MAJOR DEPRESSIVE EPISODE

This small pilot study is testing whether people who have recently gotten better from severe depression can use a simple, portable brain stimulation device at home to help keep their symptoms from coming back. Participants who improved after hospital treatment will use the device…

This study is testing a new, non-invasive brain stimulation method using focused ultrasound for people with treatment-resistant depression. Researchers will use MRI scans to personalize the treatment target and monitor brain activity during stimulation. The trial aims to see if t…

This study is testing a new tool designed to prevent major depression. It provides 1,000 Canadian adults at high risk for depression with personalized information about their risk and self-help strategies, guided by a coach. Researchers want to see if this approach motivates peop…

This study is testing if adding the drug ketamine to a standard antidepressant (venlafaxine) helps hospitalized patients with severe depression feel better more quickly. It will involve 60 adults with major depression to see if the combination reduces symptoms faster, lowers suic…

This study aims to identify biological markers that predict how well different brain stimulation and medication treatments work for severe depression and obsessive-compulsive disorder (OCD). Researchers will collect data from 1,000 patients receiving treatments like electroconvul…

This study aims to understand the brain changes linked to depression that starts after a COVID-19 infection. Researchers will use special brain scans to look at the brain chemistry of 90 adults who developed depression within 3 months of having mild or moderate COVID. The goal is…