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Could early use of stronger drugs transform mental health treatment?

NCT ID NCT05603104

Recruiting now Disease control Sponsor: Dr. Inge Winter Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether giving stronger medications earlier can help people with schizophrenia, major depression, or bipolar depression who did not get better with their first treatment. Over 1,200 participants will receive either standard second-line treatment or an intensified third-line treatment. The goal is to see if early intensification reduces symptoms and prevents unnecessary failed treatments.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Clozapine, Esketamine, Escitalopram, Sertraline, Venlafaxine, Lithium, Valproate, Quetiapine
What this could lead to
If successful, this could show that using stronger medications earlier improves outcomes and reduces the need for multiple failed treatments.
What could go wrong
This is a large Phase 3 trial, but results may not apply to all patients. Some medications have serious side effects, and the study is still recruiting.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

bipolar depression bipolar disorder major depressive disorder schizoaffective disorder schizophrenia schizophreniform disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BIPOLAR DEPRESSION MAJOR DEPRESSIVE DISORDER SCHIZOPHRENIA AND RELATED DISORDERS

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Sheba Medical Center

    RECRUITING

    Ramat Gan, Israel

    Contact Email: •••••@•••••

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