MAJOR DEPRESSIVE DISORDER (MDD)

This study tests whether non-drug approaches—like physical activity, cognitive training, and dietary supplements—can reduce depression symptoms and help prevent memory decline in adults aged 50–80 with major depressive disorder. Participants will be randomly assigned to different…

This study tests a long-acting injection of cariprazine given once a month under the skin. It is for people with schizophrenia, bipolar I disorder, or major depressive disorder who are stable on other medications. The goal is to check safety, how the drug moves in the body, and i…

This study is testing whether an experimental medication called ACP-211 can help adults with major depressive disorder who haven't gotten better with standard antidepressant treatments. Researchers will compare ACP-211 against a placebo (inactive pill) to see if it reduces depres…

This study looks at whether lifestyle changes—like regular exercise, cognitive training, and a Mediterranean diet—can help prevent memory and thinking problems in people aged 50 to 80 who have depression or depressive symptoms but no current cognitive decline. Researchers will co…

This study tests whether fecal microbiota transplantation (FMT) — transferring gut bacteria from a healthy donor — can help adults with major depression who don't get better quickly on standard antidepressants. About 214 participants will receive either FMT or a placebo, and rese…

This study tests a fast-acting, non-invasive treatment called transcranial magnetic stimulation (TMS) for teens and young adults aged 15-25 with depression and suicidal thoughts. Over 5 days, participants receive brain stimulation guided by MRI, with no surgery or medication invo…

This study tests whether a safe, non-invasive brain stimulation method called tDCS can reduce depression symptoms when used at home. About 438 adults with moderate to severe depression will either receive tDCS plus their usual care or just usual care for 10 weeks. The goal is to …

This study tests whether a safe, non-invasive brain stimulation technique called tDCS can reduce depressive symptoms in people with borderline personality disorder (BPD). Sixty adults with BPD and moderate-to-severe depression will receive either real or fake (sham) tDCS sessions…

This study compares two new group therapies for adults with major depression. One therapy helps change rigid negative thoughts, while the other boosts sensitivity to positive experiences. 150 participants will be randomly assigned to one of the therapies or a waiting list, and th…

This study tests whether a gentle, at-home brain stimulation technique called tDCS is safe and practical for people with depression that hasn't improved with standard treatments. Ten adults in San Diego will use a headset for three hours a day, five days a week, for two weeks, un…

This study tests whether a 5-day course of deep transcranial magnetic stimulation (dTMS) can safely reduce depression in adults aged 60-85 who haven't gotten relief from antidepressants. Participants receive either real or placebo stimulation to see if the treatment is well-toler…

This study tests whether a new drug called milsaperidone can help adults with major depression who haven't gotten enough relief from their current antidepressant. About 500 people will receive either milsaperidone or a placebo pill alongside their usual medication. The main goal …

This study tests a new pill combining dextromethorphan and bupropion in 30 adults with major depression. Participants take the medication for two weeks and undergo brain scans to see if it changes how the brain responds to rewards. The goal is to understand if this treatment can …

This study tests if Lemborexant, a sleep medication, can help adults with depression who still have insomnia despite treatment. About 30 participants will take either Lemborexant or a placebo daily for 6 weeks, tracking sleep and symptoms. The goal is to see if the drug improves …

This study tests whether a noninvasive magnetic brain stimulation technique called TMS can improve symptoms in people with major depression. Researchers will target the orbitofrontal cortex, a brain area involved in mood and decision-making. About 80 adults with moderate to sever…

This large study in Pakistan tests a three-step mental health plan for breast cancer survivors who also have depression. Over 26,000 women who finished initial cancer treatment will receive either the adaptive plan (starting with self-help, then therapy, then medication if needed…

This study tests whether deep transcranial magnetic stimulation (dTMS) is safe and helpful for teens aged 14-18 who are in the hospital for major depression. Sixty participants will receive either real or sham dTMS alongside their usual care. The goal is to see if dTMS can ease d…

This study tests whether adding ketamine tablets to a new antidepressant can reduce depression symptoms faster in adults with major depressive disorder. Twelve participants will take four doses of ketamine over one week while starting a standard antidepressant. The goal is to see…

This study tests whether using magnetic brain stimulation (TMS) right before electroconvulsive therapy (ECT) can make ECT work better and faster for people with severe, treatment-resistant depression. About 50 adults will receive both treatments, and researchers will measure chan…

This study tests whether a new drug called CYB003 can safely reduce symptoms of major depression. About 330 adults with moderate to severe depression will receive either CYB003 or a placebo. The goal is to see if CYB003 improves mood and daily function better than a placebo.

This study tests a new nasal spray called PRT-042 (a form of ketamine) to see if it can quickly reduce depression and suicidal thoughts in adults with major depressive disorder. About 98 participants will receive either the spray or a placebo. The main goal is to measure changes …

This study tests whether a new medicine called DT-101 can help ease depression symptoms in adults. About 300 people with major depressive disorder will receive either DT-101 or a placebo (a dummy pill) for several weeks. Researchers will track mood changes using standard question…

This study tests a noninvasive, at-home brain stimulation device (tDCS) for people with major depression. Two hundred adults will use the device themselves at home for 10 weeks, with video check-ins. The goal is to see if it safely reduces depressive symptoms compared to a placeb…

This early-stage study tests whether suvorexant, a medication used for insomnia, is safe and tolerable for veterans with major depression who are at risk for suicide. Thirty participants will take the drug daily for four weeks and complete in-person and remote assessments. The go…

This study tests a new drug called SPN-821 in 230 adults with major depressive disorder who are already taking an antidepressant but still have symptoms. Participants will receive either SPN-821 or a placebo for about a month to see if the drug safely improves depression more tha…

This study tests whether adding a physical therapy program—including gentle exercise and health education—to standard care can improve quality of life for adults hospitalized with major depression. About 50 participants will take part in twice-weekly sessions. The goal is to see …

This study tests a new drug called SPT-300 to see if it can safely reduce symptoms of major depression in adults. About 360 people aged 18 to 65 with depression will receive either the drug or a placebo for 6 weeks. The main goal is to measure changes in depression severity using…

This study tests a new therapy that uses real-time brain scans (fMRI) to help people with major depression retrain their attention away from negative thoughts. 80 adults aged 18-65 with moderate to severe depression will receive either real or fake (sham) neurofeedback while doin…

This study looks at whether adding structured exercise to a type of brain stimulation called iTBS can improve depression symptoms in people whose depression hasn't responded well to standard treatments. Twenty physically inactive adults with difficult-to-treat depression will eit…

This study explores whether a simple, non-invasive eye-tracking test using virtual reality can detect early cognitive decline in people with Alzheimer's disease, mild cognitive impairment, or depression-related memory problems. Researchers will measure how pupils react during mem…

This study looks at how ketamine works in the brain to quickly improve mood in people with major depression. Ten adults with treatment-resistant depression will get a ketamine infusion and have special brain scans to measure changes in glutamate, a key brain chemical. The goal is…

This study is testing whether a smartphone app called EMOCARE can accurately measure depression symptoms compared to standard questionnaires. About 104 adults with mild to severe depression will use the app for 6 weeks and complete several mood surveys. The goal is to see if the …

This study will follow 1,000 teenagers hospitalized for major depression or bipolar disorder. Researchers will collect data from blood tests, brain scans, wearable devices, and questionnaires to identify new risk factors and build models that predict how well a teen will respond …

This study looks at how depression affects women and men differently, focusing on symptoms, stigma, and the ability to bounce back from stress. Researchers will compare 90 adults diagnosed with major depressive disorder to better understand these differences. The goal is to help …

This study looks at how a brain protein called mGluR5 might be involved in why treating insomnia with therapy (CBT-I) also helps depression. About 42 adults with major depression and trouble sleeping will get CBT-I and have brain scans and sleep tests. The goal is to understand t…

This study explores whether a non-invasive nerve stimulation on the ear (taVNS) can improve motivation and mood in people with depression, and whether insulin sensitivity (how well the body uses sugar) affects these results. Researchers will recruit 120 participants (60 with depr…

This study watches 204 people with depression to see if brain activity returns to normal after taking antidepressants. If it does, doctors may try stopping the medication and check if depression stays away. Participants get brain tests, sleep recordings, and blood draws over seve…

This study uses powerful 7T MRI brain scans and visual perception tests to find biological markers for severe mental disorders like major depression, schizophrenia, and bipolar disorder. Researchers will compare 320 patients and healthy volunteers aged 18-45 to improve diagnosis …

This study tests whether using a life history calendar—a simple grid that helps people recall important life events—can improve how accurately adults in Hong Kong remember and report past mental health problems. Researchers will compare the standard interview method with the cale…

This study looks at brain activity in 100 adults with major depression who are receiving a type of brain stimulation called accelerated TMS. Researchers use a special imaging technique (TD-fNIRS) to measure brain responses before, during, and after treatment. The goal is to find …

This study observes 200 people already taking psychedelics in other trials to understand how these drugs change brain processing. Researchers use brain scans, computer tasks, and interviews to measure shifts in learning, perception, and electrical activity. The goal is to predict…