MAJOR DEPRESSIVE EPISODE

This pilot study tests whether a portable, at-home brain stimulation device (tDCS) can help people with depression maintain the improvements they achieved during hospital treatment with esketamine, rTMS, or ECT. Thirty adults will use the device for 30 minutes a day, five days a …

This study tests whether a coach-guided, personalized risk communication tool can help prevent major depression in adults at high risk. Researchers will recruit 1,000 participants across Canada and randomly assign them to receive either the coach-guided tool or standard depressio…

This study tests whether wearing a headset that delivers a flickering 60Hz white light for 30 minutes a day can help ease depression symptoms. Adults with major depressive disorder will use the device at home for three weeks. Researchers will measure how well people stick with th…

This study tests a new, non-invasive brain stimulation method using low-intensity ultrasound waves aimed at specific brain areas linked to depression. Researchers will personalize the treatment for each of the 30 participants based on their brain scans. The goal is to see if this…

This study tests a smartphone app called Edra PRO that lets doctors check in on patients with moderate to severe depression remotely. About 594 adults will either use the app plus usual care or just usual care for 6 months. The goal is to see if the app helps reduce symptoms and …

This study tests whether a digital program on an iPad, combined with learning thinking strategies, can improve mood and mental skills in people who have had a stroke. The study will include 70 adults who had a first stroke at least 6 months ago and now have depression and trouble…

This Phase 3 trial tests whether adding intravenous ketamine to the antidepressant venlafaxine can relieve severe depression faster than venlafaxine alone. Sixty hospitalized adults with major depression will receive either ketamine or placebo infusions over one week. The goal is…

This study tests whether a gentle brain stimulation technique called tDCS, done at home, can improve sleep quality in adults with moderate depression. Researchers will track sleep changes and see if better sleep leads to better mood. The study involves 35 participants and aims to…

This study is a registry that will follow up to 1,000 adults with treatment-resistant depression or obsessive-compulsive disorder (OCD) who receive electroconvulsive therapy (ECT), transcranial magnetic stimulation (TMS), or ketamine/esketamine. Researchers will collect data from…

This study uses PET and MRI scans to look at brain changes in people who developed depression within three months after a mild or moderate COVID-19 infection. Researchers will compare brain scans of 90 participants to see if key brain chemicals are altered. The goal is to better …