BIPOLAR DEPRESSION

This study is testing whether an investigational medicine called azetukalner can help reduce depressive symptoms in adults with bipolar I or II disorder. About 400 participants will be randomly assigned to receive either the study drug or a placebo for 6 weeks. Researchers will m…

This study is testing whether a surgically implanted brain stimulation device can help control severe depression in people with bipolar disorder who haven't responded to other treatments. Ten participants will have the device implanted and then be closely monitored for 20 months …

This study is testing if a more intense medication approach works better for people with bipolar depression when their first treatment fails. It will compare a stronger, three-drug combination given early against the usual second-choice treatment. The goal is to see if this faste…

This study is testing whether following a strict high-fat, low-carbohydrate (ketogenic) diet can help reduce depressive symptoms in people with bipolar disorder. Researchers will enroll 30 adults with bipolar depression to follow the diet and closely track changes in their mood, …

This study is testing whether a nutrition program can help lower the risk of heart disease in people with bipolar disorder. People with bipolar disorder have a much higher risk of heart problems. Researchers will work with 88 adults to see if following specific dietary guidelines…

This large international study is testing a new treatment strategy for serious mental health conditions. It aims to see if using more powerful, combination medications right after a person's first treatment fails works better than the standard, slower approach. The trial will enr…

This study is testing whether gentle, non-invasive brain stimulation can help reduce depression symptoms in teenagers with bipolar disorder. One hundred participants aged 12-18 will receive either real or fake stimulation for 10 days while continuing their regular care. Researche…

This study is testing whether a non-invasive brain stimulation technique called iTBS can help reduce depression symptoms in people with bipolar disorder who haven't responded well to other treatments. Participants will receive either real or sham stimulation for 30 days, with res…

This study is testing whether a non-invasive magnetic brain stimulation treatment can help people with bipolar depression feel better. One hundred participants will receive either real or fake stimulation alongside their regular medication to see if it reduces depression symptoms…

This study aims to identify biological markers that predict how well different brain stimulation and medication treatments work for severe depression and obsessive-compulsive disorder (OCD). Researchers will collect data from 1,000 patients receiving treatments like electroconvul…

This study aims to understand if changes in a person's RNA can help predict how well they will respond to antidepressant medications. Researchers will enroll 120 adults with unipolar or bipolar depression and measure their RNA alongside their treatment progress. The goal is to ga…