, Georgia, 30329, United States
Flourish Research Philadelphia
RECRUITING

Philadelphia, Pennsylvania, 19462, United States
Flourish Research San Antonio
RECRUITING

San Antonio, Texas, 78229, United States
Inland Psychiatric Medical Group Inc (IPMG Research)
NOT_YET_RECRUITING

San Juan Capistrano, California, 92675, United States

Contact Email: •••••@•••••
Institute for Integrative Therapies
RECRUITING

Eden Prairie, Minnesota, 55347, United States
Institute of neuropsychiatric Care (INEP)
NOT_YET_RECRUITING

Prague, Czechia

Contact Email: •••••@•••••
Johns Hopkins Medicine
NOT_YET_RECRUITING

Baltimore, Maryland, 21224, United States
King's College London
RECRUITING

London, SE5 9RS, United Kingdom
La Nua Day Hospital Mental Health Centre
RECRUITING

Galway, H91 VE03, Ireland
Lighthouse Psychiatry
RECRUITING

Gilbert, Arizona, 85234, United States
MTZ Clinical Research Powered by Pratia
RECRUITING

Warsaw, 02-172, Poland
Monash University - Notting Hill
RECRUITING

Notting Hill, Victoria, 3168, Australia
NHS Research Scotland
NOT_YET_RECRUITING

Edinburgh, EH16 4TJ, United Kingdom
NRC Research Institute
RECRUITING

Orange, California, 92868, United States
Neurocentrix Research
RECRUITING

Melbourne, Victoria, 3053, Australia
New York State Psychiatric Institute
NOT_YET_RECRUITING

New York, New York, 10032, United States
North Texas Clinical Trials
NOT_YET_RECRUITING

Fort Worth, Texas, 76104, United States
Papageorgiou General Hospital
RECRUITING

Thessaloniki, 56404, Greece
Pillar Clinical Research - Little Rock
NOT_YET_RECRUITING

Little Rock, Arkansas, 72204, United States
Promente - Centrum Neurologii i Psychogeriatrii w Bydgoszczy
RECRUITING

Bydgoszcz, 85-133, Poland
Psych Atlanta
RECRUITING

Marietta, Georgia, 30060, United States

Contact Email: •••••@•••••
Psychedelic Science Institute
RECRUITING

Santa Monica, California, 90404, United States

Contact Email: •••••@•••••
Psyon s.r.o.
NOT_YET_RECRUITING

Prague, Czechia

Contact Email: •••••@•••••
Queen Elizabeth University Hospital
NOT_YET_RECRUITING

Glasgow, G51 4TF, United Kingdom
Ramsay Clinic
RECRUITING

Melbourne, Victoria, 3004, Australia
Re:Cognition Health
RECRUITING

London, W1G9 RU, United Kingdom
Royal Prince Alfred Hospital
RECRUITING

Camperdown, New South Wales, 2050, Australia
Rush University
RECRUITING

Chicago, Illinois, 60612, United States
SP Research PLLC
NOT_YET_RECRUITING

Oklahoma City, Oklahoma, 73112, United States
Seattle Neuropsychiatric Treatment Center
RECRUITING

Seattle, Washington, 98104, United States

Contact Email: •••••@•••••
Sheaf House - Tallaght Adult Mental Health Service
RECRUITING

Dublin, D24 WK80, Ireland
Sheffield Health and Social Care NHS Foundation Trust
RECRUITING

Sheffield, S4 7QQ, United Kingdom
St Pancras Clinical Research
RECRUITING

London, EC2Y 8EA, United Kingdom
Stanford University
NOT_YET_RECRUITING

Stanford, California, 94305, United States
Sun Valley Research Center
NOT_YET_RECRUITING

Imperial, California, 92251, United States
Tandem Clinical Research
NOT_YET_RECRUITING

Marrero, Louisiana, 70006, United States
Thompson Brain & Mind Healthcare (TBMH)
RECRUITING

Maroochydore, Queensland, 4558, Australia
UAB Psychiatry and Behavioral Neurology
RECRUITING

Birmingham, Alabama, 35209, United States

Contact Email: •••••@•••••
UCK
NOT_YET_RECRUITING

Gdansk, 80-214, Poland
University Hospital Frankfurt
NOT_YET_RECRUITING

Frankfurt am Main, 60528, Germany
Universitätsklinikum des Saarlandes und Medizinische Fakultät der Universität des Saarlandes
NOT_YET_RECRUITING

Homburg, Saarland, 66421, Germany
Uniwersytecki Szpital Kliniczny W Białymstoku
NOT_YET_RECRUITING

Bialystok, 15-272, Poland
Yale School of Medicine - Yale Program for Psychedelic Science
RECRUITING

New Haven, Connecticut, 06511, United States

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