BIPOLAR DEPRESSION

This study tests whether a personalized nutrition plan can reduce heart disease risk in people with bipolar disorder. Participants will work with a dietitian in group and one-on-one sessions. The goal is to improve blood markers, weight, and overall heart health. The study is for…

This study tests if deep brain stimulation (DBS) can help people with severe bipolar depression that hasn't improved with other treatments. DBS involves surgically placing electrodes in the brain to send electrical pulses. The goal is to improve mood and daily function, but it's …

This study tests whether starting a stronger, six-week treatment plan early can help people with bipolar depression who did not get better with their first medication. About 418 adults will either receive the intensified treatment or continue with standard care. The goal is to se…

This study tests whether giving a stronger medication earlier helps people with schizophrenia, major depression, or bipolar depression whose first treatment didn't work. About 1,254 adults will receive either standard second-line treatment or an early intensified third-line treat…

This study tests an experimental drug called azetukalner to see if it can safely reduce depression in people with bipolar I or II disorder. About 400 adults currently in a depressive episode will receive either the drug or a placebo for 6 weeks. The main goal is to measure change…

This study tests if a gentle, non-invasive brain stimulation called HD-tDCS can reduce depression in 100 teens (ages 12-18) with bipolar disorder. Half get real stimulation, half get a fake version, and researchers track mood changes and brain activity over two weeks. The goal is…

This study tests if a type of brain stimulation called theta-burst stimulation can reduce depression symptoms in people with bipolar disorder that hasn't improved with other treatments. About 124 adults will receive either real or fake (sham) stimulation daily for 30 days. Resear…

This study tests whether time restricted eating (eating only during a 10-hour window each day) is a practical and helpful addition to usual treatment for people with bipolar disorder. Researchers will compare TRE to standard nutritional counseling in 40 adults with bipolar I or I…

This study tests a non-invasive treatment called deep transcranial magnetic stimulation (dTMS) for people with bipolar depression. About 100 adults aged 18-65 will receive either real or fake dTMS alongside their usual medication for 4 weeks. Researchers will check if it safely r…

This study tests whether a strict high-fat, low-carbohydrate (ketogenic) diet can help reduce depression in people with bipolar disorder. Researchers will track mood changes and heart health in 30 adults aged 18-50. Participants must be willing to change their diet completely for…

This study looks at how tiny changes in RNA, a molecule in your cells, might help predict whether depression treatments will work. Researchers at Mayo Clinic will follow 120 adults with unipolar or bipolar depression to see if these RNA changes relate to improvements in mood. The…

This study follows 1,000 adults with hard-to-treat depression or OCD who are getting advanced treatments like ECT, TMS, or ketamine. Researchers collect brain scans, voice recordings, and other tests before, during, and after treatment. The goal is to find biological markers that…