MAJOR DEPRESSIVE DISORDER (MDD)

This study tests whether a combination of physical activity, cognitive training, and dietary supplements can reduce depression symptoms and prevent memory or thinking problems in people with Major Depressive Disorder (MDD). Researchers will enroll 120 adults aged 50-80 who have M…

This study tests a long-acting injection of cariprazine given once a month, instead of daily pills, for people with schizophrenia, bipolar I disorder, or major depression. The trial involves 24 clinically stable adults and will check safety, side effects, and how well the drug wo…

This study is testing whether lifestyle changes—like following a Mediterranean diet, exercising regularly, or doing cognitive training—can prevent cognitive decline and improve mood in people aged 50 to 80 who have depressive symptoms or major depression but no current memory pro…

This study tests whether a specially designed bright light can improve cognitive problems like memory and attention in people with major depressive disorder. 120 adults with depression and cognitive issues will receive either the bright light or a dim red placebo light for four w…

This Phase 3 study tests whether CYB003, a psilocin analog (related to the active ingredient in magic mushrooms), can safely reduce depression symptoms in 330 adults with major depressive disorder. Participants receive either one of two doses of CYB003 or a placebo, along with ps…

This study tests whether adding a probiotic (Lactobacillus crispatus) to the antidepressant sertraline helps reduce depression symptoms more than sertraline alone in teens aged 12-18 with major depressive disorder. Sixty participants will take either the probiotic or a placebo fo…

This study tests whether adding multi-strain probiotics to the antidepressant sertraline helps teenagers aged 12-18 with major depression feel better than sertraline alone. Over 8 weeks, 120 participants will take either the combination or sertraline with a placebo. Researchers w…

This study tests a new medicine called ACP-211 in adults with major depression who haven't gotten better with standard antidepressants. About 153 people will receive either the drug or a placebo for 28 days. The main goal is to see if ACP-211 reduces depression symptoms more than…

This Phase 2 trial tests whether TNX-102 SL, a tablet taken under the tongue at bedtime, can improve depression symptoms in adults with moderate to severe major depressive disorder. About 360 participants will receive either the drug or a placebo nightly for 6 weeks. Researchers …

This phase 2 trial tests whether DT-101 can ease depression symptoms in adults with major depressive disorder who are already on antidepressant medication. About 118 participants will receive either DT-101 or a placebo, and researchers will track changes in depression scores over…

This study tests whether inhaling DMT, a psychedelic drug, can quickly reduce symptoms of major depression and suicidal thoughts. 140 adults with moderate-to-severe depression will receive either a high or low dose of DMT in two puffs. Those not improved after a week can get an e…

This study tests an accelerated form of transcranial magnetic stimulation (TMS) for people with major depression that hasn't improved with medication. Over five days, 35 adults will receive multiple sessions of targeted brain stimulation. Researchers will track changes in depress…

This study tests whether four intravenous ketamine infusions over two weeks can reduce suicidal thoughts in 36 adults with major depression. Participants will also have two MRI brain scans to see if changes in brain structure relate to symptom improvement. The goal is to both tre…

This study tests a new drug called SPT-300 in 360 adults with major depressive disorder, with or without anxiety. Participants will receive either the drug or a placebo for 6 weeks to see if it reduces depression symptoms. The goal is to find a safe and effective new treatment op…

This study tests whether a noninvasive magnetic stimulation technique called TMS can improve symptoms in people with major depressive disorder. Researchers will target a brain region involved in emotion and reward processing. The study will enroll 80 adults with moderate to sever…

This study tests whether psilocybin (the active ingredient in magic mushrooms) can safely reduce depression in adults with COPD, ALS, MS, or atypical Parkinson disease who have at least 6 months to live. Participants receive either two moderate-to-high doses (15mg then 25mg) or t…

This study tests if Lemborexant, a sleep medication, can improve sleep in adults whose depression is already treated but who still have insomnia. About 30 participants will take either the drug or a placebo daily for 6 weeks, tracking sleep with diaries and a wearable device. The…

This pilot study tests whether a home-use device that sends a mild electrical current to the brain (tDCS) can reduce depressive symptoms in people with borderline personality disorder (BPD). Sixty participants will receive either real or sham stimulation twice daily for one week.…

This Phase 2 trial tests whether DT-101 can reduce depression symptoms in adults with major depressive disorder. About 300 participants will receive either DT-101 or a placebo for 6 weeks, and researchers will track mood changes using standard depression scales. The study is curr…

This study tests whether a medication called dextromethorphan-bupropion (Auvelity) can change brain activity related to reward and motivation in adults with major depression. Thirty participants will take the pill daily for two weeks and undergo brain scans to see if the drug aff…

This study tests whether a new drug called SPN-821 can help adults with major depressive disorder who are already taking an antidepressant. About 230 participants will receive either SPN-821 or a placebo for 29 days. The main goal is to see if the drug reduces depression symptoms…

This study tests if a noninvasive, at-home brain stimulation device (tDCS) can safely ease symptoms of major depression. Two hundred adults with depression will use the device themselves at home for 10 weeks, with video check-ins. The goal is to see if this approach reduces depre…

This study tests a three-stage mental health plan for breast cancer survivors in Pakistan who also have depression. Over 26,000 women will start with guided self-help, then move to therapy or medication if needed. The goal is to see if this step-by-step approach can reduce depres…

This study tests a non-invasive brain stimulation treatment called TMS for teens and young adults (ages 15-25) with depression and suicidal thoughts. Over 5 days, participants receive 10 sessions of magnetic pulses per day, guided by MRI scans. Researchers want to see if this fas…

This Phase 3 study tests whether adding milsaperidone to standard antidepressant therapy helps adults with major depressive disorder who still have symptoms. About 500 participants will receive either milsaperidone or a placebo, and researchers will measure changes in depression …

This study tests whether deep transcranial magnetic stimulation (dTMS) is safe and helpful for teens aged 14-18 who are hospitalized with major depression and suicidal thoughts. About 60 participants will receive either real or sham dTMS alongside their usual care. The goal is to…

This study tests two new group therapies for adults with major depression. One therapy helps change rigid negative expectations, while the other boosts sensitivity to positive experiences. 150 participants will be randomly assigned to one of the therapies or a waiting list, and t…

This study tests a safe, non-invasive brain stimulation treatment called tDCS that people can use at home to ease depression. About 438 adults with major depression will either receive active tDCS plus their usual care, or just usual care alone. The goal is to see if adding tDCS …

This study tests a nasal spray containing (R)-Ketamine, a fast-acting drug, in 98 adults with major depression who are currently having suicidal thoughts. Participants receive either the spray or a placebo twice a week for 4 weeks. The goal is to see if the spray can quickly redu…

This study tests whether a safe, at-home brain stimulation device called tDCS can help people with depression that hasn't improved with standard treatments. Ten participants will use the device at home under remote supervision for two weeks. The goal is to see if the approach is …

This pilot study tests whether a physical therapy program—including gentle exercise, strength training, and relaxation—plus education about physical activity can improve quality of life and health in adults hospitalized for major depression. About 50 participants will receive the…

This study tests whether giving transcranial magnetic stimulation (TMS) right before electroconvulsive therapy (ECT) can lower the amount of electricity needed for ECT and speed up its antidepressant effects. Fifty adults with major depression that hasn't responded to other treat…

This study tests if adding structured exercise to a brain stimulation treatment called iTBS can help people with depression that hasn't improved with medication. Twenty physically inactive adults with difficult-to-treat depression will either get iTBS alone or iTBS plus exercise.…

This study tests whether a fecal microbiota transplant (FMT) — transferring healthy gut bacteria from a donor — can help adults with major depression who aren't getting better with standard antidepressants. About 214 participants will receive either FMT or a placebo, and research…

This study tests a new therapy that uses real-time brain scans (fMRI) to help people with major depression shift their attention away from negative thoughts. 80 adults aged 18-65 with depression will receive either real or fake neurofeedback while doing a task. The goal is to see…

This study tests whether a 5-day course of deep transcranial magnetic stimulation (dTMS) can safely reduce depression in adults aged 60-85 who haven't improved with medication. Participants receive either real or placebo stimulation to the brain's anterior cingulate cortex. The g…

This phase 2 trial tests whether suvorexant (Belsomra), a drug approved for insomnia, is safe and tolerable for veterans with major depression who are at high risk for suicide. Thirty veterans will take the drug nightly for four weeks, with in-person and remote check-ins. The stu…

This study looks at whether parents of people with bipolar II disorder or major depressive disorder have certain personality traits (called Type D, which involves negative emotions and social inhibition) and lower life satisfaction. Researchers compare these parents to parents of…

This early study is testing whether adding the drug memantine (used for Alzheimer's) to a standard antidepressant can improve how the brain processes memories in people with major depression. Thirty adults aged 18-50 will take an SSRI for 11 weeks, and for the last 6 weeks they w…

This study is looking at how environmental factors in cities—like air pollution, noise, and lack of green space—affect people with depression, anxiety, or alcohol use disorder. Researchers will have 680 participants wear smartwatches to track heart rate, activity, and other body …

This study checks how well a new version of a mental health interview (CIDI 5.0) can identify people who have had depression, anxiety, or PTSD at some point in their lives. Researchers in Hong Kong will interview 300 adults and compare the results with a detailed clinical assessm…

This study follows 252 people whose major depression is in remission to find early warning signs of relapse. Researchers will track symptoms, physical activity, sleep, thinking skills, and brain activity. The goal is to build a model that tells doctors who is likely to relapse an…

This observational study at Yale University is recruiting 200 people who are already taking part in another trial where they may receive a serotonergic psychedelic (like psilocybin or LSD) or a placebo. Researchers want to understand how these substances change the brain's inform…

This study uses powerful 7T MRI scanners and visual perception tests to find biological markers for severe mental disorders like major depression, schizophrenia, and bipolar disorder. Researchers will compare brain chemistry and vision in 320 patients and healthy volunteers. The …

This study aims to understand how ketamine produces rapid antidepressant effects by using a special brain scan (GluCEST) to measure changes in glutamate, a key brain chemical. Ten adults with treatment-resistant depression will receive a single ketamine infusion and undergo imagi…

This study looks at how depression affects men and women differently. Researchers will measure depression severity, stigma, and psychological resilience in 90 adults diagnosed with major depressive disorder. The goal is to better understand gender-specific symptoms and help creat…

This study tests whether using a life history calendar—a simple grid that helps people recall important life events—can improve the accuracy of mental health surveys. Researchers in Hong Kong will ask 2,500 adults about their mental health using either a standard interview or one…

This study uses virtual reality and eye-tracking to measure how pupils react during memory tasks. Researchers hope to find a simple, non-invasive way to detect early cognitive decline in Alzheimer's disease, mild cognitive impairment, and depression. 140 adults will be tested at …

This study looks at how cognitive behavioral therapy for insomnia (CBT-I) changes a specific brain receptor (mGluR5) in people with major depression. 42 adults with depression and insomnia will receive online CBT-I and undergo PET brain scans before and after treatment. The goal …

This study is testing whether a smartphone app called EMOCARE can accurately track emotional changes in people with mild to severe depression. About 104 adults will use the app for 6 weeks while also filling out standard depression questionnaires. The goal is to see if the app gi…

This study looks at whether brain activity tests can tell if it's safe for people with depression to stop taking antidepressants. About 204 people will have brain scans, sleep tests, and blood draws to see if their brains return to normal with treatment. The goal is to find a way…

This study tests whether a mild, non-invasive electrical stimulation of the vagus nerve through the ear can improve motivation and mood in people with depression. Researchers will compare 60 depressed patients and 60 healthy controls, looking at how insulin sensitivity affects th…

This study looks at brain activity in 100 adults with major depression who are receiving a treatment called accelerated TMS. Researchers use a special brain scanner (TD-fNIRS) to see if patterns of brain activity can predict who will respond well to the treatment. Healthy volunte…

This study is tracking 1,000 teenagers hospitalized for depression or bipolar disorder. Researchers will collect blood samples, brain scans, wearable device data, and psychological tests to identify patterns that predict how well a teen responds to treatment. The goal is to find …