Brain wave clues: could inflammation markers forecast ECT outcomes?

NCT ID NCT07748091

Recruiting now Knowledge-focused Sponsor: Istanbul University - Cerrahpasa Source: ClinicalTrials.gov ↗

First seen Aug 05, 2026 · Last updated Aug 06, 2026 · Updated 1 time

Summary

This study looks at whether brain wave patterns and inflammation markers in the blood can help predict how well electroconvulsive therapy (ECT) works for people with severe depression that hasn't improved with medication. Researchers will measure these markers before and after ECT in about 62 participants, including a healthy control group. The goal is to understand the brain changes linked to ECT and potentially guide more personalized depression treatment in the future.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Electroconvulsive therapy (ECT) using the Thymatron System IV device
What this could lead to: If successful, this could help doctors predict which patients with treatment-resistant depression will respond to ECT, and could pave the way for more personalized treatment approaches.
What could go wrong: This is an early-stage, observational study with a small number of participants. It aims to find patterns, not prove a treatment works, and the results may not apply to all patients. ECT itself carries risks like memory problems and confusion.

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Conditions

The condition(s) this trial relates to.

Depressive Disorder, Treatment-Resistant major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MAJOR DEPRESSION MAJOR DEPRESSION MODERATE MAJOR DEPRESSION SEVERE MAJOR DEPRESSION WITH COMORBID ANXIETY SYMPTOMS MAJOR DEPRESSION WITH PANIC ATTACKS MAJOR DEPRESSION WITH PSYCHOTIC FEATURES MAJOR DEPRESSIVE DISORDER (MDD) MAJOR DEPRESSIVE EPISODE

Contacts and locations

Locations

İstanbul University- Cerrahpasa, Cerrahpasa Medicine Faculty, Psychiatry Department
RECRUITING

Istanbul, Bakırköy, Turkey (Türkiye)

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