Brain wave patterns and inflammation: a clue to ECT's effectiveness in older adults?

NCT ID NCT07740694

Recruiting now Knowledge-focused Sponsor: Istanbul University - Cerrahpasa Source: ClinicalTrials.gov ↗

First seen Jul 31, 2026 · Last updated Jul 31, 2026

Summary

This study investigates whether brain wave patterns (measured by EEG) and inflammatory markers in the blood can help predict how well older adults with depression or bipolar disorder respond to electroconvulsive therapy (ECT). Researchers will compare EEG recordings and blood samples taken before and after ECT treatment, looking for changes that correlate with clinical improvement. The goal is to better understand how ECT works in the aging brain and potentially identify biomarkers that could guide personalized treatment decisions.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Electroconvulsive therapy (ECT) using the Thymatron System IV device
What this could lead to: If successful, this could help predict which older adults with depression or bipolar disorder will benefit most from ECT, and may guide more personalized treatment decisions.
What could go wrong: This is an observational study, so it won't directly test a new treatment. The findings may not apply to all patients, and the relationship between biomarkers and ECT response could be complex and not definitive.

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Conditions

The condition(s) this trial relates to.

bipolar depression bipolar disorder catatonia Depressive Disorder, Treatment-Resistant major affective disorder 6 major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BIPOLAR AFFECTIVE DISORDER BIPOLAR ANHEDONIC DEPRESSION BIPOLAR DEPRESSION BIPOLAR DEPRESSION DEPRESSED PHASE CATATONIA MAJOR DEPRESSION MODERATE MAJOR DEPRESSION SEVERE MAJOR DEPRESSION WITH COMORBID ANXIETY SYMPTOMS MAJOR DEPRESSION WITH PANIC ATTACKS MAJOR DEPRESSION WITH PSYCHOTIC FEATURES MAJOR DEPRESSIVE EPISODE

Contacts and locations

Locations

İstanbul University- Cerrahpasa, Cerrahpasa Medicine Faculty, Psychiatry Department
RECRUITING

Istanbul, Bakırköy, Turkey (Türkiye)

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