MAJOR DEPRESSIVE EPISODE

This pilot study tests whether a gentle, at-home brain stimulation device (tDCS) can help people with depression maintain their improvement after successful hospital treatments like esketamine, rTMS, or ECT. Thirty adults who have already improved will use the device for 30 minut…

This study tests a personalized tool that shares a person's risk of depression and suggests self-help strategies, guided by a coach. Researchers will recruit 1,000 high-risk adults across Canada and follow them for 12 months. The goal is to see if the tool reduces new cases of ma…

This study tests whether a single dose of ketamine, given alongside the antidepressant venlafaxine, can relieve severe depression faster than venlafaxine alone. About 60 hospitalized adults with major depression will receive either ketamine or a placebo. The goal is to see if ket…

This observational study looks at brain changes in people who developed major depression within 3 months after a mild or moderate COVID-19 infection. Researchers will use special PET scans to measure two brain chemicals in 90 adults aged 18 to 75. The goal is to understand the bi…

This study is testing a new, non-invasive way to stimulate the brain using focused ultrasound for people with depression. Researchers will use MRI scans to personalize the treatment for each of the 30 participants, aiming to see if it safely changes brain activity and improves mo…

This study follows 1,000 adults with hard-to-treat depression or OCD who are getting advanced treatments like ECT, TMS, or ketamine. Researchers collect brain scans, voice recordings, and other tests before, during, and after treatment. The goal is to find biological markers that…